1.
Ganoderma lucidum (Reishi) inhibits cancer cell growth and expression of key molecules in inflammatory breast cancer.
- Martínez-Montemayor MM, Acevedo RR, Otero-Franqui E, Cubano LA, Dharmawardhane SF.
- Nutr Cancer. Author manuscript. 2011 Sep 2;63(7):1085-94. doi: 10.1080/01635581.2011.601845.
- PMCID: PMC3201987
Martínez-Montemayor MM, et al.

Nutr Cancer. Author manuscript. 2011.

PMCID: PMC3201987

Herein we describe the potential of the medicinal mushroom Ganoderma lucidum (Reishi) as an attractive candidate for anti-IBC therapy. Reishi contains biological compounds that are cytotoxic against cancer cells. ...These findings suggest that Reish …

Herein we describe the potential of the medicinal mushroom Ganoderma lucidum (Reishi) as an attractive candidate for an …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum ( Reishi ) inhibits cancer cell growth and expression of key molecules in inflammatory breast cancer.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
2.
Evaluation on quality consistency of Ganoderma lucidum dietary supplements collected in the United States.
- Wu DT, Deng Y, Chen LX, Zhao J, Bzhelyansky A, Li SP.
- Sci Rep. 2017 Aug 10;7(1):7792. doi: 10.1038/s41598-017-06336-3.
- PMCID: PMC5552695
Wu DT, et al.

Sci Rep. 2017.

PMCID: PMC5552695

Ganoderma lucidum is a well-known medicinal mushroom. At present, numerous G. lucidum products have emerged in the form of dietary supplements in the United States due to its various benefits. ...In this study, 19 batches of products of G. lucidum (Red …

Ganoderma lucidum is a well-known medicinal mushroom. At present, numerous G. lucidum products have emerged in the form …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Evaluation on quality consistency of Ganoderma lucidum dietary supplements collected in the United States.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Quality/authentication methods study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Analytical validation (specificity/sensitivity), reference standards, and mislabeling rates. Open article.
- Why might this paper be useful to readers? Useful for quality control, sourcing, and preventing adulteration. Open article.
3.
Anti-tumor effects of Ganoderma lucidum (reishi) in inflammatory breast cancer in in vivo and in vitro models.
- Suarez-Arroyo IJ, Rosario-Acevedo R, Aguilar-Perez A, Clemente PL, Cubano LA, Serrano J, Schneider RJ, Martínez-Montemayor MM.
- PLoS One. 2013 Feb 28;8(2):e57431. doi: 10.1371/journal.pone.0057431.
- PMCID: PMC3585368
Suarez-Arroyo IJ, et al.

PLoS One. 2013.

PMCID: PMC3585368

The medicinal mushroom Ganoderma lucidum (Reishi) was tested as a potential therapeutic for Inflammatory Breast Cancer (IBC) using in vivo and in vitro IBC models. ...Our results provide evidence that Reishi suppresses protein synthesis and tumor growt …

The medicinal mushroom Ganoderma lucidum (Reishi) was tested as a potential therapeutic for Inflammatory Breast Cancer …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Anti-tumor effects of Ganoderma lucidum ( reishi ) in inflammatory breast cancer in in vivo and in vitro models.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
4.
The beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk.
- Chan SW, Tomlinson B, Chan P, Lam CWK.
- Pharm Biol. 2021 Dec;59(1):1161-1171. doi: 10.1080/13880209.2021.1969413.
- PMCID: PMC8409941
Chan SW, et al.

Pharm Biol. 2021.

PMCID: PMC8409941

The search terms used were Ganoderma lucidum, Lingzhi, Reishi, cardiovascular, hypoglycaemic, diabetes, dyslipidaemia, antihypertensive, and anti-inflammatory. ...CONCLUSIONS: The inconsistent evidence about the potential health benefits of G. lucidum …

The search terms used were Ganoderma lucidum, Lingzhi, Reishi, cardiovascular, hypoglycaemic, diabetes, dyslipidaemia, …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
5.
A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Reishi Mushroom (Ganoderma lucidum), Stinging Nettle (Urtica dioica), and Epimedium (Epimedium sagittatum).
- Younger J, Donovan EK, Hodgin KS, Ness TJ.
- Int J Environ Res Public Health. 2021 Apr 1;18(7):3671. doi: 10.3390/ijerph18073671.
- PMCID: PMC8037868
Younger J, et al.

Int J Environ Res Public Health. 2021.

PMCID: PMC8037868

We used a placebo-controlled, pseudo-randomized, crossover design to test the effects of reishi mushroom (Ganoderma lucidum), stinging nettle (Uritca dioica), and epimedium (Epimedium sagittatum) in 29 men with GWI. ...GWI symptom severity was unchanged from …

We used a placebo-controlled, pseudo-randomized, crossover design to test the effects of reishi mushroom (Ganoderma lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Reishi Mushroom ( Ganoderma lucidum ), Stinging Nettle (Urtica dioica), and Epimedium (Epimedium sagittatum).. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Participant-reported outcomes, clinical biomarkers, and safety/tolerability. Open article.
- Why might this paper be useful to readers? Provides early human data; interpret with caution and check study size and endpoints. Open article.
6.
Valorization of various lignocellulosic wastes to Ganoderma lucidum (Curtis) P. Karst (Reishi Mushroom) cultivation and their FT-IR assessments.
- Akcay C, Arslan R, Ceylan F.
- PLoS One. 2025 Jul 22;20(7):e0328732. doi: 10.1371/journal.pone.0328732.
- PMCID: PMC12282901
Akcay C, et al.

PLoS One. 2025.

PMCID: PMC12282901

Ganoderma lucidum (Curtis) P. Karst (Reishi) has significant pharmacological benefits, and optimizing its cultivation on diverse substrates enhances its commercial viability. ...FT-IR spectra indicated that this method could effectively elucidate the biodegra …

Ganoderma lucidum (Curtis) P. Karst (Reishi) has significant pharmacological benefits, and optimizing its cultivation o …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Valorization of various lignocellulosic wastes to Ganoderma lucidum (Curtis) P. Karst ( Reishi Mushroom) cultivation and their FT-IR assessments.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
7.
Use of Ganoderma lucidum (Ganodermataceae, Basidiomycota) as Radioprotector.
- González A, Atienza V, Montoro A, Soriano JM.
- Nutrients. 2020 Apr 19;12(4):1143. doi: 10.3390/nu12041143.
- PMCID: PMC7230513
González A, et al.

Nutrients. 2020.

PMCID: PMC7230513

For millennia, naturopaths and physicians have used Ganoderma lucidum (reishi mushroom) for its diverse therapeutic properties, as recorded in the oldest Chinese herbal encyclopedia. ...In vivo studies reveal the efficiency of G. lucidum aqueous extrac …

For millennia, naturopaths and physicians have used Ganoderma lucidum (reishi mushroom) for its diverse therapeutic pro …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Use of Ganoderma lucidum (Ganodermataceae, Basidiomycota) as Radioprotector.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
8.
Self-Medication with Ganoderma lucidum ("Reishi") to Combat Parkinson's Disease Symptoms: A Single Case Study.
- Kuypers KPC.
- J Med Food. 2020 Nov 9;24(7):766-773. doi: 10.1089/jmf.2020.0137.
- PMCID: PMC8311956
Kuypers KPC.

J Med Food. 2020.

PMCID: PMC8311956

Preclinical research suggests that the Traditional Chinese Medicine Ganoderma lucidum ("Reishi") can alleviate symptoms in neurological disorders like PD. However, no clinical research to date has addressed this. An (unmedicated) patient, 50 years of age and …

Preclinical research suggests that the Traditional Chinese Medicine Ganoderma lucidum ("Reishi") can alleviate symptoms …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Self-Medication with Ganoderma lucidum (" Reishi ") to Combat Parkinson's Disease Symptoms: A Single Case Study.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
9.
Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors.
- Hajjaj H, Macé C, Roberts M, Niederberger P, Fay LB.
- Appl Environ Microbiol. 2005 Jul;71(7):3653-8. doi: 10.1128/AEM.71.7.3653-3658.2005.
- PMCID: PMC1168986
Hajjaj H, et al.

Appl Environ Microbiol. 2005.

PMCID: PMC1168986

Ganoderma lucidum is a medicinal fungus belonging to the Polyporaceae family which has long been known in Japan as Reishi and has been used extensively in traditional Chinese medicine. ...We found that these oxygenated sterols from G. lucidum inhibited …

Ganoderma lucidum is a medicinal fungus belonging to the Polyporaceae family which has long been known in Japan as Reishi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
10.
The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation [corrected].
- Liu D, Gong J, Dai W, Kang X, Huang Z, Zhang HM, Liu W, Liu L, Ma J, Xia Z, Chen Y, Chen Y, Wang D, Ni P, Guo AY, Xiong X.
- PLoS One. 2012 May 2;7(5):e36146. doi: 10.1371/journal.pone.0036146.
- PMCID: PMC3342255
Liu D, et al.

PLoS One. 2012.

PMCID: PMC3342255

BACKGROUND: Ganoderma lucidum (Reishi or Ling Zhi) is one of the most famous Traditional Chinese Medicines and has been widely used in the treatment of various human diseases in Asia countries. ...We performed comprehensive annotation for G. lucidum ge …

BACKGROUND: Ganoderma lucidum (Reishi or Ling Zhi) is one of the most famous Traditional Chinese Medicines and has been …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation [corrected].. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 2

11.
Chemical, biochemical, preclinical and clinical studies of Ganoderma lucidum polysaccharide as an approved drug for treating myopathy and other diseases in China.
- Zeng P, Guo Z, Zeng X, Hao C, Zhang Y, Zhang M, Liu Y, Li H, Li J, Zhang L.
- J Cell Mol Med. 2018 Apr 24;22(7):3278-3297. doi: 10.1111/jcmm.13613.
- PMCID: PMC6010762
Zeng P, et al.

J Cell Mol Med. 2018.

PMCID: PMC6010762

Ganoderma lucidum is an edible medicinal mushroom known as "Lingzhi" in China and "Reishi or Manetake" in Japan. ...The large-scale production of the drug began in 1985 and approved by the Chinese FDA as "Polysaccharidum of G. lucidum Karst Injection" …

Ganoderma lucidum is an edible medicinal mushroom known as "Lingzhi" in China and "Reishi or Manetake" in Japan. ...The …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Chemical, biochemical, preclinical and clinical studies of Ganoderma lucidum polysaccharide as an approved drug for treating myopathy and other diseases in China.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
12.
Identifying the "Mushroom of Immortality": Assessing the Ganoderma Species Composition in Commercial Reishi Products.
- Loyd AL, Richter BS, Jusino MA, Truong C, Smith ME, Blanchette RA, Smith JA.
- Front Microbiol. 2018 Jul 16;9:1557. doi: 10.3389/fmicb.2018.01557.
- PMCID: PMC6055023
Loyd AL, et al.

Front Microbiol. 2018.

PMCID: PMC6055023

Species of Ganoderma, commonly called reishi (in Japan) or lingzhi (in China), have been used in traditional medicine for thousands of years, and their use has gained interest from pharmaceutical industries in recent years. Globally, the taxonomy of Ganoderma …

Species of Ganoderma, commonly called reishi (in Japan) or lingzhi (in China), have been used in traditional medicine for thou …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Identifying the "Mushroom of Immortality": Assessing the Ganoderma Species Composition in Commercial Reishi Products.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
13.
Ganoderma lucidum Extract Modulates Gene Expression Profiles Associated with Antioxidant Defense, Cytoprotection, and Senescence in Human Dermal Fibroblasts: Investigation of Quantitative Gene Expression by qPCR.
- Kühnel H, Seiler M, Feldhofer B, Ebrahimian A, Maurer M.
- Curr Issues Mol Biol. 2025 Feb 18;47(2):130. doi: 10.3390/cimb47020130.
- PMCID: PMC11854148
Kühnel H, et al.

Curr Issues Mol Biol. 2025.

PMCID: PMC11854148

This study investigated the potential of Ganoderma lucidum (Reishi) ethanol extract to modulate the senescent phenotype of human dermal fibroblasts. Reishi powder of two different vendors was used. The extract was produced by extracting the Reishi …

This study investigated the potential of Ganoderma lucidum (Reishi) ethanol extract to modulate the senescent phenotype …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Extract Modulates Gene Expression Profiles Associated with Antioxidant Defense, Cytoprotection, and Senescence in Human Dermal Fibroblasts: Investigation of Quantitative Gene Expression by qPCR.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
14.
Assessment of Cosmetic Properties and Safety of Use of Model Washing Gels with Reishi, Maitake and Lion's Mane Extracts.
- Ziemlewska A, Wójciak M, Mroziak-Lal K, Zagórska-Dziok M, Bujak T, Nizioł-Łukaszewska Z, Szczepanek D, Sowa I.
- Molecules. 2022 Aug 10;27(16):5090. doi: 10.3390/molecules27165090.
- PMCID: PMC9412612
Ziemlewska A, et al.

Molecules. 2022.

PMCID: PMC9412612

Water extracts of Grifolafrondosa (Maitake), Hericiumerinaceus (Lion's Mane) and Ganoderma lucidum (Reishi) were tested for their antioxidant properties, bioactive substances content, skin cell toxicity, ability to limit TEWL, effect on skin hydration and pH, …

Water extracts of Grifolafrondosa (Maitake), Hericiumerinaceus (Lion's Mane) and Ganoderma lucidum (Reishi) were tested …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Assessment of Cosmetic Properties and Safety of Use of Model Washing Gels with Reishi , Maitake and Lion's Mane Extracts.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
15.
Resolution of Cutaneous Sarcoidosis Following Topical Application of Ganoderma lucidum (Reishi Mushroom).
- Saylam Kurtipek G, Ataseven A, Kurtipek E, Kucukosmanoglu İ, Toksoz MR.
- Dermatol Ther (Heidelb). 2016 Feb 11;6(1):105-9. doi: 10.1007/s13555-016-0099-4.
- PMCID: PMC4799037
Saylam Kurtipek G, et al.

Dermatol Ther (Heidelb). 2016.

PMCID: PMC4799037

Ganoderma lucidum (reishi mushroom) has been used in traditional Chinese and Japanese medicine as a herbal remedy for over 2000 years. Studies have shown that G. lucidum has anti-allergic, anti-oxidant, anti-tumor, anti-viral, and anti-inflammatory pro …

Ganoderma lucidum (reishi mushroom) has been used in traditional Chinese and Japanese medicine as a herbal remedy for o …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Resolution of Cutaneous Sarcoidosis Following Topical Application of Ganoderma lucidum ( Reishi Mushroom).. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
16.
Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes.
- Liao SF, Liang CH, Ho MY, Hsu TL, Tsai TI, Hsieh YS, Tsai CM, Li ST, Cheng YY, Tsao SM, Lin TY, Lin ZY, Yang WB, Ren CT, Lin KI, Khoo KH, Lin CH, Hsu HY, Wu CY, Wong CH.
- Proc Natl Acad Sci U S A. 2013 Aug 1;110(34):13809-14. doi: 10.1073/pnas.1312457110.
- PMCID: PMC3752246
Liao SF, et al.

Proc Natl Acad Sci U S A. 2013.

PMCID: PMC3752246

Carbohydrate-based vaccines have shown therapeutic efficacy for infectious disease and cancer. The mushroom Ganoderma lucidum (Reishi) containing complex polysaccharides has been used as antitumor supplement, but the mechanism of immune response has rarely be …

Carbohydrate-based vaccines have shown therapeutic efficacy for infectious disease and cancer. The mushroom Ganoderma lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
17.
Emerging Roles of Ganoderma Lucidum in Anti-Aging.
- Wang J, Cao B, Zhao H, Feng J.
- Aging Dis. 2017 Dec 1;8(6):691-707. doi: 10.14336/AD.2017.0410.
- PMCID: PMC5758346
Wang J, et al.

Aging Dis. 2017.

PMCID: PMC5758346

Ganoderma lucidum is a white-rot fungus that has been viewed as a traditional Chinese tonic for promoting health and longevity. It has been revealed that several extractions from Ganoderma lucidum, such as Ethanol extract, aqueous extract, mycelia extr …

Ganoderma lucidum is a white-rot fungus that has been viewed as a traditional Chinese tonic for promoting health and longevity …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Emerging Roles of Ganoderma Lucidum in Anti-Aging.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
18.
The Impact of Ganoderma lucidum (Curtis) P. Karst. Supplementation on the Technological, Chemical, and Quality Parameters of Wheat Bread.
- Łysakowska P, Sobota A, Wirkijowska A, Zarzycki P, Blicharz-Kania A.
- Foods. 2024 Sep 28;13(19):3101. doi: 10.3390/foods13193101.
- PMCID: PMC11475047
Łysakowska P, et al.

Foods. 2024.

PMCID: PMC11475047

This study explores the incorporation of Ganoderma lucidum (Curtis) P. Karst. (Reishi mushroom) into wheat bread to develop a functional food with enhanced nutritional value. ...However, higher Reishi levels negatively impacted bread volume, possibly d …

This study explores the incorporation of Ganoderma lucidum (Curtis) P. Karst. (Reishi mushroom) into wheat bread to dev …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The Impact of Ganoderma lucidum (Curtis) P. Karst. Supplementation on the Technological, Chemical, and Quality Parameters of Wheat Bread.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Quality/authentication methods study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Analytical validation (specificity/sensitivity), reference standards, and mislabeling rates. Open article.
- Why might this paper be useful to readers? Useful for quality control, sourcing, and preventing adulteration. Open article.
19.
Hypotensive effects and angiotensin-converting enzyme inhibitory peptides of reishi (Ganoderma lingzhi) auto-digested extract.
- Tran HB, Yamamoto A, Matsumoto S, Ito H, Igami K, Miyazaki T, Kondo R, Shimizu K.
- Molecules. 2014 Aug 29;19(9):13473-85. doi: 10.3390/molecules190913473.
- PMCID: PMC6271714
Tran HB, et al.

Molecules. 2014.

PMCID: PMC6271714

Reishi (Ganoderma lingzhi) has been used as a traditional medicine for millennia. However, relatively little is known about this mushroom's proteins and their bioactivities. In this study, we used reishi's own proteases to hydrolyze its protein and obtained a …

Reishi (Ganoderma lingzhi) has been used as a traditional medicine for millennia. However, relatively little is known about th …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Hypotensive effects and angiotensin-converting enzyme inhibitory peptides of reishi ( Ganoderma lingzhi) auto-digested extract.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
20.
Incorporating Ganoderma lucidum extract and powder with probiotic cultures (Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis) enhanced the functional, textural, and sensory qualities of yogurt.
- Atik A, Atik İ, Akarca G, Denizkara AJ.
- J Food Sci Technol. 2024 Aug 21;62(4):787-798. doi: 10.1007/s13197-024-06068-z.
- PMCID: PMC11914407
- Currently Embargoed: Full text in PMC on April 1, 2026 PubMed Abstract
Atik A, et al.

J Food Sci Technol. 2024.

PMCID: PMC11914407

Currently Embargoed.

In this study, the extract and powder obtained from the Reishi mushroom (Ganoderma lucidum) were used in the production of yogurt, and also Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis bacteria were also inoculated. ...The count of pro …

In this study, the extract and powder obtained from the Reishi mushroom (Ganoderma lucidum) were used in the production …

Page 3

21.
Anticancer and Anti-Inflammatory Properties of Ganoderma lucidum Extract Effects on Melanoma and Triple-Negative Breast Cancer Treatment.
- Barbieri A, Quagliariello V, Del Vecchio V, Falco M, Luciano A, Amruthraj NJ, Nasti G, Ottaiano A, Berretta M, Iaffaioli RV, Arra C.
- Nutrients. 2017 Feb 28;9(3):210. doi: 10.3390/nu9030210.
- PMCID: PMC5372873
Barbieri A, et al.

Nutrients. 2017.

PMCID: PMC5372873

Among the most important traditional medicinal fungi, Ganoderma lucidum has been used as a therapeutic agent for the treatment of numerous diseases, including cancer, in Oriental countries. ...Taken together, these results indicate the possible use of Ganoderma …

Among the most important traditional medicinal fungi, Ganoderma lucidum has been used as a therapeutic agent for the treatment …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Anticancer and Anti-Inflammatory Properties of Ganoderma lucidum Extract Effects on Melanoma and Triple-Negative Breast Cancer Treatment.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
22.
Deep insight into the Ganoderma lucidum by comprehensive analysis of its transcriptome.
- Yu GJ, Wang M, Huang J, Yin YL, Chen YJ, Jiang S, Jin YX, Lan XQ, Wong BH, Liang Y, Sun H.
- PLoS One. 2012 Aug 27;7(8):e44031. doi: 10.1371/journal.pone.0044031.
- PMCID: PMC3428325
Yu GJ, et al.

PLoS One. 2012.

PMCID: PMC3428325

BACKGROUND: Ganoderma lucidum is a basidiomycete white rot fungus and is of medicinal importance in China, Japan and other countries in the Asiatic region. To date, much research has been performed in identifying the medicinal ingredients in Ganoderma luci …

BACKGROUND: Ganoderma lucidum is a basidiomycete white rot fungus and is of medicinal importance in China, Japan and other cou …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Deep insight into the Ganoderma lucidum by comprehensive analysis of its transcriptome.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
23.
Ganoderma lucidum (Reishi mushroom) for cancer treatment.
- Jin X, Ruiz Beguerie J, Sze DM, Chan GC.
- Cochrane Database Syst Rev. 2016 Apr 5;4(4):CD007731. doi: 10.1002/14651858.CD007731.pub3.
- PMCID: PMC6353236
Jin X, et al.

Cochrane Database Syst Rev. 2016.

PMCID: PMC6353236

BACKGROUND: Ganoderma lucidum is a natural medicine that is widely used and recommended by Asian physicians and naturopaths for its supporting effects on immune system. ...AUTHORS' CONCLUSIONS: Our review did not find sufficient evidence to justify the use of G. …

BACKGROUND: Ganoderma lucidum is a natural medicine that is widely used and recommended by Asian physicians and naturopaths fo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum ( Reishi mushroom) for cancer treatment.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
24.
The impact of continuous cultivation of Ganoderma lucidum on soil nutrients, enzyme activity, and fruiting body metabolites.
- Ji W, Zhang N, Su W, Wang X, Liu X, Wang Y, Chen K, Ren L.
- Sci Rep. 2024 May 2;14(1):10097. doi: 10.1038/s41598-024-60750-y.
- PMCID: PMC11066026
Ji W, et al.

Sci Rep. 2024.

PMCID: PMC11066026

To explore the impacts of continuous Ganoderma lucidum cultivation on soil physicochemical factors, soil enzyme activity, and the metabolome of Ganoderma lucidum fruiting bodies, this study conducted two consecutive years of cultivation on the same plo …

To explore the impacts of continuous Ganoderma lucidum cultivation on soil physicochemical factors, soil enzyme activity, and …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The impact of continuous cultivation of Ganoderma lucidum on soil nutrients, enzyme activity, and fruiting body metabolites.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
25.
Intraspecific Variation and Phylogenetic Relationships Are Revealed by ITS1 Secondary Structure Analysis and Single-Nucleotide Polymorphism in Ganoderma lucidum.
- Zhang X, Xu Z, Pei H, Chen Z, Tan X, Hu J, Yang B, Sun J.
- PLoS One. 2017 Jan 5;12(1):e0169042. doi: 10.1371/journal.pone.0169042.
- PMCID: PMC5215925
Zhang X, et al.

PLoS One. 2017.

PMCID: PMC5215925

Ganoderma lucidum is a typical polypore fungus used for traditional Chinese medical purposes. The taxonomic delimitation of Ganoderma lucidum is still debated. In this study, we sequenced seven internal transcribed spacer (ITS) sequences of Ganoderm …

Ganoderma lucidum is a typical polypore fungus used for traditional Chinese medical purposes. The taxonomic delimitation of …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Intraspecific Variation and Phylogenetic Relationships Are Revealed by ITS1 Secondary Structure Analysis and Single-Nucleotide Polymorphism in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
26.
Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors.
- Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A.
- Cochrane Database Syst Rev. 2015 Feb 17;2015(2):CD007259. doi: 10.1002/14651858.CD007259.pub2.
- PMCID: PMC6486141
Klupp NL, et al.

Cochrane Database Syst Rev. 2015.

PMCID: PMC6486141

BACKGROUND: Ganoderma lucidum (also known as lingzhi or reishi) is a mushroom that has been consumed for its broad medicinal properties in Asia for over 2000 years. G lucidum is becoming increasingly popular in western countries as a complementary medi …

BACKGROUND: Ganoderma lucidum (also known as lingzhi or reishi) is a mushroom that has been consumed for its broad medi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
27.
Ganoderma lucidum Polysaccharides as An Anti-cancer Agent.
- Sohretoglu D, Huang S.
- Anticancer Agents Med Chem. Author manuscript. 2018;18(5):667-674. doi: 10.2174/1871520617666171113121246.
- PMCID: PMC6624854
Sohretoglu D, et al.

Anticancer Agents Med Chem. Author manuscript. 2018.

PMCID: PMC6624854

The mushroom Ganoderma lucidum (G. lucidum) has been used for centuries in Asian countries to treat various diseases and to promote health and longevity. ...G. lucidum polysaccharides (GLP) is the main bioactive component in the water soluble extracts …

The mushroom Ganoderma lucidum (G. lucidum) has been used for centuries in Asian countries to treat various diseases an …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Polysaccharides as An Anti-cancer Agent.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
28.
Health-Promoting of Polysaccharides Extracted from Ganoderma lucidum.
- Seweryn E, Ziała A, Gamian A.
- Nutrients. 2021 Aug 7;13(8):2725. doi: 10.3390/nu13082725.
- PMCID: PMC8400705
Seweryn E, et al.

Nutrients. 2021.

PMCID: PMC8400705

Ganoderma lucidum is an important source of biologically active compounds. The pharmacologically active fraction of polysaccharides has antioxidant, immunomodulatory, antineurodegenerative and antidiabetic activities. In this review, we summarize the activity of …

Ganoderma lucidum is an important source of biologically active compounds. The pharmacologically active fraction of polysaccha …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Health-Promoting of Polysaccharides Extracted from Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
29.
Efficient expression of heterologous genes by the introduction of the endogenous glyceraldehyde-3-phosphate dehydrogenase gene intron 1 in Ganoderma lucidum.
- You H, Sun B, Li N, Xu JW.
- Microb Cell Fact. 2021 Aug 21;20(1):164. doi: 10.1186/s12934-021-01654-8.
- PMCID: PMC8379801
You H, et al.

Microb Cell Fact. 2021.

PMCID: PMC8379801

BACKGROUND: Ganoderma lucidum, a well-known medicinal mushroom, has received wide attention as a promising cell factory for producing bioactive compounds. ...Moreover, the insertion of the gpd intron 1 in the beta-glucuronidase gene (gus) elevates its mRNA accumulat …

BACKGROUND: Ganoderma lucidum, a well-known medicinal mushroom, has received wide attention as a promising cell factory for pr …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Efficient expression of heterologous genes by the introduction of the endogenous glyceraldehyde-3-phosphate dehydrogenase gene intron 1 in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
30.
Germplasm resources and secondary metabolism regulation in Reishi mushroom (Ganoderma lucidum).
- He X, Chen Y, Li Z, Fang L, Chen H, Liang Z, Abozeid A, Yang Z, Yang D.
- Chin Herb Med. 2023 Jun 10;15(3):376-382. doi: 10.1016/j.chmed.2023.01.005.
- PMCID: PMC10394326
He X, et al.

Chin Herb Med. 2023.

PMCID: PMC10394326

Ganoderma lucidum is a valuable medical macrofungus with a myriad of diverse secondary metabolites, in which triterpenoids are the major constituents. ...Also we overviewed G. lucidum in the components, the biological activities and biosynthetic pathways of g …

Ganoderma lucidum is a valuable medical macrofungus with a myriad of diverse secondary metabolites, in which triterpenoids are …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Germplasm resources and secondary metabolism regulation in Reishi mushroom ( Ganoderma lucidum ).. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 4

31.
Genetic engineering of Ganoderma lucidum for the efficient production of ganoderic acids.
- Xu JW, Zhong JJ.
- Bioengineered. 2015;6(6):357-60. doi: 10.1080/21655979.2015.1119341.
- PMCID: PMC4825833
Xu JW, et al.

Bioengineered. 2015.

PMCID: PMC4825833

Ganoderma lucidum is a well-known traditional medicinal mushroom that produces ganoderic acids with numerous interesting bioactivities. ...In this report, the genetic transformation systems of G. lucidum are described; current trends are also presented to imp …

Ganoderma lucidum is a well-known traditional medicinal mushroom that produces ganoderic acids with numerous interesting bioac …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Genetic engineering of Ganoderma lucidum for the efficient production of ganoderic acids.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
32.
Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake.
- Mallard B, Leach DN, Wohlmuth H, Tiralongo J.
- PLoS One. 2019 Nov 7;14(11):e0224740. doi: 10.1371/journal.pone.0224740.
- PMCID: PMC6837746
Mallard B, et al.

PLoS One. 2019.

PMCID: PMC6837746

In this study we analysed nine commercially available preparations from three mushroom species, Reishi (Ganoderma lucidum), Shiitake (Lentinula edodes) and Maitake (Grifola frondosa), for beta- and alpha-glucan content. ...

In this study we analysed nine commercially available preparations from three mushroom species, Reishi (Ganoderma lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi , Shiitake and Maitake.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
33.
Antitumour, Antimicrobial, Antioxidant and Antiacetylcholinesterase Effect of Ganoderma Lucidum Terpenoids and Polysaccharides: A Review.
- Cör D, Knez Ž, Knez Hrnčič M.
- Molecules. 2018 Mar 13;23(3):649. doi: 10.3390/molecules23030649.
- PMCID: PMC6017764
Cör D, et al.

Molecules. 2018.

PMCID: PMC6017764

Ganoderma lucidum (Reishi) is a popular medicinal mushroom and has been used in oriental medicine because of its promoting effects on health and life expectancy. G. lucidum contains various compounds with a high grade of biological activty, which incre …

Ganoderma lucidum (Reishi) is a popular medicinal mushroom and has been used in oriental medicine because of its promot …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antitumour, Antimicrobial, Antioxidant and Antiacetylcholinesterase Effect of Ganoderma Lucidum Terpenoids and Polysaccharides: A Review.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
34.
Nutritional Profile and Health Benefits of Ganoderma lucidum "Lingzhi, Reishi, or Mannentake" as Functional Foods: Current Scenario and Future Perspectives.
- El Sheikha AF.
- Foods. 2022 Apr 1;11(7):1030. doi: 10.3390/foods11071030.
- PMCID: PMC8998036
El Sheikha AF.

Foods. 2022.

PMCID: PMC8998036

Ganoderma lucidum has a long history of medicinal uses in the Far East countries of more than 2000 years due to its healing properties. ...Still, more research studies on the biotherapeutic components of G. lucidum are needed to ensure the safety and efficien …

Ganoderma lucidum has a long history of medicinal uses in the Far East countries of more than 2000 years due to its healing pr …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Nutritional Profile and Health Benefits of Ganoderma lucidum "Lingzhi, Reishi , or Mannentake" as Functional Foods: Current Scenario and Future Perspectives.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
35.
A double-blind, randomised, placebo-controlled trial of Ganoderma lucidum for the treatment of cardiovascular risk factors of metabolic syndrome.
- Klupp NL, Kiat H, Bensoussan A, Steiner GZ, Chang DH.
- Sci Rep. 2016 Aug 11;6:29540. doi: 10.1038/srep29540.
- PMCID: PMC4980683
Klupp NL, et al.

Sci Rep. 2016.

PMCID: PMC4980683

Eighty-four participants with type 2 diabetes mellitus and metabolic syndrome were randomised to one of three intervention groups: Ganoderma lucidum, Ganoderma lucidum with Cordyceps sinensis, or placebo. The dosage was 3 g/day of Ganoderma l …

Eighty-four participants with type 2 diabetes mellitus and metabolic syndrome were randomised to one of three intervention groups: Ganode …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A double-blind, randomised, placebo-controlled trial of Ganoderma lucidum for the treatment of cardiovascular risk factors of metabolic syndrome.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Participant-reported outcomes, clinical biomarkers, and safety/tolerability. Open article.
- Why might this paper be useful to readers? Provides early human data; interpret with caution and check study size and endpoints. Open article.
36.
Evaluation of Immune Modulation by beta-1,3; 1,6 D-Glucan Derived from Ganoderma lucidum in Healthy Adult Volunteers, A Randomized Controlled Trial.
- Chen SN, Nan FH, Liu MW, Yang MF, Chang YC, Chen S.
- Foods. 2023 Feb 3;12(3):659. doi: 10.3390/foods12030659.
- PMCID: PMC9914031
Chen SN, et al.

Foods. 2023.

PMCID: PMC9914031

Studies have indicated that beta-glucan derived from Ganoderma lucidum (commonly known as Reishi) holds particular promise in this regard, both in laboratory and in vivo settings. ...Overall, the study provides evidence for the ability of Reishi beta-g …

Studies have indicated that beta-glucan derived from Ganoderma lucidum (commonly known as Reishi) holds particular prom …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Evaluation of Immune Modulation by beta-1,3; 1,6 D-Glucan Derived from Ganoderma lucidum in Healthy Adult Volunteers, A Randomized Controlled Trial.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Participant-reported outcomes, clinical biomarkers, and safety/tolerability. Open article.
- Why might this paper be useful to readers? Provides early human data; interpret with caution and check study size and endpoints. Open article.
37.
The species identity of the widely cultivated Ganoderma, 'G. lucidum' (Ling-zhi), in China.
- Wang XC, Xi RJ, Li Y, Wang DM, Yao YJ.
- PLoS One. 2012 Jul 20;7(7):e40857. doi: 10.1371/journal.pone.0040857.
- PMCID: PMC3401198
Wang XC, et al.

PLoS One. 2012.

PMCID: PMC3401198

Ling-zhi, a widely cultivated fungus in China, has a long history in traditional Chinese medicine. Although the name 'Ganoderma lucidum', a species originally described from England, has been applied to the fungus, their identities are not the same. ...Specimens of …

Ling-zhi, a widely cultivated fungus in China, has a long history in traditional Chinese medicine. Although the name 'Ganoderma lu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The species identity of the widely cultivated Ganoderma , 'G. lucidum ' (Ling-zhi), in China.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
38.
Physiological changes and gene responses during Ganoderma lucidum growth with selenium supplementation.
- Zhang B, Tan W, Zhou J, Ye L, Jia D, Li X.
- PeerJ. 2022 Dec 20;10:e14488. doi: 10.7717/peerj.14488.
- PMCID: PMC9784338
Zhang B, et al.

PeerJ. 2022.

PMCID: PMC9784338

Ganoderma lucidum basidiomycota is highly appreciated for its health and nutrition value. In the present study, Ganoderma lucidum was cultivated as selenium transformation carrier, and the physiological changes and gene responses by selenium supplement …

Ganoderma lucidum basidiomycota is highly appreciated for its health and nutrition value. In the present study, Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Physiological changes and gene responses during Ganoderma lucidum growth with selenium supplementation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
39.
The Biological Activity of Ganoderma lucidum on Neurodegenerative Diseases: The Interplay between Different Active Compounds and the Pathological Hallmarks.
- Lian W, Yang X, Duan Q, Li J, Zhao Y, Yu C, He T, Sun T, Zhao Y, Wang W.
- Molecules. 2024 May 26;29(11):2516. doi: 10.3390/molecules29112516.
- PMCID: PMC11173733
Lian W, et al.

Molecules. 2024.

PMCID: PMC11173733

This literature review collates and examines the existing research on the bioactivity of active compounds and extracts from Ganoderma lucidum in modulating the pathological hallmarks of neurodegenerative diseases. ...It is clearly presented from the patterns that mo …

This literature review collates and examines the existing research on the bioactivity of active compounds and extracts from Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The Biological Activity of Ganoderma lucidum on Neurodegenerative Diseases: The Interplay between Different Active Compounds and the Pathological Hallmarks.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
40.
Genetic and metabolic intraspecific biodiversity of Ganoderma lucidum.
- Pawlik A, Janusz G, Dębska I, Siwulski M, Frąc M, Rogalski J.
- Biomed Res Int. 2015 Mar 1;2015:726149. doi: 10.1155/2015/726149.
- PMCID: PMC4359883
Pawlik A, et al.

Biomed Res Int. 2015.

PMCID: PMC4359883

Fourteen Ganoderma lucidum strains from different geographic regions were identified using ITS region sequencing. Based on the sequences obtained, the genomic relationship between the analyzed strains was determined. All G. lucidum strains were also genetical …

Fourteen Ganoderma lucidum strains from different geographic regions were identified using ITS region sequencing. Based on the …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Genetic and metabolic intraspecific biodiversity of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 5

41.
Targeted Gene Insertion and Replacement in the Basidiomycete Ganoderma lucidum by Inactivation of Nonhomologous End Joining Using CRISPR/Cas9.
- Tu JL, Bai XY, Xu YL, Li N, Xu JW.
- Appl Environ Microbiol. 2021 Sep 15;87(23):e0151021. doi: 10.1128/AEM.01510-21.
- PMCID: PMC8579997
Tu JL, et al.

Appl Environ Microbiol. 2021.

PMCID: PMC8579997

Although CRISPR/Cas9 works well for gene disruption and deletion in Ganoderma lucidum, targeted gene insertion and replacement remain a serious challenge due to the low efficiency of homologous recombination (HR) in this species. ...This tool will advance our unders …

Although CRISPR/Cas9 works well for gene disruption and deletion in Ganoderma lucidum, targeted gene insertion and replacement …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Targeted Gene Insertion and Replacement in the Basidiomycete Ganoderma lucidum by Inactivation of Nonhomologous End Joining Using CRISPR/Cas9.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
42.
Ganoderma lucidum-From Ancient Remedies to Modern Applications: Chemistry, Benefits, and Safety.
- Plosca MP, Chiș MS, Fărcaș AC, Păucean A.
- Antioxidants (Basel). 2025 Apr 25;14(5):513. doi: 10.3390/antiox14050513.
- PMCID: PMC12108272
Plosca MP, et al.

Antioxidants (Basel). 2025.

PMCID: PMC12108272

Ganoderma lucidum (G. lucidum), commonly known as Reishi or Lingzhi, is a medicinal mushroom with a rich history in traditional Asian medicine. ...Advances in extraction technologies, such as ultrasound and microwave-assisted methods, have improved the …

Ganoderma lucidum (G. lucidum), commonly known as Reishi or Lingzhi, is a medicinal mushroom with a rich history …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum -From Ancient Remedies to Modern Applications: Chemistry, Benefits, and Safety.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
43.
Antiangiogenic and Proapoptotic Activities of Atorvastatin and Ganoderma lucidum in Tumor Mouse Model via VEGF and Caspase-3 Pathways.
- El-Khashab IH.
- Asian Pac J Cancer Prev. 2021 Apr 1;22(4):1095-1104. doi: 10.31557/APJCP.2021.22.4.1095.
- PMCID: PMC8325138
El-Khashab IH.

Asian Pac J Cancer Prev. 2021.

PMCID: PMC8325138

OBJECTIVE: The present study was designed to evaluate the apoptotic and antiangiogenic effects of Atorvastatin and/or Ganoderma lucidum against Ehrlich solid tumor inoculated in female mice. MATERIALS AND METHODS: Atorvastatin (AT) or/and Ganoderma lucidum …

OBJECTIVE: The present study was designed to evaluate the apoptotic and antiangiogenic effects of Atorvastatin and/or Ganoderma lu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antiangiogenic and Proapoptotic Activities of Atorvastatin and Ganoderma lucidum in Tumor Mouse Model via VEGF and Caspase-3 Pathways.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
44.
Comparison of extraction methods of chitin from Ganoderma lucidum mushroom obtained in submerged culture.
- Ospina Álvarez SP, Ramírez Cadavid DA, Escobar Sierra DM, Ossa Orozco CP, Rojas Vahos DF, Zapata Ocampo P, Atehortúa L.
- Biomed Res Int. 2014 Jan 15;2014:169071. doi: 10.1155/2014/169071.
- PMCID: PMC3914579
Ospina Álvarez SP, et al.

Biomed Res Int. 2014.

PMCID: PMC3914579

The chitin was isolated from the Ganoderma lucidum submerged cultures mycelium as potential source of chitin under biotechnological processes. ...Obtained chitin was characterized by X-Ray Diffraction (XRD), by Fourier transform infrared spectroscopy (FTIR), and by …

The chitin was isolated from the Ganoderma lucidum submerged cultures mycelium as potential source of chitin under biotechnolo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Comparison of extraction methods of chitin from Ganoderma lucidum mushroom obtained in submerged culture.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
45.
Structure determination of beta-glucans from Ganoderma lucidum with matrix-assisted laser desorption/ionization (MALDI) mass spectrometry.
- Hung WT, Wang SH, Chen CH, Yang WB.
- Molecules. 2008 Aug 3;13(8):1538-50. doi: 10.3390/molecules13081538.
- PMCID: PMC6245394
Hung WT, et al.

Molecules. 2008.

PMCID: PMC6245394

A novel method that uses matrix-assisted laser desorption/ionization (MALDI) mass spectrometry to analyze molecular weight and sequencing of glucan in Ganoderma lucidum is presented. Thus, beta-glucan, which was isolated from fruiting bodies of G. lucidum, wa …

A novel method that uses matrix-assisted laser desorption/ionization (MALDI) mass spectrometry to analyze molecular weight and sequencing of …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Structure determination of beta-glucans from Ganoderma lucidum with matrix-assisted laser desorption/ionization (MALDI) mass spectrometry.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
46.
Enhancement of ganoderic acid accumulation by overexpression of an N-terminally truncated 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in the basidiomycete Ganoderma lucidum.
- Xu JW, Xu YN, Zhong JJ.
- Appl Environ Microbiol. 2012 Aug 31;78(22):7968-76. doi: 10.1128/AEM.01263-12.
- PMCID: PMC3485969
Xu JW, et al.

Appl Environ Microbiol. 2012.

PMCID: PMC3485969

Ganoderic acids produced by Ganoderma lucidum, a well-known traditional Chinese medicinal mushroom, exhibit antitumor and antimetastasis activities. Genetic modification of G. lucidum is difficult but critical for the enhancement of cellular accumulation of g …

Ganoderic acids produced by Ganoderma lucidum, a well-known traditional Chinese medicinal mushroom, exhibit antitumor and anti …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Enhancement of ganoderic acid accumulation by overexpression of an N-terminally truncated 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in the basidiomycete Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
47.
Autotoxicity of Endogenous Organic Acid Stress in Two Ganoderma lucidum Cultivars.
- Zou P, Guo Y, Ding S, Song Z, Cui H, Zhang Y, Zhang Z, Chen X.
- Molecules. 2022 Oct 9;27(19):6734. doi: 10.3390/molecules27196734.
- PMCID: PMC9570943
Zou P, et al.

Molecules. 2022.

PMCID: PMC9570943

Ganoderma lucidum has been used as a rare medical mushroom for centuries in China, due to its health-promoting properties. ...Here, we aimed to study the metabolite profile of G. lucidum via nontargeted metabonomic technology. Metabonomic data revealed that o …

Ganoderma lucidum has been used as a rare medical mushroom for centuries in China, due to its health-promoting properties. ... …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Autotoxicity of Endogenous Organic Acid Stress in Two Ganoderma lucidum Cultivars.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
48.
Isolation and Physicochemical Characterization of Laccase from Ganoderma lucidum-CDBT1 Isolated from Its Native Habitat in Nepal.
- Shrestha P, Joshi B, Joshi J, Malla R, Sreerama L.
- Biomed Res Int. 2016 Oct 16;2016:3238909. doi: 10.1155/2016/3238909.
- PMCID: PMC5086383
Shrestha P, et al.

Biomed Res Int. 2016.

PMCID: PMC5086383

In the present study, three fungal species, namely, Ganoderma lucidum-CDBT1, Ganoderma japonicum, and Lentinula edodes, isolated from their native habitat in Nepal were screened for laccase production, and G. lucidum-CDBT1 was found to express highest …

In the present study, three fungal species, namely, Ganoderma lucidum-CDBT1, Ganoderma japonicum, and Lentinula edodes, …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Isolation and Physicochemical Characterization of Laccase from Ganoderma lucidum -CDBT1 Isolated from Its Native Habitat in Nepal.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Relevant for eco‑friendly processing, waste upcycling, and industrial biocatalysis. Open article.
49.
Structural characteristics, sugar metabolizing enzyme activity and biological activity of Ganoderma lucidum polysaccharides at different growth stages.
- Ma S, Chen Y, Huang H, Pu X, Liang H, Kuang Y, Liu Y.
- Sci Rep. 2025 Feb 9;15(1):4834. doi: 10.1038/s41598-025-89559-z.
- PMCID: PMC11808097
Ma S, et al.

Sci Rep. 2025.

PMCID: PMC11808097

The Ganoderma lucidum polysaccharides (GLPs) content, monosaccharide composition, molecular weight, sugar metabolism-related enzyme activities and in vitro antioxidant activities of Ganoderma lucidum fruiting body (GLFB) from cassava stalk cultivation …

The Ganoderma lucidum polysaccharides (GLPs) content, monosaccharide composition, molecular weight, sugar metabolism-related e …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Structural characteristics, sugar metabolizing enzyme activity and biological activity of Ganoderma lucidum polysaccharides at different growth stages.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
50.
Increased production of ganoderic acids by overexpression of homologous farnesyl diphosphate synthase and kinetic modeling of ganoderic acid production in Ganoderma lucidum.
- Fei Y, Li N, Zhang DH, Xu JW.
- Microb Cell Fact. 2019 Jun 28;18(1):115. doi: 10.1186/s12934-019-1164-3.
- PMCID: PMC6599323
Fei Y, et al.

Microb Cell Fact. 2019.

PMCID: PMC6599323

BACKGROUND: Ganoderic acids (GAs), derived from the medicinal mushroom Ganoderma lucidum, possess anticancer and other important pharmacological activities. To improve production of GAs, a homologous farnesyl diphosphate synthase (FPS) gene was overexpressed in G. < …

BACKGROUND: Ganoderic acids (GAs), derived from the medicinal mushroom Ganoderma lucidum, possess anticancer and other importa …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Increased production of ganoderic acids by overexpression of homologous farnesyl diphosphate synthase and kinetic modeling of ganoderic acid production in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 6

51.
Changes of Active Substances in Ganoderma lucidum during Different Growth Periods and Analysis of Their Molecular Mechanism.
- Gao X, Huo H, Bao H, Wang J, Gao D.
- Molecules. 2024 May 31;29(11):2591. doi: 10.3390/molecules29112591.
- PMCID: PMC11173900
Gao X, et al.

Molecules. 2024.

PMCID: PMC11173900

Ganoderma lucidum, renowned as an essential edible and medicinal mushroom in China, remains shrouded in limited understanding concerning the intrinsic mechanisms governing the accumulation of active components and potential protein expression across its diverse deve …

Ganoderma lucidum, renowned as an essential edible and medicinal mushroom in China, remains shrouded in limited understanding …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Changes of Active Substances in Ganoderma lucidum during Different Growth Periods and Analysis of Their Molecular Mechanism.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
52.
Anti-angiotensin converting enzyme (ACE) proteins from mycelia of Ganoderma lucidum (Curtis) P. Karst.
- Mohamad Ansor N, Abdullah N, Aminudin N.
- BMC Complement Altern Med. 2013 Oct 4;13:256. doi: 10.1186/1472-6882-13-256.
- PMCID: PMC3852974
Mohamad Ansor N, et al.

BMC Complement Altern Med. 2013.

PMCID: PMC3852974

BACKGROUND: Ganoderma lucidum has been purported as a potent remedy in the treatment and prevention of several ailments, including hypertension. This study aimed to explore the anti-ACE potential of protein fractions from the mycelia of G. lucidum. METHODS: < …

BACKGROUND: Ganoderma lucidum has been purported as a potent remedy in the treatment and prevention of several ailments, inclu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Anti-angiotensin converting enzyme (ACE) proteins from mycelia of Ganoderma lucidum (Curtis) P. Karst.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
53.
PRMT5 promotes cellulase production by regulating the expression of cellulase gene eg2 through histone methylation in Ganoderma lucidum.
- Li Y, Wang Z, Li Z, Tang X, Ji T, Liu R, Zhao M.
- Microb Cell Fact. 2025 Aug 19;24(1):191. doi: 10.1186/s12934-025-02814-w.
- PMCID: PMC12363083
Li Y, et al.

Microb Cell Fact. 2025.

PMCID: PMC12363083

Simultaneously, cellulase enhances the efficiency and quality of industrial production while also demonstrating significant potential in environmental protection and bioenergy development. Ganoderma lucidum, as a white rot fungus, secret a large amount of cellulase …

Simultaneously, cellulase enhances the efficiency and quality of industrial production while also demonstrating significant potential in env …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: PRMT5 promotes cellulase production by regulating the expression of cellulase gene eg2 through histone methylation in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
54.
The APSES transcription factor Swi6B upregulates CATALASE 1 transcription to enhance oxidative stress tolerance of Ganoderma lucidum.
- Wang L, Shi L, Zhang S, Ma J, Zhang C, Chen H, Zhao M.
- Appl Environ Microbiol. 2025 Jun 18;91(7):e0067925. doi: 10.1128/aem.00679-25.
- PMCID: PMC12285235
Wang L, et al.

Appl Environ Microbiol. 2025.

PMCID: PMC12285235

Previously, we revealed that the Swi6B transcription factor is involved in the stress tolerance of Ganoderma lucidum. However, the underlying molecular mechanism is unclear. The present study demonstrated that oxidative stress increased the levels of Swi6B. ...Here, …

Previously, we revealed that the Swi6B transcription factor is involved in the stress tolerance of Ganoderma lucidum. However, …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The APSES transcription factor Swi6B upregulates CATALASE 1 transcription to enhance oxidative stress tolerance of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
55.
Discovery of Ganoderma lucidum triterpenoids as potential inhibitors against Dengue virus NS2B-NS3 protease.
- Bharadwaj S, Lee KE, Dwivedi VD, Yadava U, Panwar A, Lucas SJ, Pandey A, Kang SG.
- Sci Rep. 2019 Dec 13;9(1):19059. doi: 10.1038/s41598-019-55723-5.
- PMCID: PMC6911040
Bharadwaj S, et al.

Sci Rep. 2019.

PMCID: PMC6911040

Triterpenoids from the medicinal fungus Ganoderma lucidum have been suggested as pharmacologically bioactive compounds and tested as anti-viral agents against various viral pathogens including human immunodeficiency virus. However, no reports are available concernin …

Triterpenoids from the medicinal fungus Ganoderma lucidum have been suggested as pharmacologically bioactive compounds and tes …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Discovery of Ganoderma lucidum triterpenoids as potential inhibitors against Dengue virus NS2B-NS3 protease.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
56.
Ameliorative effect of Ganoderma lucidum on carbon tetrachloride-induced liver fibrosis in rats.
- Lin WC, Lin WL.
- World J Gastroenterol. 2006 Jan 14;12(2):265-70. doi: 10.3748/wjg.v12.i2.265.
- PMCID: PMC4066037
Lin WC, et al.

World J Gastroenterol. 2006.

PMCID: PMC4066037

AIM: To investigate the effects of Reishi mushroom, Ganoderma lucidum extract (GLE), on liver fibrosis induced by carbon tetrachloride (CCl4) in rats. ...

AIM: To investigate the effects of Reishi mushroom, Ganoderma lucidum extract (GLE), on liver fibrosis induced by carbo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ameliorative effect of Ganoderma lucidum on carbon tetrachloride-induced liver fibrosis in rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
57.
Phytochemical analysis and antimicrobial activity of Ganoderma lucidum against selected bacteria and fungi of medical importance.
- Solomon S, Oyekale AO, Ayanyinka A, Adeniyi I, Adedolapo OB, Ojeniyi FD, Oyelayo I, Olayinka O, Opaleye OO, Ojurongbe O, Olowe OA.
- Sci Rep. 2025 Aug 25;15(1):31272. doi: 10.1038/s41598-025-06068-9.
- PMCID: PMC12379213
Solomon S, et al.

Sci Rep. 2025.

PMCID: PMC12379213

Ganoderma lucidum is a rapidly growing mushroom, wood-colonizing fungus belonging to the phylum Basidiomycota. ...However, Aspergillus flavus, Aspergillus niger and Penicillium showed resistance against Ganoderma lucidum. Overall, this findings show th …

Ganoderma lucidum is a rapidly growing mushroom, wood-colonizing fungus belonging to the phylum Basidiomycota. ...However, Asp …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Phytochemical analysis and antimicrobial activity of Ganoderma lucidum against selected bacteria and fungi of medical importance.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
58.
Dual sgRNA-directed gene deletion in basidiomycete Ganoderma lucidum using the CRISPR/Cas9 system.
- Liu K, Sun B, You H, Tu JL, Yu X, Zhao P, Xu JW.
- Microb Biotechnol. 2020 Jan 20;13(2):386-396. doi: 10.1111/1751-7915.13534.
- PMCID: PMC7017817
Liu K, et al.

Microb Biotechnol. 2020.

PMCID: PMC7017817

Ganoderma lucidum is an important medicinal mushroom in traditional Chinese medicine. However, the lack of adequate genetic tools has hindered molecular genetic research in and the genetic modification of this species. ...Furthermore, genomic fragment deletions in t …

Ganoderma lucidum is an important medicinal mushroom in traditional Chinese medicine. However, the lack of adequate genetic to …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Dual sgRNA-directed gene deletion in basidiomycete Ganoderma lucidum using the CRISPR/Cas9 system.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
59.
PRMT5 regulates the polysaccharide content by controlling the splicing of thaumatin-like protein in Ganoderma lucidum.
- Liu R, Yang Z, Yang T, Wang Z, Chen X, Zhu J, Ren A, Shi L, Yu H, Zhao M.
- Microbiol Spectr. 2023 Oct 26;11(6):e0290623. doi: 10.1128/spectrum.02906-23.
- PMCID: PMC10715077
Liu R, et al.

Microbiol Spectr. 2023.

PMCID: PMC10715077

PRMT5 contributes to secondary metabolite biosynthesis in Ganoderma lucidum. However, the mechanism through which PRMT5 regulates the biosynthesis of secondary metabolites remains unclear. In the current study, PRMT5 silencing led to a significant decrease in the bi …

PRMT5 contributes to secondary metabolite biosynthesis in Ganoderma lucidum. However, the mechanism through which PRMT5 regula …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: PRMT5 regulates the polysaccharide content by controlling the splicing of thaumatin-like protein in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
60.
Hydrogen sulfide maintains mitochondrial homeostasis and regulates ganoderic acids biosynthesis by SQR under heat stress in Ganoderma lucidum.
- Shangguan J, Wu T, Tian L, Liu Y, Zhu L, Liu R, Zhu J, Shi L, Zhao M, Ren A.
- Redox Biol. 2024 Jun 6;74:103227. doi: 10.1016/j.redox.2024.103227.
- PMCID: PMC11215418
Shangguan J, et al.

Redox Biol. 2024.

PMCID: PMC11215418

Previous studies have shown that H(2)S alleviated heat-induced ganoderic acids (GAs) biosynthesis, an important quality index of Ganoderma lucidum. However, a comprehensive understanding of the physiological effects and molecular mechanisms of H(2)S in G. lucidum …

Previous studies have shown that H(2)S alleviated heat-induced ganoderic acids (GAs) biosynthesis, an important quality index of Ganoderm …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Hydrogen sulfide maintains mitochondrial homeostasis and regulates ganoderic acids biosynthesis by SQR under heat stress in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 7

61.
The Possible Role of PD-1 Protein in Ganoderma lucidum-Mediated Immunomodulation and Cancer Treatment.
- Wang G, Wang L, Zhou J, Xu X.
- Integr Cancer Ther. 2019 Jan-Dec;18:1534735419880275. doi: 10.1177/1534735419880275.
- PMCID: PMC6876169
Wang G, et al.

Integr Cancer Ther. 2019.

PMCID: PMC6876169

Background:Ganoderma lucidum has been used in Chinese medicine for thousands years to improve health and to promote longevity. ...Conclusions: PD-1 protein is an important target of G lucidum-mediated immunomodulation. G lucidum and its bioactive compo …

Background:Ganoderma lucidum has been used in Chinese medicine for thousands years to improve health and to promote longevity. …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The Possible Role of PD-1 Protein in Ganoderma lucidum -Mediated Immunomodulation and Cancer Treatment.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
62.
Ganoderma lucidum: Novel Insight into Hepatoprotective Potential with Mechanisms of Action.
- Ahmad MF, Ahmad FA, Zeyaullah M, Alsayegh AA, Mahmood SE, AlShahrani AM, Khan MS, Shama E, Hamouda A, Elbendary EY, Attia KAHA.
- Nutrients. 2023 Apr 13;15(8):1874. doi: 10.3390/nu15081874.
- PMCID: PMC10146730
Ahmad MF, et al.

Nutrients. 2023.

PMCID: PMC10146730

Ganoderma lucidum (G. lucidum) has been widely used for its health benefits as an edible and traditional medicinal mushroom for thousands of years in Asian countries. ...This review summarizes the hepatoprotective properties of G. lucidum with its vari …

Ganoderma lucidum (G. lucidum) has been widely used for its health benefits as an edible and traditional medicinal mush …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum : Novel Insight into Hepatoprotective Potential with Mechanisms of Action.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
63.
Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review.
- Łysakowska P, Sobota A, Wirkijowska A.
- Molecules. 2023 Jul 14;28(14):5393. doi: 10.3390/molecules28145393.
- PMCID: PMC10384337
Łysakowska P, et al.

Molecules. 2023.

PMCID: PMC10384337

Medicinal mushrooms, e.g., Lion's Mane (Hericium erinaceus (Bull.) Pers.), Reishi (Ganoderma lucidum (Curtis) P. Karst.), Chaga (Inonotus obliquus (Ach. ex Pers.) ...

Medicinal mushrooms, e.g., Lion's Mane (Hericium erinaceus (Bull.) Pers.), Reishi (Ganoderma lucidum (Curtis) P. Karst. …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
64.
Cross Talk between GlAQP and NOX Modulates the Effects of ROS Balance on Ganoderic Acid Biosynthesis of Ganoderma lucidum under Water Stress.
- Zhu Q, Ren A, Ding J, He J, Zhao M, Jiang A, Zhou X, Wang J, He Q.
- Microbiol Spectr. 2022 Nov 2;10(6):e0129722. doi: 10.1128/spectrum.01297-22.
- PMCID: PMC9784773
Zhu Q, et al.

Microbiol Spectr. 2022.

PMCID: PMC9784773

In this study, water stress was found to increase intracellular reactive oxygen species (ROS) level, ganoderic acid (GA) content, and NADPH oxidase (NOX) activity of Ganoderma lucidum by 148.45%, 75.32%, and 161.61%, respectively. Water stress induced the expression …

In this study, water stress was found to increase intracellular reactive oxygen species (ROS) level, ganoderic acid (GA) content, and NADPH …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Cross Talk between GlAQP and NOX Modulates the Effects of ROS Balance on Ganoderic Acid Biosynthesis of Ganoderma lucidum under Water Stress.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
65.
The effect of Ganoderma lucidum polysaccharide extract on sensitizing prostate cancer cells to flutamide and docetaxel: an in vitro study.
- Rahimnia R, Akbari MR, Yasseri AF, Taheri D, Mirzaei A, Ghajar HA, Farashah PD, Baghdadabad LZ, Aghamir SMK.
- Sci Rep. 2023 Nov 2;13(1):18940. doi: 10.1038/s41598-023-46118-8.
- PMCID: PMC10622576
Rahimnia R, et al.

Sci Rep. 2023.

PMCID: PMC10622576

Ganoderma lucidum polysaccharide is the most widely used complementary therapy in cancer. ...Ganoderma lucidum polysaccharide synergistically increased the effect of Docetaxel and Flutamide and increased the sensitivity of the prostate cancer cell line …

Ganoderma lucidum polysaccharide is the most widely used complementary therapy in cancer. ...Ganoderma lucidum p …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The effect of Ganoderma lucidum polysaccharide extract on sensitizing prostate cancer cells to flutamide and docetaxel: an in vitro study.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
66.
Expression and characteristics of manganese peroxidase from Ganoderma lucidum in Pichia pastoris and its application in the degradation of four dyes and phenol.
- Xu H, Guo MY, Gao YH, Bai XH, Zhou XW.
- BMC Biotechnol. 2017 Feb 23;17(1):19. doi: 10.1186/s12896-017-0338-5.
- PMCID: PMC5324234
Xu H, et al.

BMC Biotechnol. 2017.

PMCID: PMC5324234

BACKGROUND: Manganese peroxidase (MnP) of white rot basidiomycetes, an extracellular heme enzyme, is part of a peroxidase superfamily that is capable of degrading the different phenolic compounds. Ganoderma, a white rot basidiomycete widely distributed worldwide, could sec …

BACKGROUND: Manganese peroxidase (MnP) of white rot basidiomycetes, an extracellular heme enzyme, is part of a peroxidase superfamily that i …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Expression and characteristics of manganese peroxidase from Ganoderma lucidum in Pichia pastoris and its application in the degradation of four dyes and phenol.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Relevant for eco‑friendly processing, waste upcycling, and industrial biocatalysis. Open article.
67.
A toxicological assessment of Ganoderma lucidum and Cordyceps militaris mushroom powders.
- Chrysostomou PP, Freeman E, Murphy MM, Chaudhary A, Siddiqui N, Daoust J.
- Front Toxicol. 2024 Oct 30;6:1469348. doi: 10.3389/ftox.2024.1469348.
- PMCID: PMC11558339
Chrysostomou PP, et al.

Front Toxicol. 2024.

PMCID: PMC11558339

Gonoderma lucidum (G. lucidum) and Cordyceps militaris (C. militaris) are among the many mushrooms known for their long history of use in traditional medicine. ...The purpose of this study was to assess the potential for acute toxicity, subchronic toxicity, and geno …

Gonoderma lucidum (G. lucidum) and Cordyceps militaris (C. militaris) are among the many mushrooms known for their long histor …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A toxicological assessment of Ganoderma lucidum and Cordyceps militaris mushroom powders.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
68.
GCN4 Regulates Secondary Metabolism through Activation of Antioxidant Gene Expression under Nitrogen Limitation Conditions in Ganoderma lucidum.
- Lian L, Wang L, Song S, Zhu J, Liu R, Shi L, Ren A, Zhao M.
- Appl Environ Microbiol. 2021 Jun 25;87(14):e0015621. doi: 10.1128/AEM.00156-21.
- PMCID: PMC8231712
Lian L, et al.

Appl Environ Microbiol. 2021.

PMCID: PMC8231712

Here, we found that nitrogen limitation highly induced the expression of GCN4 and promoted the synthesis of ganoderic acid (GA), an important secondary metabolite in Ganoderma lucidum. The activated GCN4 is involved in regulating GA biosynthesis. In addition, the ac …

Here, we found that nitrogen limitation highly induced the expression of GCN4 and promoted the synthesis of ganoderic acid (GA), an importan …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: GCN4 Regulates Secondary Metabolism through Activation of Antioxidant Gene Expression under Nitrogen Limitation Conditions in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
69.
Water-Extracted Ganoderma lucidum Induces Apoptosis and S-Phase Arrest via Cyclin-CDK2 Pathway in Glioblastoma Cells.
- Cheng AY, Chien YC, Lee HC, Hsieh YH, Yu YL.
- Molecules. 2020 Aug 6;25(16):3585. doi: 10.3390/molecules25163585.
- PMCID: PMC7464863
Cheng AY, et al.

Molecules. 2020.

PMCID: PMC7464863

The current treatment is mainly surgery, chemotherapy, and radiation therapy, but the results are not satisfactory. Ganoderma lucidum (G. lucidum), also called "Lingzhi", is a medicinal mushroom that has been used as a therapeutic agent for the treatment of n …

The current treatment is mainly surgery, chemotherapy, and radiation therapy, but the results are not satisfactory. Ganoderma luci …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Water-Extracted Ganoderma lucidum Induces Apoptosis and S-Phase Arrest via Cyclin-CDK2 Pathway in Glioblastoma Cells.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
70.
Ganoderma lucidum cultivation affect microbial community structure of soil, wood segments and tree roots.
- Ren F, Zhang Y, Yu H, Zhang YA.
- Sci Rep. 2020 Feb 26;10(1):3435. doi: 10.1038/s41598-020-60362-2.
- PMCID: PMC7044327
Ren F, et al.

Sci Rep. 2020.

PMCID: PMC7044327

The popular medicinal mushroom Ganoderma lucidum (Fr.) Karst. [Ling Zhi] has been widely used for the general promotion of health and longevity in Asian countries. ...The study will provide useful information for G. lucidum cultivation and under-forest econom …

The popular medicinal mushroom Ganoderma lucidum (Fr.) Karst. [Ling Zhi] has been widely used for the general promotion of hea …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum cultivation affect microbial community structure of soil, wood segments and tree roots.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 8

71.
Heat Stress Modulates Mycelium Growth, Heat Shock Protein Expression, Ganoderic Acid Biosynthesis, and Hyphal Branching of Ganoderma lucidum via Cytosolic Ca2.
- Zhang X, Ren A, Li MJ, Cao PF, Chen TX, Zhang G, Shi L, Jiang AL, Zhao MW.
- Appl Environ Microbiol. 2016 Jun 30;82(14):4112-4125. doi: 10.1128/AEM.01036-16.
- PMCID: PMC4959220
Zhang X, et al.

Appl Environ Microbiol. 2016.

PMCID: PMC4959220

Thus, a comprehensive understanding of how organisms sense HS and respond to it is required. Ganoderma lucidum, a higher basidiomycete with bioactive secondary metabolites, has become a potential model system due to the complete sequencing of its genome, transgenic …

Thus, a comprehensive understanding of how organisms sense HS and respond to it is required. Ganoderma lucidum, a higher basid …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Heat Stress Modulates Mycelium Growth, Heat Shock Protein Expression, Ganoderic Acid Biosynthesis, and Hyphal Branching of Ganoderma lucidum via Cytosolic Ca2.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
72.
Submerged fermentation production and characterization of intracellular triterpenoids from Ganoderma lucidum using HPLC-ESI-MS.
- Cui ML, Yang HY, He GQ.
- J Zhejiang Univ Sci B. 2015 Dec;16(12):998-1010. doi: 10.1631/jzus.B1500147.
- PMCID: PMC4678043
Cui ML, et al.

J Zhejiang Univ Sci B. 2015.

PMCID: PMC4678043

As the main bioactive metabolites of Ganoderma lucidum, triterpenoids have various pharmacological effects. In this paper, the nutritional requirements and culture conditions of a submerged culture of G. lucidum were optimized using the response surface metho …

As the main bioactive metabolites of Ganoderma lucidum, triterpenoids have various pharmacological effects. In this paper, the …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Submerged fermentation production and characterization of intracellular triterpenoids from Ganoderma lucidum using HPLC-ESI-MS.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
73.
Optimization of Culture Condition for Ganoderic Acid Production in Ganoderma lucidum Liquid Static Culture and Design of a Suitable Bioreactor.
- Hu G, Zhai M, Niu R, Xu X, Liu Q, Jia J.
- Molecules. 2018 Oct 8;23(10):2563. doi: 10.3390/molecules23102563.
- PMCID: PMC6222601
Hu G, et al.

Molecules. 2018.

PMCID: PMC6222601

Ganoderma lucidum, a famous medicinal mushroom used worldwide, is a rich source of triterpenoids which, together with polysaccharides, are believed to be the main effective constituents of G. lucidum. ...Our results demonstrate the potential of industrial app …

Ganoderma lucidum, a famous medicinal mushroom used worldwide, is a rich source of triterpenoids which, together with polysacc …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Optimization of Culture Condition for Ganoderic Acid Production in Ganoderma lucidum Liquid Static Culture and Design of a Suitable Bioreactor.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
74.
Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction.
- Cheng KC, Huang HC, Chen JH, Hsu JW, Cheng HC, Ou CH, Yang WB, Chen ST, Wong CH, Juan HF.
- BMC Genomics. 2007 Nov 9;8:411. doi: 10.1186/1471-2164-8-411.
- PMCID: PMC2211495
Cheng KC, et al.

BMC Genomics. 2007.

PMCID: PMC2211495

BACKGROUND: Ganoderma lucidum has been widely used as a herbal medicine for promoting health and longevity in China and other Asian countries. Polysaccharide extracts from Ganoderma lucidum have been reported to exhibit immuno-modulating and anti-tumor …

BACKGROUND: Ganoderma lucidum has been widely used as a herbal medicine for promoting health and longevity in China and other …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
75.
Integrative Analysis of Selected Metabolites and the Fungal Transcriptome during the Developmental Cycle of Ganoderma lucidum Strain G0119 Correlates Lignocellulose Degradation with Carbohydrate and Triterpenoid Metabolism.
- Zhou S, Zhang X, Ma F, Xie S, Tang C, Tang Q, Zhang J.
- Appl Environ Microbiol. 2021 Jun 11;87(13):e0053321. doi: 10.1128/AEM.00533-21.
- PMCID: PMC8315967
Zhou S, et al.

Appl Environ Microbiol. 2021.

PMCID: PMC8315967

To systemically understand the biosynthetic pathways of bioactive substances, including triterpenoids and polysaccharides, in Ganoderma lucidum, the correlation between substrate degradation and carbohydrate and triterpenoid metabolism during growth was analyzed by …

To systemically understand the biosynthetic pathways of bioactive substances, including triterpenoids and polysaccharides, in Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Integrative Analysis of Selected Metabolites and the Fungal Transcriptome during the Developmental Cycle of Ganoderma lucidum Strain G0119 Correlates Lignocellulose Degradation with Carbohydrate and Triterpenoid Metabolism.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
76.
Genome-wide identification and characterization of long intergenic non-coding RNAs in Ganoderma lucidum.
- Li J, Wu B, Xu J, Liu C.
- PLoS One. 2014 Jun 16;9(6):e99442. doi: 10.1371/journal.pone.0099442.
- PMCID: PMC4059649
Li J, et al.

PLoS One. 2014.

PMCID: PMC4059649

Ganoderma lucidum is a white-rot fungus best-known for its medicinal activities. We have previously sequenced its genome and annotated the protein coding genes. However, long non-coding RNAs in G. lucidum genome have not been analyzed. In this study, we have …

Ganoderma lucidum is a white-rot fungus best-known for its medicinal activities. We have previously sequenced its genome and a …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Genome-wide identification and characterization of long intergenic non-coding RNAs in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
77.
The ITS region provides a reliable DNA barcode for identifying reishi/lingzhi (Ganoderma) from herbal supplements.
- Gunnels T, Creswell M, McFerrin J, Whittall JB.
- PLoS One. 2020 Nov 12;15(11):e0236774. doi: 10.1371/journal.pone.0236774.
- PMCID: PMC7660467
Gunnels T, et al.

PLoS One. 2020.

PMCID: PMC7660467

We employed a molecular phylogenetic analysis for species authentication of the commonly used fungal supplement, reishi (Ganoderma lingzhi), by amplifying and sequencing the nuclear ribosomal internal transcribed spacer regions (ITS) with genus-specific primers. PCR …

We employed a molecular phylogenetic analysis for species authentication of the commonly used fungal supplement, reishi (Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The ITS region provides a reliable DNA barcode for identifying reishi /lingzhi ( Ganoderma ) from herbal supplements.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Quality/authentication methods study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
78.
Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure-activity relationships.
- Chen S, Li X, Yong T, Wang Z, Su J, Jiao C, Xie Y, Yang BB.
- Oncotarget. 2017 Feb 7;8(6):10071-10084. doi: 10.18632/oncotarget.14336.
- PMCID: PMC5354642
Chen S, et al.

Oncotarget. 2017.

PMCID: PMC5354642

We conducted a study of Ganoderma lucidum metabolites and isolated 35 lanostane-type triterpenoids, including 5 new ganoderols (1-5). ...These results provide further evidence for anti-cancer constituents within Ganoderma lucidum, and may provide a the …

We conducted a study of Ganoderma lucidum metabolites and isolated 35 lanostane-type triterpenoids, including 5 new ganoderols …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure-activity relationships.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
79.
Antitumor activity of enzymatically hydrolyzed Ganoderma lucidum polysaccharide on U14 cervical carcinoma-bearing mice.
- Kong M, Yao Y, Zhang H.
- Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419869489. doi: 10.1177/2058738419869489.
- PMCID: PMC6716173
Kong M, et al.

Int J Immunopathol Pharmacol. 2019.

PMCID: PMC6716173

Polysaccharides from Ganoderma lucidum have been demonstrated to possess diverse biological activities. Despite lots of studies on the biological activities of Ganoderma lucidum polysaccharide (GLP), little is known regarding the medicinal potential of …

Polysaccharides from Ganoderma lucidum have been demonstrated to possess diverse biological activities. Despite lots of studie …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antitumor activity of enzymatically hydrolyzed Ganoderma lucidum polysaccharide on U14 cervical carcinoma-bearing mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
80.
Ganoderma lucidum Exerts an Anticancer Effect on Human Osteosarcoma Cells via Suppressing the Wnt/beta-Catenin Signaling Pathway.
- Zhang QH, Hu QX, Xie D, Chang B, Miao HG, Wang YG, Liu DZ, Li XD.
- Integr Cancer Ther. 2019 Jan-Dec;18:1534735419890917. doi: 10.1177/1534735419890917.
- PMCID: PMC6923688
Zhang QH, et al.

Integr Cancer Ther. 2019.

PMCID: PMC6923688

Background: Current treatment of osteosarcoma is limited in part by side effects and low tolerability, problems generally avoided with traditional Chinese medicine. Ganoderma lucidum, a traditional Chinese medicine with antitumor effects, offers a potential alternat …

Background: Current treatment of osteosarcoma is limited in part by side effects and low tolerability, problems generally avoided with tradi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Exerts an Anticancer Effect on Human Osteosarcoma Cells via Suppressing the Wnt/beta-Catenin Signaling Pathway.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 9

81.
Proteome exploration to provide a resource for the investigation of Ganoderma lucidum.
- Yu GJ, Yin YL, Yu WH, Liu W, Jin YX, Shrestha A, Yang Q, Ye XD, Sun H.
- PLoS One. 2015 Mar 10;10(3):e0119439. doi: 10.1371/journal.pone.0119439.
- PMCID: PMC4355618
Yu GJ, et al.

PLoS One. 2015.

PMCID: PMC4355618

Ganoderma lucidum is a basidiomycete white rot fungus that has been used for medicinal purposes worldwide. Although information concerning its genome and transcriptome has recently been reported, relatively little information is available for G. lucidum at th …

Ganoderma lucidum is a basidiomycete white rot fungus that has been used for medicinal purposes worldwide. Although informatio …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Proteome exploration to provide a resource for the investigation of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
82.
Heme Oxygenase/Carbon Monoxide Participates in the Regulation of Ganoderma lucidum Heat-Stress Response, Ganoderic Acid Biosynthesis, and Cell-Wall Integrity.
- Wu T, Liu X, Wang T, Tian L, Qiu H, Ge F, Zhu J, Shi L, Jiang A, Yu H, Ren A.
- Int J Mol Sci. 2022 Oct 29;23(21):13147. doi: 10.3390/ijms232113147.
- PMCID: PMC9659044
Wu T, et al.

Int J Mol Sci. 2022.

PMCID: PMC9659044

However, whether HO/CO is involved in the regulation of the heat-stress (HS) response of Ganoderma lucidum (G. lucidum) is still poorly understood. In this paper, we reported that under heat stress, the HMX1 transcription level, HO enzyme activity, and CO con …

However, whether HO/CO is involved in the regulation of the heat-stress (HS) response of Ganoderma lucidum (G. lucidum) …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Heme Oxygenase/Carbon Monoxide Participates in the Regulation of Ganoderma lucidum Heat-Stress Response, Ganoderic Acid Biosynthesis, and Cell-Wall Integrity.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
83.
A novel approach to enhancing ganoderic acid production by Ganoderma lucidum using apoptosis induction.
- You BJ, Lee MH, Tien N, Lee MS, Hsieh HC, Tseng LH, Chung YL, Lee HZ.
- PLoS One. 2013 Jan 10;8(1):e53616. doi: 10.1371/journal.pone.0053616.
- PMCID: PMC3542374
You BJ, et al.

PLoS One. 2013.

PMCID: PMC3542374

Ganoderma lucidum is one of most widely used herbal medicine and functional food in Asia, and ganoderic acids (GAs) are its active ingredients. Regulation of GA biosynthesis and enhancing GA production are critical to using G. lucidum as a medicine. However, …

Ganoderma lucidum is one of most widely used herbal medicine and functional food in Asia, and ganoderic acids (GAs) are its ac …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A novel approach to enhancing ganoderic acid production by Ganoderma lucidum using apoptosis induction.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
84.
Profiling and quantifying differential gene transcription provide insights into ganoderic acid biosynthesis in Ganoderma lucidum in response to methyl jasmonate.
- Ren A, Li MJ, Shi L, Mu DS, Jiang AL, Han Q, Zhao MW.
- PLoS One. 2013 Jun 7;8(6):e65027. doi: 10.1371/journal.pone.0065027.
- PMCID: PMC3676390
Ren A, et al.

PLoS One. 2013.

PMCID: PMC3676390

Ganoderma lucidum is a mushroom with traditional medicinal properties that has been widely used in China and other countries in Eastern Asia. Ganoderic acids (GA) produced by G. lucidum exhibit important pharmacological activities. Previous studies have demon …

Ganoderma lucidum is a mushroom with traditional medicinal properties that has been widely used in China and other countries i …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Profiling and quantifying differential gene transcription provide insights into ganoderic acid biosynthesis in Ganoderma lucidum in response to methyl jasmonate.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
85.
Enhanced production of polysaccharides and triterpenoids in Ganoderma lucidum fruit bodies on induction with signal transduction during the fruiting stage.
- Ye L, Liu S, Xie F, Zhao L, Wu X.
- PLoS One. 2018 Apr 25;13(4):e0196287. doi: 10.1371/journal.pone.0196287.
- PMCID: PMC5919040
Ye L, et al.

PLoS One. 2018.

PMCID: PMC5919040

Ganoderma lucidum is a medicinal mushroom that has been widely used in East Asia for the treatment of various diseases. ...The present study provides a useful approach to producing G. lucidum fruit bodies with high polysaccharide and triterpenoid content. Thi …

Ganoderma lucidum is a medicinal mushroom that has been widely used in East Asia for the treatment of various diseases. ...The …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Enhanced production of polysaccharides and triterpenoids in Ganoderma lucidum fruit bodies on induction with signal transduction during the fruiting stage.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
86.
Generation and analysis of the expressed sequence tags from the mycelium of Ganoderma lucidum.
- Huang YH, Wu HY, Wu KM, Liu TT, Liou RF, Tsai SF, Shiao MS, Ho LT, Tzean SS, Yang UC.
- PLoS One. 2013 May 2;8(5):e61127. doi: 10.1371/journal.pone.0061127.
- PMCID: PMC3642047
Huang YH, et al.

PLoS One. 2013.

PMCID: PMC3642047

Ganoderma lucidum (G. lucidum) is a medicinal mushroom renowned in East Asia for its potential biological effects. To enable a systematic exploration of the genes associated with the various phenotypes of the fungus, the genome consortium of G. lucidum …

Ganoderma lucidum (G. lucidum) is a medicinal mushroom renowned in East Asia for its potential biological effects. To e …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Generation and analysis of the expressed sequence tags from the mycelium of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
87.
Proteome study of dikaryotic and monokaryotic mycelia reveals the transfer between biological processes contributing to dikaryon growth advantage of the medicinal fungus Ganoderma lucidum.
- Yu H, Dong L, Zhao Q.
- BMC Genomics. 2025 Aug 1;26(1):711. doi: 10.1186/s12864-025-11905-2.
- PMCID: PMC12315474
Yu H, et al.

BMC Genomics. 2025.

PMCID: PMC12315474

BACKGROUND: Ganoderma lucidum, a well-known medicinal fungus in traditional Chinese medicine, exhibits a superior growth rate in its dikaryotic mycelia compared to monokaryons, and this is essential for its fruiting body formation and medicinal utilization. ...This …

BACKGROUND: Ganoderma lucidum, a well-known medicinal fungus in traditional Chinese medicine, exhibits a superior growth rate …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Proteome study of dikaryotic and monokaryotic mycelia reveals the transfer between biological processes contributing to dikaryon growth advantage of the medicinal fungus Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
88.
A Summary of a Cochrane Review: Ganoderma lucidum (Reishi mushroom) for the treatment of cancer.
- Santesso N, Wieland LS.
- Eur J Integr Med. Author manuscript. 2016 Jul 20;8(5):619-620. doi: 10.1016/j.eujim.2016.07.025.
- PMCID: PMC5222619
Santesso N, et al.

Eur J Integr Med. Author manuscript. 2016.

PMCID: PMC5222619
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A Summary of a Cochrane Review: Ganoderma lucidum ( Reishi mushroom) for the treatment of cancer.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
89.
Rapid Green Synthesis of Silver Nanoparticles by Reishi and Their Antibacterial Activity and Mechanisms.
- Ewunkem AJ, Priester T, Williams D, Ariyon B, Tshimanga I, Justice B, Singh DK.
- J Biomater Nanobiotechnol. Author manuscript. 2024 Jul 12;15(3):51-63. doi: 10.4236/jbnb.2024.153004.
- PMCID: PMC12393771
Ewunkem AJ, et al.

J Biomater Nanobiotechnol. Author manuscript. 2024.

PMCID: PMC12393771

Herein, the objective of this study was to examine an innovative approach to rapidly synthesis silver nanoparticles from an aqueous extract of medicinal mushroom Ganoderma lucidum (also known as reishi). The structural and dimensional dispersion of the biosyn …

Herein, the objective of this study was to examine an innovative approach to rapidly synthesis silver nanoparticles from an aqueous extract …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Rapid Green Synthesis of Silver Nanoparticles by Reishi and Their Antibacterial Activity and Mechanisms.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
90.
Ganoderma lucidum stimulates autophagy-dependent longevity pathways in Caenorhabditis elegans and human cells.
- Peng HH, Wu CY, Hsiao YC, Martel J, Ke PY, Chiu CY, Liau JC, Chang IT, Su YH, Ko YF, Young JD, Ojcius DM.
- Aging (Albany NY). 2021 May 20;13(10):13474-13495. doi: 10.18632/aging.203068.
- PMCID: PMC8202889
Peng HH, et al.

Aging (Albany NY). 2021.

PMCID: PMC8202889

The medicinal fungus Ganoderma lucidum is used as a dietary supplement and health tonic, but whether it affects longevity remains unclear. ...These results suggest that G. lucidum can increase longevity by inducing autophagy and stress resistance....

The medicinal fungus Ganoderma lucidum is used as a dietary supplement and health tonic, but whether it affects longevity rema …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum stimulates autophagy-dependent longevity pathways in Caenorhabditis elegans and human cells.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 10

91.
Induction of apoptosis and ganoderic acid biosynthesis by cAMP signaling in Ganoderma lucidum.
- You BJ, Tien N, Lee MH, Bao BY, Wu YS, Hu TC, Lee HZ.
- Sci Rep. 2017 Mar 23;7(1):318. doi: 10.1038/s41598-017-00281-x.
- PMCID: PMC5428012
You BJ, et al.

Sci Rep. 2017.

PMCID: PMC5428012

However, apoptosis signaling in relation to secondary metabolite biosynthesis in plants and fungi remains a mystery. The fungus Ganoderma lucidum is a popular herbal medicine worldwide, but the biosynthetic regulation of its active ingredients (ganoderic acids, GAs) …

However, apoptosis signaling in relation to secondary metabolite biosynthesis in plants and fungi remains a mystery. The fungus Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Induction of apoptosis and ganoderic acid biosynthesis by cAMP signaling in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
92.
Abundant and selective RNA-editing events in the medicinal mushroom Ganoderma lucidum.
- Zhu Y, Luo H, Zhang X, Song J, Sun C, Ji A, Xu J, Chen S.
- Genetics. 2014 Feb 4;196(4):1047-57. doi: 10.1534/genetics.114.161414.
- PMCID: PMC3982681
Zhu Y, et al.

Genetics. 2014.

PMCID: PMC3982681

In this study, we screened for fungal RNA editing sites at the genomic level in Ganoderma lucidum, a valuable medicinal fungus. On the basis of our pipeline that predicted the editing sites from genomic and transcriptomic data, a total of 8906 possible RNA-editing s …

In this study, we screened for fungal RNA editing sites at the genomic level in Ganoderma lucidum, a valuable medicinal fungus …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Abundant and selective RNA-editing events in the medicinal mushroom Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
93.
Ionic Liquid-Based Ultrasonic-Assisted Extraction Coupled with HPLC and Artificial Neural Network Analysis for Ganoderma lucidum.
- Li C, Cui Y, Lu J, Liu C, Chen S, Ma C, Liu Z, Wang J, Kang W.
- Molecules. 2020 Mar 13;25(6):1309. doi: 10.3390/molecules25061309.
- PMCID: PMC7144108
Li C, et al.

Molecules. 2020.

PMCID: PMC7144108

Ganoderma lucidum is widely used in traditional Chinese medicine (TCM). Ganoderic acid A and D are the main bioactive components with anticancer effects in G. lucidum. To obtain the maximum content of two compounds from G. lucidum, a novel extraction m …

Ganoderma lucidum is widely used in traditional Chinese medicine (TCM). Ganoderic acid A and D are the main bioactive componen …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ionic Liquid-Based Ultrasonic-Assisted Extraction Coupled with HPLC and Artificial Neural Network Analysis for Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
94.
Purification, crystallization and preliminary X-ray structure analysis of the laccase from Ganoderma lucidum.
- Lyashenko AV, Belova O, Gabdulkhakov AG, Lashkov AA, Lisov AV, Leontievsky AA, Mikhailov AM.
- Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 20;67(Pt 8):926-9. doi: 10.1107/S1744309111021129.
- PMCID: PMC3151130
Lyashenko AV, et al.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011.

PMCID: PMC3151130

This paper presents the purification, crystallization and preliminary X-ray analysis of the laccase from the ligninolytic basidiomycete Ganoderma lucidum....

This paper presents the purification, crystallization and preliminary X-ray analysis of the laccase from the ligninolytic basidiomycete G …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Purification, crystallization and preliminary X-ray structure analysis of the laccase from Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Relevant for eco‑friendly processing, waste upcycling, and industrial biocatalysis. Open article.
95.
The Anti-Melanogenic Effects of Ganodermanontriol from the Medicinal Mushroom Ganoderma lucidum through the Regulation of the CREB and MAPK Signaling Pathways in B16F10 Cells.
- Park CH, Oh YL, Shin JH, Park YJ.
- Molecules. 2024 Aug 22;29(16):3976. doi: 10.3390/molecules29163976.
- PMCID: PMC11357533
Park CH, et al.

Molecules. 2024.

PMCID: PMC11357533

Ganoderma lucidum, a member of the Basidiomycetes family, is attracting attention for its medicinal potential due to its biological activity and the presence of numerous bioactive compounds. ...Finally, the biosynthesis of GT and other substances by G. lucidum …

Ganoderma lucidum, a member of the Basidiomycetes family, is attracting attention for its medicinal potential due to its biolo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The Anti-Melanogenic Effects of Ganodermanontriol from the Medicinal Mushroom Ganoderma lucidum through the Regulation of the CREB and MAPK Signaling Pathways in B16F10 Cells.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
96.
Genome sequence of the model medicinal mushroom Ganoderma lucidum.
- Chen S, Xu J, Liu C, Zhu Y, Nelson DR, Zhou S, Li C, Wang L, Guo X, Sun Y, Luo H, Li Y, Song J, Henrissat B, Levasseur A, Qian J, Li J, Luo X, Shi L, He L, Xiang L, Xu X, Niu Y, Li Q, Han MV, Yan H, Zhang J, Chen H, Lv A, Wang Z, Liu M, Schwartz DC, Sun C.
- Nat Commun. 2012 Jun 26;3:913. doi: 10.1038/ncomms1923.
- PMCID: PMC3621433
Chen S, et al.

Nat Commun. 2012.

PMCID: PMC3621433

Ganoderma lucidum is a widely used medicinal macrofungus in traditional Chinese medicine that creates a diverse set of bioactive compounds. ...Moreover, 78 CYP genes are coexpressed with lanosterol synthase, and 16 of these show high similarity to fungal CYPs that s …

Ganoderma lucidum is a widely used medicinal macrofungus in traditional Chinese medicine that creates a diverse set of bioacti …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Genome sequence of the model medicinal mushroom Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
97.
Screening and Analysis of the Marker Components in Ganoderma lucidum by HPLC and HPLC-MS(n) with the Aid of Chemometrics.
- Wu L, Liang W, Chen W, Li S, Cui Y, Qi Q, Zhang L.
- Molecules. 2017 Apr 6;22(4):584. doi: 10.3390/molecules22040584.
- PMCID: PMC6154496
Wu L, et al.

Molecules. 2017.

PMCID: PMC6154496

Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, which is a popularly used traditional Chinese medicine for complementary cancer therapy. ...This study provides helpful chemical information for further research on the anti …

Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, which is a popularly used traditi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Screening and Analysis of the Marker Components in Ganoderma lucidum by HPLC and HPLC-MS(n) with the Aid of Chemometrics.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
98.
GlPRMT5 inhibits GlPP2C1 via symmetric dimethylation and regulates the biosynthesis of secondary metabolites in Ganoderma lucidum.
- Wang Z, Qiu H, Li Y, Zhao M, Liu R.
- Commun Biol. 2024 Feb 28;7(1):241. doi: 10.1038/s42003-024-05942-y.
- PMCID: PMC10902306
Wang Z, et al.

Commun Biol. 2024.

PMCID: PMC10902306

Secondary metabolites are vital pharmacological compounds in Ganoderma lucidum, and their content is an important indicator for evaluating the quality of G. lucidum. ...In addition, silencing GlPP2C1 clearly reduced GA content, indicating that GlPP2C1 positiv …

Secondary metabolites are vital pharmacological compounds in Ganoderma lucidum, and their content is an important indicator fo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: GlPRMT5 inhibits GlPP2C1 via symmetric dimethylation and regulates the biosynthesis of secondary metabolites in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
99.
A Systematic Review of in-vivo Studies on Dietary Mushroom Supplementation for Cognitive Impairment (P14-021-19).
- Nkodo A.
- Curr Dev Nutr. 2019 Jun 13;3(Suppl 1):nzz052.P14-021-19. doi: 10.1093/cdn/nzz052.P14-021-19.
- PMCID: PMC6574952
Nkodo A.

Curr Dev Nutr. 2019.

PMCID: PMC6574952

OBJECTIVES: A systematic review was undertaken of the evidence on the use of Hericium erinaceus (Reishi), Ganoderma lucidum (Lion's Mane), Ophiocordyceps sinensis (Cordyceps) and Cordyceps militaris (Cordyceps), dietary supplementation on cognitive impairment …

OBJECTIVES: A systematic review was undertaken of the evidence on the use of Hericium erinaceus (Reishi), Ganoderma lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A Systematic Review of in-vivo Studies on Dietary Mushroom Supplementation for Cognitive Impairment (P14-021-19).. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
100.
Determination of volatile aroma compounds of Ganoderma lucidum by gas chromatography mass spectrometry (HS-GC/MS).
- Taşkın H, Kafkas E, Çakıroğlu Ö, Büyükalaca S.
- Afr J Tradit Complement Altern Med. 2012 Dec 31;10(2):353-5.
- PMCID: PMC3746584
Taşkın H, et al.

Afr J Tradit Complement Altern Med. 2012.

PMCID: PMC3746584

This study was conducted at Horticulture Department of Cukurova University, Adana, Turkey during 2010-2011. Fresh sample of Ganoderma lucidum collected from Mersin province of Turkey was used as material. Volatile aroma compounds were performed by Headspace Gas Chro …

This study was conducted at Horticulture Department of Cukurova University, Adana, Turkey during 2010-2011. Fresh sample of Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Determination of volatile aroma compounds of Ganoderma lucidum by gas chromatography mass spectrometry (HS-GC/MS).. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 11

101.
Transcriptome dynamics and metabolite analysis revealed the candidate genes and regulatory mechanism of ganoderic acid biosynthesis during liquid superficial-static culture of Ganoderma lucidum.
- Wang Q, Xu M, Zhao L, Wang F, Li Y, Shi G, Ding Z.
- Microb Biotechnol. 2020 Sep 25;14(2):600-613. doi: 10.1111/1751-7915.13670.
- PMCID: PMC7936306
Wang Q, et al.

Microb Biotechnol. 2020.

PMCID: PMC7936306

Ganoderic acid (GA), an important secondary metabolite of Ganoderma lucidum, exhibited many significant pharmacological activities. In this study, the biosynthetic mechanism of GAs was investigated by comparing metabolites and transcriptome dynamics during liquid su …

Ganoderic acid (GA), an important secondary metabolite of Ganoderma lucidum, exhibited many significant pharmacological activi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Transcriptome dynamics and metabolite analysis revealed the candidate genes and regulatory mechanism of ganoderic acid biosynthesis during liquid superficial-static culture of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
102.
Production Ganoderma lucidum extract nanoparticles by expansion of supercritical fluid solution and evaluation of the antioxidant ability.
- Karimi M, Raofie F, Karimi M.
- Sci Rep. 2022 Jun 14;12(1):9904. doi: 10.1038/s41598-022-13727-8.
- PMCID: PMC9198024
Karimi M, et al.

Sci Rep. 2022.

PMCID: PMC9198024

Due to the growing human tendency to treat with natural substances, fungi such as Ganoderma lucidum can be a good source to meet this need. Effectiveness, ease of use and a rich source of active ingredients such as ganoderic acids have caused G. lucidum to be …

Due to the growing human tendency to treat with natural substances, fungi such as Ganoderma lucidum can be a good source to me …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Production Ganoderma lucidum extract nanoparticles by expansion of supercritical fluid solution and evaluation of the antioxidant ability.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
103.
Ganoderma lucidum-Derived Meroterpenoids Show Anti-Inflammatory Activity In Vitro.
- Liu YY, Cai D, Tang XP, Cheng YX.
- Molecules. 2024 Mar 5;29(5):1149. doi: 10.3390/molecules29051149.
- PMCID: PMC10935275
Liu YY, et al.

Molecules. 2024.

PMCID: PMC10935275

Ganoderma lucidum, known as the "herb of spiritual potency", is used for the treatment and prevention of various diseases, but the responsible constituents for its therapeutic effects are largely unknown. ...The current study will aid in enriching the structural and …

Ganoderma lucidum, known as the "herb of spiritual potency", is used for the treatment and prevention of various diseases, but …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum -Derived Meroterpenoids Show Anti-Inflammatory Activity In Vitro.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
104.
Elimination of quiescent slow-cycling cells via reducing quiescence depth by natural compounds purified from Ganoderma lucidum.
- Dai J, Miller MA, Everetts NJ, Wang X, Li P, Li Y, Xu JH, Yao G.
- Oncotarget. 2017 Feb 21;8(8):13770-13781. doi: 10.18632/oncotarget.14634.
- PMCID: PMC5355137
Dai J, et al.

Oncotarget. 2017.

PMCID: PMC5355137

The medical mushroom Ganoderma lucidum has long been used in traditional Chinese medicine and shown effective in the treatment of many diseases including cancer. Here we studied the cytotoxic effects of two natural compounds purified from Ganoderma lucidum …

The medical mushroom Ganoderma lucidum has long been used in traditional Chinese medicine and shown effective in the treatment …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Elimination of quiescent slow-cycling cells via reducing quiescence depth by natural compounds purified from Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
105.
Ganoderma lucidum, a promising agent possessing antioxidant and anti-inflammatory effects for treating calvarial defects with graft application in rats.
- Laçin N, İzol SB, İpek F, Tuncer MC.
- Acta Cir Bras. 2019 Nov 25;34(9):e201900904. doi: 10.1590/s0102-865020190090000004.
- PMCID: PMC6887096
Laçin N, et al.

Acta Cir Bras. 2019.

PMCID: PMC6887096

PURPOSE: Ganoderma lucidum, a kind of mushroom used for its antioxidant, anti-inflammatory, and immunomodulatory activities, was investigated in the present study for its possible healing effect on calvarial defects with bone grafts. METHODS: Wistar male rats (n = 3 …

PURPOSE: Ganoderma lucidum, a kind of mushroom used for its antioxidant, anti-inflammatory, and immunomodulatory activities, w …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum , a promising agent possessing antioxidant and anti-inflammatory effects for treating calvarial defects with graft application in rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
106.
Systematic analysis of the lysine succinylome in the model medicinal mushroom Ganoderma lucidum.
- Wang G, Xu L, Yu H, Gao J, Guo L.
- BMC Genomics. 2019 Jul 16;20(1):585. doi: 10.1186/s12864-019-5962-0.
- PMCID: PMC6636155
Wang G, et al.

BMC Genomics. 2019.

PMCID: PMC6636155

BACKGROUND: Ganoderma lucidum, one of the best-known medicinal mushrooms in the world, produces more than 400 different bioactive compounds. ...Although it has been studied for a long time, its function is still unclear in G. lucidum. In this study, a global …

BACKGROUND: Ganoderma lucidum, one of the best-known medicinal mushrooms in the world, produces more than 400 different bioact …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Systematic analysis of the lysine succinylome in the model medicinal mushroom Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
107.
Utilization of Response Surface Methodology in Optimization of Polysaccharides Extraction from Vietnamese Red Ganoderma lucidum by Ultrasound-Assisted Enzymatic Method and Examination of Bioactivities of the Extract.
- Do DT, Lam DH, Nguyen T, Phuong Mai TT, Phan LTM, Vuong HT, Nguyen DV, Linh NTT, Hoang MN, Mai TP, Nguyen HH.
- ScientificWorldJournal. 2021 Feb 11;2021:7594092. doi: 10.1155/2021/7594092.
- PMCID: PMC7892253
Do DT, et al.

ScientificWorldJournal. 2021.

PMCID: PMC7892253

Red Ganoderma lucidum (G. lucidum) is a popular medicinal herb commonly used in Vietnamese traditional remedies due to its potential value for health. ...This result suggested that UAEE could be considered as an appropriate and effective extraction method for …

Red Ganoderma lucidum (G. lucidum) is a popular medicinal herb commonly used in Vietnamese traditional remedies due to …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Utilization of Response Surface Methodology in Optimization of Polysaccharides Extraction from Vietnamese Red Ganoderma lucidum by Ultrasound-Assisted Enzymatic Method and Examination of Bioactivities of the Extract.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
108.
Selected strains of the Ganoderma lucidum complex from Finnish forests have excellent broadly acting antiviral properties.
- Reshamwala D, Shroff S, Liimatainen J, Tienaho J, Kuukkanen I, Laajala M, Civra A, Francese R, Veteli P, Cortina-Escribano M, Sarjala T, Karonen M, Lembo D, Linnakoski R, Marjomäki V.
- Sci Rep. 2025 Jul 2;15(1):23565. doi: 10.1038/s41598-025-08377-5.
- PMCID: PMC12223054
Reshamwala D, et al.

Sci Rep. 2025.

PMCID: PMC12223054

Thus, the current study aims to investigate the broad-spectrum antiviral activity of ferments of selected strains belonging to the Ganoderma lucidum complex isolated from Finland and investigate their mechanism of action. ...The results show great promise for the fu …

Thus, the current study aims to investigate the broad-spectrum antiviral activity of ferments of selected strains belonging to the Ganode …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Selected strains of the Ganoderma lucidum complex from Finnish forests have excellent broadly acting antiviral properties.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
109.
Complete mitochondrial genome of the medicinal mushroom Ganoderma lucidum.
- Li J, Zhang J, Chen H, Chen X, Lan J, Liu C.
- PLoS One. 2013 Aug 26;8(8):e72038. doi: 10.1371/journal.pone.0072038.
- PMCID: PMC3753355
Li J, et al.

PLoS One. 2013.

PMCID: PMC3753355

Ganoderma lucidum is one of the well-known medicinal basidiomycetes worldwide. The mitochondrion, referred to as the second genome, is an organelle found in most eukaryotic cells and participates in critical cellular functions. Elucidating the structure and function …

Ganoderma lucidum is one of the well-known medicinal basidiomycetes worldwide. The mitochondrion, referred to as the second ge …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Complete mitochondrial genome of the medicinal mushroom Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
110.
Optimization of Laccase from Ganoderma lucidum Decolorizing Remazol Brilliant Blue R and Glac1 as Main Laccase-Contributing Gene.
- Qin P, Wu Y, Adil B, Wang J, Gu Y, Yu X, Zhao K, Zhang X, Ma M, Chen Q, Chen X, Zhang Z, Xiang Q.
- Molecules. 2019 Oct 30;24(21):3914. doi: 10.3390/molecules24213914.
- PMCID: PMC6864837
Qin P, et al.

Molecules. 2019.

PMCID: PMC6864837

In this work, the influence of reaction time, pH, temperature, dye concentration, metal ions, and mediators on laccase-catalyzed Remazol Brilliant Blue R dye (RBBR) decolorization were investigated in vitro using crude laccase from the white-rot fungus Ganoderma lucidum …

In this work, the influence of reaction time, pH, temperature, dye concentration, metal ions, and mediators on laccase-catalyzed Remazol Bri …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Optimization of Laccase from Ganoderma lucidum Decolorizing Remazol Brilliant Blue R and Glac1 as Main Laccase-Contributing Gene.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Relevant for eco‑friendly processing, waste upcycling, and industrial biocatalysis. Open article.

Page 12

111.
GlMPC activated by GCN4 regulates secondary metabolism under nitrogen limitation conditions in Ganoderma lucidum.
- Wang Z, Chen J, Ding J, Han J, Shi L.
- mBio. 2023 Sep 21;14(5):e0135623. doi: 10.1128/mbio.01356-23.
- PMCID: PMC10653791
Wang Z, et al.

mBio. 2023.

PMCID: PMC10653791

In this study, we report that GCN4 can directly bind to the promoter region and activate the expression of GlMPC, thereby regulating the tricarboxylic acid cycle and secondary metabolism under nitrogen limitation conditions in Ganoderma lucidum. These findings provi …

In this study, we report that GCN4 can directly bind to the promoter region and activate the expression of GlMPC, thereby regulating the tri …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: GlMPC activated by GCN4 regulates secondary metabolism under nitrogen limitation conditions in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
112.
Enhanced Ganoderic Acids Accumulation and Transcriptional Responses of Biosynthetic Genes in Ganoderma lucidum Fruiting Bodies by Elicitation Supplementation.
- Meng L, Bai X, Zhang S, Zhang M, Zhou S, Mukhtar I, Wang L, Li Z, Wang W.
- Int J Mol Sci. 2019 Jun 10;20(11):2830. doi: 10.3390/ijms20112830.
- PMCID: PMC6600565
Meng L, et al.

Int J Mol Sci. 2019.

PMCID: PMC6600565

Ganoderic acids (GAs) are a type of highly oxygenated lanostane-type triterpenoids that are responsible for the pharmacological activities of Ganoderma lucidum. They have been investigated for their biological activities, including antibacterial, antiviral, antitumo …

Ganoderic acids (GAs) are a type of highly oxygenated lanostane-type triterpenoids that are responsible for the pharmacological activities o …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Enhanced Ganoderic Acids Accumulation and Transcriptional Responses of Biosynthetic Genes in Ganoderma lucidum Fruiting Bodies by Elicitation Supplementation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
113.
Postharvest Drying Techniques Regulate Secondary Metabolites and Anti-Neuroinflammatory Activities of Ganoderma lucidum.
- Sadiq NB, Ryu DH, Cho JY, Lee AH, Song DG, Dorjsembe B, Kim JC, Jung JH, Nho CW, Hamayun M, Yang SH, Kim HY.
- Molecules. 2021 Jul 25;26(15):4484. doi: 10.3390/molecules26154484.
- PMCID: PMC8347575
Sadiq NB, et al.

Molecules. 2021.

PMCID: PMC8347575

Ganoderma lucidum extract is a potent traditional remedy for curing various ailments. Drying is the most important postharvest step during the processing of Ganoderma lucidum. ...We investigated the effects of different postharvest drying protocols on …

Ganoderma lucidum extract is a potent traditional remedy for curing various ailments. Drying is the most important postharvest …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Postharvest Drying Techniques Regulate Secondary Metabolites and Anti-Neuroinflammatory Activities of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
114.
Transcriptional Dynamics of Genes Purportedly Involved in the Control of Meiosis, Carbohydrate, and Secondary Metabolism during Sporulation in Ganoderma lucidum.
- Cai M, Liang X, Liu Y, Hu H, Xie Y, Chen S, Gao X, Li X, Xiao C, Chen D, Wu Q.
- Genes (Basel). 2021 Mar 29;12(4):504. doi: 10.3390/genes12040504.
- PMCID: PMC8066989
Cai M, et al.

Genes (Basel). 2021.

PMCID: PMC8066989

Ganoderma lucidum spores (GLS), the mature germ cells ejected from the abaxial side of the pileus, have diverse pharmacological effects. ...Our results provide a dataset of dynamic gene expression during sporulation in G. lucidum. They also shed light on gene …

Ganoderma lucidum spores (GLS), the mature germ cells ejected from the abaxial side of the pileus, have diverse pharmacologica …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Transcriptional Dynamics of Genes Purportedly Involved in the Control of Meiosis, Carbohydrate, and Secondary Metabolism during Sporulation in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
115.
Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats.
- Matsuzaki H, Shimizu Y, Iwata N, Kamiuchi S, Suzuki F, Iizuka H, Hibino Y, Okazaki M.
- BMC Complement Altern Med. 2013 Dec 26;13:370. doi: 10.1186/1472-6882-13-370.
- PMCID: PMC3879659
Matsuzaki H, et al.

BMC Complement Altern Med. 2013.

PMCID: PMC3879659

BACKGROUND: Ganoderma lucidum is a popular medicinal mushroom used for promoting health and longevity in Asian countries. Previously, we reported that a water-soluble extract from a culture medium of Ganoderma lucidum mycelia (MAK) exerts antioxidative …

BACKGROUND: Ganoderma lucidum is a popular medicinal mushroom used for promoting health and longevity in Asian countries. Prev …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
116.
Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum.
- Kim JW, Kim HI, Kim JH, Kwon OC, Son ES, Lee CS, Park YJ.
- Int J Mol Sci. 2016 Oct 27;17(11):1798. doi: 10.3390/ijms17111798.
- PMCID: PMC5133799
Kim JW, et al.

Int J Mol Sci. 2016.

PMCID: PMC5133799

Ganoderma lucidum, a species of the Basidiomycetes class, has been attracting international attention owing to its wide variety of biological activities and great potential as an ingredient in skin care cosmetics including "skin-whitening" products. ...Therefore, th …

Ganoderma lucidum, a species of the Basidiomycetes class, has been attracting international attention owing to its wide variet …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
117.
Ganoderma lucidum inhibits proliferation of human ovarian cancer cells by suppressing VEGF expression and up-regulating the expression of connexin 43.
- Dai S, Liu J, Sun X, Wang N.
- BMC Complement Altern Med. 2014 Nov 5;14:434. doi: 10.1186/1472-6882-14-434.
- PMCID: PMC4232730
Dai S, et al.

BMC Complement Altern Med. 2014.

PMCID: PMC4232730

BACKGROUND: Ganoderma lucidum (G. lucidum, Reishimax) is an herbal mushroom known to have inhibitory effect on tumor cell growth. ...METHODS: Human ovarian cancer cells HO 8910 (HOCC) and human primary ovarian cells (HPOC) were treated with G. lucidum. …

BACKGROUND: Ganoderma lucidum (G. lucidum, Reishimax) is an herbal mushroom known to have inhibitory effect on tumor ce …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum inhibits proliferation of human ovarian cancer cells by suppressing VEGF expression and up-regulating the expression of connexin 43.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
118.
Methanolic Extract of Ganoderma lucidum Induces Autophagy of AGS Human Gastric Tumor Cells.
- Reis FS, Lima RT, Morales P, Ferreira IC, Vasconcelos MH.
- Molecules. 2015 Sep 29;20(10):17872-82. doi: 10.3390/molecules201017872.
- PMCID: PMC6332321
Reis FS, et al.

Molecules. 2015.

PMCID: PMC6332321

Ganoderma lucidum is one of the most widely studied mushroom species, particularly in what concerns its medicinal properties. ...The results obtained proved that, in AGS cells, the methanolic extract of G. lucidum causes an induction of autophagy, rather than …

Ganoderma lucidum is one of the most widely studied mushroom species, particularly in what concerns its medicinal properties. …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Methanolic Extract of Ganoderma lucidum Induces Autophagy of AGS Human Gastric Tumor Cells.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
119.
The development and application of a multiple gene co-silencing system using endogenous URA3 as a reporter gene in Ganoderma lucidum.
- Mu D, Shi L, Ren A, Li M, Wu F, Jiang A, Zhao M.
- PLoS One. 2012 Aug 24;7(8):e43737. doi: 10.1371/journal.pone.0043737.
- PMCID: PMC3427163
Mu D, et al.

PLoS One. 2012.

PMCID: PMC3427163

Ganoderma lucidum is one of the most important medicinal mushrooms; however, molecular genetics research on this species has been limited due to a lack of reliable reverse genetic tools. ...To highlight the advantages of the dual promoter system, we constructed a co …

Ganoderma lucidum is one of the most important medicinal mushrooms; however, molecular genetics research on this species has b …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The development and application of a multiple gene co-silencing system using endogenous URA3 as a reporter gene in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
120.
The CBS/H(2)S signalling pathway regulated by the carbon repressor CreA promotes cellulose utilization in Ganoderma lucidum.
- Shangguan J, Qiao J, Liu H, Zhu L, Han X, Shi L, Zhu J, Liu R, Ren A, Zhao M.
- Commun Biol. 2024 Apr 17;7(1):466. doi: 10.1038/s42003-024-06180-y.
- PMCID: PMC11024145
Shangguan J, et al.

Commun Biol. 2024.

PMCID: PMC11024145

In this paper, we found that the hydrogen sulfide (H(2)S) concentration under cellulose culture condition increased to approximately 2.3-fold compared with that under glucose culture condition in Ganoderma lucidum. Further evidence shown that cellulase activities of …

In this paper, we found that the hydrogen sulfide (H(2)S) concentration under cellulose culture condition increased to approximately 2.3-fol …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The CBS/H(2)S signalling pathway regulated by the carbon repressor CreA promotes cellulose utilization in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 13

121.
Integrated Proteomics and Metabolomics Analysis Provides Insights into Ganoderic Acid Biosynthesis in Response to Methyl Jasmonate in Ganoderma Lucidum.
- Jiang AL, Liu YN, Liu R, Ren A, Ma HY, Shu LB, Shi L, Zhu J, Zhao MW.
- Int J Mol Sci. 2019 Dec 4;20(24):6116. doi: 10.3390/ijms20246116.
- PMCID: PMC6941157
Jiang AL, et al.

Int J Mol Sci. 2019.

PMCID: PMC6941157

Ganoderma lucidum is widely recognized as a medicinal basidiomycete. It was previously reported that the plant hormone methyl jasmonate (MeJA) could induce the biosynthesis of ganoderic acids (GAs), which are the main active ingredients of G. lucidum. ...In c …

Ganoderma lucidum is widely recognized as a medicinal basidiomycete. It was previously reported that the plant hormone methyl …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Integrated Proteomics and Metabolomics Analysis Provides Insights into Ganoderic Acid Biosynthesis in Response to Methyl Jasmonate in Ganoderma Lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Maps pathways and components that can guide future lab and clinical research. Open article.
122.
Structural characterization and antioxidative activity of low-molecular-weights beta-1,3-glucan from the residue of extracted Ganoderma lucidum fruiting bodies.
- Kao PF, Wang SH, Hung WT, Liao YH, Lin CM, Yang WB.
- J Biomed Biotechnol. 2011 Dec 6;2012:673764. doi: 10.1155/2012/673764.
- PMCID: PMC3236510
Kao PF, et al.

J Biomed Biotechnol. 2011.

PMCID: PMC3236510

The major cell wall constituent of Ganoderma lucidum (G. lucidum) is beta-1,3-glucan. This study examined the polysaccharide from the residues of alkaline-extracted fruiting bodies using high-performance anion-exchange chromatography (HPAEC), and it employed …

The major cell wall constituent of Ganoderma lucidum (G. lucidum) is beta-1,3-glucan. This study examined the polysacch …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Structural characterization and antioxidative activity of low-molecular-weights beta-1,3-glucan from the residue of extracted Ganoderma lucidum fruiting bodies.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
123.
Ganoderma lucidum aqueous extract inducing PHGPx to inhibite membrane lipid hydroperoxides and regulate oxidative stress based on single-cell animal transcriptome.
- Ding W, Zhang X, Yin X, Zhang Q, Wang Y, Guo C, Chen Y.
- Sci Rep. 2022 Feb 24;12(1):3139. doi: 10.1038/s41598-022-06985-z.
- PMCID: PMC8873301
Ding W, et al.

Sci Rep. 2022.

PMCID: PMC8873301

In this study, the single-cell eukaryotic model organism Tetrahymena thermophila was used as an experimental material to reveal the anti-aging mechanism of Ganoderma lucidum aqueous extract. After treatment with the G. lucidum aqueous extract, the logarithmic …

In this study, the single-cell eukaryotic model organism Tetrahymena thermophila was used as an experimental material to reveal the anti-agi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum aqueous extract inducing PHGPx to inhibite membrane lipid hydroperoxides and regulate oxidative stress based on single-cell animal transcriptome.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
124.
Spermidine enhances the heat tolerance of Ganoderma lucidum by promoting mitochondrial respiration driven by fatty acid beta-oxidation.
- Han X, Wang Z, Shi L, Wei Z, Shangguan J, Shi L, Zhao M.
- Appl Environ Microbiol. 2025 Jan 29;91(2):e0097924. doi: 10.1128/aem.00979-24.
- PMCID: PMC11837530
Han X, et al.

Appl Environ Microbiol. 2025.

PMCID: PMC11837530

In conclusion, spermidine enhances key TCA cycle and ETC enzyme activities and is involved in heat stress-induced fatty acid beta-oxidation by promoting the translation of LCAD and HADH, thereby improving the heat tolerance of Ganoderma lucidum. IMPORTANCE: Polyamin …

In conclusion, spermidine enhances key TCA cycle and ETC enzyme activities and is involved in heat stress-induced fatty acid beta-oxidation …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Spermidine enhances the heat tolerance of Ganoderma lucidum by promoting mitochondrial respiration driven by fatty acid beta-oxidation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
125.
The protective effect of Ganoderma lucidum on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury.
- Doğan G, İpek H.
- Acta Cir Bras. 2020 Mar 20;35(1):e202000103. doi: 10.1590/s0102-865020200010000003.
- PMCID: PMC7092665
Doğan G, et al.

Acta Cir Bras. 2020.

PMCID: PMC7092665

PURPOSE: To investigate the protective effect of Ganoderma lucidum on testicular torsion/detorsion (T/D)-induced ischemia-reperfusion (I/R) injury. METHODS: Thirty male Wistar albino rats were randomly categorized into 3 groups: Group 1: sham, Group 2 ( T/D): 2,5 ho …

PURPOSE: To investigate the protective effect of Ganoderma lucidum on testicular torsion/detorsion (T/D)-induced ischemia-repe …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The protective effect of Ganoderma lucidum on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
126.
Structure and bioactivities of a polysaccharide isolated from Ganoderma lucidum in submerged fermentation.
- Ai-Lati A, Liu S, Ji Z, Zhang H, Mao J.
- Bioengineered. 2017 Jan 31;8(5):565-571. doi: 10.1080/21655979.2017.1283459.
- PMCID: PMC5639833
Ai-Lati A, et al.

Bioengineered. 2017.

PMCID: PMC5639833

In this study, a Ganoderma lucidum polysaccharide GLP-1-1 was isolated from a culture broth with Mw of 22014 Da. ...

In this study, a Ganoderma lucidum polysaccharide GLP-1-1 was isolated from a culture broth with Mw of 22014 Da. ...
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Structure and bioactivities of a polysaccharide isolated from Ganoderma lucidum in submerged fermentation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
127.
Optimization of ultrasonic-assisted extraction of polysaccharides and triterpenoids from the medicinal mushroom Ganoderma lucidum and evaluation of their in vitro antioxidant capacities.
- Zheng S, Zhang W, Liu S.
- PLoS One. 2020 Dec 31;15(12):e0244749. doi: 10.1371/journal.pone.0244749.
- PMCID: PMC7774858
Zheng S, et al.

PLoS One. 2020.

PMCID: PMC7774858

Ganoderma lucidum (Fr.) Krast, commonly known as "Lingzhi" in Chinese, is a medicinal mushroom that is rich in biologically active substances. ...The present study is the first report on the simultaneous extraction of polysaccharides and triterpenoids from G. luc …

Ganoderma lucidum (Fr.) Krast, commonly known as "Lingzhi" in Chinese, is a medicinal mushroom that is rich in biologically ac …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Optimization of ultrasonic-assisted extraction of polysaccharides and triterpenoids from the medicinal mushroom Ganoderma lucidum and evaluation of their in vitro antioxidant capacities.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
128.
Purification and Characterization of Antibacterial Activity against Phytopathogenic Bacteria in Culture Fluids from Ganoderma lucidum.
- Robles-Hernández L, Salas-Salazar NA, Gonzalez-Franco AC.
- Molecules. 2021 Sep 13;26(18):5553. doi: 10.3390/molecules26185553.
- PMCID: PMC8465007
Robles-Hernández L, et al.

Molecules. 2021.

PMCID: PMC8465007

Previous studies of Ganoderma lucidum have focused on its medicinal applications. Limited information is available about its antibacterial activity against plant pathogens. ...This is the first report of small polysaccharides produced by G. lucidum with activ …

Previous studies of Ganoderma lucidum have focused on its medicinal applications. Limited information is available about its a …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Purification and Characterization of Antibacterial Activity against Phytopathogenic Bacteria in Culture Fluids from Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
129.
Structure Identification and Anti-Cancer Pharmacological Prediction of Triterpenes from Ganoderma lucidum.
- Shao Y, Qiao L, Wu L, Sun X, Zhu D, Yang G, Zhang X, Mao X, Chen W, Liang W, Zhang Y, Zhang L.
- Molecules. 2016 May 21;21(5):678. doi: 10.3390/molecules21050678.
- PMCID: PMC6273610
Shao Y, et al.

Molecules. 2016.

PMCID: PMC6273610

Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, which is a popularly used traditional Chinese medicine for complementary cancer therapy. In the present study, systematic isolation, and in silico pharmacological prediction …

Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, which is a popularly used traditi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Structure Identification and Anti-Cancer Pharmacological Prediction of Triterpenes from Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
130.
In vitro and in vivo protective effects of proteoglycan isolated from mycelia of Ganoderma lucidum on carbon tetrachloride-induced liver injury.
- Yang XJ, Liu J, Ye LB, Yang F, Ye L, Gao JR, Wu ZH.
- World J Gastroenterol. 2006 Mar 7;12(9):1379-85. doi: 10.3748/wjg.v12.i9.1379.
- PMCID: PMC4124314
Yang XJ, et al.

World J Gastroenterol. 2006.

PMCID: PMC4124314

AIM: To investigate the possible mechanism of the protective effects of a bioactive fraction,Ganoderma lucidum proteoglycan (GLPG) isolated from Ganoderma lucidum mycelia, against carbon tetrachloride-induced liver injury. ...

AIM: To investigate the possible mechanism of the protective effects of a bioactive fraction,Ganoderma lucidum proteoglycan (G …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: In vitro and in vivo protective effects of proteoglycan isolated from mycelia of Ganoderma lucidum on carbon tetrachloride-induced liver injury.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 14

131.
Comparison of polysaccharides from two species of Ganoderma.
- Xie J, Zhao J, Hu DJ, Duan JA, Tang YP, Li SP.
- Molecules. 2012 Jan 13;17(1):740-52. doi: 10.3390/molecules17010740.
- PMCID: PMC6268238
Xie J, et al.

Molecules. 2012.

PMCID: PMC6268238

Ganoderma lucidum and Ganoderma sinense, known as Lingzhi in Chinese, are commonly used Chinese medicines with excellent beneficial health effects. ...However, the content of triterpenes differs significantly between the two species of Ganoderma. To da …

Ganoderma lucidum and Ganoderma sinense, known as Lingzhi in Chinese, are commonly used Chinese medicines with excellen …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Comparison of polysaccharides from two species of Ganoderma .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
132.
Antitumor and Immunomodulatory Activities of Ganoderma lucidum Polysaccharides in Glioma-Bearing Rats.
- Wang C, Shi S, Chen Q, Lin S, Wang R, Wang S, Chen C.
- Integr Cancer Ther. 2018 Apr 2;17(3):674-683. doi: 10.1177/1534735418762537.
- PMCID: PMC6142075
Wang C, et al.

Integr Cancer Ther. 2018.

PMCID: PMC6142075

Recently, scientific attention has been focused on Ganoderma lucidum polysaccharides (GL-PS), one of the critical bioactive components of G lucidum, which have been recognized as a promising natural source of immunomodulatory and anticancer compounds. ...

Recently, scientific attention has been focused on Ganoderma lucidum polysaccharides (GL-PS), one of the critical bioactive co …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antitumor and Immunomodulatory Activities of Ganoderma lucidum Polysaccharides in Glioma-Bearing Rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
133.
Identification and characterization of circular RNAs in Ganoderma lucidum.
- Shao J, Wang L, Liu X, Yang M, Chen H, Wu B, Liu C.
- Sci Rep. 2019 Nov 11;9(1):16522. doi: 10.1038/s41598-019-52932-w.
- PMCID: PMC6848116
Shao J, et al.

Sci Rep. 2019.

PMCID: PMC6848116

However, no circRNAs have been reported in Ganoderma lucidum. Here, we carried out a genome-wide identification of the circRNAs in G.lucidum using RNA-Seq data, and analyzed their features. ...Our results indicated that circRNAs are present in G. lucidum …

However, no circRNAs have been reported in Ganoderma lucidum. Here, we carried out a genome-wide identification of the circRNA …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Identification and characterization of circular RNAs in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
134.
A water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia attenuates the small intestinal injury induced by anti-cancer drugs.
- Kashimoto N, Ishii S, Myojin Y, Ushijima M, Hayama M, Watanabe H.
- Oncol Lett. 2010 Jan 1;1(1):63-68. doi: 10.3892/ol_00000011.
- PMCID: PMC3436462
Kashimoto N, et al.

Oncol Lett. 2010.

PMCID: PMC3436462

The present study investigated whether a water-soluble extract from the culture medium of Ganoderma lucidum (Reishi) mycelia (MAK) is able to protect the small intestine against damage induced by anti-cancer drugs. ...

The present study investigated whether a water-soluble extract from the culture medium of Ganoderma lucidum (Reishi) my …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A water-soluble extract from cultured medium of Ganoderma lucidum ( Reishi ) mycelia attenuates the small intestinal injury induced by anti-cancer drugs.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
135.
Structure Identification of Ganoderma lucidum Spore Polysaccharides and Their Antitumor Activity In Vivo.
- Liu HM, Cheng J, Wang XY, Jiang Y, Ni J, Zhang Y, Wang W.
- Molecules. 2024 May 16;29(10):2348. doi: 10.3390/molecules29102348.
- PMCID: PMC11124482
Liu HM, et al.

Molecules. 2024.

PMCID: PMC11124482

Ganoderma lucidum spore powder, valued for its nutritional and medicinal properties, contains polysaccharides crucial for its efficacy. ...This study aimed to investigate the effects of acid heat treatment on Ganoderma lucidum spore polysaccharides (GL …

Ganoderma lucidum spore powder, valued for its nutritional and medicinal properties, contains polysaccharides crucial for its …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Structure Identification of Ganoderma lucidum Spore Polysaccharides and Their Antitumor Activity In Vivo.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
136.
Anticancer and Antioxidant Activities in Ganoderma lucidum Wild Mushrooms in Poland, as Well as Their Phenolic and Triterpenoid Compounds.
- Kolniak-Ostek J, Oszmiański J, Szyjka A, Moreira H, Barg E.
- Int J Mol Sci. 2022 Aug 19;23(16):9359. doi: 10.3390/ijms23169359.
- PMCID: PMC9408863
Kolniak-Ostek J, et al.

Int J Mol Sci. 2022.

PMCID: PMC9408863

The goal of this study was to the assess anti-cancer and antioxidant properties of the Ganoderma lucidum fruiting body, and to identify bioactive compounds found in their extracts. ...Resveratrol was the most abundant phenolic in the extract (5155.7 mg/100 g DM). Th …

The goal of this study was to the assess anti-cancer and antioxidant properties of the Ganoderma lucidum fruiting body, and to …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Anticancer and Antioxidant Activities in Ganoderma lucidum Wild Mushrooms in Poland, as Well as Their Phenolic and Triterpenoid Compounds.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
137.
Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum.
- Grienke U, Mihály-Bison J, Schuster D, Afonyushkin T, Binder M, Guan SH, Cheng CR, Wolber G, Stuppner H, Guo DA, Bochkov VN, Rollinger JM.
- Bioorg Med Chem. 2011 Sep 29;19(22):6779-91. doi: 10.1016/j.bmc.2011.09.039.
- PMCID: PMC3254236
Grienke U, et al.

Bioorg Med Chem. 2011.

PMCID: PMC3254236

Virtual screening experiments of our in-house Chinese Herbal Medicine database with structure-based pharmacophore models, previously generated and validated, revealed mainly lanostane-type triterpenes of the TCM fungus Ganoderma lucidum Karst. as putative FXR ligand …

Virtual screening experiments of our in-house Chinese Herbal Medicine database with structure-based pharmacophore models, previously generat …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
138.
Improvement of Echinacea purpurea and Ganoderma lucidum Extracts with Cell Model on Influenza A/B Infection.
- Chen BK, Chan CH, Tsao A, Wang CK.
- Molecules. 2024 Jul 30;29(15):3609. doi: 10.3390/molecules29153609.
- PMCID: PMC11314549
Chen BK, et al.

Molecules. 2024.

PMCID: PMC11314549

This study investigated the inhibitory effects of extracts of Echinacea purpurea (EP) and Ganoderma lucidum (G. lucidum) and the advanced G. lucidum drink (AG) on influenza A/B viruses. To determine whether EP and G. lucidum extracts enhance cel …

This study investigated the inhibitory effects of extracts of Echinacea purpurea (EP) and Ganoderma lucidum (G. lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Improvement of Echinacea purpurea and Ganoderma lucidum Extracts with Cell Model on Influenza A/B Infection.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
139.
Amelioration of CCl(4)-induced oxidative stress and hepatotoxicity by Ganoderma lucidum in long evans rats.
- Johra FT, Hossain S, Jain P, Bristy AT, Emran T, Ahmed R, Sharker SM, Bepari AK, Reza HM.
- Sci Rep. 2023 Jun 19;13(1):9909. doi: 10.1038/s41598-023-35228-y.
- PMCID: PMC10279652
Johra FT, et al.

Sci Rep. 2023.

PMCID: PMC10279652

The present study aimed to investigate the protective effects of Ganoderma lucidum against CCl(4)-induced liver toxicity in rats. The experimental Long Evans rats were divided into five groups, of which four groups were treated with carbon tetrachloride (CCl(4)). .. …

The present study aimed to investigate the protective effects of Ganoderma lucidum against CCl(4)-induced liver toxicity in ra …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Amelioration of CCl(4)-induced oxidative stress and hepatotoxicity by Ganoderma lucidum in long evans rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
140.
Ergosterol peroxide isolated from Ganoderma lucidum abolishes microRNA miR-378-mediated tumor cells on chemoresistance.
- Wu QP, Xie YZ, Deng Z, Li XM, Yang W, Jiao CW, Fang L, Li SZ, Pan HH, Yee AJ, Lee DY, Li C, Zhang Z, Guo J, Yang BB.
- PLoS One. 2012 Aug 30;7(8):e44579. doi: 10.1371/journal.pone.0044579.
- PMCID: PMC3431381
Wu QP, et al.

PLoS One. 2012.

PMCID: PMC3431381

We found that the biologically active component isolated from Ganoderma lucidum could overcome the drug-resistance conferred by miR-378. We purified and identified the biologically active component of Ganoderma lucidum as ergosterol peroxide. ...

We found that the biologically active component isolated from Ganoderma lucidum could overcome the drug-resistance conferred b …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ergosterol peroxide isolated from Ganoderma lucidum abolishes microRNA miR-378-mediated tumor cells on chemoresistance.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 15

141.
Optimization of ultrasonic-assisted debittering of Ganoderma lucidum using response surface methodology, characterization, and evaluation of antioxidant activity.
- Chen S, Song S, Tan Y, He S, Ren X, Li Z, Liu Y.
- PeerJ. 2024 Oct 14;12:e17943. doi: 10.7717/peerj.17943.
- PMCID: PMC11485051
Chen S, et al.

PeerJ. 2024.

PMCID: PMC11485051

BACKGROUND: Ganoderma lucidum (G. lucidum) has gained increasing attention as a potential health care product and food source. However, the bitter taste of G. lucidum has limited its development and utilization for the food industry. METHONDS: The resp …

BACKGROUND: Ganoderma lucidum (G. lucidum) has gained increasing attention as a potential health care product and food …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Optimization of ultrasonic-assisted debittering of Ganoderma lucidum using response surface methodology, characterization, and evaluation of antioxidant activity.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
142.
Ganoderma lucidum Spore Polysaccharide Inhibits the Growth of Hepatocellular Carcinoma Cells by Altering Macrophage Polarity and Induction of Apoptosis.
- Song M, Li ZH, Gu HS, Tang RY, Zhang R, Zhu YL, Liu JL, Zhang JJ, Wang LY.
- J Immunol Res. 2021 Mar 5;2021:6696606. doi: 10.1155/2021/6696606.
- PMCID: PMC7954632
Song M, et al.

J Immunol Res. 2021.

PMCID: PMC7954632

BACKGROUND: Ganoderma lucidum has certain components with known pharmacological effects, including strengthening immunity and anti-inflammatory activity. G. lucidum seeds inherit all its biological characteristics. G. lucidum spore polysaccharide (GLSP …

BACKGROUND: Ganoderma lucidum has certain components with known pharmacological effects, including strengthening immunity and …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Spore Polysaccharide Inhibits the Growth of Hepatocellular Carcinoma Cells by Altering Macrophage Polarity and Induction of Apoptosis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
143.
Comparison of the dried properties of Ganoderma lucidum produced by the convective dryer and infrared dryer.
- Naseri M, Movagharnejad K, Nanvakenari S.
- Sci Rep. 2023 Aug 3;13(1):12636. doi: 10.1038/s41598-023-39883-z.
- PMCID: PMC10400541
Naseri M, et al.

Sci Rep. 2023.

PMCID: PMC10400541

Ganoderma lucidum is a promising medicine with a high amount of antioxidants and calcium. ...This study aimed to investigate the effects of air velocity and temperature in the convective dryer, sample distance, and infrared power in infrared dryers on the drying kin …

Ganoderma lucidum is a promising medicine with a high amount of antioxidants and calcium. ...This study aimed to investigate t …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Comparison of the dried properties of Ganoderma lucidum produced by the convective dryer and infrared dryer.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
144.
Potential Anti-Rheumatoid Arthritis Activities and Mechanisms of Ganoderma lucidum Polysaccharides.
- Meng M, Yao J, Zhang Y, Sun H, Liu M.
- Molecules. 2023 Mar 8;28(6):2483. doi: 10.3390/molecules28062483.
- PMCID: PMC10052150
Meng M, et al.

Molecules. 2023.

PMCID: PMC10052150

In this review, we summarized the available reports on the protective effects of Ganoderma lucidum polysaccharides (GLP) on RA in terms of anti-inflammatory, immunomodulatory, anti-angiogenic and osteoprotective effects. ...

In this review, we summarized the available reports on the protective effects of Ganoderma lucidum polysaccharides (GLP) on RA …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Potential Anti-Rheumatoid Arthritis Activities and Mechanisms of Ganoderma lucidum Polysaccharides.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
145.
Ganoderma lucidum Polysaccharide Enzymatic Hydrolysate Suppresses the Growth of Human Colon Cancer Cells via Inducing Apoptosis.
- Bai JH, Xu J, Zhao J, Zhang R.
- Cell Transplant. 2020 Jan-Dec;29:963689720931435. doi: 10.1177/0963689720931435.
- PMCID: PMC7563825
Bai JH, et al.

Cell Transplant. 2020.

PMCID: PMC7563825

Ganoderma lucidum is a popular traditional Chinese medicine used in China to improve health. Previous researches have revealed that the polysaccharide from G. lucidum could exert diversity activities, including immunomodulation, antioxidant, and antitumor eff …

Ganoderma lucidum is a popular traditional Chinese medicine used in China to improve health. Previous researches have revealed …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Polysaccharide Enzymatic Hydrolysate Suppresses the Growth of Human Colon Cancer Cells via Inducing Apoptosis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
146.
Unlocking the therapeutic potential of bioactive compounds in Ganoderma lucidum: a new frontier in natural medicine.
- Khanal S, Thakur P, Sharma A, Kumar A, Pillai M, Kumar D, Kumar A, Verma R, Tapwal A, Kumar D, Kumar V, Bala A.
- 3 Biotech. 2025 Jun 7;15(7):203. doi: 10.1007/s13205-025-04353-y.
- PMCID: PMC12144018
- Currently Embargoed: Full text in PMC on July 1, 2026 PubMed Abstract
Khanal S, et al.

3 Biotech. 2025.

PMCID: PMC12144018

Currently Embargoed.

Ganoderma lucidum (Reishi), a valued medicinal fungus used in traditional medicine for over 2000 years, has sparked widespread scientific attention due to its extensive range of bioactive ingredients and therapeutic promise in modern medicine. ...It subsequen …

Ganoderma lucidum (Reishi), a valued medicinal fungus used in traditional medicine for over 2000 years, has sparked wid …
147.
The Cas9-gRNA ribonucleoprotein complex-mediated editing of pyrG in Ganoderma lucidum and unexpected insertion of contaminated DNA fragments.
- Eom H, Choi YJ, Nandre R, Han HG, Kim S, Kim M, Oh YL, Nakazawa T, Honda Y, Ro HS.
- Sci Rep. 2023 Jul 10;13(1):11133. doi: 10.1038/s41598-023-38331-2.
- PMCID: PMC10333205
Eom H, et al.

Sci Rep. 2023.

PMCID: PMC10333205

In this study, we successfully edited pyrG of Ganoderma lucidum using a preassembled Cas9-gRNA ribonucleoprotein complex, which primarily induced a double-strand break (DSB) at the fourth position prior to the protospacer adjacent motif. ...Despite this unexpected f …

In this study, we successfully edited pyrG of Ganoderma lucidum using a preassembled Cas9-gRNA ribonucleoprotein complex, whic …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The Cas9-gRNA ribonucleoprotein complex-mediated editing of pyrG in Ganoderma lucidum and unexpected insertion of contaminated DNA fragments.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
148.
Ganoderma lucidum Extract Reduces Insulin Resistance by Enhancing AMPK Activation in High-Fat Diet-Induced Obese Mice.
- Lee HA, Cho JH, Afinanisa Q, An GH, Han JG, Kang HJ, Choi SH, Seong HA.
- Nutrients. 2020 Oct 30;12(11):3338. doi: 10.3390/nu12113338.
- PMCID: PMC7693844
Lee HA, et al.

Nutrients. 2020.

PMCID: PMC7693844

Ganoderma lucidum is used widely in oriental medicine to treat obesity and metabolic diseases. Bioactive substances extracted from G. lucidum have been shown to ameliorate dyslipidemia, insulin resistance, and type 2 diabetes in mice via multiple 5' AMP-activ …

Ganoderma lucidum is used widely in oriental medicine to treat obesity and metabolic diseases. Bioactive substances extracted …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Extract Reduces Insulin Resistance by Enhancing AMPK Activation in High-Fat Diet-Induced Obese Mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
149.
Ganoderma lucidum polysaccharides protect fibroblasts against UVB-induced photoaging.
- Zeng Q, Zhou F, Lei L, Chen J, Lu J, Zhou J, Cao K, Gao L, Xia F, Ding S, Huang L, Xiang H, Wang J, Xiao Y, Xiao R, Huang J.
- Mol Med Rep. 2016 Dec 12;15(1):111-116. doi: 10.3892/mmr.2016.6026.
- PMCID: PMC5355704
Zeng Q, et al.

Mol Med Rep. 2016.

PMCID: PMC5355704

Ganoderma lucidum has featured in traditional Chinese medicine for >1,000 years. Ganoderma polysaccharides (GL-PS), a major active ingredient in Ganoderma, confer immune regulation, antitumor effects and significant antioxidant effects. ...

Ganoderma lucidum has featured in traditional Chinese medicine for >1,000 years. Ganoderma polysaccharides (GL-PS), …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum polysaccharides protect fibroblasts against UVB-induced photoaging.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
150.
The ethanol extracts of sporoderm-broken spores of Ganoderma lucidum inhibit colorectal cancer in vitro and in vivo.
- Li K, Na K, Sang T, Wu K, Wang Y, Wang X.
- Oncol Rep. 2017 Sep 27;38(5):2803-2813. doi: 10.3892/or.2017.6010.
- PMCID: PMC5780033
Li K, et al.

Oncol Rep. 2017.

PMCID: PMC5780033

The medicinal mushroom Ganoderma lucidum (G. lucidum) has been reported to possess a variety of pharmacological activities including anticancer effects. ...Our results suggest that triterpenoids of sporoderm-broken spores of G. lucidum ethanol extracts …

The medicinal mushroom Ganoderma lucidum (G. lucidum) has been reported to possess a variety of pharmacological activit …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The ethanol extracts of sporoderm-broken spores of Ganoderma lucidum inhibit colorectal cancer in vitro and in vivo.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 16

151.
Cross Talk between Nitric Oxide and Calcium-Calmodulin Regulates Ganoderic Acid Biosynthesis in Ganoderma lucidum under Heat Stress.
- Liu R, Shi L, Zhu T, Yang T, Ren A, Zhu J, Zhao MW.
- Appl Environ Microbiol. 2018 May 1;84(10):e00043-18. doi: 10.1128/AEM.00043-18.
- PMCID: PMC5930367
Liu R, et al.

Appl Environ Microbiol. 2018.

PMCID: PMC5930367

We previously reported that high temperature impacts ganoderic acid (GA) biosynthesis in Ganoderma lucidum via Ca(2+) Therefore, to further understand the signal-regulating network of the organism's response to heat stress (HS), we examined the role of nitric oxide …

We previously reported that high temperature impacts ganoderic acid (GA) biosynthesis in Ganoderma lucidum via Ca(2+) Therefor …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Cross Talk between Nitric Oxide and Calcium-Calmodulin Regulates Ganoderic Acid Biosynthesis in Ganoderma lucidum under Heat Stress.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
152.
Abscisic acid-mediated cytosolic Ca(2+) modulates triterpenoid accumulation of Ganoderma lucidum.
- Cui M, Zhao Y, Zhang X, Zhao W.
- J Zhejiang Univ Sci B. 2023 Dec 15;24(12):1174-1179. doi: 10.1631/jzus.B2300279.
- PMCID: PMC10710909
Cui M, et al.

J Zhejiang Univ Sci B. 2023.

PMCID: PMC10710909

Ganoderma lucidum is a mushroom widely used for its edible and medicinal properties. Primary bioactive constituents of G. lucidum are ganoderic triterpenoids (GTs), which exhibit important pharmacological activity. ...

Ganoderma lucidum is a mushroom widely used for its edible and medicinal properties. Primary bioactive constituents of G. l …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Abscisic acid-mediated cytosolic Ca(2+) modulates triterpenoid accumulation of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
153.
Enhancing in vitro ruminal digestibility of oil palm empty fruit bunch by biological pre-treatment with Ganoderma lucidum fungal culture.
- Nur-Nazratul FMY, Rakib MRM, Zailan MZ, Yaakub H.
- PLoS One. 2021 Sep 30;16(9):e0258065. doi: 10.1371/journal.pone.0258065.
- PMCID: PMC8483372
Nur-Nazratul FMY, et al.

PLoS One. 2021.

PMCID: PMC8483372

The changes in lignocellulosic biomass composition and in vitro rumen digestibility of oil palm empty fruit bunch (OPEFB) after pre-treatment with the fungus Ganoderma lucidum were evaluated. The results demonstrated that the pre-treatment for 2-12 weeks has gradual …

The changes in lignocellulosic biomass composition and in vitro rumen digestibility of oil palm empty fruit bunch (OPEFB) after pre-treatmen …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Enhancing in vitro ruminal digestibility of oil palm empty fruit bunch by biological pre-treatment with Ganoderma lucidum fungal culture.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
154.
Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress.
- Zhong D, Wang H, Liu M, Li X, Huang M, Zhou H, Lin S, Lin Z, Yang B.
- Sci Rep. 2015 Nov 25;5:16910. doi: 10.1038/srep16910.
- PMCID: PMC4658483
Zhong D, et al.

Sci Rep. 2015.

PMCID: PMC4658483

Ganoderma lucidum polysaccharide peptide (GLPP) scavenges oxygen free radicals that are a key factor in the pathogenesis of renal ischemia reperfusion injury (RIRI). ...

Ganoderma lucidum polysaccharide peptide (GLPP) scavenges oxygen free radicals that are a key factor in the pathogenesis of re …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
155.
Hypereosinophilia with Hepatic Nodule Formation Caused by Ganoderma lucidum.
- Kogure T, Koiwai A, Fukushi D, Satoh M, Murakami K, Hirota M, Endo K, Murakami K, Satoh K.
- Intern Med. 2021 Dec 15;60(24):3897-3903. doi: 10.2169/internalmedicine.7431-21.
- PMCID: PMC8758446
Kogure T, et al.

Intern Med. 2021.

PMCID: PMC8758446

He had been taking the commercial herbal medicine Ganoderma lucidum for his liver function. After discontinuing G. lucidum, the eosinophil counts and liver enzyme levels rapidly resolved, and the nodules disappeared completely. ...

He had been taking the commercial herbal medicine Ganoderma lucidum for his liver function. After discontinuing G. lucidum< …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Hypereosinophilia with Hepatic Nodule Formation Caused by Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
156.
In vitro anti-Toxoplasma gondii activity of Ganoderma lucidum extracts.
- Ahmadi M, Salimi M, Saraei M, Nezhad NS, Javadi A, Mohammadi F, Heydarian P, Ali E, Hajialilo E.
- BMC Res Notes. 2023 May 18;16(1):82. doi: 10.1186/s13104-023-06355-6.
- PMCID: PMC10197208
Ahmadi M, et al.

BMC Res Notes. 2023.

PMCID: PMC10197208

This study was aimed to determine the lethal and inhibitory effects of aqueous, hydroalcoholic, and alcoholic extracts of Ganoderma lucidum on Toxoplasma gondii RH strain tachyzoites, in vitro. RESULTS: All three types of extracts showed toxoplasmacidal effects. ... …

This study was aimed to determine the lethal and inhibitory effects of aqueous, hydroalcoholic, and alcoholic extracts of Ganoderma < …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: In vitro anti-Toxoplasma gondii activity of Ganoderma lucidum extracts.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
157.
Improving the fermentation production of the individual key triterpene ganoderic acid me by the medicinal fungus Ganoderma lucidum in submerged culture.
- Liu GQ, Wang XL, Han WJ, Lin QL.
- Molecules. 2012 Oct 24;17(11):12575-86. doi: 10.3390/molecules171112575.
- PMCID: PMC6269005
Liu GQ, et al.

Molecules. 2012.

PMCID: PMC6269005

Enhanced ganoderic acid Me (GA-Me, an important anti-tumor triterpene) yield was attained with the medicinal fungus Ganoderma lucidum using response surface methodology (RSM). Interactions were studied with three variables, viz. glucose, peptone and culture time usi …

Enhanced ganoderic acid Me (GA-Me, an important anti-tumor triterpene) yield was attained with the medicinal fungus Ganoderma luci …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Improving the fermentation production of the individual key triterpene ganoderic acid me by the medicinal fungus Ganoderma lucidum in submerged culture.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
158.
Acetylcholinesterase inhibition and in vitro and in vivo antioxidant activities of Ganoderma lucidum grown on germinated brown rice.
- Hasnat A, Pervin M, Lim BO.
- Molecules. 2013 Jun 7;18(6):6663-78. doi: 10.3390/molecules18066663.
- PMCID: PMC6269759
Hasnat A, et al.

Molecules. 2013.

PMCID: PMC6269759

In this study, the acetylcholinesterase inhibition and in vitro and in vivo antioxidant activities of Ganoderma lucidum grown on germinated brown rice (GLBR) were evaluated. In antioxidant assays in vitro, GLBR was found to have strong metal chelating activity, DPPH …

In this study, the acetylcholinesterase inhibition and in vitro and in vivo antioxidant activities of Ganoderma lucidum grown …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Acetylcholinesterase inhibition and in vitro and in vivo antioxidant activities of Ganoderma lucidum grown on germinated brown rice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
159.
Triterpenes and Aromatic Meroterpenoids with Antioxidant Activity and Neuroprotective Effects from Ganoderma lucidum.
- Wang C, Liu X, Lian C, Ke J, Liu J.
- Molecules. 2019 Nov 28;24(23):4353. doi: 10.3390/molecules24234353.
- PMCID: PMC6930543
Wang C, et al.

Molecules. 2019.

PMCID: PMC6930543

There is a great interest in developing new antioxidants from Ganoderma fungus due to its low toxicity. As part of our ongoing search for antioxidative constituents from the fruiting bodies of Ganoderma lucidum, the chemical constituents were investigated and …

There is a great interest in developing new antioxidants from Ganoderma fungus due to its low toxicity. As part of our ongoing search …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Triterpenes and Aromatic Meroterpenoids with Antioxidant Activity and Neuroprotective Effects from Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
160.
Ganoderma lucidum Ameliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking.
- Nascimento CP, Luz DA, da Silva CCS, Malcher CMR, Fernandes LMP, Dalla Santa HS, Gomes ARQ, Monteiro MC, Ribeiro CHMA, Fontes-Júnior EA, Maia CSF.
- Oxid Med Cell Longev. 2020 Jul 30;2020:2497845. doi: 10.1155/2020/2497845.
- PMCID: PMC7415090
Nascimento CP, et al.

Oxid Med Cell Longev. 2020.

PMCID: PMC7415090

Ganoderma lucidum, mushroom used for centuries by Asian peoples as food supplement, has been shown interesting biological activities, including over the Central Nervous System. ...In this study, we investigated whether the Aqueous Extract of G. lucidum (AEGl) …

Ganoderma lucidum, mushroom used for centuries by Asian peoples as food supplement, has been shown interesting biological acti …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Ameliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 17

161.
Cross Talk between Calcium and Reactive Oxygen Species Regulates Hyphal Branching and Ganoderic Acid Biosynthesis in Ganoderma lucidum under Copper Stress.
- Gao T, Shi L, Zhang T, Ren A, Jiang A, Yu H, Zhao M.
- Appl Environ Microbiol. 2018 Jun 18;84(13):e00438-18. doi: 10.1128/AEM.00438-18.
- PMCID: PMC6007119
Gao T, et al.

Appl Environ Microbiol. 2018.

PMCID: PMC6007119

Ganoderma lucidum is among the best known medicinal basidiomycetes due to its production of many pharmacologically active compounds. ...These results indicated that cytosolic ROS and Ca(2+) levels exert important cross talk in the regulation of hyphal growth and GA …

Ganoderma lucidum is among the best known medicinal basidiomycetes due to its production of many pharmacologically active comp …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Cross Talk between Calcium and Reactive Oxygen Species Regulates Hyphal Branching and Ganoderic Acid Biosynthesis in Ganoderma lucidum under Copper Stress.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
162.
Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease.
- Huang S, Mao J, Ding K, Zhou Y, Zeng X, Yang W, Wang P, Zhao C, Yao J, Xia P, Pei G.
- Stem Cell Reports. 2017 Jan 10;8(1):84-94. doi: 10.1016/j.stemcr.2016.12.007.
- PMCID: PMC5233449
Huang S, et al.

Stem Cell Reports. 2017.

PMCID: PMC5233449

Promoting neurogenesis is a promising strategy for the treatment of cognition impairment associated with Alzheimer's disease (AD). Ganoderma lucidum is a revered medicinal mushroom for health-promoting benefits in the Orient. Here, we found that oral administration …

Promoting neurogenesis is a promising strategy for the treatment of cognition impairment associated with Alzheimer's disease (AD). Ganode …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
163.
Effect of common foods as supplements for the mycelium growth of Ganoderma lucidum and Pleurotus ostreatus on solid substrates.
- Soh E, Saeidi N, Javadian A, Hebel DE, Le Ferrand H.
- PLoS One. 2021 Nov 30;16(11):e0260170. doi: 10.1371/journal.pone.0260170.
- PMCID: PMC8631619
Soh E, et al.

PLoS One. 2021.

PMCID: PMC8631619

In this paper, we study the effects of the addition of food supplements on the growth of two fungal species, Ganoderma lucidum and Pleurotus ostreatus. The substrates, the food supplements, and the mycelia are characterized using Fourier-transform infrared spectrosc …

In this paper, we study the effects of the addition of food supplements on the growth of two fungal species, Ganoderma lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effect of common foods as supplements for the mycelium growth of Ganoderma lucidum and Pleurotus ostreatus on solid substrates.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
164.
Optimization of alkaline extraction of polysaccharides from Ganoderma lucidum and their effect on immune function in mice.
- Huang SQ, Li JW, Wang Z, Pan HX, Chen JX, Ning ZX.
- Molecules. 2010 May 25;15(5):3694-708. doi: 10.3390/molecules15053694.
- PMCID: PMC6263365
Huang SQ, et al.

Molecules. 2010.

PMCID: PMC6263365

Response surface methodology was employed to optimize the conditions for alkaline extraction of polysaccharides from Ganoderma lucidum. The results indicated that the optimum conditions were an extraction temperature of 60.1 degrees C, an extraction time of 77.3 min …

Response surface methodology was employed to optimize the conditions for alkaline extraction of polysaccharides from Ganoderma luc …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Optimization of alkaline extraction of polysaccharides from Ganoderma lucidum and their effect on immune function in mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
165.
Heme oxygenase-1/carbon monoxide signaling participates in the accumulation of triterpenoids of Ganoderma lucidum.
- Cui M, Ma Y, Yu Y.
- J Zhejiang Univ Sci B. 2021 Nov 15;22(11):941-953. [Article in English] doi: 10.1631/jzus.B2000818.
- PMCID: PMC8593529
Cui M, et al.

J Zhejiang Univ Sci B. 2021. [Article in English]

PMCID: PMC8593529

Ganoderic triterpenoids (GTs) are the primary bioactive constituents of the Basidiomycotina fungus, Ganoderma lucidum. These compounds exhibit antitumor, anti-hyperlipidemic, and immune-modulatory pharmacological activities. This study focused on GT accumulation in …

Ganoderic triterpenoids (GTs) are the primary bioactive constituents of the Basidiomycotina fungus, Ganoderma lucidum. These c …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Heme oxygenase-1/carbon monoxide signaling participates in the accumulation of triterpenoids of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
166.
A retrospective study of Ganoderma Lucidum Spore Powder for patients with epilepsy.
- Wang GH, Li X, Cao WH, Li J, Wang LH.
- Medicine (Baltimore). 2018 Jun;97(23):e10941. doi: 10.1097/MD.0000000000010941.
- PMCID: PMC5999473
Wang GH, et al.

Medicine (Baltimore). 2018.

PMCID: PMC5999473

This study firstly investigated the feasibility effect and safety of Ganoderma Lucidum Spore Powder (GLSP) for treating patients with epilepsy.Eighteen eligible patients with epilepsy were included. ...

This study firstly investigated the feasibility effect and safety of Ganoderma Lucidum Spore Powder (GLSP) for treating patien …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A retrospective study of Ganoderma Lucidum Spore Powder for patients with epilepsy.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
167.
Recombinant Lz-8 from Ganoderma lucidum induces endoplasmic reticulum stress-mediated autophagic cell death in SGC-7901 human gastric cancer cells.
- Liang C, Li H, Zhou H, Zhang S, Liu Z, Zhou Q, Sun F.
- Oncol Rep. 2011 Dec 14;27(4):1079-89. doi: 10.3892/or.2011.1593.
- PMCID: PMC3583434
Liang C, et al.

Oncol Rep. 2011.

PMCID: PMC3583434

In Asia, the mushroom of the fungus Ganoderma lucidum has been widely used as a traditional medicine for the past two millennia. ...

In Asia, the mushroom of the fungus Ganoderma lucidum has been widely used as a traditional medicine for the past two millenni …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Recombinant Lz-8 from Ganoderma lucidum induces endoplasmic reticulum stress-mediated autophagic cell death in SGC-7901 human gastric cancer cells.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
168.
Ganoderma lucidum total triterpenes prevent gamma-radiation induced oxidative stress in Swiss albino mice in vivo.
- Smina TP, Joseph J, Janardhanan KK.
- Redox Rep. 2016 Feb 5;21(6):254-61. doi: 10.1080/13510002.2015.1126098.
- PMCID: PMC6837450
Smina TP, et al.

Redox Rep. 2016.

PMCID: PMC6837450

OBJECTIVES: The in vivo radio-protective effect of total triterpenes isolated from Ganoderma lucidum (Fr.) P. Karst was evaluated using Swiss albino mice, by pre-treatment with total triterpenes for 14 days, followed by a whole body exposure to gamma-radiation. ...D …

OBJECTIVES: The in vivo radio-protective effect of total triterpenes isolated from Ganoderma lucidum (Fr.) P. Karst was evalua …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum total triterpenes prevent gamma-radiation induced oxidative stress in Swiss albino mice in vivo.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
169.
The role of polysaccharide peptide of Ganoderma lucidum as a potent antioxidant against atherosclerosis in high risk and stable angina patients.
- Sargowo D, Ovianti N, Susilowati E, Ubaidillah N, Widya Nugraha A, Vitriyaturrida, Siwi Proboretno K, Failasufi M, Ramadhan F, Wulandari H, Waranugraha Y, Hayuning Putri D.
- Indian Heart J. 2017 Dec 14;70(5):608-614. doi: 10.1016/j.ihj.2017.12.007.
- PMCID: PMC6204443
Sargowo D, et al.

Indian Heart J. 2017.

PMCID: PMC6204443

Polysaccharide Peptide (PsP) derived from Ganoderma lucidum has an active substance in the form of beta-glucan. Previous studies have proven the PsP of Ganoderma lucidum as an effective antioxidant in atherosclerotic rats and shows no toxicity in anima …

Polysaccharide Peptide (PsP) derived from Ganoderma lucidum has an active substance in the form of beta-glucan. Previous studi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The role of polysaccharide peptide of Ganoderma lucidum as a potent antioxidant against atherosclerosis in high risk and stable angina patients.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
170.
Targeted insertion of heterogenous DNA using Cas9-gRNA ribonucleoprotein-mediated gene editing in Ganoderma lucidum.
- Eom H, Choi YJ, Nandre R, Kim M, Oh YL, Kim S, Nakazawa T, Honda Y, Ro HS.
- Bioengineered. 2025 Jan 29;16(1):2458376. doi: 10.1080/21655979.2025.2458376.
- PMCID: PMC11781247
Eom H, et al.

Bioengineered. 2025.

PMCID: PMC11781247

Co-transformation of donor DNAs with RNP targeting the pyrG gene in Ganoderma lucidum yielded 184 transformants without homologous arms and 781 with 300-bp homologous arms (HR_donor DNAs). ...

Co-transformation of donor DNAs with RNP targeting the pyrG gene in Ganoderma lucidum yielded 184 transformants without homolo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Targeted insertion of heterogenous DNA using Cas9-gRNA ribonucleoprotein-mediated gene editing in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 18

171.
Ganoderma Lucidum Polysaccharides Ameliorates Hepatic Steatosis and Oxidative Stress in db/db Mice via Targeting Nuclear Factor E2 (Erythroid-Derived 2)-Related Factor-2/Heme Oxygenase-1 (HO-1) Pathway.
- Li HN, Zhao LL, Zhou DY, Chen DQ.
- Med Sci Monit. 2020 Apr 4;26:e921905. doi: 10.12659/MSM.921905.
- PMCID: PMC7154563
Li HN, et al.

Med Sci Monit. 2020.

PMCID: PMC7154563

BACKGROUND Type 2 diabetes mellitus (T2DM) and its comorbidities, including obesity, hypertension, and hyperlipidemia, are commonly associated with non-alcoholic fatty liver disease (NAFLD). Ganoderma lucidum polysaccharide (GDLP) is one of the central bioactive com …

BACKGROUND Type 2 diabetes mellitus (T2DM) and its comorbidities, including obesity, hypertension, and hyperlipidemia, are commonly associat …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma Lucidum Polysaccharides Ameliorates Hepatic Steatosis and Oxidative Stress in db/db Mice via Targeting Nuclear Factor E2 (Erythroid-Derived 2)-Related Factor-2/Heme Oxygenase-1 (HO-1) Pathway.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
172.
Involvement of NFkB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS.
- Hilliard A, Mendonca P, Soliman KFA.
- J Neuroimmunol. Author manuscript. 2020 May 26;345:577269. doi: 10.1016/j.jneuroim.2020.577269.
- PMCID: PMC7382303
Hilliard A, et al.

J Neuroimmunol. Author manuscript. 2020.

PMCID: PMC7382303

Ganoderma lucidum extract (GLE) is a potent ancient Asian remedy for the treatment of various diseases. ...

Ganoderma lucidum extract (GLE) is a potent ancient Asian remedy for the treatment of various diseases. ...
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Involvement of NFkB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
173.
Sporoderm-Removed Ganoderma lucidum Spore Powder May Suppress the Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma Cells Through PI3K/AKT/mTOR and Erk Pathway.
- Liu J, Zeng T.
- Integr Cancer Ther. 2021 Jan-Dec;20:15347354211062157. doi: 10.1177/15347354211062157.
- PMCID: PMC8649442
Liu J, et al.

Integr Cancer Ther. 2021.

PMCID: PMC8649442

Emerging evidence suggests that sporoderm-removed Ganoderma lucidum spore powder can suppress tumor growth and metastasis. However, the molecular mechanisms of action remain elusive. ...Finally, we found that sporoderm-removed Ganoderma lucidum spore p …

Emerging evidence suggests that sporoderm-removed Ganoderma lucidum spore powder can suppress tumor growth and metastasis. How …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Sporoderm-Removed Ganoderma lucidum Spore Powder May Suppress the Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma Cells Through PI3K/AKT/mTOR and Erk Pathway.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
174.
Ganoderma lucidum polysaccharides ameliorate lipopolysaccharide-induced acute pneumonia via inhibiting NRP1-mediated inflammation.
- Zhang X, Wu D, Tian Y, Chen X, Lan J, Wei F, Li Y, Luo Y, Sun X.
- Pharm Biol. 2022 Dec;60(1):2201-2209. doi: 10.1080/13880209.2022.2142615.
- PMCID: PMC9665083
Zhang X, et al.

Pharm Biol. 2022.

PMCID: PMC9665083

CONTEXT: Ganoderma lucidum polysaccharides (GLP), from Ganoderma lucidum (Leyss. ex Fr.) Karst. (Ganodermataceae), are reported to have anti-inflammatory effects, including anti-neuroinflammation and anti-colitis. ...

CONTEXT: Ganoderma lucidum polysaccharides (GLP), from Ganoderma lucidum (Leyss. ex Fr.) Karst. (Ganodermataceae …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum polysaccharides ameliorate lipopolysaccharide-induced acute pneumonia via inhibiting NRP1-mediated inflammation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
175.
Anticarcinogenic effects of water extract of sporoderm-broken spores of Ganoderma lucidum on colorectal cancer in vitro and in vivo.
- Na K, Li K, Sang T, Wu K, Wang Y, Wang X.
- Int J Oncol. 2017 Mar 29;50(5):1541-1554. doi: 10.3892/ijo.2017.3939.
- PMCID: PMC5403400
Na K, et al.

Int J Oncol. 2017.

PMCID: PMC5403400

Ganoderma lucidum (G. lucidum) polysaccharides (GLPs) have been used as traditional Chinese medicine for cancer prevention for many years. ...In addition, it is unclear whether sporoderm-broken spores of G. lucidum water extract (BSGLWE), which contain …

Ganoderma lucidum (G. lucidum) polysaccharides (GLPs) have been used as traditional Chinese medicine for cancer prevent …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Anticarcinogenic effects of water extract of sporoderm-broken spores of Ganoderma lucidum on colorectal cancer in vitro and in vivo.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
176.
Identification of potential neuroprotective compound from Ganoderma lucidum extract targeting microtubule affinity regulation kinase 4 involved in Alzheimer's disease through molecular dynamics simulation and MMGBSA.
- Ahmad F, Singh G, Soni H, Tandon S.
- Aging Med (Milton). 2022 Dec 12;6(2):144-154. doi: 10.1002/agm2.12232.
- PMCID: PMC10242270
Ahmad F, et al.

Aging Med (Milton). 2022.

PMCID: PMC10242270

According to a recent study, microtubule affinity regulation kinase 4 (MARK4) is attributed as one of the most promising drug targets for AD, thus, being selected for this study. Compounds from Ganoderma lucidum (Reishi mushroom) extracts were selected to be …

According to a recent study, microtubule affinity regulation kinase 4 (MARK4) is attributed as one of the most promising drug targets for AD …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Identification of potential neuroprotective compound from Ganoderma lucidum extract targeting microtubule affinity regulation kinase 4 involved in Alzheimer's disease through molecular dynamics simulation and MMGBSA.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
177.
The GCN4-Swi6B module mediates low nitrogen-induced cell wall remodeling in Ganoderma lucidum.
- Shi L, Wang L, Liu R, Zhu J, Shi L, Ren A, Chen H, Zhao M.
- Appl Environ Microbiol. 2025 Mar 27;91(4):e0016425. doi: 10.1128/aem.00164-25.
- PMCID: PMC12016525
Shi L, et al.

Appl Environ Microbiol. 2025.

PMCID: PMC12016525

Here, we found that compared with those under normal nitrogen conditions, both the cell wall thickness and polysaccharide content of Ganoderma lucidum are increased under low nitrogen conditions. Furthermore, the abundance of SWI6B, a transcription factor that parti …

Here, we found that compared with those under normal nitrogen conditions, both the cell wall thickness and polysaccharide content of Gano …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The GCN4-Swi6B module mediates low nitrogen-induced cell wall remodeling in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
178.
A Review on the Sources, Structures, and Pharmacological Activities of Lucidenic Acids.
- Zheng C, Rangsinth P, Shiu PHT, Wang W, Li R, Li J, Kwan YW, Leung GPH.
- Molecules. 2023 Feb 12;28(4):1756. doi: 10.3390/molecules28041756.
- PMCID: PMC9962123
Zheng C, et al.

Molecules. 2023.

PMCID: PMC9962123

Ganoderma lucidum has long been used as a multi-purpose plant and functional food. The pharmacological properties of G. lucidum are primarily attributed to its polysaccharides and triterpenoids. Ganoderic and lucidenic acids are the two major triterpenoids gr …

Ganoderma lucidum has long been used as a multi-purpose plant and functional food. The pharmacological properties of G. luc …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A Review on the Sources, Structures, and Pharmacological Activities of Lucidenic Acids.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
179.
SA inhibits complex III activity to generate reactive oxygen species and thereby induces GA overproduction in Ganoderma lucidum.
- Liu R, Cao P, Ren A, Wang S, Yang T, Zhu T, Shi L, Zhu J, Jiang AL, Zhao MW.
- Redox Biol. 2018 Mar 31;16:388-400. doi: 10.1016/j.redox.2018.03.018.
- PMCID: PMC5953243
Liu R, et al.

Redox Biol. 2018.

PMCID: PMC5953243

Ganoderma lucidum has high commercial value because it produces many active compounds, such as ganoderic acids (GAs). Salicylic acid (SA) was previously reported to induce the biosynthesis of GA in G. lucidum. In this study, we found that SA induces GA biosyn …

Ganoderma lucidum has high commercial value because it produces many active compounds, such as ganoderic acids (GAs). Salicyli …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: SA inhibits complex III activity to generate reactive oxygen species and thereby induces GA overproduction in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
180.
Genome-wide Identification and Characterization of Natural Antisense Transcripts by Strand-specific RNA Sequencing in Ganoderma lucidum.
- Shao J, Chen H, Yang D, Jiang M, Zhang H, Wu B, Li J, Yuan L, Liu C.
- Sci Rep. 2017 Jul 18;7(1):5711. doi: 10.1038/s41598-017-04303-6.
- PMCID: PMC5515960
Shao J, et al.

Sci Rep. 2017.

PMCID: PMC5515960

Ganoderma lucidum is a white-rot fungus best-known for its medicinal and ligninolytic activities. ...

Ganoderma lucidum is a white-rot fungus best-known for its medicinal and ligninolytic activities. ...
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Genome-wide Identification and Characterization of Natural Antisense Transcripts by Strand-specific RNA Sequencing in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 19

181.
Decolorization applicability of sol-gel matrix immobilized manganese peroxidase produced from an indigenous white rot fungal strain Ganoderma lucidum.
- Muhammad Nasir Iqbal H, Asgher M.
- BMC Biotechnol. 2013 Jul 13;13:56. doi: 10.1186/1472-6750-13-56.
- PMCID: PMC3717284
Muhammad Nasir Iqbal H, et al.

BMC Biotechnol. 2013.

PMCID: PMC3717284

By keeping in mind the extensive industrial applications of ligninolytic enzymes, this study was performed to purify, and immobilize the manganese peroxidase (MnP) produced from an indigenous strain of Ganoderma lucidum. The present study was also focused on investi …

By keeping in mind the extensive industrial applications of ligninolytic enzymes, this study was performed to purify, and immobilize the man …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Decolorization applicability of sol-gel matrix immobilized manganese peroxidase produced from an indigenous white rot fungal strain Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Relevant for eco‑friendly processing, waste upcycling, and industrial biocatalysis. Open article.
182.
Chemical characterization and antitumor activities of polysaccharide extracted from Ganoderma lucidum.
- Liang Z, Yi Y, Guo Y, Wang R, Hu Q, Xiong X.
- Int J Mol Sci. 2014 May 22;15(5):9103-16. doi: 10.3390/ijms15059103.
- PMCID: PMC4057777
Liang Z, et al.

Int J Mol Sci. 2014.

PMCID: PMC4057777

Ganoderma lucidum polysaccharide (GLP) is a biologically active substance reported to possess anti-tumor ability. ...

Ganoderma lucidum polysaccharide (GLP) is a biologically active substance reported to possess anti-tumor ability. ...
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Chemical characterization and antitumor activities of polysaccharide extracted from Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
183.
Anti-inflammatory Effects of Ganoderma lucidum Triterpenoid in Human Crohn's Disease Associated with Downregulation of NF-kappaB Signaling.
- Liu C, Dunkin D, Lai J, Song Y, Ceballos C, Benkov K, Li XM.
- Inflamm Bowel Dis. Author manuscript. 2015 Aug;21(8):1918-25. doi: 10.1097/MIB.0000000000000439.
- PMCID: PMC4509964
Liu C, et al.

Inflamm Bowel Dis. Author manuscript. 2015.

PMCID: PMC4509964

Here, we investigated the anti-inflammatory effects of a bioactive compound isolated from Ganoderma lucidum (G. lucidum), a key herbal constituent of Food Allergy Herbal Formula-2, in CD in vitro. ...GAC1 is a key beneficial constituent in G. lucidum a …

Here, we investigated the anti-inflammatory effects of a bioactive compound isolated from Ganoderma lucidum (G. lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Anti-inflammatory Effects of Ganoderma lucidum Triterpenoid in Human Crohn's Disease Associated with Downregulation of NF-kappaB Signaling.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
184.
ATP deficiency triggers ganoderic acids accumulation via fatty acid beta-oxidation pathway in Ganoderma lucidum.
- Liu W, Sun Y, Yue S, Kong Y, Cong Q, Lan Y, Zhao M, Shi L.
- Microb Cell Fact. 2025 Mar 11;24(1):62. doi: 10.1186/s12934-025-02668-2.
- PMCID: PMC11900599
Liu W, et al.

Microb Cell Fact. 2025.

PMCID: PMC11900599

BACKGROUND: Ganoderic acids (GAs), recognized as significant triterpenoid bioactive components in Ganoderma lucidum, exhibit a broad spectrum of pharmacological activities, including immunomodulation, anti-cancer, and anti-aging properties. ...However, the specific …

BACKGROUND: Ganoderic acids (GAs), recognized as significant triterpenoid bioactive components in Ganoderma lucidum, exhibit a …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: ATP deficiency triggers ganoderic acids accumulation via fatty acid beta-oxidation pathway in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
185.
Ganoderma lucidum spore ethanol extract attenuates atherosclerosis by regulating lipid metabolism via upregulation of liver X receptor alpha.
- Lai P, Cao X, Xu Q, Liu Y, Li R, Zhang J, Zhang M.
- Pharm Biol. 2020 Dec;58(1):760-770. doi: 10.1080/13880209.2020.1798471.
- PMCID: PMC7470073
Lai P, et al.

Pharm Biol. 2020.

PMCID: PMC7470073

CONTEXT: Ganoderma lucidum (Leyss.ex Fr.) Karst (Ganodermataceae) is a fungus that has been used in traditional Chinese medicine. OBJECTIVE: This is the first investigation of the lipid-lowering and anti-atherosclerotic effects of Ganoderma lucidum spo …

CONTEXT: Ganoderma lucidum (Leyss.ex Fr.) Karst (Ganodermataceae) is a fungus that has been used in traditional Chinese medici …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum spore ethanol extract attenuates atherosclerosis by regulating lipid metabolism via upregulation of liver X receptor alpha.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
186.
Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review.
- Shaher F, Qiu H, Wang S, Hu Y, Wang W, Zhang Y, Wei Y, Al-Ward H, Abdulghani MAM, Alenezi SK, Baldi S, Zhou S.
- Biomed Res Int. 2020 Jul 25;2020:7136075. doi: 10.1155/2020/7136075.
- PMCID: PMC7397440
Shaher F, et al.

Biomed Res Int. 2020.

PMCID: PMC7397440

This work is aimed at systemically reviewing literature and addressing cell targets in DCM through the possible cardioprotection of G. lucidum through its antioxidant effects by using the Open Targets Platform (OTP) website. ...Among the 1731 studies of indexed PubMed arti …

This work is aimed at systemically reviewing literature and addressing cell targets in DCM through the possible cardioprotection of G. lu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
187.
Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice.
- Yao C, Wang Z, Jiang H, Yan R, Huang Q, Wang Y, Xie H, Zou Y, Yu Y, Lv L.
- Sci Rep. 2021 Jul 1;11(1):13660. doi: 10.1038/s41598-021-92913-6.
- PMCID: PMC8249598
Yao C, et al.

Sci Rep. 2021.

PMCID: PMC8249598

Ganoderma lucidum is a medicinal mushroom used in traditional Chinese medicine with putative tranquilizing effects. However, the component of G. lucidum that promotes sleep has not been clearly identified. Here, the effect and mechanism of the acidic part of …

Ganoderma lucidum is a medicinal mushroom used in traditional Chinese medicine with putative tranquilizing effects. However, t …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
188.
Accessing biological actions of Ganoderma secondary metabolites by in silico profiling.
- Grienke U, Kaserer T, Pfluger F, Mair CE, Langer T, Schuster D, Rollinger JM.
- Phytochemistry. Author manuscript. 2014 Nov 6;114:114-24. doi: 10.1016/j.phytochem.2014.10.010.
- PMCID: PMC4948669
Grienke U, et al.

Phytochemistry. Author manuscript. 2014.

PMCID: PMC4948669

The species complex around the medicinal fungus Ganoderma lucidum Karst. (Ganodermataceae) is widely known in traditional medicines, as well as in modern applications such as functional food or nutraceuticals. ...Accordingly, this study discloses putative ligand tar …

The species complex around the medicinal fungus Ganoderma lucidum Karst. (Ganodermataceae) is widely known in traditional medi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Accessing biological actions of Ganoderma secondary metabolites by in silico profiling.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
189.
Characterization and Hepatoprotections of Ganoderma lucidum Polysaccharides against Multiple Organ Dysfunction Syndrome in Mice.
- Zhang Y, Feng Y, Wang W, Jia L, Zhang J.
- Oxid Med Cell Longev. 2021 Feb 3;2021:9703682. doi: 10.1155/2021/9703682.
- PMCID: PMC7876828
Zhang Y, et al.

Oxid Med Cell Longev. 2021.

PMCID: PMC7876828

In recent years, there have been many studies on Ganoderma lucidum polysaccharides (GLP), but the role of GLP in MODS is still unclear. The purpose of this work was to explore the antioxidant, anti-inflammatory, and protective effects of GLP on the liver in MODS mod …

In recent years, there have been many studies on Ganoderma lucidum polysaccharides (GLP), but the role of GLP in MODS is still …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Characterization and Hepatoprotections of Ganoderma lucidum Polysaccharides against Multiple Organ Dysfunction Syndrome in Mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
190.
The transcription factor GCN4 contributes to maintaining intracellular amino acid contents under nitrogen-limiting conditions in the mushroom Ganoderma lucidum.
- Lian L, Qiao J, Guo X, Xing Z, Ren A, Zhao M, Zhu J.
- Microb Cell Fact. 2023 Oct 10;22(1):205. doi: 10.1186/s12934-023-02213-z.
- PMCID: PMC10563202
Lian L, et al.

Microb Cell Fact. 2023.

PMCID: PMC10563202

A previous study revealed that GCN4 plays a pivotal role in nitrogen utilization and growth in Ganoderma lucidum. However, its regulation is nearly unknown in mushrooms. RESULTS: In this study, we found that the amino acid contents reached 120.51 mg per gram of myce …

A previous study revealed that GCN4 plays a pivotal role in nitrogen utilization and growth in Ganoderma lucidum. However, its …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The transcription factor GCN4 contributes to maintaining intracellular amino acid contents under nitrogen-limiting conditions in the mushroom Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 20

191.
The Efficacy of Ganoderma lucidum Extracts on Treating Endometrial Cancer: A Network Pharmacology Approach.
- Shi M.
- Reprod Sci. 2024 Mar 6;31(7):1881-1894. doi: 10.1007/s43032-024-01500-3.
- PMCID: PMC11217070
Shi M.

Reprod Sci. 2024.

PMCID: PMC11217070

Ganoderma lucidum (GL) is a prominent medicinal mushroom in traditional Chinese medicine, known for its potent antitumor properties. ...

Ganoderma lucidum (GL) is a prominent medicinal mushroom in traditional Chinese medicine, known for its potent antitumor prope …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The Efficacy of Ganoderma lucidum Extracts on Treating Endometrial Cancer: A Network Pharmacology Approach.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Participant-reported outcomes, clinical biomarkers, and safety/tolerability. Open article.
- Why might this paper be useful to readers? Provides early human data; interpret with caution and check study size and endpoints. Open article.
192.
The effect of Ganodermalucidum spore oil in early skin wound healing: interactions of skin microbiota and inflammation.
- Jiao C, Xie Y, Yun H, Liang H, He C, Jiang A, Wu Q, Yang BB.
- Aging (Albany NY). 2020 Jul 21;12(14):14125-14140. doi: 10.18632/aging.103412.
- PMCID: PMC7425473
Jiao C, et al.

Aging (Albany NY). 2020.

PMCID: PMC7425473

The mushroom Ganoderma lucidum (G. lucidum Leyss. ex Fr.) Karst has been a traditional Chinese medicine for millennia. In this study, we isolated the Ganoderma lucidum spore oil (GLSO) and evaluated the effect of GLSO on skin burn wound healing …

The mushroom Ganoderma lucidum (G. lucidum Leyss. ex Fr.) Karst has been a traditional Chinese medicine for millennia. …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The effect of Ganoderma lucidum spore oil in early skin wound healing: interactions of skin microbiota and inflammation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
193.
Effect of Ganoderma lucidum spores intervention on glucose and lipid metabolism gene expression profiles in type 2 diabetic rats.
- Wang F, Zhou Z, Ren X, Wang Y, Yang R, Luo J, Strappe P.
- Lipids Health Dis. 2015 May 22;14:49. doi: 10.1186/s12944-015-0045-y.
- PMCID: PMC4443549
Wang F, et al.

Lipids Health Dis. 2015.

PMCID: PMC4443549

BACKGROUND: The fruiting body of Ganoderma lucidum has been used as a traditional herbal medicine for many years. However, to the date, there is no detailed study for describing the effect of G. lucidum spores on oxidative stress, blood glucose level and lipi …

BACKGROUND: The fruiting body of Ganoderma lucidum has been used as a traditional herbal medicine for many years. However, to …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effect of Ganoderma lucidum spores intervention on glucose and lipid metabolism gene expression profiles in type 2 diabetic rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
194.
Comprehensive comparison of polysaccharides from Ganoderma lucidum and G. sinense: chemical, antitumor, immunomodulating and gut-microbiota modulatory properties.
- Li LF, Liu HB, Zhang QW, Li ZP, Wong TL, Fung HY, Zhang JX, Bai SP, Lu AP, Han QB.
- Sci Rep. 2018 Apr 18;8(1):6172. doi: 10.1038/s41598-018-22885-7.
- PMCID: PMC5906605
Li LF, et al.

Sci Rep. 2018.

PMCID: PMC5906605

Both Ganoderma lucidum (GL) and G. sinense (GS) are used as Lingzhi in China. Their functions are assumed to mainly derive from triterpenes and polysaccharides; however, the two species have very different triterpenes profiles, if this was the case, then the bioacti …

Both Ganoderma lucidum (GL) and G. sinense (GS) are used as Lingzhi in China. Their functions are assumed to mainly derive fro …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Comprehensive comparison of polysaccharides from Ganoderma lucidum and G. sinense: chemical, antitumor, immunomodulating and gut-microbiota modulatory properties.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
195.
Mushroom-Based Supplements in Italy: Let's Open Pandora's Box.
- Risoli S, Nali C, Sarrocco S, Cicero AFG, Colletti A, Bosco F, Venturella G, Gadaleta A, Gargano ML, Marcotuli I.
- Nutrients. 2023 Feb 2;15(3):776. doi: 10.3390/nu15030776.
- PMCID: PMC9919834
Risoli S, et al.

Nutrients. 2023.

PMCID: PMC9919834

The molecular identification of the sequences with those deposited in GenBank allowed for identifying 6 out of 19 samples, matching with those deposited belonging to the species indicated in the label, i.e., Lentinula edodes (samples 1, 4, 12 and 18) and Ganoderma lucid …

The molecular identification of the sequences with those deposited in GenBank allowed for identifying 6 out of 19 samples, matching with tho …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Mushroom-Based Supplements in Italy: Let's Open Pandora's Box.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
196.
Computational analysis and low-scale constitutive expression of laccases synthetic genes GlLCC1 from Ganoderma lucidum and POXA 1B from Pleurotus ostreatus in Pichia pastoris.
- Rivera-Hoyos CM, Morales-Álvarez ED, Poveda-Cuevas SA, Reyes-Guzmán EA, Poutou-Piñales RA, Reyes-Montaño EA, Pedroza-Rodríguez AM, Rodríguez-Vázquez R, Cardozo-Bernal ÁM.
- PLoS One. 2015 Jan 22;10(1):e0116524. doi: 10.1371/journal.pone.0116524.
- PMCID: PMC4303304
Rivera-Hoyos CM, et al.

PLoS One. 2015.

PMCID: PMC4303304

In this work we selected fungal genes encoding for laccase enzymes GlLCC1 in Ganoderma lucidum and POXA 1B in Pleurotus ostreatus. These genes were optimized for codon use, GC content, and regions generating secondary structures. ...Interaction analysis of the 3D mo …

In this work we selected fungal genes encoding for laccase enzymes GlLCC1 in Ganoderma lucidum and POXA 1B in Pleurotus ostrea …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Computational analysis and low-scale constitutive expression of laccases synthetic genes GlLCC1 from Ganoderma lucidum and POXA 1B from Pleurotus ostreatus in Pichia pastoris.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Relevant for eco‑friendly processing, waste upcycling, and industrial biocatalysis. Open article.
197.
Sporoderm-broken spores of Ganoderma lucidum modulate hepatoblastoma malignancy by regulating RACK1-mediated autophagy and tumour immunity.
- Shen R, Ge Y, Qin Y, Gao H, Yu H, Wu H, Song H.
- J Cell Mol Med. 2024 Mar;28(6):e18223. doi: 10.1111/jcmm.18223.
- PMCID: PMC10919157
Shen R, et al.

J Cell Mol Med. 2024.

PMCID: PMC10919157

Hepatoblastoma (HB), a primary liver tumour, is notorious for its high metastatic potential and poor prognosis. Ganoderma lucidum, an edible mushroom species utilized in traditional Chinese medicine for addressing various tumour types, presents an intriguing avenue …

Hepatoblastoma (HB), a primary liver tumour, is notorious for its high metastatic potential and poor prognosis. Ganoderma lucidum< …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Sporoderm-broken spores of Ganoderma lucidum modulate hepatoblastoma malignancy by regulating RACK1-mediated autophagy and tumour immunity.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
198.
Ganoderma lucidum methanolic extract as a potent phytoconstituent: characterization, in-vitro antimicrobial and cytotoxic activity.
- Mousavi SM, Hashemi SA, Gholami A, Omidifar N, Chiang WH, Neralla VR, Yousefi K, Shokripour M.
- Sci Rep. 2023 Oct 13;13(1):17326. doi: 10.1038/s41598-023-44135-1.
- PMCID: PMC10576041
Mousavi SM, et al.

Sci Rep. 2023.

PMCID: PMC10576041

Ganoderma lucidum methanolic extract (GLME) has attracted tremendous attention due to its exceptional antimicrobial and anticancer properties that can be delicately tuned by controlling the initial extraction's content and concentration. ...

Ganoderma lucidum methanolic extract (GLME) has attracted tremendous attention due to its exceptional antimicrobial and antica …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum methanolic extract as a potent phytoconstituent: characterization, in-vitro antimicrobial and cytotoxic activity.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
199.
Target of Rapamycin Mediated Ornithine Decarboxylase Antizyme Modulate Intracellular Putrescine and Ganoderic Acid Content in Ganoderma lucidum.
- Wu T, Xia J, Ge F, Qiu H, Tian L, Liu X, Liu R, Jiang A, Zhu J, Shi L, Yu H, Zhao M, Ren A.
- Microbiol Spectr. 2022 Sep 20;10(5):e0163322. doi: 10.1128/spectrum.01633-22.
- PMCID: PMC9604110
Wu T, et al.

Microbiol Spectr. 2022.

PMCID: PMC9604110

In addition, GlAZ upregulated the metabolic pathway of ganoderic acid (GA) biosynthesis in Ganoderma lucidum by modulating the intracellular Put content. However, a target of rapamycin (TOR) was found to promote the accumulation of intracellular Put after the GlTOR …

In addition, GlAZ upregulated the metabolic pathway of ganoderic acid (GA) biosynthesis in Ganoderma lucidum by modulating the …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Target of Rapamycin Mediated Ornithine Decarboxylase Antizyme Modulate Intracellular Putrescine and Ganoderic Acid Content in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
200.
An active ingredient isolated from Ganoderma lucidum promotes burn wound healing via TRPV1/SMAD signaling.
- Jiao C, Yun H, Liang H, Lian X, Li S, Chen J, Qadir J, Yang BB, Xie Y.
- Aging (Albany NY). 2022 Jun 13;14(13):5376-5389. doi: 10.18632/aging.204119.
- PMCID: PMC9320545
Jiao C, et al.

Aging (Albany NY). 2022.

PMCID: PMC9320545

The mushroom Ganoderma lucidum is a traditional Chinese medicine and G. lucidum spore oil (GLSO) is the lipid fraction isolated from Ganoderma spores. ...

The mushroom Ganoderma lucidum is a traditional Chinese medicine and G. lucidum spore oil (GLSO) is the lipid fraction …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: An active ingredient isolated from Ganoderma lucidum promotes burn wound healing via TRPV1/SMAD signaling.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 21

201.
Spore powder of Ganoderma lucidum for the treatment of Alzheimer disease: A pilot study.
- Wang GH, Wang LH, Wang C, Qin LH.
- Medicine (Baltimore). 2018 May;97(19):e0636. doi: 10.1097/MD.0000000000010636.
- PMCID: PMC5959386
Wang GH, et al.

Medicine (Baltimore). 2018.

PMCID: PMC5959386

BACKGROUND: This study explored the feasible efficacy and safety of the Spore Powder of Ganoderma Lucidum (SPGL) for treating patients with Alzheimer disease (AD). METHODS: Forty-two eligible patients with AD were recruited. ...

BACKGROUND: This study explored the feasible efficacy and safety of the Spore Powder of Ganoderma Lucidum (SPGL) for treating …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Spore powder of Ganoderma lucidum for the treatment of Alzheimer disease: A pilot study.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Participant-reported outcomes, clinical biomarkers, and safety/tolerability. Open article.
- Why might this paper be useful to readers? Provides early human data; interpret with caution and check study size and endpoints. Open article.
202.
Encapsulation of progesterone in reishi mushroom composite for optimized hormone replacement and targeted anticancer therapy.
- Mahgoub SM, Alawam AS, Rudayni HA, Allam AA, Shaban A, Khaled E, Mokhtar AM, Aleem Abdel Aziz SA, Mahmoud R.
- RSC Adv. 2025 Jun 20;15(24):19392-19416. doi: 10.1039/d5ra02368h.
- PMCID: PMC12179686
Mahgoub SM, et al.

RSC Adv. 2025.

PMCID: PMC12179686

To address these issues, this study develops an innovative progesterone-reishi mushroom (Ganoderma lucidum) composite, leveraging the natural bioactive properties of reishi mushrooms to enhance therapeutic efficacy. The composite was prepared by encaps …

To address these issues, this study develops an innovative progesterone-reishi mushroom (Ganoderma lucidum) composite, …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Encapsulation of progesterone in reishi mushroom composite for optimized hormone replacement and targeted anticancer therapy.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
203.
GPP (Composition of Ganoderma Lucidum Poly-saccharides and Polyporus Umbellatus Poly-saccharides) Enhances Innate Immune Function in Mice.
- Huang Q, Li L, Chen H, Liu Q, Wang Z.
- Nutrients. 2019 Jun 28;11(7):1480. doi: 10.3390/nu11071480.
- PMCID: PMC6682870
Huang Q, et al.

Nutrients. 2019.

PMCID: PMC6682870

Modern research has found that Ganoderma lucidum polysaccharides (GLP) and Polyporus umbellatus polysaccharides (PUP) mainly exhibit immunoregulation. ...

Modern research has found that Ganoderma lucidum polysaccharides (GLP) and Polyporus umbellatus polysaccharides (PUP) mainly e …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: GPP (Composition of Ganoderma Lucidum Poly-saccharides and Polyporus Umbellatus Poly-saccharides) Enhances Innate Immune Function in Mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
204.
Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury.
- Abate M, Pepe G, Randino R, Pisanti S, Basilicata MG, Covelli V, Bifulco M, Cabri W, D'Ursi AM, Campiglia P, Rodriquez M.
- Pharmaceuticals (Basel). 2020 Aug 29;13(9):224. doi: 10.3390/ph13090224.
- PMCID: PMC7557611
Abate M, et al.

Pharmaceuticals (Basel). 2020.

PMCID: PMC7557611

Ganoderma lucidum or Reishi is recognized as the most potent adaptogen present in nature, and its anti-inflammatory, antioxidant, immunomodulatory and anticancer activities are well known. Moreover, lately, there has been an increasing interest from pharmaceu …

Ganoderma lucidum or Reishi is recognized as the most potent adaptogen present in nature, and its anti-inflammatory, an …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
205.
Performance of wild-Serbian Ganoderma lucidum mycelium in treating synthetic sewage loading using batch bioreactor.
- Mohd Hanafiah Z, Wan Mohtar WHM, Abu Hasan H, Jensen HS, Klaus A, Wan-Mohtar WAAQI.
- Sci Rep. 2019 Nov 6;9(1):16109. doi: 10.1038/s41598-019-52493-y.
- PMCID: PMC6834664
Mohd Hanafiah Z, et al.

Sci Rep. 2019.

PMCID: PMC6834664

Thus, the performance of pre-grown wild-Serbian Ganoderma lucidum mycelial pellets (GLMPs) was evaluated on four different synthetic domestic wastewaters under different conditions of initial pH (pH 4, 5, and 7) and chemical oxygen demand (COD) to nitrogen (COD/N) r …

Thus, the performance of pre-grown wild-Serbian Ganoderma lucidum mycelial pellets (GLMPs) was evaluated on four different syn …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Performance of wild-Serbian Ganoderma lucidum mycelium in treating synthetic sewage loading using batch bioreactor.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
206.
Ganoderma lucidum-derived polysaccharide enhances coix oil-based microemulsion on stability and lung cancer-targeted therapy.
- Guo J, Yuan C, Huang M, Liu Y, Chen Y, Liu C, Chen Y.
- Drug Deliv. 2018 Nov;25(1):1802-1810. doi: 10.1080/10717544.2018.1516006.
- PMCID: PMC6201799
Guo J, et al.

Drug Deliv. 2018.

PMCID: PMC6201799

The aim of this study is to explore the influence of Ganoderma lucidum-derived polysaccharides (GLP) to coix oil-based microemulsion on pharmaceutical performance and anti-lung cancer treatment. ...

The aim of this study is to explore the influence of Ganoderma lucidum-derived polysaccharides (GLP) to coix oil-based microem …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum -derived polysaccharide enhances coix oil-based microemulsion on stability and lung cancer-targeted therapy.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
207.
Ganoderma lucidum Extract Reduces the Motility of Breast Cancer Cells Mediated by the RAC-Lamellipodin Axis.
- Acevedo-Díaz A, Ortiz-Soto G, Suárez-Arroyo IJ, Zayas-Santiago A, Martínez Montemayor MM.
- Nutrients. 2019 May 19;11(5):1116. doi: 10.3390/nu11051116.
- PMCID: PMC6567024
Acevedo-Díaz A, et al.

Nutrients. 2019.

PMCID: PMC6567024

Here, we aimed to investigate the therapeutic efficacy of Ganoderma lucidum extract (GLE)-a medicinal mushroom with anticancer properties-on BC motility via the Rac/Lamellipodin pathway. ...

Here, we aimed to investigate the therapeutic efficacy of Ganoderma lucidum extract (GLE)-a medicinal mushroom with anticancer …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Extract Reduces the Motility of Breast Cancer Cells Mediated by the RAC-Lamellipodin Axis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
208.
Combination of Spirulina platensis, Ganoderma lucidum and Moringa oleifera Improves Cardiac Functions and Reduces Pro-Inflammatory Biomarkers in Preclinical Models of Short-Term Doxorubicin-Mediated Cardiotoxicity: New Frontiers in Cardioncology?
- Quagliariello V, Basilicata MG, Pepe G, De Anseris R, Di Mauro A, Scognamiglio G, Palma G, Vestuto V, Buccolo S, Luciano A, Barbieri M, Bruzzese F, Maurea C, Pumpo R, Ostacolo C, Campiglia P, Berretta M, Maurea N.
- J Cardiovasc Dev Dis. 2022 Nov 28;9(12):423. doi: 10.3390/jcdd9120423.
- PMCID: PMC9780956
Quagliariello V, et al.

J Cardiovasc Dev Dis. 2022.

PMCID: PMC9780956

Whilst prolonging cancer-related survival, these agents can induce drug-related cardiotoxicity. Spirulina, Reishi (Ganoderma lucidum) and Moringa are three nutraceuticals with anti-inflammatory effects that are currently used in cancer patients as complementa …

Whilst prolonging cancer-related survival, these agents can induce drug-related cardiotoxicity. Spirulina, Reishi (Ganoderma < …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Combination of Spirulina platensis, Ganoderma lucidum and Moringa oleifera Improves Cardiac Functions and Reduces Pro-Inflammatory Biomarkers in Preclinical Models of Short-Term Doxorubicin-Mediated Cardiotoxicity: New Frontiers in Cardioncology?. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
209.
Antihyperglycemic effect of ganoderma lucidum polysaccharides on streptozotocin-induced diabetic mice.
- Li F, Zhang Y, Zhong Z.
- Int J Mol Sci. 2011 Sep 20;12(9):6135-45. doi: 10.3390/ijms12096135.
- PMCID: PMC3189773
Li F, et al.

Int J Mol Sci. 2011.

PMCID: PMC3189773

The current study evaluated the glucose-lowering effect of ganoderma lucidum polysaccharides (Gl-PS) in streptozotocin (STZ)-induced diabetic mice. ...

The current study evaluated the glucose-lowering effect of ganoderma lucidum polysaccharides (Gl-PS) in streptozotocin (STZ)-i …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antihyperglycemic effect of ganoderma lucidum polysaccharides on streptozotocin-induced diabetic mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
210.
The mushroom Ganoderma lucidum suppresses breast-to-lung cancer metastasis through the inhibition of pro-invasive genes.
- Loganathan J, Jiang J, Smith A, Jedinak A, Thyagarajan-Sahu A, Sandusky GE, Nakshatri H, Sliva D.
- Int J Oncol. 2014 Apr 9;44(6):2009-15. doi: 10.3892/ijo.2014.2375.
- PMCID: PMC4735696
Loganathan J, et al.

Int J Oncol. 2014.

PMCID: PMC4735696

In the present study, we evaluated a well-characterized extract from the medicinal mushroom Ganoderma lucidum (GLE) for its affects on tumor growth and breast-to-lung cancer metastasis. ...

In the present study, we evaluated a well-characterized extract from the medicinal mushroom Ganoderma lucidum (GLE) for its af …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The mushroom Ganoderma lucidum suppresses breast-to-lung cancer metastasis through the inhibition of pro-invasive genes.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 22

211.
Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast.
- Yuan W, Jiang C, Wang Q, Fang Y, Wang J, Wang M, Xiao H.
- Nat Commun. 2022 Dec 14;13(1):7740. doi: 10.1038/s41467-022-35500-1.
- PMCID: PMC9748899
Yuan W, et al.

Nat Commun. 2022.

PMCID: PMC9748899

Type II ganoderic acids (GAs) produced by the traditional medicinal mushroom Ganoderma are a group of triterpenoids with superior biological activities. However, challenges in the genetic manipulation of the native producer, low level of accumulation in the farmed mushroom …

Type II ganoderic acids (GAs) produced by the traditional medicinal mushroom Ganoderma are a group of triterpenoids with superior bio …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
212.
Ganoderma lucidum Mycelia Mass and Bioactive Compounds Production through Grape Pomace and Cheese Whey Valorization.
- Kachrimanidou V, Papadaki A, Papapostolou H, Alexandri M, Gonou-Zagou Z, Kopsahelis N.
- Molecules. 2023 Aug 30;28(17):6331. doi: 10.3390/molecules28176331.
- PMCID: PMC10489755
Kachrimanidou V, et al.

Molecules. 2023.

PMCID: PMC10489755

Numerous compounds obtained from the medicinal mushroom Ganoderma lucidum have evidenced renowned bioactive characteristics. Controlled fermentation to generate fungal mycelia confers several advantages, specifically when the valorization of agro-industrial streams …

Numerous compounds obtained from the medicinal mushroom Ganoderma lucidum have evidenced renowned bioactive characteristics. C …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Mycelia Mass and Bioactive Compounds Production through Grape Pomace and Cheese Whey Valorization.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
213.
Ganoderma lucidum Polysaccharides Reduce Lipopolysaccharide-Induced Interleukin-1 beta Expression in Cultured Smooth Muscle Cells and in Thoracic Aortas in Mice.
- Liang CJ, Lee CW, Sung HC, Chen YH, Chiang YC, Hsu HY, Tseng YC, Li CY, Wang SH, Chen YL.
- Evid Based Complement Alternat Med. 2014 Mar 4;2014:305149. doi: 10.1155/2014/305149.
- PMCID: PMC3960732
Liang CJ, et al.

Evid Based Complement Alternat Med. 2014.

PMCID: PMC3960732

The aim of the present study was to examine the effects of an extract of Ganoderma lucidum (Reishi) polysaccharides (EORPs), which is effective against immunological disorders, on interleukin- (IL-) 1 beta expression by human aortic smooth muscle cells (HASMC …

The aim of the present study was to examine the effects of an extract of Ganoderma lucidum (Reishi) polysaccharides (EO …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Polysaccharides Reduce Lipopolysaccharide-Induced Interleukin-1 beta Expression in Cultured Smooth Muscle Cells and in Thoracic Aortas in Mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
214.
Immuno-physiological effects of dietary reishi mushroom powder as a source of beta-glucan on Rohu, Labeo rohita challenged with Aeromonas veronii.
- Saha TK, Mariom, Rahman T, Moniruzzaman M, Min T, Hossain Z.
- Sci Rep. 2023 Sep 5;13(1):14652. doi: 10.1038/s41598-023-41557-9.
- PMCID: PMC10480226
Saha TK, et al.

Sci Rep. 2023.

PMCID: PMC10480226

We studied how supplementing Labeo rohita's diet with reishi mushroom powder containing beta-glucan influenced immunological function. A supplemented diet containing 10% reishi mushroom powder was administered for 120 days. ...Therefore, the results indicated that a …

We studied how supplementing Labeo rohita's diet with reishi mushroom powder containing beta-glucan influenced immunological function …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Immuno-physiological effects of dietary reishi mushroom powder as a source of beta-glucan on Rohu, Labeo rohita challenged with Aeromonas veronii.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
215.
Ganoderma lucidum Modulates Inflammatory Responses following 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Administration in Mice.
- Ren Z, Ding H, Zhou M, Chan P.
- Nutrients. 2022 Sep 19;14(18):3872. doi: 10.3390/nu14183872.
- PMCID: PMC9505693
Ren Z, et al.

Nutrients. 2022.

PMCID: PMC9505693

Ganoderma lucidum, one of the most valued medicinal mushrooms, has been used for health supplements and medicine in China. Our previous studies have proved that Ganoderma lucidum extract (GLE) could inhibit activation of microglia and protect dopaminer …

Ganoderma lucidum, one of the most valued medicinal mushrooms, has been used for health supplements and medicine in China. Our …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Modulates Inflammatory Responses following 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Administration in Mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
216.
Screening of active components of Ganoderma lucidum and decipher its molecular mechanism to improve learning and memory disorders.
- Zhang XT, Ji CL, Fu YJ, Yang Y, Xu GY.
- Biosci Rep. 2024 Jul 31;44(7):BSR20232068. doi: 10.1042/BSR20232068.
- PMCID: PMC11292473
Zhang XT, et al.

Biosci Rep. 2024.

PMCID: PMC11292473

Recently, more and more studies have shown that Ganoderma lucidum (GL) can improve the symptoms of LMI. The active ingredients in GL and their corresponding targets were screened through TCMSP (Traditional Chinese Medicine Systems Pharmacology Database and Analysis …

Recently, more and more studies have shown that Ganoderma lucidum (GL) can improve the symptoms of LMI. The active ingredients …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Screening of active components of Ganoderma lucidum and decipher its molecular mechanism to improve learning and memory disorders.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
217.
Peroxidase-Like Platinum Clusters Synthesized by Ganoderma lucidum Polysaccharide for Sensitively Colorimetric Detection of Dopamine.
- Lai X, Han Y, Zhang J, Zhang J, Lin W, Liu Z, Wang L.
- Molecules. 2021 May 6;26(9):2738. doi: 10.3390/molecules26092738.
- PMCID: PMC8125108
Lai X, et al.

Molecules. 2021.

PMCID: PMC8125108

In this study, we reported the colorimetric detection of DA using Ganoderma lucidum polysaccharide (GLP) stabilized platinum nanoclusters (Pt(n)-GLP NCs). ...

In this study, we reported the colorimetric detection of DA using Ganoderma lucidum polysaccharide (GLP) stabilized platinum n …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Peroxidase-Like Platinum Clusters Synthesized by Ganoderma lucidum Polysaccharide for Sensitively Colorimetric Detection of Dopamine.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
218.
Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers.
- Chiu HF, Fu HY, Lu YY, Han YC, Shen YC, Venkatakrishnan K, Golovinskaia O, Wang CK.
- Pharm Biol. 2017 Dec;55(1):1041-1046. doi: 10.1080/13880209.2017.1288750.
- PMCID: PMC6130508
Chiu HF, et al.

Pharm Biol. 2017.

PMCID: PMC6130508

CONTEXT: Ganoderma lucidum (Leyss: Fr) Karst. (Polyporaceae) is an oriental medicinal fungus, commonly used in traditional Chinese medicine (TCM) for treating various condition or diseases such as hypertension, hyperglycaemia, hepatitis and cancer. OBJECTIVE: The cu …

CONTEXT: Ganoderma lucidum (Leyss: Fr) Karst. (Polyporaceae) is an oriental medicinal fungus, commonly used in traditional Chi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum : a randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Participant-reported outcomes, clinical biomarkers, and safety/tolerability. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
219.
Antidiabetic, antihyperlipidemic and antioxidant activities of a novel proteoglycan from ganoderma lucidum fruiting bodies on db/db mice and the possible mechanism.
- Pan D, Zhang D, Wu J, Chen C, Xu Z, Yang H, Zhou P.
- PLoS One. 2013 Jul 11;8(7):e68332. doi: 10.1371/journal.pone.0068332.
- PMCID: PMC3708940
Pan D, et al.

PLoS One. 2013.

PMCID: PMC3708940

Previously, we screened a proteoglycan for anti-hyperglycemic, named FYGL, from Ganoderma Lucidum. For further research of the antidiabetic mechanisms of FYGL in vivo, the glucose homeostasis, activities of insulin-sensitive enzymes, glucose transporter expression a …

Previously, we screened a proteoglycan for anti-hyperglycemic, named FYGL, from Ganoderma Lucidum. For further research of the …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antidiabetic, antihyperlipidemic and antioxidant activities of a novel proteoglycan from ganoderma lucidum fruiting bodies on db/db mice and the possible mechanism.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
220.
Innovative eco-sustainable reishi mushroom-based adsorbents for progesterone removal and agricultural sustainability.
- Abdelwahab A, Alenezi KM, Humaidi JR, Haque A, Mahgoub SM, Mokhtar AM, Shaban A, Mansour M M M, Mahmoud R.
- RSC Adv. 2025 May 20;15(21):16690-16707. doi: 10.1039/d5ra01906k.
- PMCID: PMC12089978
Abdelwahab A, et al.

RSC Adv. 2025.

PMCID: PMC12089978

This study introduces an innovative, eco-friendly approach utilizing non-edible reishi mushroom (Ganoderma lucidum) and its calcined form as natural adsorbents for progesterone removal while simultaneously exploring the potential of the formed composites as s …

This study introduces an innovative, eco-friendly approach utilizing non-edible reishi mushroom (Ganoderma lucidum) and …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Innovative eco-sustainable reishi mushroom-based adsorbents for progesterone removal and agricultural sustainability.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 23

221.
Clinical Evaluation of Ganoderma lucidum Spore Oil for Triglyceride Reduction: A Randomized, Double-Blind, Crossover Study.
- Wang X, Wang X, Zhao L, Zhou F.
- Nutrients. 2025 Feb 28;17(5):844. doi: 10.3390/nu17050844.
- PMCID: PMC11901880
Wang X, et al.

Nutrients. 2025.

PMCID: PMC11901880

Background: Ganoderma lucidum spore oil (GLSO) is widely recognized for its notable medicinal and nutritional properties. ...

Background: Ganoderma lucidum spore oil (GLSO) is widely recognized for its notable medicinal and nutritional properties. ...
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Clinical Evaluation of Ganoderma lucidum Spore Oil for Triglyceride Reduction: A Randomized, Double-Blind, Crossover Study.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Participant-reported outcomes, clinical biomarkers, and safety/tolerability. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
222.
Mexican Ganoderma Lucidum Extracts Decrease Lipogenesis Modulating Transcriptional Metabolic Networks and Gut Microbiota in C57BL/6 Mice Fed with a High-Cholesterol Diet.
- Romero-Córdoba SL, Salido-Guadarrama I, Meneses ME, Cosentino G, Iorio MV, Tagliabue E, Torres N, Sánchez-Tapia M, Bonilla M, Castillo I, Petlacalco B, Tovar AR, Martínez-Carrera D.
- Nutrients. 2020 Dec 24;13(1):38. doi: 10.3390/nu13010038.
- PMCID: PMC7823885
Romero-Córdoba SL, et al.

Nutrients. 2020.

PMCID: PMC7823885

Natural products, such as the medicinal mushroom Ganoderma lucidum (Gl), have demonstrated hypocholesterolemic, prebiotic and antidiabetic properties. ...

Natural products, such as the medicinal mushroom Ganoderma lucidum (Gl), have demonstrated hypocholesterolemic, prebiotic and …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Mexican Ganoderma Lucidum Extracts Decrease Lipogenesis Modulating Transcriptional Metabolic Networks and Gut Microbiota in C57BL/6 Mice Fed with a High-Cholesterol Diet.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
223.
Ganoderma lucidum Rhodiola compound preparation prevent D-galactose-induced immune impairment and oxidative stress in aging rat model.
- Yuan S, Yang Y, Li J, Tan X, Cao Y, Li S, Hong HD, Liu L, Zhang Q.
- Sci Rep. 2020 Nov 6;10(1):19244. doi: 10.1038/s41598-020-76249-1.
- PMCID: PMC7648061
Yuan S, et al.

Sci Rep. 2020.

PMCID: PMC7648061

This research aims to study the anti-aging effects of GRCP, a compound preparation made by Ganoderma lucidum and Rhodiola rosen, in aging rats. Rats were subcutaneously injected with 400 mg/kg of D-galactose daily, and aging could be induced after 8 weeks. ...

This research aims to study the anti-aging effects of GRCP, a compound preparation made by Ganoderma lucidum and Rhodiola rose …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Rhodiola compound preparation prevent D-galactose-induced immune impairment and oxidative stress in aging rat model.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
224.
Polysaccharides from Ganoderma lucidum attenuate microglia-mediated neuroinflammation and modulate microglial phagocytosis and behavioural response.
- Cai Q, Li Y, Pei G.
- J Neuroinflammation. 2017 Mar 24;14(1):63. doi: 10.1186/s12974-017-0839-0.
- PMCID: PMC5364682
Cai Q, et al.

J Neuroinflammation. 2017.

PMCID: PMC5364682

BACKGROUND: Ganoderma lucidum (GL) has been widely used in Asian countries for hundreds of years to promote health and longevity. The pharmacological functions of which had been classified, including the activation of innate immune responses, suppression of tumour a …

BACKGROUND: Ganoderma lucidum (GL) has been widely used in Asian countries for hundreds of years to promote health and longevi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Polysaccharides from Ganoderma lucidum attenuate microglia-mediated neuroinflammation and modulate microglial phagocytosis and behavioural response.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
225.
Unlocking Reishi's secrets: nutritional and medicinal traits of Ganoderma lucidum isolated from tree bark in Egypt.
- Shady RM, El-Gayar MH, El-Gebaly E, Abbass HS, Yassein MA.
- AMB Express. 2025 Jul 12;15(1):104. doi: 10.1186/s13568-025-01905-6.
- PMCID: PMC12255602
Shady RM, et al.

AMB Express. 2025.

PMCID: PMC12255602

Ganoderma lucidum is an edible mushroom with high consumption rates in many cultures especially East Asian. This study assessed the in-vitro antimicrobial, antitumor, antiviral as well as antioxidant capacity of Ganoderma lucidum water extract (GLWE). …

Ganoderma lucidum is an edible mushroom with high consumption rates in many cultures especially East Asian. This study assesse …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Unlocking Reishi 's secrets: nutritional and medicinal traits of Ganoderma lucidum isolated from tree bark in Egypt.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
226.
Quercetin Synergistically Inhibit EBV-Associated Gastric Carcinoma with Ganoderma lucidum Extracts.
- Huh S, Lee S, Choi SJ, Wu Z, Cho JH, Kim L, Shin YS, Kang BW, Kim JG, Liu K, Cho H, Kang H.
- Molecules. 2019 Oct 24;24(21):3834. doi: 10.3390/molecules24213834.
- PMCID: PMC6864608
Huh S, et al.

Molecules. 2019.

PMCID: PMC6864608

Mycotherapy has been shown to improve the overall response rate during cancer treatment and reduce some chemotherapy-related adverse events. Ganoderma lucidum is a traditional mushroom used for pharmaceutical purposes. G. lucidum extracts (GLE) showed potenti …

Mycotherapy has been shown to improve the overall response rate during cancer treatment and reduce some chemotherapy-related adverse events. …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Quercetin Synergistically Inhibit EBV-Associated Gastric Carcinoma with Ganoderma lucidum Extracts.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
227.
Antitumor Activity of Extract From the Sporoderm-Breaking Spore of Ganoderma lucidum: Restoration on Exhausted Cytotoxic T Cell With Gut Microbiota Remodeling.
- Su J, Su L, Li D, Shuai O, Zhang Y, Liang H, Jiao C, Xu Z, Lai Y, Xie Y.
- Front Immunol. 2018 Jul 31;9:1765. doi: 10.3389/fimmu.2018.01765.
- PMCID: PMC6079217
Su J, et al.

Front Immunol. 2018.

PMCID: PMC6079217

Recently, active components from the spores of Ganoderma lucidum have attracted much attention for their versatile biological activities owing to the advance in sporoderm-breaking technology. Here, anticancer potential of an extract derived from the sporoderm-breaki …

Recently, active components from the spores of Ganoderma lucidum have attracted much attention for their versatile biological …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antitumor Activity of Extract From the Sporoderm-Breaking Spore of Ganoderma lucidum : Restoration on Exhausted Cytotoxic T Cell With Gut Microbiota Remodeling.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
228.
GCN4 Enhances the Transcriptional Regulation of AreA by Interacting with SKO1 To Mediate Nitrogen Utilization in Ganoderma lucidum.
- Lian L, Shi L, Zhu J, Shi L, Ren A, You H, Liu R, Zhao M.
- Appl Environ Microbiol. 2022 Nov 7;88(22):e0132222. doi: 10.1128/aem.01322-22.
- PMCID: PMC9680636
Lian L, et al.

Appl Environ Microbiol. 2022.

PMCID: PMC9680636

However, the mechanism by which GCN4 regulates nitrogen utilization in Ganoderma lucidum is not well understood. In this study, we found that GCN4 physically interacts with SKO1, a bZIP (basic leucine zipper) transcription factor. ...

However, the mechanism by which GCN4 regulates nitrogen utilization in Ganoderma lucidum is not well understood. In this study …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: GCN4 Enhances the Transcriptional Regulation of AreA by Interacting with SKO1 To Mediate Nitrogen Utilization in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
229.
Study on Quality Control of Compound Anoectochilus roxburghii (Wall.) Lindl. by Liquid Chromatography-Tandem Mass Spectrometry.
- Zhang Q, Huang L, Wu Y, Huang L, Xu X, Lin R.
- Molecules. 2022 Jun 27;27(13):4130. doi: 10.3390/molecules27134130.
- PMCID: PMC9268268
Zhang Q, et al.

Molecules. 2022.

PMCID: PMC9268268

(A. roxburghii) oral liquid (CAROL) is a hospital preparation of A. roxburghii and Ganoderma lucidum (G. lucidum), which have hepatoprotective effects. Eight active components (five nucleosides/nucleobases and three triterpenoid acids) in CAROL, A. roxburghii …

(A. roxburghii) oral liquid (CAROL) is a hospital preparation of A. roxburghii and Ganoderma lucidum (G. lucidum), whic …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Study on Quality Control of Compound Anoectochilus roxburghii (Wall.) Lindl. by Liquid Chromatography-Tandem Mass Spectrometry.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Quality/authentication methods study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Analytical validation (specificity/sensitivity), reference standards, and mislabeling rates. Open article.
- Why might this paper be useful to readers? Useful for quality control, sourcing, and preventing adulteration. Open article.
230.
Improved antitumor activity of cisplatin combined with Ganoderma lucidum polysaccharides in U14 cervical carcinoma-bearing mice.
- Zhu J, Xu J, Jiang LL, Huang JQ, Yan JY, Chen YW, Yang Q.
- Kaohsiung J Med Sci. 2019 Apr 8;35(4):222-229. doi: 10.1002/kjm2.12020.
- PMCID: PMC11900711
Zhu J, et al.

Kaohsiung J Med Sci. 2019.

PMCID: PMC11900711

Our main goal of this study is to investigate the improvement of Ganoderma lucidum polysaccharides (GPS) on CIS-induced antitumor effect of in U14 cervical carcinoma-bearing mice. ...

Our main goal of this study is to investigate the improvement of Ganoderma lucidum polysaccharides (GPS) on CIS-induced antitu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Improved antitumor activity of cisplatin combined with Ganoderma lucidum polysaccharides in U14 cervical carcinoma-bearing mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.

Page 24

231.
Multi-omics analysis reveals inhibition of osteosarcoma progression by sporoderm-removed Ganoderma lucidum spores via targeting glycerophospholipid and fatty acid metabolism.
- Pan H, Li C, Wang M, Ye K, Fan X, Fu Y, Yang J, Li Z.
- Sci Rep. 2025 Jul 1;15(1):22111. doi: 10.1038/s41598-025-05890-5.
- PMCID: PMC12219779
Pan H, et al.

Sci Rep. 2025.

PMCID: PMC12219779

This study explored the potential of sporoderm-removed Ganoderma lucidum spores (RGLS) as a novel therapeutic agent against OS and elucidated its mechanism of action. ...

This study explored the potential of sporoderm-removed Ganoderma lucidum spores (RGLS) as a novel therapeutic agent against OS …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Multi-omics analysis reveals inhibition of osteosarcoma progression by sporoderm-removed Ganoderma lucidum spores via targeting glycerophospholipid and fatty acid metabolism.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
232.
Multiple Fingerprint-Activity Relationship Assessment of Immunomodulatory Polysaccharides from Ganoderma lucidum Based on Chemometric Methods.
- Liu J, Zhang J, Feng J, Tang C, Yan M, Zhou S, Chen W, Wang W, Liu Y.
- Molecules. 2023 Mar 24;28(7):2913. doi: 10.3390/molecules28072913.
- PMCID: PMC10096448
Liu J, et al.

Molecules. 2023.

PMCID: PMC10096448

Polysaccharides with molecular weights ranging from 1.75 10(3) to 1.14 10(4) g/mol were obtained from the fruit bodies of Ganoderma lucidum. The multiple fingerprints and macrophage immunostimulatory activity of these fractions were analyzed as well as the fingerpri …

Polysaccharides with molecular weights ranging from 1.75 10(3) to 1.14 10(4) g/mol were obtained from the fruit bodies of Ganoderma < …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Multiple Fingerprint-Activity Relationship Assessment of Immunomodulatory Polysaccharides from Ganoderma lucidum Based on Chemometric Methods.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
233.
Ganoderma lucidum Polysaccharides Ameliorate Acetaminophen-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Apoptosis along the Nrf2 Pathway.
- Zhang N, Han Z, Zhang R, Liu L, Gao Y, Li J, Yan M.
- Nutrients. 2024 Jun 13;16(12):1859. doi: 10.3390/nu16121859.
- PMCID: PMC11206445
Zhang N, et al.

Nutrients. 2024.

PMCID: PMC11206445

The excessive employment of acetaminophen (APAP) is capable of generating oxidative stress and apoptosis, which ultimately result in acute liver injury (ALI). Ganoderma lucidum polysaccharides (GLPs) exhibit hepatoprotective activity, yet the protective impact and p …

The excessive employment of acetaminophen (APAP) is capable of generating oxidative stress and apoptosis, which ultimately result in acute l …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Polysaccharides Ameliorate Acetaminophen-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Apoptosis along the Nrf2 Pathway.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
234.
The effect of Ganoderma lucidum extract on immunological function and identify its anti-tumor immunostimulatory activity based on the biological network.
- Zhao R, Chen Q, He YM.
- Sci Rep. 2018 Aug 23;8(1):12680. doi: 10.1038/s41598-018-30881-0.
- PMCID: PMC6107651
Zhao R, et al.

Sci Rep. 2018.

PMCID: PMC6107651

Ganoderma lucidum extract (GLE) has shown positive effects for tumor treatment. However, the molecular mechanism of GLE treatment is unknown. ...

Ganoderma lucidum extract (GLE) has shown positive effects for tumor treatment. However, the molecular mechanism of GLE treatm …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The effect of Ganoderma lucidum extract on immunological function and identify its anti-tumor immunostimulatory activity based on the biological network.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
235.
Synthesis and Evaluation of Herbal Chitosan from Ganoderma Lucidum Spore Powder for Biomedical Applications.
- Zhu LF, Yao ZC, Ahmad Z, Li JS, Chang MW.
- Sci Rep. 2018 Oct 2;8(1):14608. doi: 10.1038/s41598-018-33088-5.
- PMCID: PMC6168458
Zhu LF, et al.

Sci Rep. 2018.

PMCID: PMC6168458

In the current work, chitosan is obtained from an herbal source (Ganoderma lucidum spore powder (GLSP)) for the first time. To show this, both standard (thermochemical deacetylation, (TCD)) and emerging (ultrasound-assisted deacetylation (USAD)) methods of chitosan …

In the current work, chitosan is obtained from an herbal source (Ganoderma lucidum spore powder (GLSP)) for the first time. To …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Synthesis and Evaluation of Herbal Chitosan from Ganoderma Lucidum Spore Powder for Biomedical Applications.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
236.
Hypocholesterolemic Properties and Prebiotic Effects of Mexican Ganoderma lucidum in C57BL/6 Mice.
- Meneses ME, Martínez-Carrera D, Torres N, Sánchez-Tapia M, Aguilar-López M, Morales P, Sobal M, Bernabé T, Escudero H, Granados-Portillo O, Tovar AR.
- PLoS One. 2016 Jul 20;11(7):e0159631. doi: 10.1371/journal.pone.0159631.
- PMCID: PMC4954724
Meneses ME, et al.

PLoS One. 2016.

PMCID: PMC4954724

Edible and medicinal mushrooms contain bioactive compounds with promising effects on several cardiovascular risk biomarkers. However, strains of Ganoderma lucidum of Mexican origin have not yet been studied. Standardized extracts of G. lucidum (Gl) were given …

Edible and medicinal mushrooms contain bioactive compounds with promising effects on several cardiovascular risk biomarkers. However, strain …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Hypocholesterolemic Properties and Prebiotic Effects of Mexican Ganoderma lucidum in C57BL/6 Mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
237.
Hepatoprotective effects of mushrooms.
- Soares AA, de Sá-Nakanishi AB, Bracht A, da Costa SM, Koehnlein EA, de Souza CG, Peralta RM.
- Molecules. 2013 Jul 1;18(7):7609-30. doi: 10.3390/molecules18077609.
- PMCID: PMC6270077
Soares AA, et al.

Molecules. 2013.

PMCID: PMC6270077

The present article outlines and discusses the available information about the protective effects of mushroom extracts against liver damage induced by exogenous compounds. Among mushrooms, Ganoderma lucidum is indubitably the most widely studied species. In this rev …

The present article outlines and discusses the available information about the protective effects of mushroom extracts against liver damage …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Hepatoprotective effects of mushrooms.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
238.
Unlocking the Potential of Ganoderma lucidum (Curtis): Botanical Overview, Therapeutic Applications, and Nanotechnological Advances.
- Eira A, Gonçalves MBS, Fongang YSF, Domingues C, Jarak I, Mascarenhas-Melo F, Figueiras A.
- Pharmaceutics. 2025 Mar 26;17(4):422. doi: 10.3390/pharmaceutics17040422.
- PMCID: PMC12030363
Eira A, et al.

Pharmaceutics. 2025.

PMCID: PMC12030363

Background:Ganoderma lucidum (GL), commonly known as the "Lingzhi" or "Reishi" mushroom, has long been recognized for its potential health benefits and medicinal properties in traditional Chinese medicine. ...

Background:Ganoderma lucidum (GL), commonly known as the "Lingzhi" or "Reishi" mushroom, has long been recognized for i …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Unlocking the Potential of Ganoderma lucidum (Curtis): Botanical Overview, Therapeutic Applications, and Nanotechnological Advances.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
239.
Immuno-modulatory activity of Ganoderma lucidum-derived polysacharide on human monocytoid dendritic cells pulsed with Der p 1 allergen.
- Jan RH, Lin TY, Hsu YC, Lee SS, Lo SY, Chang M, Chen LK, Lin YL.
- BMC Immunol. 2011 May 25;12:31. doi: 10.1186/1471-2172-12-31.
- PMCID: PMC3127845
Jan RH, et al.

BMC Immunol. 2011.

PMCID: PMC3127845

BACKGROUND: Ganoderma lucidum-derived polysaccharide (PS-G) can rapidly and effectively promote the activation and maturation of immature dendritic cells (DCs), suggesting that PS-G possesses the capacity to regulate immune responses. ...

BACKGROUND: Ganoderma lucidum-derived polysaccharide (PS-G) can rapidly and effectively promote the activation and maturation …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Immuno-modulatory activity of Ganoderma lucidum -derived polysacharide on human monocytoid dendritic cells pulsed with Der p 1 allergen.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
240.
The medicinal mushroom Ganoderma lucidum attenuates UV-induced skin carcinogenesis and immunosuppression.
- Shahid A, Huang M, Liu M, Shamim MA, Parsa C, Orlando R, Huang Y.
- PLoS One. 2022 Mar 21;17(3):e0265615. doi: 10.1371/journal.pone.0265615.
- PMCID: PMC8936451
Shahid A, et al.

PLoS One. 2022.

PMCID: PMC8936451

The medicinal mushroom Ganoderma lucidum is traditionally used for treating multiple diseases, including cancer. ...

The medicinal mushroom Ganoderma lucidum is traditionally used for treating multiple diseases, including cancer. ...
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The medicinal mushroom Ganoderma lucidum attenuates UV-induced skin carcinogenesis and immunosuppression.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 25

241.
Ultrasonic-assisted supercritical fluid separation removing plasticizers from ganoderma lucidum spores' oil.
- Li C, Ma Y, Shen X, Chen W, Zhou Y, Zhi X.
- Ultrason Sonochem. 2023 Sep 23;100:106622. doi: 10.1016/j.ultsonch.2023.106622.
- PMCID: PMC10550761
Li C, et al.

Ultrason Sonochem. 2023.

PMCID: PMC10550761

Ultrasonic-assisted supercritical fluid separation (USFS) was firstly applied to regulate solubility and remove plasticizers from ganoderma lucidum spores' oil to improve product safety. Separation efficiency was related with four variables, including temperature, p …

Ultrasonic-assisted supercritical fluid separation (USFS) was firstly applied to regulate solubility and remove plasticizers from ganoder …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ultrasonic-assisted supercritical fluid separation removing plasticizers from ganoderma lucidum spores' oil.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
242.
Triterpenoids and Polysaccharides from Ganoderma lucidum Improve the Histomorphology and Function of Testes in Middle-Aged Male Mice by Alleviating Oxidative Stress and Cellular Apoptosis.
- Li Y, Liang W, Han Y, Zhao W, Wang S, Qin C.
- Nutrients. 2022 Nov 9;14(22):4733. doi: 10.3390/nu14224733.
- PMCID: PMC9696538
Li Y, et al.

Nutrients. 2022.

PMCID: PMC9696538

Aging is an inevitable physiological process accompanied by a decline in body physiology, including male fertility. A preparation from Ganoderma lucidum (GL) containing triterpenes and polysaccharides has been shown to have anti-aging properties. ...

Aging is an inevitable physiological process accompanied by a decline in body physiology, including male fertility. A preparation from Ga …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Triterpenoids and Polysaccharides from Ganoderma lucidum Improve the Histomorphology and Function of Testes in Middle-Aged Male Mice by Alleviating Oxidative Stress and Cellular Apoptosis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
243.
Ganoderma lucidum extract ameliorates MPTP-induced parkinsonism and protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis.
- Ren ZL, Wang CD, Wang T, Ding H, Zhou M, Yang N, Liu YY, Chan P.
- Acta Pharmacol Sin. 2018 Jul 10;40(4):441-450. doi: 10.1038/s41401-018-0077-8.
- PMCID: PMC6461997
Ren ZL, et al.

Acta Pharmacol Sin. 2018.

PMCID: PMC6461997

Neuroprotection targeting mitochondrial dysfunction has been proposed as an important therapeutic strategy for Parkinson's disease. Ganoderma lucidum (GL) has emerged as a novel agent that protects neurons from oxidative stress. ...

Neuroprotection targeting mitochondrial dysfunction has been proposed as an important therapeutic strategy for Parkinson's disease. Ganod …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum extract ameliorates MPTP-induced parkinsonism and protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
244.
Ganoderma lucidum Triterpenoids (GLTs) Reduce Neuronal Apoptosis via Inhibition of ROCK Signal Pathway in APP/PS1 Transgenic Alzheimer's Disease Mice.
- Yu N, Huang Y, Jiang Y, Zou L, Liu X, Liu S, Chen F, Luo J, Zhu Y.
- Oxid Med Cell Longev. 2020 Jan 28;2020:9894037. doi: 10.1155/2020/9894037.
- PMCID: PMC7008260
Yu N, et al.

Oxid Med Cell Longev. 2020.

PMCID: PMC7008260

Alzheimer's disease (AD) is the most common cause of dementia among senior citizen. Ganoderma lucidum triterpenoids (GLTs) have nutritional health benefits and has been shown to promote health and longevity, but a protective effect of GLTs on AD damage has not yet b …

Alzheimer's disease (AD) is the most common cause of dementia among senior citizen. Ganoderma lucidum triterpenoids (GLTs) hav …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Triterpenoids (GLTs) Reduce Neuronal Apoptosis via Inhibition of ROCK Signal Pathway in APP/PS1 Transgenic Alzheimer's Disease Mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
245.
Ganoderma lucidum polysaccharides reduce methotrexate-induced small intestinal damage in mice via induction of epithelial cell proliferation and migration.
- Chen LH, Lin ZB, Li WD.
- Acta Pharmacol Sin. 2011 Oct 24;32(12):1505-12. doi: 10.1038/aps.2011.126.
- PMCID: PMC4010208
Chen LH, et al.

Acta Pharmacol Sin. 2011.

PMCID: PMC4010208

AIM: To study the effects of Ganoderma lucidum polysaccharides (Gl-PS) on methotrexate (MTX)-induced small intestinal damage in mice and the underlying mechanisms. ...

AIM: To study the effects of Ganoderma lucidum polysaccharides (Gl-PS) on methotrexate (MTX)-induced small intestinal damage i …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum polysaccharides reduce methotrexate-induced small intestinal damage in mice via induction of epithelial cell proliferation and migration.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
246.
Ganoderma lucidum aqueous extract prevents hypobaric hypoxia induced memory deficit by modulating neurotransmission, neuroplasticity and maintaining redox homeostasis.
- Sharma P, Tulsawani R.
- Sci Rep. 2020 Jun 2;10(1):8944. doi: 10.1038/s41598-020-65812-5.
- PMCID: PMC7265456
Sharma P, et al.

Sci Rep. 2020.

PMCID: PMC7265456

Owing to contraindications of current drug therapies, the aim of the study was to investigate memory enhancing potential of aqueous extract of Ganoderma lucidum (GLAQ) and underlying neuroprotective mechanism using rat hypobaric hypoxia test model. ...

Owing to contraindications of current drug therapies, the aim of the study was to investigate memory enhancing potential of aqueous extract …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum aqueous extract prevents hypobaric hypoxia induced memory deficit by modulating neurotransmission, neuroplasticity and maintaining redox homeostasis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
247.
Ganoderma lucidum polysaccharides can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory function.
- Chan WK, Cheung CC, Law HK, Lau YL, Chan GC.
- J Hematol Oncol. 2008 Jul 21;1:9. doi: 10.1186/1756-8722-1-9.
- PMCID: PMC2517069
Chan WK, et al.

J Hematol Oncol. 2008.

PMCID: PMC2517069

BACKGROUND: Previous studies demonstrated Ganoderma lucidum polysaccharides (GL-PS), a form of bioactive beta-glucan can stimulate the maturation of monocyte-derived dendritic cells (DC). ...

BACKGROUND: Previous studies demonstrated Ganoderma lucidum polysaccharides (GL-PS), a form of bioactive beta-glucan can stimu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum polysaccharides can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory function.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
248.
Natural Bio-Compounds from Ganoderma lucidum and Their Beneficial Biological Actions for Anticancer Application: A Review.
- Cadar E, Negreanu-Pirjol T, Pascale C, Sirbu R, Prasacu I, Negreanu-Pirjol BS, Tomescu CL, Ionescu AM.
- Antioxidants (Basel). 2023 Oct 25;12(11):1907. doi: 10.3390/antiox12111907.
- PMCID: PMC10669212
Cadar E, et al.

Antioxidants (Basel). 2023.

PMCID: PMC10669212

Ganoderma lucidum (G. lucidum) has been known for many centuries in Asian countries under different names, varying depending on the country. ...The potential health benefits of G. lucidum are systematized based on biological actions. The findings prese …

Ganoderma lucidum (G. lucidum) has been known for many centuries in Asian countries under different names, varying depe …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Natural Bio-Compounds from Ganoderma lucidum and Their Beneficial Biological Actions for Anticancer Application: A Review.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
249.
Polysaccharide peptide (PsP) Ganoderma lucidum: a potential inducer for vascular repair in type 2 diabetes mellitus model.
- Heriansyah T, Nurwidyaningtyas W, Sargowo D, Tjahjono CT, Wihastuti TA.
- Vasc Health Risk Manag. 2019 Oct 3;15:419-427. doi: 10.2147/VHRM.S205996.
- PMCID: PMC6781740
Heriansyah T, et al.

Vasc Health Risk Manag. 2019.

PMCID: PMC6781740

This study aims to prove the effect of the polysaccharide peptide (PsP) Ganoderma lucidum on improving vascular damage through an increase of circulating endothelial cells and circulating endothelial cells (CEC) ratio, decreased H2O2, triglyceride (TG), total choles …

This study aims to prove the effect of the polysaccharide peptide (PsP) Ganoderma lucidum on improving vascular damage through …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Polysaccharide peptide (PsP) Ganoderma lucidum : a potential inducer for vascular repair in type 2 diabetes mellitus model.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
250.
Exploring the Therapeutic Potential of Ganoderma lucidum in Cancer.
- Cancemi G, Caserta S, Gangemi S, Pioggia G, Allegra A.
- J Clin Med. 2024 Feb 18;13(4):1153. doi: 10.3390/jcm13041153.
- PMCID: PMC10889924
Cancemi G, et al.

J Clin Med. 2024.

PMCID: PMC10889924

Moreover, research clarified the capability of molecules from Ganoderma lucidum to induce mitochondrial damage in acute promyelocytic leukemia cells, without cytotoxic effects in normal mononuclear cells. ...Our review presents data revealing the possibility of empl …

Moreover, research clarified the capability of molecules from Ganoderma lucidum to induce mitochondrial damage in acute promye …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Exploring the Therapeutic Potential of Ganoderma lucidum in Cancer.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 26

251.
Ganoderma lucidum polysaccharide (GLP) enhances antitumor immune response by regulating differentiation and inhibition of MDSCs via a CARD9-NF-kappaB-IDO pathway.
- Wang Y, Fan X, Wu X.
- Biosci Rep. 2020 Jun 26;40(6):BSR20201170. doi: 10.1042/BSR20201170.
- PMCID: PMC7313449
Wang Y, et al.

Biosci Rep. 2020.

PMCID: PMC7313449

A homogeneous polysaccharide (GLP), with an average molecular weight of 4.44 104 Da, was isolated and purified from the fruiting bodies of Ganoderma lucidum. In this work, we examined the antitumor activities of GLP using a mouse Lewis lung cancer (LLC) model and ex …

A homogeneous polysaccharide (GLP), with an average molecular weight of 4.44 104 Da, was isolated and purified from the fruiting bodies of < …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum polysaccharide (GLP) enhances antitumor immune response by regulating differentiation and inhibition of MDSCs via a CARD9-NF-kappaB-IDO pathway.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
252.
Gastroprotective Effects of Ganoderma lucidum Polysaccharides with Different Molecular Weights on Ethanol-Induced Acute Gastric Injury in Rats.
- Tian B, Zhao Q, Xing H, Xu J, Li Z, Zhu H, Yang K, Sun P, Cai M.
- Nutrients. 2022 Apr 1;14(7):1476. doi: 10.3390/nu14071476.
- PMCID: PMC9002462
Tian B, et al.

Nutrients. 2022.

PMCID: PMC9002462

Ganoderma lucidum is known as a medicine food homology that can ameliorate gastrointestinal diseases. To evaluate the gastroprotective effects on different Ganoderma lucidum polysaccharides (GLPs), GLP was separated into three parts with different mole …

Ganoderma lucidum is known as a medicine food homology that can ameliorate gastrointestinal diseases. To evaluate the gastropr …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Gastroprotective Effects of Ganoderma lucidum Polysaccharides with Different Molecular Weights on Ethanol-Induced Acute Gastric Injury in Rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
253.
A new class of natural glycopeptides with sugar moiety-dependent antioxidant activities derived from Ganoderma lucidum fruiting bodies.
- Wu Y, Wang D.
- J Proteome Res. Author manuscript. 2009 Feb;8(2):436-42. doi: 10.1021/pr800554w.
- PMCID: PMC2656399
Wu Y, et al.

J Proteome Res. Author manuscript. 2009.

PMCID: PMC2656399

A water-soluble glycopeptide (PGY), fractionated and purified from the aqueous extract of the fruiting bodies of Ganoderma lucidum via two-step dialysis, anion exchange, and gel permeation chromatography, was constituted of two moieties of carbohydrate and peptide. …

A water-soluble glycopeptide (PGY), fractionated and purified from the aqueous extract of the fruiting bodies of Ganoderma lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A new class of natural glycopeptides with sugar moiety-dependent antioxidant activities derived from Ganoderma lucidum fruiting bodies.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
254.
Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder.
- Fijałkowska A, Jędrejko K, Sułkowska-Ziaja K, Ziaja M, Kała K, Muszyńska B.
- Foods. 2022 May 20;11(10):1489. doi: 10.3390/foods11101489.
- PMCID: PMC9141008
Fijałkowska A, et al.

Foods. 2022.

PMCID: PMC9141008

We specifically highlight the results of preclinical and clinical studies on dietary supplementation with three selected mushroom species: Lion's mane (Hericium erinaceus), Caterpillar mushroom (Cordyceps militaris), and Lingzhi/Reishi (Ganoderma lucidum). Pr …

We specifically highlight the results of preclinical and clinical studies on dietary supplementation with three selected mushroom species: L …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
255.
Ganoderma triterpenoids attenuate tumour angiogenesis in lung cancer tumour-bearing nude mice.
- Liu W, Yuan R, Hou A, Tan S, Liu X, Tan P, Huang X, Wang J.
- Pharm Biol. 2020 Dec;58(1):1061-1068. doi: 10.1080/13880209.2020.1839111.
- PMCID: PMC7655057
Liu W, et al.

Pharm Biol. 2020.

PMCID: PMC7655057

CONTEXT: Ganoderma lucidum (Leyss. ex Fr.) Karst. (Polyporaceae) triterpenoids (GLTs), the main components and bioactive metabolites of G. lucidum, have antitumour activity. ...

CONTEXT: Ganoderma lucidum (Leyss. ex Fr.) Karst. (Polyporaceae) triterpenoids (GLTs), the main components and bioactive metab …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma triterpenoids attenuate tumour angiogenesis in lung cancer tumour-bearing nude mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
256.
Inhibition on alpha-Glucosidase Activity and Non-Enzymatic Glycation by an Anti-Oxidative Proteoglycan from Ganoderma lucidum.
- Zhang Y, Pan Y, Li J, Zhang Z, He Y, Yang H, Zhou P.
- Molecules. 2022 Feb 22;27(5):1457. doi: 10.3390/molecules27051457.
- PMCID: PMC8912016
Zhang Y, et al.

Molecules. 2022.

PMCID: PMC8912016

In this study, an anti-oxidative proteoglycan (named FYGL) extracted from Ganoderma lucidum was investigated in vitro for its inhibitory effect on alpha-glucosidase and non-enzymatic glycation using molecular kinetics, intrinsic fluorescence assay, and bovine serum …

In this study, an anti-oxidative proteoglycan (named FYGL) extracted from Ganoderma lucidum was investigated in vitro for its …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Inhibition on alpha-Glucosidase Activity and Non-Enzymatic Glycation by an Anti-Oxidative Proteoglycan from Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
257.
Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation.
- Pan H, Wang Y, Na K, Wang Y, Wang L, Li Z, Guo C, Guo D, Wang X.
- Cell Death Dis. 2019 Jun 11;10(6):456. doi: 10.1038/s41419-019-1653-7.
- PMCID: PMC6560101
Pan H, et al.

Cell Death Dis. 2019.

PMCID: PMC6560101

Targeting autophagy may serve as a promising strategy for cancer therapy. Ganoderma lucidum polysaccharide (GLP) has been shown to exert promising anti-cancer effects. ...

Targeting autophagy may serve as a promising strategy for cancer therapy. Ganoderma lucidum polysaccharide (GLP) has been show …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
258.
Khz (fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating JNK and NADPH oxidase-dependent generation of reactive oxygen species.
- Kim TH, Kim Js, Kim Zh, Huang RB, Wang RS.
- PLoS One. 2012 Oct 8;7(10):e46208. doi: 10.1371/journal.pone.0046208.
- PMCID: PMC3466234
Kim TH, et al.

PLoS One. 2012.

PMCID: PMC3466234

Khz is a compound derived from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia that inhibits the growth of cancer cells. ...

Khz is a compound derived from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia that inhibits the growth of ca …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Khz (fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating JNK and NADPH oxidase-dependent generation of reactive oxygen species.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Relevant for eco‑friendly processing, waste upcycling, and industrial biocatalysis. Open article.
259.
Ganoderma lucidum beta 1,3/1,6 glucan as an immunomodulator in inflammation induced by a high-cholesterol diet.
- Wu YS, Ho SY, Nan FH, Chen SN.
- BMC Complement Altern Med. 2016 Dec 3;16(1):500. doi: 10.1186/s12906-016-1476-3.
- PMCID: PMC5135828
Wu YS, et al.

BMC Complement Altern Med. 2016.

PMCID: PMC5135828

BACKGROUND: Binding of beta 1,3/1,6 glucan of Ganoderma lucidum (G. lucidum) with the receptor results in a series of signal transfers (signalling cascades), which activates the transcription factors for regulating inflammation. ...METHODS: The current study …

BACKGROUND: Binding of beta 1,3/1,6 glucan of Ganoderma lucidum (G. lucidum) with the receptor results in a series of s …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum beta 1,3/1,6 glucan as an immunomodulator in inflammation induced by a high-cholesterol diet.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
260.
Spermidine Regulates Mitochondrial Function by Enhancing eIF5A Hypusination and Contributes to Reactive Oxygen Species Production and Ganoderic Acid Biosynthesis in Ganoderma lucidum.
- Han X, Shangguan J, Wang Z, Li Y, Fan J, Ren A, Zhao M.
- Appl Environ Microbiol. 2022 Feb 2;88(6):e0203721. doi: 10.1128/AEM.02037-21.
- PMCID: PMC8939328
Han X, et al.

Appl Environ Microbiol. 2022.

PMCID: PMC8939328

To explore the mechanism by which spermidine regulates ganoderic acid (GA) biosynthesis in Ganoderma lucidum, the effects of spermidine on GA and reactive oxygen species (ROS) contents were examined. ...

To explore the mechanism by which spermidine regulates ganoderic acid (GA) biosynthesis in Ganoderma lucidum, the effects of s …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Spermidine Regulates Mitochondrial Function by Enhancing eIF5A Hypusination and Contributes to Reactive Oxygen Species Production and Ganoderic Acid Biosynthesis in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 27

261.
Improved 1-Deoxynojirimycin (DNJ) production in mulberry leaves fermented by microorganism.
- Jiang YG, Wang CY, Jin C, Jia JQ, Guo X, Zhang GZ, Gui ZZ.
- Braz J Microbiol. 2014 Aug 29;45(2):721-9. doi: 10.1590/s1517-83822014000200048.
- PMCID: PMC4166305
Jiang YG, et al.

Braz J Microbiol. 2014.

PMCID: PMC4166305

In this study, we focus on screening an appropriate microorganism for performing fermentation to improve DNJ content in mulberry leaf. Results showed that Ganoderma lucidum was selected from 8 species and shown to be the most effective in improvement of DNJ producti …

In this study, we focus on screening an appropriate microorganism for performing fermentation to improve DNJ content in mulberry leaf. Resul …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Improved 1-Deoxynojirimycin (DNJ) production in mulberry leaves fermented by microorganism.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
262.
Heat Treatment of Reishi Medicinal Mushroom (Ganoderma lingzhi) Basidiocarp Enhanced Its beta-glucan Solubility, Antioxidant Capacity and Lactogenic Properties.
- Kiss A, Grünvald P, Ladányi M, Papp V, Papp I, Némedi E, Mirmazloum I.
- Foods. 2021 Aug 27;10(9):2015. doi: 10.3390/foods10092015.
- PMCID: PMC8466132
Kiss A, et al.

Foods. 2021.

PMCID: PMC8466132

The effect of heat treatment on dried fruiting bodies of Reishi medicinal mushroom (Ganoderma lingzhi) is investigated. Control and samples treated for 20 min at temperatures of 70, 120, 150 and 180 C were subjected for their free radical scavenging capacity, differ …

The effect of heat treatment on dried fruiting bodies of Reishi medicinal mushroom (Ganoderma lingzhi) is investigated. Contro …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Heat Treatment of Reishi Medicinal Mushroom ( Ganoderma lingzhi) Basidiocarp Enhanced Its beta-glucan Solubility, Antioxidant Capacity and Lactogenic Properties.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
263.
Polysaccharide of Ganoderma lucidum Ameliorates Cachectic Myopathy Induced by the Combination Cisplatin plus Docetaxel in Mice.
- Wu SY, Ou CC, Lee ML, Hsin IL, Kang YT, Jan MS, Ko JL.
- Microbiol Spectr. 2023 May 22;11(3):e0313022. doi: 10.1128/spectrum.03130-22.
- PMCID: PMC10269453
Wu SY, et al.

Microbiol Spectr. 2023.

PMCID: PMC10269453

Mounting evidence suggests a correlation between cachexia and intestinal microbiota, but there is presently no effective treatment for cachexia. Whether the Ganoderma lucidum polysaccharide Liz-H exerts protective effects on cachexia and gut microbiota dysbiosis ind …

Mounting evidence suggests a correlation between cachexia and intestinal microbiota, but there is presently no effective treatment for cache …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Polysaccharide of Ganoderma lucidum Ameliorates Cachectic Myopathy Induced by the Combination Cisplatin plus Docetaxel in Mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
264.
Suppression of Cisplatin-Induced Hepatic Injury in Rats Through Alarmin High-Mobility Group Box-1 Pathway by Ganoderma lucidum: Theoretical and Experimental Study.
- Hassan HM, Al-Wahaibi LH, Elmorsy MA, Mahran YF.
- Drug Des Devel Ther. 2020 Jun 11;14:2335-2353. doi: 10.2147/DDDT.S249093.
- PMCID: PMC7296982
Hassan HM, et al.

Drug Des Devel Ther. 2020.

PMCID: PMC7296982

The aim of this study was to investigate the molecular mechanisms by which Ganoderma lucidum mushroom (GLM) may ameliorate cisplatin (CP)-induced hepatotoxicity theoretically and experimentally. MATERIALS AND METHODS: Thirty-six male Sprague-Dawley (SD) rats were di …

The aim of this study was to investigate the molecular mechanisms by which Ganoderma lucidum mushroom (GLM) may ameliorate cis …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Suppression of Cisplatin-Induced Hepatic Injury in Rats Through Alarmin High-Mobility Group Box-1 Pathway by Ganoderma lucidum : Theoretical and Experimental Study.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
265.
Balancing adipocyte production and lipid metabolism to treat obesity-induced diabetes with a novel proteoglycan from Ganoderma lucidum.
- Wang Y, Yu F, Zheng X, Li J, Zhang Z, Zhang Q, Chen J, He Y, Yang H, Zhou P.
- Lipids Health Dis. 2023 Aug 8;22(1):120. doi: 10.1186/s12944-023-01880-6.
- PMCID: PMC10408226
Wang Y, et al.

Lipids Health Dis. 2023.

PMCID: PMC10408226

Based on previous findings, FYGL, a natural hyperbranched proteoglycan extracted from the G. lucidum fruiting body, can decrease blood glucose and reduce body weight in diabetic mice. ...

Based on previous findings, FYGL, a natural hyperbranched proteoglycan extracted from the G. lucidum fruiting body, can decrease bloo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Balancing adipocyte production and lipid metabolism to treat obesity-induced diabetes with a novel proteoglycan from Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
266.
Benzothiazole-An Antifungal Compound Derived from Medicinal Mushroom Ganoderma lucidum against Mango Anthracnose Pathogen Colletotrichum gloeosporioides (Penz and (Sacc.)).
- Muniyappan G, Gurudevan T, Thangaraj P, Balamurali AS, Iyadurai AP, Suppaiah R, Subbiah KA, Shanmugam H.
- Molecules. 2023 Mar 8;28(6):2476. doi: 10.3390/molecules28062476.
- PMCID: PMC10053814
Muniyappan G, et al.

Molecules. 2023.

PMCID: PMC10053814

The present investigation is focused on exploring the possibilities of identifying biomolecules from the fruiting body of the medicinal mushroom Ganoderma lucidum against the mango anthracnose pathogen Colletotrichum gloeosporioides. ...The research on biomolecular …

The present investigation is focused on exploring the possibilities of identifying biomolecules from the fruiting body of the medicinal mush …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Benzothiazole-An Antifungal Compound Derived from Medicinal Mushroom Ganoderma lucidum against Mango Anthracnose Pathogen Colletotrichum gloeosporioides (Penz and (Sacc.)).. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
267.
Ginseng and Ganoderma lucidum use after breast cancer diagnosis and quality of life: a report from the Shanghai Breast Cancer Survival Study.
- Bao PP, Lu W, Cui Y, Zheng Y, Gu K, Chen Z, Zheng W, Shu XO.
- PLoS One. 2012 Jun 20;7(6):e39343. doi: 10.1371/journal.pone.0039343.
- PMCID: PMC3379976
Bao PP, et al.

PLoS One. 2012.

PMCID: PMC3379976

OBJECTIVE: To evaluate associations between quality of life (QOL) and use of ginseng and Ganoderma lucidum (G. lucidum) among breast cancer survivors. METHODS: Included in this study were 4,149 women with breast cancer who participated in the Shanghai Breast …

OBJECTIVE: To evaluate associations between quality of life (QOL) and use of ginseng and Ganoderma lucidum (G. lucidum) …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ginseng and Ganoderma lucidum use after breast cancer diagnosis and quality of life: a report from the Shanghai Breast Cancer Survival Study.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Quality/authentication methods study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Analytical validation (specificity/sensitivity), reference standards, and mislabeling rates. Open article.
- Why might this paper be useful to readers? Useful for quality control, sourcing, and preventing adulteration. Open article.
268.
Protective effect of Ganoderma lucidum-fermented crop extracts against hydrogen peroxide- or beta-amyloid-induced damage in human neuronal SH-SY5Y cells.
- Huang CH, Liao YT, Chen CL, Tsai GJ.
- BMC Complement Med Ther. 2024 Apr 5;24(1):148. doi: 10.1186/s12906-024-04409-1.
- PMCID: PMC10996153
Huang CH, et al.

BMC Complement Med Ther. 2024.

PMCID: PMC10996153

Although the neuroprotective effects of Ganoderma lucidum aqueous extract and G. lucidum-derived triterpenoids and polysaccharides have been reported, the influence of G. lucidum-fermented crops on AD still lacks clarity. METHODS: This study aimed to i …

Although the neuroprotective effects of Ganoderma lucidum aqueous extract and G. lucidum-derived triterpenoids and poly …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Protective effect of Ganoderma lucidum -fermented crop extracts against hydrogen peroxide- or beta-amyloid-induced damage in human neuronal SH-SY5Y cells.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
269.
Reishi Protein LZ-8 Induces FOXP3(+) Treg Expansion via a CD45-Dependent Signaling Pathway and Alleviates Acute Intestinal Inflammation in Mice.
- Hsu HY, Kuan YC, Lin TY, Tsao SM, Hsu J, Ma LJ, Sheu F.
- Evid Based Complement Alternat Med. 2013 Jun 24;2013:513542. doi: 10.1155/2013/513542.
- PMCID: PMC3707273
Hsu HY, et al.

Evid Based Complement Alternat Med. 2013.

PMCID: PMC3707273

LZ-8, an immunomodulatory protein isolated from Ganoderma lucidum (also known as Ling-Zhi or Reishi), has been shown to promote cell proliferation and IL-2 production in T cells. ...

LZ-8, an immunomodulatory protein isolated from Ganoderma lucidum (also known as Ling-Zhi or Reishi), has been shown to …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Reishi Protein LZ-8 Induces FOXP3(+) Treg Expansion via a CD45-Dependent Signaling Pathway and Alleviates Acute Intestinal Inflammation in Mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
270.
A Novel Strain Breeding of Ganoderma lucidum UV119 (Agaricomycetes) with High Spores Yield and Strong Resistant Ability to Other Microbes' Invasions.
- Tang C, Tan Y, Zhang J, Zhou S, Honda Y, Zhang H.
- Foods. 2023 Jan 19;12(3):465. doi: 10.3390/foods12030465.
- PMCID: PMC9914782
Tang C, et al.

Foods. 2023.

PMCID: PMC9914782

The spore powder of Ganoderma lucidum (G. lucidum) has been proven to have a variety of pharmacological activities, and it has become a new resource for the development of health products and pharmaceuticals. ...In conclusion, this study suggested that ultrav …

The spore powder of Ganoderma lucidum (G. lucidum) has been proven to have a variety of pharmacological activities, and …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A Novel Strain Breeding of Ganoderma lucidum UV119 (Agaricomycetes) with High Spores Yield and Strong Resistant Ability to Other Microbes' Invasions.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 28

271.
Effects of non-steroidal anti-inflammatory drug-activated gene-1 on Ganoderma lucidum polysaccharides-induced apoptosis of human prostate cancer PC-3 cells.
- Wu K, Na K, Chen D, Wang Y, Pan H, Wang X.
- Int J Oncol. 2018 Sep 28;53(6):2356-2368. doi: 10.3892/ijo.2018.4578.
- PMCID: PMC6203158
Wu K, et al.

Int J Oncol. 2018.

PMCID: PMC6203158

Ganoderma lucidum polysaccharides (GLP) has been demonstrated to elicit antitumorigenic and proapoptotic activities in cancer; however, the molecular mechanisms underlying the anticancer effects of GLP have yet to be elucidated. ...

Ganoderma lucidum polysaccharides (GLP) has been demonstrated to elicit antitumorigenic and proapoptotic activities in cancer; …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effects of non-steroidal anti-inflammatory drug-activated gene-1 on Ganoderma lucidum polysaccharides-induced apoptosis of human prostate cancer PC-3 cells.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
272.
Interaction of ganoderic acid on HIV related target: molecular docking studies.
- Akbar R, Yam WK.
- Bioinformation. 2011 Dec 21;7(8):413-7. doi: 10.6026/97320630007413.
- PMCID: PMC3280442
Akbar R, et al.

Bioinformation. 2011.

PMCID: PMC3280442

The idea of finding cure from known pharmacologically active natural occurring compounds is intriguing and practical. Ganoderma lucidum (Ling-Zhi or Reishi) is one of the most productive and pharmacologically active compounds found in Asian countries. ...This …

The idea of finding cure from known pharmacologically active natural occurring compounds is intriguing and practical. Ganoderma lu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Interaction of ganoderic acid on HIV related target: molecular docking studies.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
273.
Synergy of de-walled Ganoderma Lucidum spore powder (GLSP) on targeted therapy in advanced non-squamous non-small cell lung cancer with epidermal growth factor receptor (EGFR) mutant: protocol for a randomized, double-blind, placebo-controlled study.
- Wu TT, Chen YY, Yuan ZC, Yang GW, Zhang GL.
- BMC Complement Med Ther. 2024 Mar 18;24(1):125. doi: 10.1186/s12906-024-04416-2.
- PMCID: PMC10949790
Wu TT, et al.

BMC Complement Med Ther. 2024.

PMCID: PMC10949790

However the adverse effects, primarily fatigue, remain an overwhelming deficiency of Osimertinib, hindering it from achieving adequate clinical efficacy for such NSCLC. Ganoderma lucidum has been used for thousands of years in China to combat fatigue, while Ganod …

However the adverse effects, primarily fatigue, remain an overwhelming deficiency of Osimertinib, hindering it from achieving adequate clini …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Synergy of de-walled Ganoderma Lucidum spore powder (GLSP) on targeted therapy in advanced non-squamous non-small cell lung cancer with epidermal growth factor receptor (EGFR) mutant: protocol for a randomized, double-blind, placebo-controlled study.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Provides early human data; interpret with caution and check study size and endpoints. Open article.
274.
Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota.
- Chang CJ, Lin CS, Lu CC, Martel J, Ko YF, Ojcius DM, Tseng SF, Wu TR, Chen YY, Young JD, Lai HC.
- Nat Commun. 2015 Jun 23;6:7489. doi: 10.1038/ncomms8489.
- PMCID: PMC4557287
Chang CJ, et al.

Nat Commun. 2015.

PMCID: PMC4557287

Obesity is associated with low-grade chronic inflammation and intestinal dysbiosis. Ganoderma lucidum is a medicinal mushroom used in traditional Chinese medicine with putative anti-diabetic effects. Here, we show that a water extract of Ganoderma lucidum< …

Obesity is associated with low-grade chronic inflammation and intestinal dysbiosis. Ganoderma lucidum is a medicinal mushroom …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
275.
GSNOR regulates ganoderic acid content in Ganoderma lucidum under heat stress through S-nitrosylation of catalase.
- Liu R, Zhu T, Chen X, Wang Z, Yang Z, Ren A, Shi L, Yu H, Zhao M.
- Commun Biol. 2022 Jan 11;5(1):32. doi: 10.1038/s42003-021-02988-0.
- PMCID: PMC8752759
Liu R, et al.

Commun Biol. 2022.

PMCID: PMC8752759
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: GSNOR regulates ganoderic acid content in Ganoderma lucidum under heat stress through S-nitrosylation of catalase.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
276.
Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice.
- Sliva D, Loganathan J, Jiang J, Jedinak A, Lamb JG, Terry C, Baldridge LA, Adamec J, Sandusky GE, Dudhgaonkar S.
- PLoS One. 2012 Oct 30;7(10):e47873. doi: 10.1371/journal.pone.0047873.
- PMCID: PMC3484149
Sliva D, et al.

PLoS One. 2012.

PMCID: PMC3484149

We have recently demonstrated anticancer and anti-inflammatory activity of triterpene extract isolated from mushroom Ganoderma lucidum (GLT). The aim of the present study was to evaluate whether GLT prevents colitis-associated carcinogenesis in mice. ...

We have recently demonstrated anticancer and anti-inflammatory activity of triterpene extract isolated from mushroom Ganoderma luc …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
277.
Intervention effects of ganoderma lucidum spores on epileptiform discharge hippocampal neurons and expression of neurotrophin-4 and N-cadherin.
- Wang SQ, Li XJ, Zhou S, Sun DX, Wang H, Cheng PF, Ma XR, Liu L, Liu JX, Wang FF, Liang YF, Wu JM.
- PLoS One. 2013 Apr 24;8(4):e61687. doi: 10.1371/journal.pone.0061687.
- PMCID: PMC3634853
Wang SQ, et al.

PLoS One. 2013.

PMCID: PMC3634853

Epilepsy can cause cerebral transient dysfunctions. Ganoderma lucidum spores (GLS), a traditional Chinese medicinal herb, has shown some antiepileptic effects in our previous studies. ...

Epilepsy can cause cerebral transient dysfunctions. Ganoderma lucidum spores (GLS), a traditional Chinese medicinal herb, has …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Intervention effects of ganoderma lucidum spores on epileptiform discharge hippocampal neurons and expression of neurotrophin-4 and N-cadherin.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
278.
Anti-epileptic effect of Ganoderma lucidum polysaccharides by inhibition of intracellular calcium accumulation and stimulation of expression of CaMKII alpha in epileptic hippocampal neurons.
- Wang SQ, Li XJ, Qiu HB, Jiang ZM, Simon M, Ma XR, Liu L, Liu JX, Wang FF, Liang YF, Wu JM, Di WH, Zhou S.
- PLoS One. 2014 Jul 10;9(7):e102161. doi: 10.1371/journal.pone.0102161.
- PMCID: PMC4092074
Wang SQ, et al.

PLoS One. 2014.

PMCID: PMC4092074

PURPOSE: To investigate the mechanism of the anti-epileptic effect of Ganoderma lucidum polysaccharides (GLP), the changes of intracellular calcium and CaMK II alpha expression in a model of epileptic neurons were investigated. ...

PURPOSE: To investigate the mechanism of the anti-epileptic effect of Ganoderma lucidum polysaccharides (GLP), the changes of …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Anti-epileptic effect of Ganoderma lucidum polysaccharides by inhibition of intracellular calcium accumulation and stimulation of expression of CaMKII alpha in epileptic hippocampal neurons.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
279.
Effects of spore powder of ganoderma lucidum on CaSR and apoptosis-related proteins in hippocampus tissue of epilepsy following dementia: A protocol of systematic review.
- Qin LH, Wang C, Jiang XX, Song Y, Feng Y, Qin LW, Zhang SP.
- Medicine (Baltimore). 2020 Aug 14;99(33):e21711. doi: 10.1097/MD.0000000000021711.
- PMCID: PMC7437730
Qin LH, et al.

Medicine (Baltimore). 2020.

PMCID: PMC7437730

BACKGROUND: This study will investigate the effects of Spore Powder of Ganoderma Lucidum (SPGL) on CaSR and apoptosis-related proteins (ARP) in hippocampus tissue of epilepsy following dementia. ...

BACKGROUND: This study will investigate the effects of Spore Powder of Ganoderma Lucidum (SPGL) on CaSR and apoptosis-related …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effects of spore powder of ganoderma lucidum on CaSR and apoptosis-related proteins in hippocampus tissue of epilepsy following dementia: A protocol of systematic review.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
280.
Ganoderma lingzhi (Reishi Mushroom)-Induced Acute Liver Injury in the Setting of Alcohol Use: A Case Report and Review of the Literature.
- Guedikian R, Kim B, Singh G, Alexander R.
- Cureus. 2023 Sep 25;15(9):e45953. doi: 10.7759/cureus.45953.
- PMCID: PMC10599861
Guedikian R, et al.

Cureus. 2023.

PMCID: PMC10599861

We present a case of a 47-year-old male who presented to the hospital with headache and abdominal pain after consuming Reishi Mushroom (Ganoderma lingzhi) powder and alcohol. The patient was found to have acute hepatitis with significant transaminitis, which was man …

We present a case of a 47-year-old male who presented to the hospital with headache and abdominal pain after consuming Reishi Mushroo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lingzhi ( Reishi Mushroom)-Induced Acute Liver Injury in the Setting of Alcohol Use: A Case Report and Review of the Literature.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 29

281.
Ganoderma lucidum: Unutilized natural medicine and promising future solution to emerging diseases in Africa.
- Oke MA, Afolabi FJ, Oyeleke OO, Kilani TA, Adeosun AR, Olanbiwoninu AA, Adebayo EA.
- Front Pharmacol. 2022 Aug 22;13:952027. doi: 10.3389/fphar.2022.952027.
- PMCID: PMC9441938
Oke MA, et al.

Front Pharmacol. 2022.

PMCID: PMC9441938

Ganoderma lucidum is a well-known medicinal mushroom that has been used for the prevention and treatment of different ailments to enhance longevity and health specifically in China, Japan, and Korea. ...Various formulations have been developed, patented, and utilize …

Ganoderma lucidum is a well-known medicinal mushroom that has been used for the prevention and treatment of different ailments …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum : Unutilized natural medicine and promising future solution to emerging diseases in Africa.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
282.
Advanced mycelium materials as potential self-growing biomedical scaffolds.
- Antinori ME, Contardi M, Suarato G, Armirotti A, Bertorelli R, Mancini G, Debellis D, Athanassiou A.
- Sci Rep. 2021 Jun 16;11(1):12630. doi: 10.1038/s41598-021-91572-x.
- PMCID: PMC8209158
Antinori ME, et al.

Sci Rep. 2021.

PMCID: PMC8209158

In this study, the entire fibrous structures of mycelia of the edible fungi Pleurotus ostreatus and Ganoderma lucidum are presented as self-growing bio-composites that mimic the extracellular matrix of human body tissues, ideal as tissue engineering bio-scaffolds. . …

In this study, the entire fibrous structures of mycelia of the edible fungi Pleurotus ostreatus and Ganoderma lucidum are pres …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Advanced mycelium materials as potential self-growing biomedical scaffolds.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
283.
Medicinal Fungi with Antiviral Effect.
- Zhang Y, Zhang G, Ling J.
- Molecules. 2022 Jul 12;27(14):4457. doi: 10.3390/molecules27144457.
- PMCID: PMC9322162
Zhang Y, et al.

Molecules. 2022.

PMCID: PMC9322162

However, drug research and development is a very difficult task, and finding new antiviral compounds is desirable. A range of medicinal fungi such as Ganoderma lucidum and Cordyceps sinensis are widely used all over the world, and they can enhance human immunity and …

However, drug research and development is a very difficult task, and finding new antiviral compounds is desirable. A range of medicinal fung …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Medicinal Fungi with Antiviral Effect.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
284.
Application of 2,3-naphthalenediamine in labeling natural carbohydrates for capillary electrophoresis.
- Kuo CY, Wang SH, Lin C, Liao SK, Hung WT, Fang JM, Yang WB.
- Molecules. 2012 Jun 15;17(6):7387-400. doi: 10.3390/molecules17067387.
- PMCID: PMC6269047
Kuo CY, et al.

Molecules. 2012.

PMCID: PMC6269047

Neutral and acidic monosaccharide components in Ganoderma lucidum polysaccharide are readily labeled with 2,3-naphthalenediamine, and the resulting saccharide-naphthimidazole (NAIM) derivatives are quantified by capillary electrophoresis (CE) in borate buffer. ...

Neutral and acidic monosaccharide components in Ganoderma lucidum polysaccharide are readily labeled with 2,3-naphthalenediami …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Application of 2,3-naphthalenediamine in labeling natural carbohydrates for capillary electrophoresis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
285.
Antioxidant, antibacterial, antitumor, antifungal, antiviral, anti-inflammatory, and nevro-protective activity of Ganoderma lucidum: An overview.
- Cör Andrejč D, Knez Ž, Knez Marevci M.
- Front Pharmacol. 2022 Jul 22;13:934982. doi: 10.3389/fphar.2022.934982.
- PMCID: PMC9353308
Cör Andrejč D, et al.

Front Pharmacol. 2022.

PMCID: PMC9353308

Ganoderma lucidum is a very medicinal mushroom that has been utilized in Oriental medicine for many years. ...In addition, most of the included studies were small, and there were concerns about the methodological quality of each study. Studies have shown that Gan …

Ganoderma lucidum is a very medicinal mushroom that has been utilized in Oriental medicine for many years. ...In addition, mos …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antioxidant, antibacterial, antitumor, antifungal, antiviral, anti-inflammatory, and nevro-protective activity of Ganoderma lucidum : An overview.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
286.
GLSP and GLSP-derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis.
- Zheng G, Zhao Y, Li Z, Hua Y, Zhang J, Miao Y, Guo Y, Li L, Shi J, Dong Z, Yang S, Fan G, Ma C.
- Theranostics. 2023 Feb 21;13(4):1325-1341. doi: 10.7150/thno.80250.
- PMCID: PMC10008734
Zheng G, et al.

Theranostics. 2023.

PMCID: PMC10008734

Presently, the drug to treat aortic calcification remains not to be available. Ganoderma lucidum spore powder (GLSP) is from Ganoderma lucidum which is a Traditional Chinese Medicine with the homology of medicine and food. ...

Presently, the drug to treat aortic calcification remains not to be available. Ganoderma lucidum spore powder (GLSP) is from < …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: GLSP and GLSP-derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
287.
A Polysaccharide Purified From Ganoderma lucidum Acts as a Potent Mucosal Adjuvant That Promotes Protective Immunity Against the Lethal Challenge With Enterovirus A71.
- Lin YL, Shih C, Cheng PY, Chin CL, Liou AT, Lee PY, Chiang BL.
- Front Immunol. 2020 Sep 29;11:561758. doi: 10.3389/fimmu.2020.561758.
- PMCID: PMC7550786
Lin YL, et al.

Front Immunol. 2020.

PMCID: PMC7550786

It is known that polysaccharide purified from Ganoderma lucidum (PS-G) can effectively modulate immune function. Here, we used PS-G as an adjuvant with the EV-A71 mucosal vaccine and studied its effects. ...

It is known that polysaccharide purified from Ganoderma lucidum (PS-G) can effectively modulate immune function. Here, we used …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A Polysaccharide Purified From Ganoderma lucidum Acts as a Potent Mucosal Adjuvant That Promotes Protective Immunity Against the Lethal Challenge With Enterovirus A71.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
288.
Advanced Materials From Fungal Mycelium: Fabrication and Tuning of Physical Properties.
- Haneef M, Ceseracciu L, Canale C, Bayer IS, Heredia-Guerrero JA, Athanassiou A.
- Sci Rep. 2017 Jan 24;7:41292. doi: 10.1038/srep41292.
- PMCID: PMC5259796
Haneef M, et al.

Sci Rep. 2017.

PMCID: PMC5259796

Mycelia from two types of edible, medicinal fungi, Ganoderma lucidum and Pleurotus ostreatus, have been carefully cultivated, being fed by two bio-substrates: cellulose and cellulose/potato-dextrose, the second being easier to digest by mycelium due to presence of s …

Mycelia from two types of edible, medicinal fungi, Ganoderma lucidum and Pleurotus ostreatus, have been carefully cultivated, …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Advanced Materials From Fungal Mycelium: Fabrication and Tuning of Physical Properties.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
289.
Ganoderma Lucidum from Red Mushroom Attenuates Formaldehyde-Induced Liver Damage in Experimental Male Rat Model.
- Oluwafemi Adetuyi B, Olamide Okeowo T, Adefunke Adetuyi O, Abraham Adebisi O, Ogunlana OO, Janet Oretade O, Marraiki N, Beshbishy AM, N Welson N, Batiha GE.
- Biology (Basel). 2020 Sep 27;9(10):313. doi: 10.3390/biology9100313.
- PMCID: PMC7601706
Oluwafemi Adetuyi B, et al.

Biology (Basel). 2020.

PMCID: PMC7601706

This study, therefore, examines the protective potential of Ganoderma lucidum (100 mg/kg body weight) on formaldehyde-induced (40%) liver oxido-inflammation in male rats. ...Additionally, Ganoderma lucidum reversed a large decline in proinflammatory ma …

This study, therefore, examines the protective potential of Ganoderma lucidum (100 mg/kg body weight) on formaldehyde-induced …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma Lucidum from Red Mushroom Attenuates Formaldehyde-Induced Liver Damage in Experimental Male Rat Model.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
290.
Ganoderma Lucidum Triterpenoids Improve Maternal Separation-Induced Anxiety- and Depression-like Behaviors in Mice by Mitigating Inflammation in the Periphery and Brain.
- Mi X, Zeng GR, Liu JQ, Luo ZS, Zhang L, Dai XM, Fang WT, Zhang J, Chen XC.
- Nutrients. 2022 May 28;14(11):2268. doi: 10.3390/nu14112268.
- PMCID: PMC9182879
Mi X, et al.

Nutrients. 2022.

PMCID: PMC9182879

Although early life stress (ELS) can increase susceptibility to adulthood psychiatric disorders and produce a greater inflammatory response in a stressful event, targeted preventive and therapeutic drugs still remain scarce. Ganoderma lucidum triterpenoids (GLTs) ca …

Although early life stress (ELS) can increase susceptibility to adulthood psychiatric disorders and produce a greater inflammatory response …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma Lucidum Triterpenoids Improve Maternal Separation-Induced Anxiety- and Depression-like Behaviors in Mice by Mitigating Inflammation in the Periphery and Brain.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.

Page 30

291.
Influence of Humidity on the Acoustic Properties of Mushroom Mycelium Films Used as Sensitive Layers for Acoustic Humidity Sensors.
- Kuznetsova I, Zaitsev B, Krasnopolskaya L, Teplykh A, Semyonov A, Avtonomova A, Ziangirova M, Smirnov A, Kolesov V.
- Sensors (Basel). 2020 May 9;20(9):2711. doi: 10.3390/s20092711.
- PMCID: PMC7248784
Kuznetsova I, et al.

Sensors (Basel). 2020.

PMCID: PMC7248784

The influence of humidity on the density, shear elastic module, viscosity, and thickness of the mushroom Pleurotus eryngii and Ganoderma lucidum mycelium films was studied. These data were obtained by comparing the theoretical and experimental frequency dependencies …

The influence of humidity on the density, shear elastic module, viscosity, and thickness of the mushroom Pleurotus eryngii and Ganoderma< …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Influence of Humidity on the Acoustic Properties of Mushroom Mycelium Films Used as Sensitive Layers for Acoustic Humidity Sensors.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
292.
Ganoderma lucidum spore powder alleviates rheumatoid arthritis-associated pain hypersensitivity through inhibiting accumulation, N1 polarization, and ROS production of neutrophils in mice.
- Huang S, Zhan Z, Xu F, Liu X, Fang Z, Wu W, Liang Z, Liu G, Wang M, da Silva HS, Luo X, Mo K.
- Front Immunol. 2025 Apr 30;16:1569295. doi: 10.3389/fimmu.2025.1569295.
- PMCID: PMC12075414
Huang S, et al.

Front Immunol. 2025.

PMCID: PMC12075414

The limited understanding of the pathological mechanisms underlying RA-related pain poses challenges for effective clinical pain management. Ganoderma lucidum spore powder (GLSP) has demonstrated therapeutic benefits in various diseases, with no reported toxicity or …

The limited understanding of the pathological mechanisms underlying RA-related pain poses challenges for effective clinical pain management. …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum spore powder alleviates rheumatoid arthritis-associated pain hypersensitivity through inhibiting accumulation, N1 polarization, and ROS production of neutrophils in mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
293.
Spore powder of Ganoderma lucidum for Alzheimer's disease: A protocol for systematic review.
- Qin LH, Wang C, Qin LW, Liang YF, Wang GH.
- Medicine (Baltimore). 2019 Feb;98(5):e14382. doi: 10.1097/MD.0000000000014382.
- PMCID: PMC6380698
Qin LH, et al.

Medicine (Baltimore). 2019.

PMCID: PMC6380698

BACKGROUND: Previous studies have reported that spore powder of Ganoderma lucidum (SPGL) may be effective for the treatment of Alzheimer's disease (AD). ...

BACKGROUND: Previous studies have reported that spore powder of Ganoderma lucidum (SPGL) may be effective for the treatment of …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Spore powder of Ganoderma lucidum for Alzheimer's disease: A protocol for systematic review.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
294.
Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients.
- Liu C, Yang N, Song Y, Wang L, Zi J, Zhang S, Dunkin D, Busse P, Weir D, Tversky J, Miller RL, Goldfarb J, Zhan J, Li XM.
- Int Immunopharmacol. Author manuscript. 2015 May 21;27(2):224-31. doi: 10.1016/j.intimp.2015.05.018.
- PMCID: PMC4635663
Liu C, et al.

Int Immunopharmacol. Author manuscript. 2015.

PMCID: PMC4635663

ASHMITM, aqueous extract of three medicinal herbs-Ganoderma lucidum (G. lucidum), Sophora flavescens Ait (S. flavescens) and Glycyrrhiza uralensis Fischer (G. uralensis), showed a high safety profile and was clinically beneficial in asthma patients. ...The ob …

ASHMITM, aqueous extract of three medicinal herbs-Ganoderma lucidum (G. lucidum), Sophora flavescens Ait (S. flavescens …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
295.
Exploring the Potential Medicinal Benefits of Ganoderma lucidum: From Metabolic Disorders to Coronavirus Infections.
- Ekiz E, Oz E, Abd El-Aty AM, Proestos C, Brennan C, Zeng M, Tomasevic I, Elobeid T, Çadırcı K, Bayrak M, Oz F.
- Foods. 2023 Apr 3;12(7):1512. doi: 10.3390/foods12071512.
- PMCID: PMC10094145
Ekiz E, et al.

Foods. 2023.

PMCID: PMC10094145

Ganoderma lucidum is a medicinal mushroom that has been traditionally used in Chinese medicine for centuries. ...Therefore, it would be premature to draw any definitive conclusions about the effectiveness of G. lucidum in preventing or treating coronavirus in …

Ganoderma lucidum is a medicinal mushroom that has been traditionally used in Chinese medicine for centuries. ...Therefore, it …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Exploring the Potential Medicinal Benefits of Ganoderma lucidum : From Metabolic Disorders to Coronavirus Infections.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
296.
SNP and SCAR Markers for Specific Discrimination of Antler-Shaped Ganoderma lucidum.
- Kwon OC, Lee CS, Park YJ.
- Microorganisms. 2019 Jan 9;7(1):12. doi: 10.3390/microorganisms7010012.
- PMCID: PMC6352128
Kwon OC, et al.

Microorganisms. 2019.

PMCID: PMC6352128

In this study we identified single nucleotide polymorphism (SNP) and sequence characteristic amplification region (SCAR) markers for specific identification of antler-shaped Ganoderma lucidum strains. When the partial mitochondrial SSU rDNA gene sequence of various …

In this study we identified single nucleotide polymorphism (SNP) and sequence characteristic amplification region (SCAR) markers for specifi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: SNP and SCAR Markers for Specific Discrimination of Antler-Shaped Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
297.
Khz-cp (crude polysaccharide extract obtained from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating P38 and NADPH oxidase-dependent generation of reactive oxygen species in SNU-1 cells.
- Kim TH, Kim JS, Kim ZH, Huang RB, Chae YL, Wang RS.
- BMC Complement Altern Med. 2014 Jul 10;14:236. doi: 10.1186/1472-6882-14-236.
- PMCID: PMC4227278
Kim TH, et al.

BMC Complement Altern Med. 2014.

PMCID: PMC4227278

BACKGROUND: Khz-cp is a crude polysaccharide extract that is obtained after nuclear fusion in Ganoderma lucidum and Polyporus umbellatus mycelia (Khz). It inhibits the growth of cancer cells. ...

BACKGROUND: Khz-cp is a crude polysaccharide extract that is obtained after nuclear fusion in Ganoderma lucidum and Polyporus …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Khz-cp (crude polysaccharide extract obtained from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating P38 and NADPH oxidase-dependent generation of reactive oxygen species in SNU-1 cells.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
298.
Dye decolorization and detoxification potential of Ca-alginate beads immobilized manganese peroxidase.
- Bilal M, Asgher M.
- BMC Biotechnol. 2015 Dec 10;15:111. doi: 10.1186/s12896-015-0227-8.
- PMCID: PMC4676175
Bilal M, et al.

BMC Biotechnol. 2015.

PMCID: PMC4676175

In present study, a promising and eco-friendly entrapment approach was adopted to immobilize purified manganese peroxidase (MnP) produced from an indigenous strain of Ganoderma lucidum IBL-05 on Ca-alginate beads. The immobilized MnP was subsequently used for enhanc …

In present study, a promising and eco-friendly entrapment approach was adopted to immobilize purified manganese peroxidase (MnP) produced fr …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Dye decolorization and detoxification potential of Ca-alginate beads immobilized manganese peroxidase.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Relevant for eco‑friendly processing, waste upcycling, and industrial biocatalysis. Open article.
299.
Preliminary Efficacy and Safety of Reishi & Privet Formula on Quality of Life Among Non-Small Cell Lung Cancer Patients Undergoing Chemotherapy: A Randomized Placebo-Controlled Trial.
- Liu J, Mao JJ, Li SQ, Lin H.
- Integr Cancer Ther. 2020 Jan-Dec;19:1534735420944491. doi: 10.1177/1534735420944491.
- PMCID: PMC7450289
Liu J, et al.

Integr Cancer Ther. 2020.

PMCID: PMC7450289

This study aimed to determine the preliminary efficacy and safety of Reishi & Privet Formula (RPF) for maintaining quality of life among patients with non-small cell lung cancer (NSCLC) undergoing chemotherapy. ...

This study aimed to determine the preliminary efficacy and safety of Reishi & Privet Formula (RPF) for maintaining quality of lif …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Preliminary Efficacy and Safety of Reishi & Privet Formula on Quality of Life Among Non-Small Cell Lung Cancer Patients Undergoing Chemotherapy: A Randomized Placebo-Controlled Trial.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Useful for quality control, sourcing, and preventing adulteration. Open article.
300.
Effects of Mexican Ganoderma lucidum extracts on liver, kidney, and the gut microbiota of Wistar rats: A repeated dose oral toxicity study.
- Meneses ME, Martínez-Carrera D, González-Ibáñez L, Torres N, Sánchez-Tapia M, Márquez-Mota CC, Rendón G, Mitzi V, Morales A, Tello-Salgado I, Tovar AR.
- PLoS One. 2023 Apr 6;18(4):e0283605. doi: 10.1371/journal.pone.0283605.
- PMCID: PMC10079091
Meneses ME, et al.

PLoS One. 2023.

PMCID: PMC10079091

Well-characterized and standardized extracts of a Mexican genotype of Ganoderma lucidum (Gl), a medicinal mushroom, cultivated on oak sawdust (Gl-1) or oak sawdust plus acetylsalicylic acid (Gl-2, ASA), have been shown to exert antioxidant, hypocholesterolemic, anti …

Well-characterized and standardized extracts of a Mexican genotype of Ganoderma lucidum (Gl), a medicinal mushroom, cultivated …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effects of Mexican Ganoderma lucidum extracts on liver, kidney, and the gut microbiota of Wistar rats: A repeated dose oral toxicity study.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 31

301.
Protective Effects of Sporoderm-Broken Spores of Ganderma lucidum on Growth Performance, Antioxidant Capacity and Immune Function of Broiler Chickens Exposed to Low Level of Aflatoxin B1.
- Liu T, Ma Q, Zhao L, Jia R, Zhang J, Ji C, Wang X.
- Toxins (Basel). 2016 Sep 24;8(10):278. doi: 10.3390/toxins8100278.
- PMCID: PMC5086638
Liu T, et al.

Toxins (Basel). 2016.

PMCID: PMC5086638

This study was conducted to investigate the toxic effects of aflatoxin B1 (AFB1) and evaluate the effects of sporoderm-broken spores of Ganoderma lucidum (SSGL) in relieving aflatoxicosis in broilers. A total of 300 one-day-old male Arbor Acre broiler chickens were …

This study was conducted to investigate the toxic effects of aflatoxin B1 (AFB1) and evaluate the effects of sporoderm-broken spores of G …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Protective Effects of Sporoderm-Broken Spores of Ganderma lucidum on Growth Performance, Antioxidant Capacity and Immune Function of Broiler Chickens Exposed to Low Level of Aflatoxin B1.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
302.
Ganoderma lucidum: Insight into antimicrobial and antioxidant properties with development of secondary metabolites.
- Ahmad MF, A Alsayegh A, Ahmad FA, Akhtar MS, Alavudeen SS, Bantun F, Wahab S, Ahmed A, Ali M, Elbendary EY, Raposo A, Kambal N, H Abdelrahman M.
- Heliyon. 2024 Feb 4;10(3):e25607. doi: 10.1016/j.heliyon.2024.e25607.
- PMCID: PMC10865332
Ahmad MF, et al.

Heliyon. 2024.

PMCID: PMC10865332

Ganoderma lucidum is a versatile mushroom. Polysaccharides and triterpenoids are the major bioactive compounds and have been used as traditional medicinal mushrooms since ancient times. They are currently used as nutraceuticals and functional foods. G. lucidum …

Ganoderma lucidum is a versatile mushroom. Polysaccharides and triterpenoids are the major bioactive compounds and have been u …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum : Insight into antimicrobial and antioxidant properties with development of secondary metabolites.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
303.
Functional properties of Ganoderma lucidum supplementation in canine nutrition.
- Kayser E, Castaneda PL, Soto-Diaz K, Steelman AJ, Murphy A, Spindola M, He F, de Godoy MRC.
- J Anim Sci. 2024 Jan 3;102:skae051. doi: 10.1093/jas/skae051.
- PMCID: PMC11025632
Kayser E, et al.

J Anim Sci. 2024.

PMCID: PMC11025632

Ganoderma lucidum (GL) is a mushroom that has been widely used in Asia for its immunostimulatory and anti-inflammatory capacity, which has been hypothesized to be attributed mainly to the recognition of its cell-surface patterns by cells of the immune system present …

Ganoderma lucidum (GL) is a mushroom that has been widely used in Asia for its immunostimulatory and anti-inflammatory capacit …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Functional properties of Ganoderma lucidum supplementation in canine nutrition.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
304.
The Nutritional Significance of Ganoderma lucidum on Human Health: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials.
- Jafari A, Mardani H, Mirzaei Fashtali Z, Arghavan B.
- Food Sci Nutr. 2025 Jun 12;13(6):e70423. doi: 10.1002/fsn3.70423.
- PMCID: PMC12160064
Jafari A, et al.

Food Sci Nutr. 2025.

PMCID: PMC12160064

This study aimed to assess the impact of Ganoderma lucidum supplementation (200-11,200 mg/day, 1-24 weeks) on health-related indices in populations including healthy, at-risk, and chronic disease individuals. ...Ganoderma lucidum supplementation may ha …

This study aimed to assess the impact of Ganoderma lucidum supplementation (200-11,200 mg/day, 1-24 weeks) on health-related i …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The Nutritional Significance of Ganoderma lucidum on Human Health: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Participant-reported outcomes, clinical biomarkers, and safety/tolerability. Open article.
- Why might this paper be useful to readers? Provides early human data; interpret with caution and check study size and endpoints. Open article.
305.
Evaluating the Application Potential of a Recombinant Ganoderma Protein as Bioactive Ingredients in Cosmetics.
- Guo ZJ, Liu Y, Yang JY, Jin MY, Mao PW, Zhou XW.
- Molecules. 2023 Apr 6;28(7):3272. doi: 10.3390/molecules28073272.
- PMCID: PMC10096787
Guo ZJ, et al.

Molecules. 2023.

PMCID: PMC10096787

The aim of this study was to evaluate the application potential of a recombinant fungal immunomodulatory protein from Ganoderma lucidum (rFIP-glu). First, a recombinant plasmid pPIC9K::FIP-glu-His was transferred into Pichia pastoris for the production of protein. . …

The aim of this study was to evaluate the application potential of a recombinant fungal immunomodulatory protein from Ganoderma lu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Evaluating the Application Potential of a Recombinant Ganoderma Protein as Bioactive Ingredients in Cosmetics.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
306.
Inhibitory activity of medicinal mushroom Ganoderma lucidum on colorectal cancer by attenuating inflammation.
- Liu MM, Liu T, Yeung S, Wang Z, Andresen B, Parsa C, Orlando R, Zhou B, Wu W, Li X, Zhang Y, Wang C, Huang Y.
- Precis Clin Med. 2021 Aug 28;4(4):231-245. doi: 10.1093/pcmedi/pbab023.
- PMCID: PMC8982591
Liu MM, et al.

Precis Clin Med. 2021.

PMCID: PMC8982591

The medicinal mushroom Ganoderma lucidum (GL, Reishi or Lingzhi) exhibits an inhibitory effect on cancers. However, the underlying mechanism of the antitumor activity of GL is not fully understood. ...

The medicinal mushroom Ganoderma lucidum (GL, Reishi or Lingzhi) exhibits an inhibitory effect on cancers. However, the …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Inhibitory activity of medicinal mushroom Ganoderma lucidum on colorectal cancer by attenuating inflammation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
307.
Bioactive components, pharmacological properties and underlying mechanism of Ganoderma lucidum spore oil: A review.
- Liu J, Zhang B, Wang L, Li S, Long Q, Xiao X.
- Chin Herb Med. 2024 Jan 17;16(3):375-391. doi: 10.1016/j.chmed.2023.09.007.
- PMCID: PMC11283234
Liu J, et al.

Chin Herb Med. 2024.

PMCID: PMC11283234

Ganoderma lucidum is a Chinese medicinal fungus with a long history of use in healthcare and disease treatment. ...They contain all the genetic active substances of G. lucidum. G. lucidum spore oil (GLSO) is a lipid component extracted from broken-wall …

Ganoderma lucidum is a Chinese medicinal fungus with a long history of use in healthcare and disease treatment. ...They contai …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Bioactive components, pharmacological properties and underlying mechanism of Ganoderma lucidum spore oil: A review.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
308.
Potential Cosmetic Applications of the Combined Extract of Panax ginseng, Ganoderma lucidum, Cordyceps militaris, and Several Asian Plants.
- Wang W, Zhong M, Liu R, Zhao S, Wei X, Zheng Q, Zhong Q, Shen Y, He F.
- J Cosmet Dermatol. 2025 Aug;24(8):e70343. doi: 10.1111/jocd.70343.
- PMCID: PMC12322945
Wang W, et al.

J Cosmet Dermatol. 2025.

PMCID: PMC12322945

This study aimed to evaluate the stability of a combined extract of Panax ginseng, Ganoderma lucidum, Cordyceps militaris, and several Asian plants (PGC), and its multifunctional efficacy for acne-related skin dysfunction. ...

This study aimed to evaluate the stability of a combined extract of Panax ginseng, Ganoderma lucidum, Cordyceps militaris, and …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Potential Cosmetic Applications of the Combined Extract of Panax ginseng, Ganoderma lucidum , Cordyceps militaris, and Several Asian Plants.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
309.
Regulatory effect of Ganoderma lucidum and its active components on gut flora in diseases.
- Qin X, Fang Z, Zhang J, Zhao W, Zheng N, Wang X.
- Front Microbiol. 2024 Mar 18;15:1362479. doi: 10.3389/fmicb.2024.1362479.
- PMCID: PMC10990249
Qin X, et al.

Front Microbiol. 2024.

PMCID: PMC10990249

Driven by the good developmental potential and favorable environment at this stage, Ganoderma lucidum is recognized as a precious large fungus with medicinal and nutritional health care values. ...The purpose of this paper is to summarize the regulatory effects of G …

Driven by the good developmental potential and favorable environment at this stage, Ganoderma lucidum is recognized as a preci …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Regulatory effect of Ganoderma lucidum and its active components on gut flora in diseases.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
310.
Comparison of sterols and fatty acids in two species of Ganoderma.
- Lv GP, Zhao J, Duan JA, Tang YP, Li SP.
- Chem Cent J. 2012 Jan 31;6(1):10. doi: 10.1186/1752-153X-6-10.
- PMCID: PMC3287153
Lv GP, et al.

Chem Cent J. 2012.

PMCID: PMC3287153

BACKGROUND: Two species of Ganoderma, G. sinense and G. lucidum, are used as Lingzhi in China. Howerver, the content of triterpenoids and polysaccharides, main actives compounds, are significant different, though the extracts of both G. lucidum and G. sinense …

BACKGROUND: Two species of Ganoderma, G. sinense and G. lucidum, are used as Lingzhi in China. Howerver, the content of triter …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Comparison of sterols and fatty acids in two species of Ganoderma .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 32

311.
Optimization of Growth Conditions and Biological Activities of Nepalese Ganoderma lucidum Strain Philippine.
- Subedi K, Basnet BB, Panday R, Neupane M, Tripathi GR.
- Adv Pharmacol Pharm Sci. 2021 Oct 4;2021:4888979. doi: 10.1155/2021/4888979.
- PMCID: PMC8505087
Subedi K, et al.

Adv Pharmacol Pharm Sci. 2021.

PMCID: PMC8505087

Ganoderma lucidum has been extensively studied for its valuable medicinal importance. In this study, the artificial cultivation of G. lucidum strain Philippine in different culture media, including sawdust substrate, was performed and optimized on the Potato …

Ganoderma lucidum has been extensively studied for its valuable medicinal importance. In this study, the artificial cultivatio …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Optimization of Growth Conditions and Biological Activities of Nepalese Ganoderma lucidum Strain Philippine.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
312.
Signaling mechanisms of enhanced neutrophil phagocytosis and chemotaxis by the polysaccharide purified from Ganoderma lucidum.
- Hsu MJ, Lee SS, Lee ST, Lin WW.
- Br J Pharmacol. 2003 May;139(2):289-98. doi: 10.1038/sj.bjp.0705243.
- PMCID: PMC1573843
Hsu MJ, et al.

Br J Pharmacol. 2003.

PMCID: PMC1573843

1 The polysaccharide from Ganoderma lucidum (PS-G) has been reported to enhance immune responses and to elicit antitumor effects. ...Moreover, chemotactic action of PS-G requires the activities of PI3K, p38 MAPK, Src tyrosine kinases and PKC. 6 All these results dem …

1 The polysaccharide from Ganoderma lucidum (PS-G) has been reported to enhance immune responses and to elicit antitumor effec …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Signaling mechanisms of enhanced neutrophil phagocytosis and chemotaxis by the polysaccharide purified from Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
313.
Lucidenic acid A inhibits the binding of hACE2 receptor with spike protein to prevent SARS-CoV-2 invasion.
- Xu J, Yang W, Pan Y, Xu H, He L, Zheng B, Xie Y, Wu X.
- Food Chem Toxicol. 2022 Sep 28;169:113438. doi: 10.1016/j.fct.2022.113438.
- PMCID: PMC9526994
Xu J, et al.

Food Chem Toxicol. 2022.

PMCID: PMC9526994

High infection caused by mutations of SARS-CoV-2 calls for new prevention strategy. Ganoderma lucidum known as a superior immunoenhancer exhibits various antiviral effects, whether it can resist SARS-CoV-2 remains unclear. ...

High infection caused by mutations of SARS-CoV-2 calls for new prevention strategy. Ganoderma lucidum known as a superior immu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Lucidenic acid A inhibits the binding of hACE2 receptor with spike protein to prevent SARS-CoV-2 invasion.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
314.
Ganoderma lucidum Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis.
- Mahran YF, Hassan HM.
- Oxid Med Cell Longev. 2020 Jul 6;2020:4932587. doi: 10.1155/2020/4932587.
- PMCID: PMC7362286
Mahran YF, et al.

Oxid Med Cell Longev. 2020.

PMCID: PMC7362286

However, CDDP has been blamed for its nephrotoxicity, which is the main dose-limiting adverse effect. Ganoderma lucidum (GL), a medicinal mushroom, has antioxidant and inflammatory activities. ...

However, CDDP has been blamed for its nephrotoxicity, which is the main dose-limiting adverse effect. Ganoderma lucidum (GL), …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
315.
Ganoderma lucidum put forth anti-tumor activity against PC-3 prostate cancer cells via inhibition of Jak-1/STAT-3 activity.
- Wang X, Wang B, Zhou L, Wang X, Veeraraghavan VP, Mohan SK, Xin F.
- Saudi J Biol Sci. 2020 Jun 3;27(10):2632-2637. doi: 10.1016/j.sjbs.2020.05.044.
- PMCID: PMC7499110
Wang X, et al.

Saudi J Biol Sci. 2020.

PMCID: PMC7499110

In present study, we examined the anticancer potentials of Ganoderma lucidum against the prostate cancer (PC-3) cells by inflection of JAK-1/STAT-3 signalling pathway. ...CONCLUSION: In the end our finding concluded that Ganoderma lucidum hinder prosta …

In present study, we examined the anticancer potentials of Ganoderma lucidum against the prostate cancer (PC-3) cells by infle …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum put forth anti-tumor activity against PC-3 prostate cancer cells via inhibition of Jak-1/STAT-3 activity.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
316.
Surface-Engineered Cubosomes Serve as a Novel Vaccine Adjuvant to Modulate Innate Immunity and Improve Adaptive Immunity in vivo.
- Liu Z, Yu L, Gu P, Bo R, Xu S, Wusiman A, Liu J, Hu Y, Wang D.
- Int J Nanomedicine. 2020 Nov 4;15:8595-8608. doi: 10.2147/IJN.S266165.
- PMCID: PMC7650836
Liu Z, et al.

Int J Nanomedicine. 2020.

PMCID: PMC7650836

METHODS: Here, we exploit the effects of surface chemistry on the adjuvant activity of Ganoderma lucidum polysaccharide cubosomes (GLPC) by placing two kinds of molecules, that is, cetyltrimethylammonium bromide (CTAB) and poly(diallydimethyl ammonium chloride) (PDD …

METHODS: Here, we exploit the effects of surface chemistry on the adjuvant activity of Ganoderma lucidum polysaccharide cuboso …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Surface-Engineered Cubosomes Serve as a Novel Vaccine Adjuvant to Modulate Innate Immunity and Improve Adaptive Immunity in vivo.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
317.
Chemodiversity, pharmacological activity, and biosynthesis of specialized metabolites from medicinal model fungi Ganoderma lucidum.
- Du Y, Tian L, Wang Y, Li Z, Xu Z.
- Chin Med. 2024 Mar 22;19(1):51. doi: 10.1186/s13020-024-00922-0.
- PMCID: PMC10958966
Du Y, et al.

Chin Med. 2024.

PMCID: PMC10958966

Ganoderma lucidum is a precious fungus, particularly valued for its dual use as both medicine and food. ...Furthermore, we summarized the omics data, genetic transformation system, and cultivation techniques of G. lucidum, described as medicinal model fungi. …

Ganoderma lucidum is a precious fungus, particularly valued for its dual use as both medicine and food. ...Furthermore, we sum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Chemodiversity, pharmacological activity, and biosynthesis of specialized metabolites from medicinal model fungi Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
318.
A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge.
- Lin YL, Cheng PY, Chin CL, Chuang KT, Lin JY, Chang N, Pan CK, Lin CS, Pan SC, Chiang BL.
- J Biomed Sci. 2023 Dec 18;30(1):96. doi: 10.1186/s12929-023-00987-3.
- PMCID: PMC10729491
Lin YL, et al.

J Biomed Sci. 2023.

PMCID: PMC10729491

METHODS: In this study, formalin-inactivated EV-A71 and EV-D68 were used as antigens, while PS-G, a polysaccharide from Ganoderma lucidum, was used as an adjuvant. Natural polysaccharides have the characteristics of intrinsic immunomodulation, biocompatibility, low …

METHODS: In this study, formalin-inactivated EV-A71 and EV-D68 were used as antigens, while PS-G, a polysaccharide from Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
319.
Effects and Mechanism of Ganoderma lucidum Polysaccharides in the Treatment of Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats.
- Hu Y, Wang SX, Wu FY, Wu KJ, Shi RP, Qin LH, Lu CF, Wang SQ, Wang FF, Zhou S.
- Biomed Res Int. 2022 Mar 8;2022:4314415. doi: 10.1155/2022/4314415.
- PMCID: PMC8923773
Hu Y, et al.

Biomed Res Int. 2022.

PMCID: PMC8923773

Ganoderma lucidum polysaccharides (GLP) have renal protection effect but there was no study on the diabetic nephropathy. ...

Ganoderma lucidum polysaccharides (GLP) have renal protection effect but there was no study on the diabetic nephropathy. ...
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effects and Mechanism of Ganoderma lucidum Polysaccharides in the Treatment of Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
320.
Ling Zhi-8, a fungal immunomodulatory protein in Ganoderma lucidum, alleviates CPT-11-induced intestinal injury via restoring claudin-1 expression.
- Li JP, Chu CL, Chao WR, Yeh CS, Lee YJ, Chen DC, Yang SF, Chao YH.
- Aging (Albany NY). 2023 May 5;15(9):3621-3634. doi: 10.18632/aging.204695.
- PMCID: PMC10449289
Li JP, et al.

Aging (Albany NY). 2023.

PMCID: PMC10449289

Ling Zhi-8 (LZ-8), a fungal immunomodulatory protein in Ganoderma lucidum mycelia, has potential for drug development due to its multiple bioactivities and functions. ...

Ling Zhi-8 (LZ-8), a fungal immunomodulatory protein in Ganoderma lucidum mycelia, has potential for drug development due to i …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ling Zhi-8, a fungal immunomodulatory protein in Ganoderma lucidum , alleviates CPT-11-induced intestinal injury via restoring claudin-1 expression.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 33

321.
A review of anti-tumour effects of Ganoderma lucidum in gastrointestinal cancer.
- Ye T, Ge Y, Jiang X, Song H, Peng C, Liu B.
- Chin Med. 2023 Aug 28;18(1):107. doi: 10.1186/s13020-023-00811-y.
- PMCID: PMC10463474
Ye T, et al.

Chin Med. 2023.

PMCID: PMC10463474

Clinically, surgical excision and chemotherapy are the main treatment methods for GI cancer, which is unfortunately accompanied with serious adverse reactions and drug toxicity, bringing irreversible damage to patients and seriously affecting the quality of life. Ganoderma …

Clinically, surgical excision and chemotherapy are the main treatment methods for GI cancer, which is unfortunately accompanied with serious …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A review of anti-tumour effects of Ganoderma lucidum in gastrointestinal cancer.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
322.
Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice.
- Zhang GL, Wang YH, Ni W, Teng HL, Lin ZB.
- World J Gastroenterol. 2002 Aug;8(4):728-33. doi: 10.3748/wjg.v8.i4.728.
- PMCID: PMC4656329
Zhang GL, et al.

World J Gastroenterol. 2002.

PMCID: PMC4656329

AIM: To examine the effect of ganoderma lucidum polysaccharide (GLP) on the immune liver injury induced by BCG infection, and investigate the relationship between degrees of hepatic damage and NO production in mice. ...

AIM: To examine the effect of ganoderma lucidum polysaccharide (GLP) on the immune liver injury induced by BCG infection, and …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
323.
Current Advancements in Antitumor Properties and Mechanisms of Medicinal Components in Edible Mushrooms.
- Xu J, Shen R, Jiao Z, Chen W, Peng D, Wang L, Yu N, Peng C, Cai B, Song H, Chen F, Liu B.
- Nutrients. 2022 Jun 24;14(13):2622. doi: 10.3390/nu14132622.
- PMCID: PMC9268676
Xu J, et al.

Nutrients. 2022.

PMCID: PMC9268676

Edible and medicinal fungi, a group of eukaryotic organisms with numerous varieties, including Coriolus versicolor, Ganoderma lucidum, Cordyceps sinensis, Pleurotus ostreatus, and Grifola frondosa, have been demonstrated to possess a board range of pharmaceutical pr …

Edible and medicinal fungi, a group of eukaryotic organisms with numerous varieties, including Coriolus versicolor, Ganoderma luci …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Current Advancements in Antitumor Properties and Mechanisms of Medicinal Components in Edible Mushrooms.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
324.
Pharmacological Activities and Safety of Ganoderma lucidum Spores: A Systematic Review.
- Thuy NHL, Tu VL, Thu LNA, Giang TT, Huyen DTK, Loc DH, Tam DNH, Phat NT, Huynh HH, Truyen TTTT, Nguyen QH, Do U, Nguyen D, Dat TV, Minh LHN.
- Cureus. 2023 Sep 2;15(9):e44574. doi: 10.7759/cureus.44574.
- PMCID: PMC10545004
Thuy NHL, et al.

Cureus. 2023.

PMCID: PMC10545004

Ganoderma lucidum is traditionally used to prevent and treat some diseases such as liver disorders, hypertension, insomnia, diabetes, and cancer. ...G. lucidum sporoderm-broken extract demonstrated higher efficiency than unbroken spore extract. ...

Ganoderma lucidum is traditionally used to prevent and treat some diseases such as liver disorders, hypertension, insomnia, di …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Pharmacological Activities and Safety of Ganoderma lucidum Spores: A Systematic Review.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
325.
Cytotoxic Activities and Fingerprint Analysis of Triterpenes by HPTLC Technique for Distinguishing Ganoderma Species from Vietnam and other Asian Countries.
- Viet Hung T, Thang PNT, Hien HM, Diep VT, Thu NT, Tan DM, Pham DT, Thi Ha D, Huynh DTM.
- Plants (Basel). 2022 Dec 6;11(23):3397. doi: 10.3390/plants11233397.
- PMCID: PMC9738896
Viet Hung T, et al.

Plants (Basel). 2022.

PMCID: PMC9738896

Ganoderma lucidum (Fr.) P. Karst. (Ganodermataceae), commonly called Linhzhi, is traditionally employed in the treatment of human diseases, including hepatitis, liver disorders, hypercholesterolemia, arthritis, bronchitis, and tumorigenic diseases. In this study, th …

Ganoderma lucidum (Fr.) P. Karst. (Ganodermataceae), commonly called Linhzhi, is traditionally employed in the treatment of hu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Cytotoxic Activities and Fingerprint Analysis of Triterpenes by HPTLC Technique for Distinguishing Ganoderma Species from Vietnam and other Asian Countries.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
326.
Ergosterol Peroxide from the Medicinal Mushroom Ganoderma lucidum Inhibits Differentiation and Lipid Accumulation of 3T3-L1 Adipocytes.
- Jeong YU, Park YJ.
- Int J Mol Sci. 2020 Jan 10;21(2):460. doi: 10.3390/ijms21020460.
- PMCID: PMC7014426
Jeong YU, et al.

Int J Mol Sci. 2020.

PMCID: PMC7014426
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ergosterol Peroxide from the Medicinal Mushroom Ganoderma lucidum Inhibits Differentiation and Lipid Accumulation of 3T3-L1 Adipocytes.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
327.
Identification of Biologically Active Ganoderma lucidum Compounds and Synthesis of Improved Derivatives That Confer Anti-cancer Activities in vitro.
- Martínez-Montemayor MM, Ling T, Suárez-Arroyo IJ, Ortiz-Soto G, Santiago-Negrón CL, Lacourt-Ventura MY, Valentín-Acevedo A, Lang WH, Rivas F.
- Front Pharmacol. 2019 Feb 19;10:115. doi: 10.3389/fphar.2019.00115.
- PMCID: PMC6389703
Martínez-Montemayor MM, et al.

Front Pharmacol. 2019.

PMCID: PMC6389703

We previously reported that Ganoderma lucidum extract (GLE) demonstrate significant anti-cancer activity against triple negative inflammatory breast cancer models. ...The combined studies indicate that EP from Ganoderma lucidum extract is a promising m …

We previously reported that Ganoderma lucidum extract (GLE) demonstrate significant anti-cancer activity against triple negati …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Identification of Biologically Active Ganoderma lucidum Compounds and Synthesis of Improved Derivatives That Confer Anti-cancer Activities in vitro.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
328.
Taxonomic Position and Species Identity of the Cultivated Yeongji 'Ganoderma lucidum' in Korea.
- Kwon OC, Park YJ, Kim HI, Kong WS, Cho JH, Lee CS.
- Mycobiology. 2016 Mar 31;44(1):1-6. doi: 10.5941/MYCO.2016.44.1.1.
- PMCID: PMC4838586
Kwon OC, et al.

Mycobiology. 2016.

PMCID: PMC4838586

Ganoderma lucidum has a long history of use as a traditional medicine in Asian countries. ...Recently, it was proposed that G. lucidum from China be renamed as G. sichuanense or G. lingzhi. In the present study, phylogenetic analysis using the internal transc …

Ganoderma lucidum has a long history of use as a traditional medicine in Asian countries. ...Recently, it was proposed that G. …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Taxonomic Position and Species Identity of the Cultivated Yeongji ' Ganoderma lucidum ' in Korea.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
329.
The anti-cancer components of Ganoderma lucidum possesses cardiovascular protective effect by regulating circular RNA expression.
- Xie YZ, Yang F, Tan W, Li X, Jiao C, Huang R, Yang BB.
- Oncoscience. 2016 Aug 28;3(7-8):203-207. doi: 10.18632/oncoscience.316.
- PMCID: PMC5043070
Xie YZ, et al.

Oncoscience. 2016.

PMCID: PMC5043070

Our preliminary results demonstrated a potential cardioprotective role for spore oil extracted from Ganoderma. We found that Ganoderma treatment normalized ejection fraction and corrected the fractional shortening generated by TAC. ...We found reduced expression of …

Our preliminary results demonstrated a potential cardioprotective role for spore oil extracted from Ganoderma. We found that Ganod …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The anti-cancer components of Ganoderma lucidum possesses cardiovascular protective effect by regulating circular RNA expression.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
330.
Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-Fc fusion proteins.
- Hsu TL, Cheng SC, Yang WB, Chin SW, Chen BH, Huang MT, Hsieh SL, Wong CH.
- J Biol Chem. 2009 Oct 16;284(50):34479-89. doi: 10.1074/jbc.M109.065961.
- PMCID: PMC2787309
Hsu TL, et al.

J Biol Chem. 2009.

PMCID: PMC2787309

Our studies indicate that the immune modulating properties of many herbal drugs, for instance, the medicinal fungus Reishi (Ganoderma lucidum) and Cordyceps sinensis, could be attributed to their polysaccharide components. ...The results show that several inn …

Our studies indicate that the immune modulating properties of many herbal drugs, for instance, the medicinal fungus Reishi (Ganode …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-Fc fusion proteins.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 34

331.
Research Progress on the Biological Activity of Ganoderic Acids in Ganoderma lucidum over the Last Five Years.
- Wang S, Wang L, Shangguan J, Jiang A, Ren A.
- Life (Basel). 2024 Oct 21;14(10):1339. doi: 10.3390/life14101339.
- PMCID: PMC11509451
Wang S, et al.

Life (Basel). 2024.

PMCID: PMC11509451

Ganoderma lucidum (G. lucidum) is a traditional edible and medicinal mushroom in China. The main bioactive components in G. lucidum include triterpenoids, polysaccharides, steroids, and sterols. Ganoderic acids (GAs) are one of the most abundant triter …

Ganoderma lucidum (G. lucidum) is a traditional edible and medicinal mushroom in China. The main bioactive components i …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Research Progress on the Biological Activity of Ganoderic Acids in Ganoderma lucidum over the Last Five Years.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
332.
A Review of Bioactive Components and Pharmacological Effects of Ganoderma lucidum.
- Ren S, Liu H, Sang Q, Lu M, Gao Q, Chen W.
- Food Sci Nutr. 2025 Jul 13;13(7):e70623. doi: 10.1002/fsn3.70623.
- PMCID: PMC12256279
Ren S, et al.

Food Sci Nutr. 2025.

PMCID: PMC12256279

Ganoderma lucidum, a distinguished traditional medicinal herb, has long been recognized for its purported benefits in promoting physical well-being, enhancing stamina, and boosting vitality. ...Despite its established status as a functional food and potential therap …

Ganoderma lucidum, a distinguished traditional medicinal herb, has long been recognized for its purported benefits in promotin …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A Review of Bioactive Components and Pharmacological Effects of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
333.
Ganoderic acid A attenuated hepatic impairment by down-regulating the intracellular JAK2-STAT3 signaling pathway in induced mushroom poisoning.
- Xiao C, Huang G, Cao X, Li X.
- Am J Transl Res. 2024 Jan 15;16(1):295-303. doi: 10.62347/ERWA6712.
- PMCID: PMC10839386
Xiao C, et al.

Am J Transl Res. 2024.

PMCID: PMC10839386

In the present study, we verified that Ganoderma lucidum may be an effective approach for treatment of acute mushroom poisoning. ...CONCLUSION: Ganoderma lucidum is very effective in treating mushroom poisoning by alpha-amanita and is worth promoting.. …

In the present study, we verified that Ganoderma lucidum may be an effective approach for treatment of acute mushroom poisonin …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderic acid A attenuated hepatic impairment by down-regulating the intracellular JAK2-STAT3 signaling pathway in induced mushroom poisoning.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
334.
Effect of Ganoderma lucidum Powder on Oxidative Stability, Microbial and Sensory Properties of Emulsion Type Sausage.
- Ghobadi R, Mohammadi R, Chabavizade J, Sami M.
- Adv Biomed Res. 2018 Feb 16;7:24. doi: 10.4103/2277-9175.225595.
- PMCID: PMC5840970
Ghobadi R, et al.

Adv Biomed Res. 2018.

PMCID: PMC5840970

BACKGROUND: Ganoderma lucidum from Ganodermataceae family is a kind of mushroom known to have various therapeutic properties such as lowering high blood sugar and high blood pressure, boosting the immune system as well as its antibacterial and antioxidant effects. M …

BACKGROUND: Ganoderma lucidum from Ganodermataceae family is a kind of mushroom known to have various therapeutic properties s …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effect of Ganoderma lucidum Powder on Oxidative Stability, Microbial and Sensory Properties of Emulsion Type Sausage.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
335.
Supercritical fluid extraction effectively removes phthalate plasticizers in spores of Ganoderma lucidum.
- Li P, Liang ZH, Jiang Z, Qiu Z, Du B, Liu YB, Li WZ, Tan LH.
- Food Sci Biotechnol. 2018 Jun 8;27(6):1857-1864. doi: 10.1007/s10068-018-0404-3.
- PMCID: PMC6233416
Li P, et al.

Food Sci Biotechnol. 2018.

PMCID: PMC6233416

Phthalate plasticizers residue in food is a serious threat to public health. Spores of Ganoderma lucidum are easy to be contaminated with phthalates during collection and processing. In this study, supercritical fluid extraction (SFE) was performed to remove phthala …

Phthalate plasticizers residue in food is a serious threat to public health. Spores of Ganoderma lucidum are easy to be contam …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Supercritical fluid extraction effectively removes phthalate plasticizers in spores of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
336.
Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial.
- Pakravan F, Yegdaneh A, Taymouri S, Rahimi S, Ghahremani N.
- Front Dent. 2024 Dec 1;21:45. doi: 10.18502/fid.v21i45.17178.
- PMCID: PMC11792735
Pakravan F, et al.

Front Dent. 2024.

PMCID: PMC11792735

Objectives: This study aimed to compare the antifungal efficacy of Ganoderma lucidum (G. lucidum) and clotrimazole for treatment of denture stomatitis (DS). ...Conclusion: No significant difference existed between the antifungal efficacy of G. lucidum …

Objectives: This study aimed to compare the antifungal efficacy of Ganoderma lucidum (G. lucidum) and clotrimazole for …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Participant-reported outcomes, clinical biomarkers, and safety/tolerability. Open article.
- Why might this paper be useful to readers? Provides early human data; interpret with caution and check study size and endpoints. Open article.
337.
MALDI-TOF MS analysis of native and permethylated or benzimidazole-derivatized polysaccharides.
- Hung WT, Wang SH, Chen YT, Yu HM, Chen CH, Yang WB.
- Molecules. 2012 Apr 30;17(5):4950-61. doi: 10.3390/molecules17054950.
- PMCID: PMC6268202
Hung WT, et al.

Molecules. 2012.

PMCID: PMC6268202

Polysaccharides including dextran, glucomannan, arabinoxylan, arabinogalactan and beta-1,3-glucan, isolated from nutritional supplements of Ganoderma lucidum and Saccharomyces pastorianus were measured using MALDI-TOF MS with 2,5-dihydroxybenzoic acid (2,5-DHB) as t …

Polysaccharides including dextran, glucomannan, arabinoxylan, arabinogalactan and beta-1,3-glucan, isolated from nutritional supplements of …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: MALDI-TOF MS analysis of native and permethylated or benzimidazole-derivatized polysaccharides.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
338.
Mass Spectrometry-Based Untargeted Metabolomics and alpha-Glucosidase Inhibitory Activity of Lingzhi (Ganoderma lingzhi) During the Developmental Stages.
- Satria D, Tamrakar S, Suhara H, Kaneko S, Shimizu K.
- Molecules. 2019 May 29;24(11):2044. doi: 10.3390/molecules24112044.
- PMCID: PMC6600326
Satria D, et al.

Molecules. 2019.

PMCID: PMC6600326

Lingzhi is a Ganoderma mushroom species which has a wide range of bioactivities. Analysis of the changes in metabolites during the developmental stages of lingzhi is important to understand the underlying mechanism of its biosynthesis, as well as its bioactivity. ...

Lingzhi is a Ganoderma mushroom species which has a wide range of bioactivities. Analysis of the changes in metabolites during the de …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Mass Spectrometry-Based Untargeted Metabolomics and alpha-Glucosidase Inhibitory Activity of Lingzhi ( Ganoderma lingzhi) During the Developmental Stages.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Broad molecular profiling and pathway/statistical analyses. Open article.
- Why might this paper be useful to readers? Maps pathways and components that can guide future lab and clinical research. Open article.
339.
Phenolic Rich Fractions from Mycelium and Fruiting Body of Ganoderma lucidum Inhibit Bacterial Pathogens Mediated by Generation of Reactive Oxygen Species and Protein Leakage and Modulate Hypoxic Stress in HEK 293 Cell Line.
- Mishra J, Joshi A, Rajput R, Singh K, Bansal A, Misra K.
- Adv Pharmacol Sci. 2018 Dec 17;2018:6285615. doi: 10.1155/2018/6285615.
- PMCID: PMC6311817
Mishra J, et al.

Adv Pharmacol Sci. 2018.

PMCID: PMC6311817

Ganoderma lucidum (G. lucidum) fungus (Family Ganodermataceae) is widely used as a traditional medicine in China, Japan, and many Asian countries on account of its numerous medicinal properties such as antioxidant, anticancer, antimicrobial, energy enhancing, …

Ganoderma lucidum (G. lucidum) fungus (Family Ganodermataceae) is widely used as a traditional medicine in China, Japan …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Phenolic Rich Fractions from Mycelium and Fruiting Body of Ganoderma lucidum Inhibit Bacterial Pathogens Mediated by Generation of Reactive Oxygen Species and Protein Leakage and Modulate Hypoxic Stress in HEK 293 Cell Line.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
340.
Identification of Potential Anticancer Activities of Novel Ganoderma lucidum Extracts Using Gene Expression and Pathway Network Analysis.
- Kao CH, Bishop KS, Xu Y, Han DY, Murray PM, Marlow GJ, Ferguson LR.
- Genomics Insights. 2016 Feb 16;9:1-16. doi: 10.4137/GEI.S32477.
- PMCID: PMC4778854
Kao CH, et al.

Genomics Insights. 2016.

PMCID: PMC4778854

Ganoderma lucidum (lingzhi) has been used for the general promotion of health in Asia for many centuries. ...The anticancer effect of G. lucidum, using whiskey and rice wine-based extraction methods, has not been previously reported. ...

Ganoderma lucidum (lingzhi) has been used for the general promotion of health in Asia for many centuries. ...The anticancer ef …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Identification of Potential Anticancer Activities of Novel Ganoderma lucidum Extracts Using Gene Expression and Pathway Network Analysis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 35

341.
Ganoderma lucidum Modulates Glucose, Lipid Peroxidation and Hepatic Metabolism in Streptozotocin-Induced Diabetic Pregnant Rats.
- Viroel FJM, Laurino LF, Caetano ÉLA, Jozala AF, Spim SRV, Pickler TB, Sercundes MK, Gomes MC, Hataka A, Grotto D, Gerenutti M.
- Antioxidants (Basel). 2022 May 24;11(6):1035. doi: 10.3390/antiox11061035.
- PMCID: PMC9219838
Viroel FJM, et al.

Antioxidants (Basel). 2022.

PMCID: PMC9219838

The consumption of functional foods, such as mushrooms, apparently influences Gestational Diabetes Mellitus (GDM), and brings benefits to maternal-fetal health. Ganoderma lucidum contains a variety of bioactive compounds, such as polysaccharides, proteins and polyph …

The consumption of functional foods, such as mushrooms, apparently influences Gestational Diabetes Mellitus (GDM), and brings benefits to ma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Modulates Glucose, Lipid Peroxidation and Hepatic Metabolism in Streptozotocin-Induced Diabetic Pregnant Rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
342.
A Ribonuclease Isolated from Wild Ganoderma Lucidum Suppressed Autophagy and Triggered Apoptosis in Colorectal Cancer Cells.
- Dan X, Liu W, Wong JH, Ng TB.
- Front Pharmacol. 2016 Jul 25;7:217. doi: 10.3389/fphar.2016.00217.
- PMCID: PMC4958627
Dan X, et al.

Front Pharmacol. 2016.

PMCID: PMC4958627

The mushroom Ganoderma lucidum (G. lucidum) has been consumed in China as a medicine for promoting health and longevity for thousands of years. ...Herein, we reported the isolation of a protein (Ganoderma lucidum ribonuclease, GLR) with anti-col …

The mushroom Ganoderma lucidum (G. lucidum) has been consumed in China as a medicine for promoting health and longevity …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A Ribonuclease Isolated from Wild Ganoderma Lucidum Suppressed Autophagy and Triggered Apoptosis in Colorectal Cancer Cells.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
343.
A Spironolactone-Based Prototype of an Innovative Biomedical Patch for Wound Dressing Applications.
- Aquino G, Viscusi G, D'Alterio MC, Covelli V, Gorrasi G, Pellecchia C, Rizzo P, D'Ursi AM, Pepe G, Amante C, Del Gaudio P, Rodriquez M.
- Int J Mol Sci. 2024 Sep 5;25(17):9608. doi: 10.3390/ijms25179608.
- PMCID: PMC11395607
Aquino G, et al.

Int J Mol Sci. 2024.

PMCID: PMC11395607

This study aims to create and characterize electrospun PLLA membranes loaded with spironolactone (SP), mimicking active compounds of Ganoderma lucidum (GL), to develop a biodegradable patch for topical wound-healing applications. ...

This study aims to create and characterize electrospun PLLA membranes loaded with spironolactone (SP), mimicking active compounds of Gano …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A Spironolactone-Based Prototype of an Innovative Biomedical Patch for Wound Dressing Applications.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
344.
Ganodermataceae-current status, research, and development in Lower Mekong Basin.
- Karunarathna SC, Patabendige NM, Luangharn T, Hapuarachchi KK.
- Front Cell Infect Microbiol. 2025 May 12;15:1545135. doi: 10.3389/fcimb.2025.1545135.
- PMCID: PMC12104286
Karunarathna SC, et al.

Front Cell Infect Microbiol. 2025.

PMCID: PMC12104286

The family Ganodermataceae encompasses several genera, including the widely studied Ganoderma, which is prominent in traditional medicine for its therapeutic properties. Species within this family, particularly Ganoderma lucidum, have been valued for centurie …

The family Ganodermataceae encompasses several genera, including the widely studied Ganoderma, which is prominent in traditional medi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganodermataceae-current status, research, and development in Lower Mekong Basin.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
345.
Identification of a Novel Metabolic Target for Bioactive Triterpenoids Biosynthesis in Ganoderma lucidum.
- Xu J, Wang Y, Zhang Y, Xiong K, Yan X, Ruan S, Wu X.
- Front Microbiol. 2022 May 9;13:878110. doi: 10.3389/fmicb.2022.878110.
- PMCID: PMC9125208
Xu J, et al.

Front Microbiol. 2022.

PMCID: PMC9125208

Triterpenoids are crucial active ingredients of Ganoderma lucidum (G. lucidum) with various health benefits. Yet the low biosynthesis greatly restricts their industrial applications, novel metabolic engineering strategies are needed to further enhance Gano …

Triterpenoids are crucial active ingredients of Ganoderma lucidum (G. lucidum) with various health benefits. Yet the lo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Identification of a Novel Metabolic Target for Bioactive Triterpenoids Biosynthesis in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
346.
Optimal Medium Conditions for the Detection of Cellulolytic Activity in Ganoderma lucidum.
- Jo WS, Bae SH, Cho DH, Park SD, Yoo YB, Park SC.
- Mycobiology. 2009 Dec 31;37(4):313-6. doi: 10.4489/MYCO.2009.37.4.313.
- PMCID: PMC3749426
Jo WS, et al.

Mycobiology. 2009.

PMCID: PMC3749426

On the whole, the best protocol called for Ganoderma lucidum transfer onto media containing Congo red with pH adjusted to 7.0, followed by incubation at 25 for 5 days. Our results will be useful to researchers who aim to study extracellular enzyme activity in Gan …

On the whole, the best protocol called for Ganoderma lucidum transfer onto media containing Congo red with pH adjusted to 7.0, …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Optimal Medium Conditions for the Detection of Cellulolytic Activity in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
347.
Chemical Constituents and Antimicrobial Activity of a Ganoderma lucidum (Curtis.) P. Karst. Aqueous Ammonia Extract.
- Sánchez-Hernández E, Teixeira A, Pereira C, Cruz A, Martín-Gil J, Oliveira R, Martín-Ramos P.
- Plants (Basel). 2023 Jun 11;12(12):2271. doi: 10.3390/plants12122271.
- PMCID: PMC10305452
Sánchez-Hernández E, et al.

Plants (Basel). 2023.

PMCID: PMC10305452

This study investigates the chemical profile of an aqueous ammonia extract obtained from the carpophores of Ganoderma lucidum, which grows on Quercus ilex trees, and explores its valorization as a biorational. ...Subsequent ex situ testing of the COS-G. lucidum …

This study investigates the chemical profile of an aqueous ammonia extract obtained from the carpophores of Ganoderma lucidum, …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Chemical Constituents and Antimicrobial Activity of a Ganoderma lucidum (Curtis.) P. Karst. Aqueous Ammonia Extract.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
348.
Chemical Characterization and Evaluation of Antimicrobial Properties of the Wild Medicinal Mushroom Ganoderma lucidum Growing in Northern Moroccan Forests.
- Erbiai EH, Amina B, Kaoutar A, Saidi R, Lamrani Z, Pinto E, Esteves da Silva JCG, Maouni A, Pinto da Silva L.
- Life (Basel). 2023 May 19;13(5):1217. doi: 10.3390/life13051217.
- PMCID: PMC10223331
Erbiai EH, et al.

Life (Basel). 2023.

PMCID: PMC10223331

Ganoderma lucidum is an extensively famous medicinal mushroom distributed worldwide. Despite being widely grown in Moroccan forests, there are no studies on its nutritional, nutraceutical and pharmaceutical values. Herein, the objective of this study was to investig …

Ganoderma lucidum is an extensively famous medicinal mushroom distributed worldwide. Despite being widely grown in Moroccan fo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Chemical Characterization and Evaluation of Antimicrobial Properties of the Wild Medicinal Mushroom Ganoderma lucidum Growing in Northern Moroccan Forests.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
349.
Bioactivities and industrial standardization status of Ganoderma lucidum: A comprehensive review.
- Wu P, Zhang C, Yin Y, Zhang X, Li Q, Yuan L, Sun Y, Zhou S, Ying S, Wu J.
- Heliyon. 2024 Aug 29;10(19):e36987. doi: 10.1016/j.heliyon.2024.e36987.
- PMCID: PMC11492437
Wu P, et al.

Heliyon. 2024.

PMCID: PMC11492437

Ganoderma lucidum (GL) is a potent source of bioactive compounds with diverse nutritional and pharmacological benefits. ...

Ganoderma lucidum (GL) is a potent source of bioactive compounds with diverse nutritional and pharmacological benefits. ...
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Bioactivities and industrial standardization status of Ganoderma lucidum : A comprehensive review.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Participant-reported outcomes, clinical biomarkers, and safety/tolerability. Open article.
- Why might this paper be useful to readers? Provides early human data; interpret with caution and check study size and endpoints. Open article.
350.
B-glucans from Grifola frondosa and Ganoderma lucidum in breast cancer: an example of complementary and integrative medicine.
- Rossi P, Difrancia R, Quagliariello V, Savino E, Tralongo P, Randazzo CL, Berretta M.
- Oncotarget. 2018 May 15;9(37):24837-24856. doi: 10.18632/oncotarget.24984.
- PMCID: PMC5973856
Rossi P, et al.

Oncotarget. 2018.

PMCID: PMC5973856

Clinical effects of mycotherapy (specifically, the use of Ganoderma lucidum and Grifola frondosa) on long-term survival, tumor response, host immune functions, inflammation, and QoL in cancer patients were also addressed. ...Emerging data point to a potential role o …

Clinical effects of mycotherapy (specifically, the use of Ganoderma lucidum and Grifola frondosa) on long-term survival, tumor …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: B-glucans from Grifola frondosa and Ganoderma lucidum in breast cancer: an example of complementary and integrative medicine.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

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351.
Ganoderic Acid A targeting leucine-rich repeat kinase 2 involved in Parkinson's disease-A computational study.
- Ahmad F.
- Aging Med (Milton). 2022 Dec 20;6(3):272-280. doi: 10.1002/agm2.12235.
- PMCID: PMC10498832
Ahmad F.

Aging Med (Milton). 2022.

PMCID: PMC10498832

Therefore, GAA needs further validation through in vitro and in vivo studies. CONCLUSION: Ganoderma lucidum exhibits cytotoxic, hepatoprotective, antioxidative, anticancer, and antinociceptive activities. This study predicted that Ganoderma lucidum cou …

Therefore, GAA needs further validation through in vitro and in vivo studies. CONCLUSION: Ganoderma lucidum exhibits cytotoxic …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderic Acid A targeting leucine-rich repeat kinase 2 involved in Parkinson's disease-A computational study.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
352.
Potential Active Compounds of Ganoderma lucidum and Their Anticancer Effects: A Comprehensive Review.
- Liu Y, Ren S, Sang Q, Cheng X, Bi Y.
- Food Sci Nutr. 2025 Aug 1;13(8):e70741. doi: 10.1002/fsn3.70741.
- PMCID: PMC12314313
Liu Y, et al.

Food Sci Nutr. 2025.

PMCID: PMC12314313

Chinese herbal medicine, as an alternative therapy, can effectively alleviate clinical symptoms of cancer patients by preventing or stabilizing tumor growth. Ganoderma lucidum is a medicinal fungus that contains a variety of bioactive compounds in its fruiting body …

Chinese herbal medicine, as an alternative therapy, can effectively alleviate clinical symptoms of cancer patients by preventing or stabiliz …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Potential Active Compounds of Ganoderma lucidum and Their Anticancer Effects: A Comprehensive Review.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
353.
Quality control of Ganoderma lucidum by using C, H, O, and N stable isotopes and C and N contents for geographical traceability.
- Zhang Y, Jiang K, Chen S, Wang L, Zhang X, Xu W, Yam MF, Wu C, Xu W, Lin Y.
- Front Plant Sci. 2023 Oct 11;14:1234729. doi: 10.3389/fpls.2023.1234729.
- PMCID: PMC10598867
Zhang Y, et al.

Front Plant Sci. 2023.

PMCID: PMC10598867

RATIONALE: Ganoderma lucidum (G. lucidum) is a popular medicinal fungus that has been used in traditional medicine for decades, with its provenance influencing its medicinal and commercial worth. ...CONCLUSION: C, H, O, and N stable isotopes and C and N conte …

RATIONALE: Ganoderma lucidum (G. lucidum) is a popular medicinal fungus that has been used in traditional medicine for …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Quality control of Ganoderma lucidum by using C, H, O, and N stable isotopes and C and N contents for geographical traceability.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Quality/authentication methods study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Analytical validation (specificity/sensitivity), reference standards, and mislabeling rates. Open article.
- Why might this paper be useful to readers? Useful for quality control, sourcing, and preventing adulteration. Open article.
354.
Total Syntheses and Biological Evaluation of the Ganoderma lucidum Alkaloids Lucidimines B and C.
- Chen Y, Lan P.
- ACS Omega. 2018 Mar 26;3(3):3471-3481. doi: 10.1021/acsomega.8b00295.
- PMCID: PMC6045472
Chen Y, et al.

ACS Omega. 2018.

PMCID: PMC6045472

Although a range of pharmacologically active compounds has been obtained from the mycelium and fruiting bodies of Ganoderma lucidum, the biological properties of the alkaloids present in this functional food remain unknown. ...This work thus demonstrates, for the fi …

Although a range of pharmacologically active compounds has been obtained from the mycelium and fruiting bodies of Ganoderma lucidu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Total Syntheses and Biological Evaluation of the Ganoderma lucidum Alkaloids Lucidimines B and C.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
355.
Optimisation of biomass, exopolysaccharide and intracellular polysaccharide production from the mycelium of an identified Ganoderma lucidum strain QRS 5120 using response surface methodology.
- Supramani S, Ahmad R, Ilham Z, Annuar MSM, Klaus A, Wan-Mohtar WAAQI.
- AIMS Microbiol. 2019 Jan 22;5(1):19-38. doi: 10.3934/microbiol.2019.1.19.
- PMCID: PMC6646932
Supramani S, et al.

AIMS Microbiol. 2019.

PMCID: PMC6646932

Wild-cultivated medicinal mushroom Ganoderma lucidum was morphologically identified and sequenced using phylogenetic software. ...Molecularly, the G. lucidum strain QRS 5120 generated 637 base pairs, which was commensurate with related Ganoderma specie …

Wild-cultivated medicinal mushroom Ganoderma lucidum was morphologically identified and sequenced using phylogenetic software. …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Optimisation of biomass, exopolysaccharide and intracellular polysaccharide production from the mycelium of an identified Ganoderma lucidum strain QRS 5120 using response surface methodology.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
356.
Favorable Culture Conditions for Mycelial Growth of Korean Wild Strains in Ganoderma lucidum.
- Jayasinghe C, Imtiaj A, Hur H, Lee GW, Lee TS, Lee UY.
- Mycobiology. 2008 Mar 31;36(1):28-33. doi: 10.4489/MYCO.2008.36.1.028.
- PMCID: PMC3755248
Jayasinghe C, et al.

Mycobiology. 2008.

PMCID: PMC3755248

Ganoderma lucidum (Fr.) Karst (Polyporaceae), belonging to basidiomycota, is one of the most famous medicinal mushrooms. ...Generally, Hamada, Glucose peptone, YM, Mushroom complete and Lilly media were the most suitable for the mycelial growth of G. lucidum. …

Ganoderma lucidum (Fr.) Karst (Polyporaceae), belonging to basidiomycota, is one of the most famous medicinal mushrooms. ...Ge …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Favorable Culture Conditions for Mycelial Growth of Korean Wild Strains in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
357.
Application of Electronic tongue and HPLC in rapid determination of functional triterpenes and origins of Ganoderma lucidum.
- Tian J, Wei J, Liu Y, Li C, Ma C, Kang W.
- Front Nutr. 2024 Oct 21;11:1446956. doi: 10.3389/fnut.2024.1446956.
- PMCID: PMC11532027
Tian J, et al.

Front Nutr. 2024.

PMCID: PMC11532027

INTRODUCTION: Ganoderma lucidum is one well known functional food resource. The triterpenes, such as Ganoderic acid A and Ganoderic acid D, as well as the sensory characteristics could reflect the quality of G. lucidum. METHODS: In order to find rapid methods …

INTRODUCTION: Ganoderma lucidum is one well known functional food resource. The triterpenes, such as Ganoderic acid A and Gano …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Application of Electronic tongue and HPLC in rapid determination of functional triterpenes and origins of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
358.
Effect of Strain, Wood Substrate and Cold Treatment on the Yield and beta-Glucan Content of Ganoderma lucidum Fruiting Bodies.
- Cortina-Escribano M, Pihlava JM, Miina J, Veteli P, Linnakoski R, Vanhanen H.
- Molecules. 2020 Oct 15;25(20):4732. doi: 10.3390/molecules25204732.
- PMCID: PMC7587577
Cortina-Escribano M, et al.

Molecules. 2020.

PMCID: PMC7587577

The aim of this study was to evaluate the suitability of wood residues for the cultivation of Ganoderma lucidum originating from boreal forests. The substrates tested included sawdust and wood chips of Betula spp., Populus tremula, Picea abies, Pinus sylvestris and …

The aim of this study was to evaluate the suitability of wood residues for the cultivation of Ganoderma lucidum originating fr …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effect of Strain, Wood Substrate and Cold Treatment on the Yield and beta-Glucan Content of Ganoderma lucidum Fruiting Bodies.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
359.
Differences in Antioxidants, Polyphenols, Protein Digestibility and Nutritional Profile between Ganoderma lingzhi from Industrial Crops in Asia and Ganoderma lucidum from Cultivation and Iberian Origin.
- Fraile-Fabero R, Ozcariz-Fermoselle MV, Oria-de-Rueda-Salgueiro JA, Garcia-Recio V, Cordoba-Diaz D, Del P Jiménez-López M, Girbés-Juan T.
- Foods. 2021 Jul 29;10(8):1750. doi: 10.3390/foods10081750.
- PMCID: PMC8394434
Fraile-Fabero R, et al.

Foods. 2021.

PMCID: PMC8394434

Carpophores of Ganoderma lingzhi (GZ) from industrial crops in China were analysed and compared with carpophores of three Iberian strains of cultivated Ganoderma lucidum (GL) (Aveiro, Madrid, Palencia) previously genetically characterized. ...

Carpophores of Ganoderma lingzhi (GZ) from industrial crops in China were analysed and compared with carpophores of three Iberian str …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Differences in Antioxidants, Polyphenols, Protein Digestibility and Nutritional Profile between Ganoderma lingzhi from Industrial Crops in Asia and Ganoderma lucidum from Cultivation and Iberian Origin.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Participant-reported outcomes, clinical biomarkers, and safety/tolerability. Open article.
- Why might this paper be useful to readers? Provides early human data; interpret with caution and check study size and endpoints. Open article.
360.
Effects of ganoderic acid A on lipopolysaccharide-induced proinflammatory cytokine release from primary mouse microglia cultures.
- Chi B, Wang S, Bi S, Qin W, Wu D, Luo Z, Gui S, Wang D, Yin X, Wang F.
- Exp Ther Med. 2017 Nov 8;15(1):847-853. doi: 10.3892/etm.2017.5472.
- PMCID: PMC5772755
Chi B, et al.

Exp Ther Med. 2017.

PMCID: PMC5772755

For several thousand years, Ganoderma lucidum (Ling-Zhi in Chinese and Reishi in Japanese) has been widely used as a traditional medication for the prevention and treatment of various diseases in Asia. ...

For several thousand years, Ganoderma lucidum (Ling-Zhi in Chinese and Reishi in Japanese) has been widely used as a tr …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effects of ganoderic acid A on lipopolysaccharide-induced proinflammatory cytokine release from primary mouse microglia cultures.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.

Page 37

361.
Structural characterization of polysaccharides after fermentation from Ganoderma lucidum and its antioxidant activity in HepG2 cells induced by H(2)O(2).
- Zhao Y, Li Q, Wang M, Wang Y, Piao C, Yu H, Liu J, Li Z.
- Food Chem X. 2023 Apr 23;18:100682. doi: 10.1016/j.fochx.2023.100682.
- PMCID: PMC10165195
Zhao Y, et al.

Food Chem X. 2023.

PMCID: PMC10165195

In this study, Lactiplantibacillus plantarum ATCC14917 was used to ferment Ganoderma lucidum spore powder. Two polysaccharides were purified from unfermented (GLP) and fermented (FGLP) Ganoderma lucidum spore powder. ...This experiment is beneficial to …

In this study, Lactiplantibacillus plantarum ATCC14917 was used to ferment Ganoderma lucidum spore powder. Two polysaccharides …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Structural characterization of polysaccharides after fermentation from Ganoderma lucidum and its antioxidant activity in HepG2 cells induced by H(2)O(2).. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
362.
Symptom improvements and adverse effects with Reishi mushroom use: A Cross-Sectional survey of cancer patients.
- Li X, Sun L, Chimonas S, Li SQ, Feng P, Yang Y, Mao JJ.
- Integr Med Res. 2024 Sep 30;13(4):101089. doi: 10.1016/j.imr.2024.101089.
- PMCID: PMC11614793
Li X, et al.

Integr Med Res. 2024.

PMCID: PMC11614793

However, data around patients' experiences with Reishi in oncology are lacking, limiting safe, effective clinical applications. We thus sought to evaluate patient reported benefits and harms of using Reishi. METHODS: We conducted a cross-sectional survey among Chine …

However, data around patients' experiences with Reishi in oncology are lacking, limiting safe, effective clinical applications. We th …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Symptom improvements and adverse effects with Reishi mushroom use: A Cross-Sectional survey of cancer patients.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
363.
High-Pressure Supercritical CO(2) Extracts of Ganoderma lucidum Fruiting Body and Their Anti-hepatoma Effect Associated With the Ras/Raf/MEK/ERK Signaling Pathway.
- Zhu L, Wu M, Li P, Zhou Y, Zhong J, Zhang Z, Li Y, Yao W, Xu J.
- Front Pharmacol. 2020 Dec 14;11:602702. doi: 10.3389/fphar.2020.602702.
- PMCID: PMC7768272
Zhu L, et al.

Front Pharmacol. 2020.

PMCID: PMC7768272

As a noted medicinal mushroom, Ganoderma lucidum (G. lucidum) has been reported to have a number of pharmacological effects such as anti-tumor and liver protection. Compared with the common ethanol reflux method, supercritical CO(2) extraction has obvious adv …

As a noted medicinal mushroom, Ganoderma lucidum (G. lucidum) has been reported to have a number of pharmacological eff …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: High-Pressure Supercritical CO(2) Extracts of Ganoderma lucidum Fruiting Body and Their Anti-hepatoma Effect Associated With the Ras/Raf/MEK/ERK Signaling Pathway.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
364.
Exploring Nutrient Profiles, Phytochemical Composition, and the Antiproliferative Activity of Ganoderma lucidum and Ganoderma leucocontextum: A Comprehensive Comparative Study.
- Peng G, Xiong C, Zeng X, Jin Y, Huang W.
- Foods. 2024 Feb 18;13(4):614. doi: 10.3390/foods13040614.
- PMCID: PMC10888466
Peng G, et al.

Foods. 2024.

PMCID: PMC10888466

Ganoderma, often hailed as a holistic "health package", comprises an array of nutritional components and active compounds, contributing to its esteemed status in the realm of healthy foods. In this study, a comprehensive analysis was performed to elucidate the diverse nutr …

Ganoderma, often hailed as a holistic "health package", comprises an array of nutritional components and active compounds, contributi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Exploring Nutrient Profiles, Phytochemical Composition, and the Antiproliferative Activity of Ganoderma lucidum and Ganoderma leucocontextum: A Comprehensive Comparative Study.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
365.
Promotion of Myelopoiesis in Myelosuppressed Mice by Ganoderma lucidum Polysaccharides.
- Zhu XL, Liu JH, Li WD, Lin ZB.
- Front Pharmacol. 2012 Feb 24;3:20. doi: 10.3389/fphar.2012.00020.
- PMCID: PMC3288721
Zhu XL, et al.

Front Pharmacol. 2012.

PMCID: PMC3288721

Our previous studies demonstrated that Ganoderma lucidum polysaccharides (Gl-PS) exhibit potent immunomodulating effects. Immunomodulation plays an important role in hematopoiesis. ...

Our previous studies demonstrated that Ganoderma lucidum polysaccharides (Gl-PS) exhibit potent immunomodulating effects. Immu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Promotion of Myelopoiesis in Myelosuppressed Mice by Ganoderma lucidum Polysaccharides.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
366.
Growth performance of Ganoderma lucidum using billet method in Garhwal Himalaya, India.
- Bijalwan A, Bahuguna K, Vasishth A, Singh A, Chaudhary S, Dongariyal A, Kumar Thakur T, Kaushik S, Javed Ansari M, Alfarraj S, Ali Alharbi S, Skalicky M, Brestic M.
- Saudi J Biol Sci. 2021 Mar 23;28(5):2709-2717. doi: 10.1016/j.sjbs.2021.03.030.
- PMCID: PMC8117109
Bijalwan A, et al.

Saudi J Biol Sci. 2021.

PMCID: PMC8117109

Medicinal mushrooms have been used in various treatments from a very long time, among which, Ganoderma lucidum is one of the most important medicinal mushroom. It is cultivated worldwide to meet its ever-increasing demand in the market. ...The farmers' field with em …

Medicinal mushrooms have been used in various treatments from a very long time, among which, Ganoderma lucidum is one of the m …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Growth performance of Ganoderma lucidum using billet method in Garhwal Himalaya, India.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
367.
Optimization of exopolysaccharides production from a novel strain of Ganoderma lucidum CAU5501 in submerged culture.
- Yuan B, Chi X, Zhang R.
- Braz J Microbiol. 2012 Jun 1;43(2):490-7. doi: 10.1590/S1517-83822012000200009.
- PMCID: PMC3768814
Yuan B, et al.

Braz J Microbiol. 2012.

PMCID: PMC3768814

This study aimed at optimizing the medium of a new Ganoderma lucidum strain CAU5501 to enhance the yield of exopolysaccharides (EPS) and mycelial growth. ...Results obtained in this study are beneficial to further study for enhancing the production of Ganoderma …

This study aimed at optimizing the medium of a new Ganoderma lucidum strain CAU5501 to enhance the yield of exopolysaccharides …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Optimization of exopolysaccharides production from a novel strain of Ganoderma lucidum CAU5501 in submerged culture.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
368.
Lucidumol A, Purified Directly from Ganoderma lucidum, Exhibits Anticancer Effect and Cellular Inflammatory Response in Colorectal Cancer.
- Shin MJ, Chae HJ, Lee JW, Koo MH, Kim HJ, Seo JB, yanIllia S, Park SH, Lo HE, Kim SH, Youn UJ, Jeon YJ, Suh SS.
- Evid Based Complement Alternat Med. 2022 Nov 8;2022:7404493. doi: 10.1155/2022/7404493.
- PMCID: PMC9666013
Shin MJ, et al.

Evid Based Complement Alternat Med. 2022.

PMCID: PMC9666013

Colorectal cancer (CRC) is a deadly disease regardless of sex, and a few therapeutic approaches have been fully developed at advanced stages, even if some strategies have durable clinical benefits, such as immunotherapy and chemotherapy. Ganoderma lucidum has been r …

Colorectal cancer (CRC) is a deadly disease regardless of sex, and a few therapeutic approaches have been fully developed at advanced stages …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Lucidumol A, Purified Directly from Ganoderma lucidum , Exhibits Anticancer Effect and Cellular Inflammatory Response in Colorectal Cancer.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
369.
Effect of electromagnetic fields and antioxidants on the trace element content of rat teeth.
- Dogan MS, Yavas MC, Yavuz Y, Erdogan S, Yener İ, Simsek İ, Akkus Z, Eratilla V, Tanik A, Akdag MZ.
- Drug Des Devel Ther. 2017 May 4;11:1393-1398. doi: 10.2147/DDDT.S132308.
- PMCID: PMC5422323
Dogan MS, et al.

Drug Des Devel Ther. 2017.

PMCID: PMC5422323

The purpose of this study was to examine the possible effect of extremely low-frequency electromagnetic fields (ELF-EMFs), from a high-voltage source, on rat teeth in terms of changes in trace elements (TEs) and the effect of antioxidants (melatonin [MLT] and Ganoderma …

The purpose of this study was to examine the possible effect of extremely low-frequency electromagnetic fields (ELF-EMFs), from a high-volta …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effect of electromagnetic fields and antioxidants on the trace element content of rat teeth.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
370.
Degradation and Detoxification of Chlorophenols with Different Structure by LAC-4 Laccase Purified from White-Rot Fungus Ganoderma lucidum.
- Deng W, Zhao W, Yang Y.
- Int J Environ Res Public Health. 2022 Jul 2;19(13):8150. doi: 10.3390/ijerph19138150.
- PMCID: PMC9266351
Deng W, et al.

Int J Environ Res Public Health. 2022.

PMCID: PMC9266351

A laccase named LAC-4 was purified from Ganoderma lucidum. Firstly, the enzymatic properties of purified LAC-4 laccase, and the degradation of three chlorophenol pollutants 2,6-dichlorophenol (2,6-DCP), 2,3,6-trichlorophenol (2,3,6-TCP) and 3-chlorophenol (3-CP) by …

A laccase named LAC-4 was purified from Ganoderma lucidum. Firstly, the enzymatic properties of purified LAC-4 laccase, and th …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Degradation and Detoxification of Chlorophenols with Different Structure by LAC-4 Laccase Purified from White-Rot Fungus Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Relevant for eco‑friendly processing, waste upcycling, and industrial biocatalysis. Open article.

Page 38

371.
In Vitro Antimicrobial Efficacy Assessment of Ethanolic, Aqueous, and Dual Solvent Extracts of Mushroom Ganoderma lucidum: Genomic and Morphological Analysis.
- Akamu E, Merrills L, Williams Z, Justice B, Iloghalu U, Williams V, Singh D.
- Antibiotics (Basel). 2024 Nov 21;13(12):1109. doi: 10.3390/antibiotics13121109.
- PMCID: PMC11672760
Akamu E, et al.

Antibiotics (Basel). 2024.

PMCID: PMC11672760

This work aimed to investigate the phytochemical constituents and antimicrobial potential of ethanolic, aqueous, and dual solvent extracts of mushroom Ganoderma lucidum. Methods: The antimicrobial studies were carried out by broth dilution against Gram-positive Stap …

This work aimed to investigate the phytochemical constituents and antimicrobial potential of ethanolic, aqueous, and dual solvent extracts o …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: In Vitro Antimicrobial Efficacy Assessment of Ethanolic, Aqueous, and Dual Solvent Extracts of Mushroom Ganoderma lucidum : Genomic and Morphological Analysis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Maps pathways and components that can guide future lab and clinical research. Open article.
372.
Unraveling the Polysaccharide Biosynthesis Potential of Ganoderma lucidum: A Chromosome-Level Assembly Using Hi-C Sequencing.
- Sonets IV, Dovidchenko NV, Ulianov SV, Yarina MS, Koshechkin SI, Razin SV, Krasnopolskaya LM, Tyakht AV.
- J Fungi (Basel). 2023 Oct 16;9(10):1020. doi: 10.3390/jof9101020.
- PMCID: PMC10608111
Sonets IV, et al.

J Fungi (Basel). 2023.

PMCID: PMC10608111

Ganoderma lucidum exhibits the ability to synthesize a diverse range of biologically active molecules with significant pharmaceutical potential, including xylomannan and fucogalactan, which have demonstrated antitumor activity. ...We employed high-throughput shotgun …

Ganoderma lucidum exhibits the ability to synthesize a diverse range of biologically active molecules with significant pharmac …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Unraveling the Polysaccharide Biosynthesis Potential of Ganoderma lucidum : A Chromosome-Level Assembly Using Hi-C Sequencing.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
373.
Unveiling triterpenoid superiority in a newly developed Ganoderma lucidum variety through untargeted metabolomics approach.
- Pan Z, Lin J, Luo G, Cheng W, Li Y, Wu C.
- Front Nutr. 2025 Apr 10;12:1541162. doi: 10.3389/fnut.2025.1541162.
- PMCID: PMC12018227
Pan Z, et al.

Front Nutr. 2025.

PMCID: PMC12018227

The fruiting bodies of Ganoderma lucidum are renowned for their therapeutic properties, primarily due to their triterpenoid content. Variability in G. lucidum strains may influence the composition and abundance of triterpenoids. In this study, we explored the …

The fruiting bodies of Ganoderma lucidum are renowned for their therapeutic properties, primarily due to their triterpenoid co …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Unveiling triterpenoid superiority in a newly developed Ganoderma lucidum variety through untargeted metabolomics approach.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Broad molecular profiling and pathway/statistical analyses. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
374.
Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs.
- Berger A, Rein D, Kratky E, Monnard I, Hajjaj H, Meirim I, Piguet-Welsch C, Hauser J, Mace K, Niederberger P.
- Lipids Health Dis. 2004 Feb 18;3:2. doi: 10.1186/1476-511X-3-2.
- PMCID: PMC385249
Berger A, et al.

Lipids Health Dis. 2004.

PMCID: PMC385249

We studied cholesterol lowering properties of Ganoderma lucidum (Gl), a renowned medicinal species. RESULTS: Organic fractions containing oxygenated lanosterol derivatives inhibited cholesterol synthesis in T9A4 hepatocytes. ...

We studied cholesterol lowering properties of Ganoderma lucidum (Gl), a renowned medicinal species. RESULTS: Organic fractions …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
375.
Exploring the anti-cancer potential of Ganoderma lucidum polysaccharides (GLPs) and their versatile role in enhancing drug delivery systems: a multifaceted approach to combat cancer.
- Gao X, Homayoonfal M.
- Cancer Cell Int. 2023 Dec 16;23(1):324. doi: 10.1186/s12935-023-03146-8.
- PMCID: PMC10724890
Gao X, et al.

Cancer Cell Int. 2023.

PMCID: PMC10724890

There has been a growing global interest in the potential health benefits of edible natural bioactive products in recent years. Ganoderma lucidum, a medicinal mushroom, has gained attention for its decadent array of therapeutic and pharmaceutical compounds. Notably, …

There has been a growing global interest in the potential health benefits of edible natural bioactive products in recent years. Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Exploring the anti-cancer potential of Ganoderma lucidum polysaccharides (GLPs) and their versatile role in enhancing drug delivery systems: a multifaceted approach to combat cancer.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
376.
Comparative analysis of multifaceted properties of Agaricus bisporus and Ganoderma lucidum macro-fungi powder: Techno-functional and structural characterization, mineral uptake, and photocatalytic activity.
- Singh V, Bains A, Goksen G, Capozzi V, Arjun AD, Ali N, Iqbal M, Chawla P.
- Food Chem X. 2024 Oct 29;24:101937. doi: 10.1016/j.fochx.2024.101937.
- PMCID: PMC11585834
Singh V, et al.

Food Chem X. 2024.

PMCID: PMC11585834

Macro-fungi are recognized for food, medicinal, and environmental applications, therefore, the study focuses on multifaceted nutritional, techno-functional, and bioremediation-related uses of Agaricus bisporus and Ganoderma lucidum powders. Herein, A. bisporus exhib …

Macro-fungi are recognized for food, medicinal, and environmental applications, therefore, the study focuses on multifaceted nutritional, te …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Comparative analysis of multifaceted properties of Agaricus bisporus and Ganoderma lucidum macro-fungi powder: Techno-functional and structural characterization, mineral uptake, and photocatalytic activity.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
377.
Effects of Efficient Expression of Vitreoscilla Hemoglobin on Production, Monosaccharide Composition, and Antioxidant Activity of Exopolysaccharides in Ganoderma lucidum.
- Wang ZX, Li N, Xu JW.
- Microorganisms. 2021 Jul 21;9(8):1551. doi: 10.3390/microorganisms9081551.
- PMCID: PMC8401987
Wang ZX, et al.

Microorganisms. 2021.

PMCID: PMC8401987

A Vitreoscilla hemoglobin (VHb) gene was efficiently expressed by the optimization of codons and intron addition in G. lucidum. Expression of the VHb gene was confirmed by genome PCR, quantitative real-time PCR and carbon monoxide (CO)-difference spectrum analysis in the t …

A Vitreoscilla hemoglobin (VHb) gene was efficiently expressed by the optimization of codons and intron addition in G. lucidum. Expre …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effects of Efficient Expression of Vitreoscilla Hemoglobin on Production, Monosaccharide Composition, and Antioxidant Activity of Exopolysaccharides in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
378.
Hepatoprotective Evaluation of Ganoderma lucidum Pharmacopuncture: In vivo Studies of Ethanol-induced Acute Liver Injury.
- Jang SH, Cho SW, Yoon HM, Jang KJ, Song CH, Kim CH.
- J Pharmacopuncture. 2014 Sep;17(3):16-24. doi: 10.3831/KPI.2014.17.022.
- PMCID: PMC4332019
Jang SH, et al.

J Pharmacopuncture. 2014.

PMCID: PMC4332019

This study was aimed at investigating the protective effect of Ganoderma lucidum pharmacopuncture (GLP) against hepatotoxicity induced by acute ethanol (EtOH) intoxication in rats. ...The NP and the GLP groups were treated daily with injections of normal saline and …

This study was aimed at investigating the protective effect of Ganoderma lucidum pharmacopuncture (GLP) against hepatotoxicity …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Hepatoprotective Evaluation of Ganoderma lucidum Pharmacopuncture: In vivo Studies of Ethanol-induced Acute Liver Injury.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
379.
Effect of Ganoderma lucidum on serum lipid profiles: A systematic review and meta-analysis on animal studies.
- Aref M, Khoshhali M, Ghasemi P, Adeli S, Heidari-Beni M, Kelishadi R.
- J Res Med Sci. 2023 Sep 29;28:70. doi: 10.4103/jrms.jrms_175_23.
- PMCID: PMC10729684
Aref M, et al.

J Res Med Sci. 2023.

PMCID: PMC10729684

BACKGROUND: Ganoderma lucidum (G. lucidum) is one of the most popular edible mushrooms in the world which has various pharmacological components. ...CONCLUSION: G. lucidum has favorable effects on TG, TC, LDL-C, HDL-C, and VLDL. Different doses of G. < …

BACKGROUND: Ganoderma lucidum (G. lucidum) is one of the most popular edible mushrooms in the world which has various p …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effect of Ganoderma lucidum on serum lipid profiles: A systematic review and meta-analysis on animal studies.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
380.
Clinical Isolate of Candida tropicalis from a Patient in North Carolina: Identification, Whole-Genome Sequence Analysis, and Anticandidal Activity of Ganoderma lucidum.
- Ewunkem A, Merrills L, Williams Z, Maness L, Meixner J, Justice B, Iloghalu U, Williams V, Kiki L, Singh D.
- Open J Med Microbiol. Author manuscript. 2025 Mar 5;15(1):11-35. doi: 10.4236/ojmm.2025.151002.
- PMCID: PMC12094522
Ewunkem A, et al.

Open J Med Microbiol. Author manuscript. 2025.

PMCID: PMC12094522

Thus, this study also investigated anticandida activity of three solvent extracts of Ganoderma lucidum against the clinical isolate of Candida sp. The findings of this study provided evidence that Candida tropicalis MYA-3404 was the only strain present in the clinic …

Thus, this study also investigated anticandida activity of three solvent extracts of Ganoderma lucidum against the clinical is …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Clinical Isolate of Candida tropicalis from a Patient in North Carolina: Identification, Whole-Genome Sequence Analysis, and Anticandidal Activity of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 39

381.
Ganoderma lucidum polysaccharide attenuates retinal ischemia-reperfusion injury by regulating microglial M1/M2 polarization, suppressing neuroinflammation and inhibiting JAK2/STAT3 pathway.
- Zhu G, Liu Y, Luo S, Tang C, Zhao C, Lu X.
- Biochem Biophys Rep. 2025 Jan 29;41:101926. doi: 10.1016/j.bbrep.2025.101926.
- PMCID: PMC11815960
Zhu G, et al.

Biochem Biophys Rep. 2025.

PMCID: PMC11815960

In recent years, targeting the suppression of microglia-mediated neuroinflammation has emerged as a principal therapeutic strategy for RIR. Ganoderma lucidum polysaccharide (GLP), a pivotal bioactive extract of Ganoderma lucidum, has been demonstrated …

In recent years, targeting the suppression of microglia-mediated neuroinflammation has emerged as a principal therapeutic strategy for RIR. …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum polysaccharide attenuates retinal ischemia-reperfusion injury by regulating microglial M1/M2 polarization, suppressing neuroinflammation and inhibiting JAK2/STAT3 pathway.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
382.
GC-based chemoprofile of lipophilic compounds in Altaian Ganoderma lucidum sample.
- Shevelev OB, Seryapina AA, Zavjalov EL, Gerlinskaya LA, Goryachkovskaya TN, Slynko NM, Kuibida LV, Peltek SE, Markel AL, Moshkin MP.
- Data Brief. 2018 Mar 26;18:1054-1056. doi: 10.1016/j.dib.2018.03.098.
- PMCID: PMC5996614
Shevelev OB, et al.

Data Brief. 2018.

PMCID: PMC5996614

The presented data contains information about component composition of lipophilic compounds in Ganoderma lucidum fungal body sample obtained using gas chromatography and subsequent mass spectrometry....

The presented data contains information about component composition of lipophilic compounds in Ganoderma lucidum fungal body s …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: GC-based chemoprofile of lipophilic compounds in Altaian Ganoderma lucidum sample.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
383.
Ganoderma lucidum: Current advancements of characteristic components and experimental progress in anti-liver fibrosis.
- Peng H, Zhong L, Cheng L, Chen L, Tong R, Shi J, Bai L.
- Front Pharmacol. 2023 Jan 9;13:1094405. doi: 10.3389/fphar.2022.1094405.
- PMCID: PMC9872944
Peng H, et al.

Front Pharmacol. 2023.

PMCID: PMC9872944

Ganoderma lucidum (G. lucidum, Lingzhi) is a well-known herbal medicine with a variety of pharmacological effects. ...Among them, the triterpenoids and polysaccharide components of G. lucidum have a wide range of anti-liver fibrotic effects. Currently, …

Ganoderma lucidum (G. lucidum, Lingzhi) is a well-known herbal medicine with a variety of pharmacological effects. ...A …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum : Current advancements of characteristic components and experimental progress in anti-liver fibrosis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
384.
Antifibrotic activity a fermentation filtrate of Ganoderma lucidum.
- Kwon SC, Kim YB.
- Lab Anim Res. 2011 Dec 19;27(4):369-71. doi: 10.5625/lar.2011.27.4.369.
- PMCID: PMC3251772
Kwon SC, et al.

Lab Anim Res. 2011.

PMCID: PMC3251772

The effects of a fermentation filtrate of Ganoderma lucidum (FGL) on carbon tetrachloride (CCl(4))-induced hepatic fibrosis were investigated in rats. ...

The effects of a fermentation filtrate of Ganoderma lucidum (FGL) on carbon tetrachloride (CCl(4))-induced hepatic fibrosis we …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antifibrotic activity a fermentation filtrate of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
385.
WSG, a Glucose-Rich Polysaccharide from Ganoderma lucidum, Combined with Cisplatin Potentiates Inhibition of Lung Cancer In Vitro and In Vivo.
- Qiu WL, Hsu WH, Tsao SM, Tseng AJ, Lin ZH, Hua WJ, Yeh H, Lin TE, Chen CC, Chen LS, Lin TY.
- Polymers (Basel). 2021 Dec 13;13(24):4353. doi: 10.3390/polym13244353.
- PMCID: PMC8705874
Qiu WL, et al.

Polymers (Basel). 2021.

PMCID: PMC8705874

In this study, we investigated the effect of WSG, a glucose-rich, water soluble polysaccharide derived from Ganoderma lucidum, on cisplatin-based treatment for lung cancer. Murine Lewis lung carcinoma (LLC1) cells were injected into C57BL/6 mice subcutaneously and t …

In this study, we investigated the effect of WSG, a glucose-rich, water soluble polysaccharide derived from Ganoderma lucidum, …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: WSG, a Glucose-Rich Polysaccharide from Ganoderma lucidum , Combined with Cisplatin Potentiates Inhibition of Lung Cancer In Vitro and In Vivo.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
386.
Recombinant Expression and Bioactivity Comparison of Four Typical Fungal Immunomodulatory Proteins from Three Main Ganoderma Species.
- Qu ZW, Zhou SY, Guan SX, Gao R, Duan ZW, Zhang X, Sun WY, Fan WL, Chen SS, Chen LJ, Lin JW, Ruan YY.
- BMC Biotechnol. 2018 Dec 14;18(1):80. doi: 10.1186/s12896-018-0488-0.
- PMCID: PMC6295072
Qu ZW, et al.

BMC Biotechnol. 2018.

PMCID: PMC6295072

In the current study, two FIP genes termed FIP-gap1 and FIP-gap2 from G. applanatum, along with LZ-8 and FIP-gsi, another two representative Ganoderma FIP genes from G. lucidum and G. sinense were functionally expressed in Pichia. ...Both similarities and difference …

In the current study, two FIP genes termed FIP-gap1 and FIP-gap2 from G. applanatum, along with LZ-8 and FIP-gsi, another two representative …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Recombinant Expression and Bioactivity Comparison of Four Typical Fungal Immunomodulatory Proteins from Three Main Ganoderma Species.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
387.
Prophylactic Use of Ganoderma lucidum Extract May Inhibit Mycobacterium tuberculosis Replication in a New Mouse Model of Spontaneous Latent Tuberculosis Infection.
- Zhan L, Tang J, Lin S, Xu Y, Xu Y, Qin C.
- Front Microbiol. 2016 Jan 8;6:1490. doi: 10.3389/fmicb.2015.01490.
- PMCID: PMC4705449
Zhan L, et al.

Front Microbiol. 2016.

PMCID: PMC4705449

The model was used to demonstrate the comparative effects of prophylactic and therapeutic administration of Ganoderma lucidum extract (spores and spores lipid) in preventing H37Rv replication in both lung and spleen. H37Rv was inhibited with prophylactic use of G. < …

The model was used to demonstrate the comparative effects of prophylactic and therapeutic administration of Ganoderma lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Prophylactic Use of Ganoderma lucidum Extract May Inhibit Mycobacterium tuberculosis Replication in a New Mouse Model of Spontaneous Latent Tuberculosis Infection.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
388.
Inhibitory effects of Ganoderma lucidum triterpenoid on the growth and metastasis of hepatocellular carcinoma.
- Ding Z, Zhou Z, Cheng X, Wang H, Liu J, Cai Y, Liu H, Lv M, Pan Y, Xiao E.
- Am J Transl Res. 2023 May 15;15(5):3410-3423.
- PMCID: PMC10251039
Ding Z, et al.

Am J Transl Res. 2023.

PMCID: PMC10251039

OBJECTIVE: To investigate the inhibitory effects and mechanisms of triterpenoids from Ganoderma lucidum (G. lucidum triterpenoids) on the growth and metastasis of hepatocellular carcinoma (HCC) both in vitro and in vivo. ...RESULTS: i. In in-vitro experiments …

OBJECTIVE: To investigate the inhibitory effects and mechanisms of triterpenoids from Ganoderma lucidum (G. lucidum tri …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Inhibitory effects of Ganoderma lucidum triterpenoid on the growth and metastasis of hepatocellular carcinoma.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
389.
Characterizing novel anti-oncogenic triterpenoids from ganoderma.
- Li X, Xie Y, Yang BB.
- Cell Cycle. 2018;17(5):527-528. doi: 10.1080/15384101.2017.1315493.
- PMCID: PMC5969549
Li X, et al.

Cell Cycle. 2018.

PMCID: PMC5969549
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Characterizing novel anti-oncogenic triterpenoids from ganoderma .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
390.
Selective Antineoplastic Potential of Fractionated Caribbean Native Ganoderma Species Extracts on Triple-Negative Breast Cancer Cells.
- Arroyo-Cruz LV, Sagardía-González S, Miller K, Ling T, Rivas F, Martínez-Montemayor MM.
- Pharmaceuticals (Basel). 2024 Jul 1;17(7):864. doi: 10.3390/ph17070864.
- PMCID: PMC11279663
Arroyo-Cruz LV, et al.

Pharmaceuticals (Basel). 2024.

PMCID: PMC11279663

Natural products derived from mushrooms have gained significant attention in neoplastic therapy due to their potential medicinal properties. The therapeutic potential of Ganoderma lucidum in breast cancer has been highlighted by our group, suggesting its use as an a …

Natural products derived from mushrooms have gained significant attention in neoplastic therapy due to their potential medicinal properties. …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Selective Antineoplastic Potential of Fractionated Caribbean Native Ganoderma Species Extracts on Triple-Negative Breast Cancer Cells.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 40

391.
Dynamic succession of substrate-associated bacterial composition and function during Ganoderma lucidum growth.
- Zhang B, Yan L, Li Q, Zou J, Tan H, Tan W, Peng W, Li X, Zhang X.
- PeerJ. 2018 Jun 13;6:e4975. doi: 10.7717/peerj.4975.
- PMCID: PMC6004108
Zhang B, et al.

PeerJ. 2018.

PMCID: PMC6004108

BACKGROUND: Ganoderma lucidum, a valuable medicinal fungus, is widely distributed in China. It grows alongside with a complex microbial ecosystem in the substrate. ...DISCUSSION: The changes in bacterial community composition, diversity and predicted functions were …

BACKGROUND: Ganoderma lucidum, a valuable medicinal fungus, is widely distributed in China. It grows alongside with a complex …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Dynamic succession of substrate-associated bacterial composition and function during Ganoderma lucidum growth.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
392.
Effects of Ganoderma lucidum polysaccharide peptide ameliorating cyclophosphamide-induced immune dysfunctions based on metabolomics analysis.
- Xie J, Lin D, Li J, Zhou T, Lin S, Lin Z.
- Front Nutr. 2023 May 25;10:1179749. doi: 10.3389/fnut.2023.1179749.
- PMCID: PMC10248424
Xie J, et al.

Front Nutr. 2023.

PMCID: PMC10248424

Ganoderma lucidum polysaccharide peptide (GLPP) is one of the most abundant constituents of Ganoderma lucidum (G. lucidum), with a wide range of functional activities. ...

Ganoderma lucidum polysaccharide peptide (GLPP) is one of the most abundant constituents of Ganoderma lucidum (G …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effects of Ganoderma lucidum polysaccharide peptide ameliorating cyclophosphamide-induced immune dysfunctions based on metabolomics analysis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
393.
Ganoderma lucidum polysaccharides eradicates the blocking effect of fibrinogen on NK cytotoxicity against melanoma cells.
- Zheng S, Jia Y, Zhao J, Wei Q, Liu Y.
- Oncol Lett. 2011 Dec 6;3(3):613-616. doi: 10.3892/ol.2011.515.
- PMCID: PMC3362652
Zheng S, et al.

Oncol Lett. 2011.

PMCID: PMC3362652

However, NK cytotoxicity against tumor cells may be inhibited by a fibrinogen coat adhered to the surface of tumor cells. Ganoderma lucidum (G. lucidum) polysaccharides have been reported for their inhibitory ability on the adhesion of type I collagen, hyalur …

However, NK cytotoxicity against tumor cells may be inhibited by a fibrinogen coat adhered to the surface of tumor cells. Ganoderma < …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum polysaccharides eradicates the blocking effect of fibrinogen on NK cytotoxicity against melanoma cells.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
394.
Influence of cultivation substrate on antioxidant activities and triterpenoid profiles of the fruiting body of Ganoderma lucidum.
- Luo G, Pan Z, Liu Z, Cheng W, Yu T.
- Front Nutr. 2024 Feb 7;11:1329579. doi: 10.3389/fnut.2024.1329579.
- PMCID: PMC10879320
Luo G, et al.

Front Nutr. 2024.

PMCID: PMC10879320

INTRODUCTION: The fruiting body of Ganoderma lucidum has been believed to possess a wide range of therapeutic effects. There are two main methods for artificial cultivation of G. lucidum to produce the fruiting body, namely wood log cultivation and substitute …

INTRODUCTION: The fruiting body of Ganoderma lucidum has been believed to possess a wide range of therapeutic effects. There a …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Influence of cultivation substrate on antioxidant activities and triterpenoid profiles of the fruiting body of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
395.
Removing the sporoderm from the sporoderm-broken spores of Ganoderma lucidum improves the anticancer and immune-regulatory activity of the water-soluble polysaccharide.
- Fang L, Zhao Q, Guo C, Guo D, Li Z, Xu J, Guo C, Sang T, Wang Y, Chen J, Chen C, Chen R, Wu J, Wang X.
- Front Nutr. 2022 Sep 16;9:1006127. doi: 10.3389/fnut.2022.1006127.
- PMCID: PMC9524850
Fang L, et al.

Front Nutr. 2022.

PMCID: PMC9524850

The aim of the current study was to compare the chemical property and the anticancer effects of polysaccharides extracted from the sporoderm-removed spores of the medicinal mushroom Ganoderma lucidum (RSGLP), which removed the sporoderm completely, with polysacchari …

The aim of the current study was to compare the chemical property and the anticancer effects of polysaccharides extracted from the sporoderm …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Removing the sporoderm from the sporoderm-broken spores of Ganoderma lucidum improves the anticancer and immune-regulatory activity of the water-soluble polysaccharide.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
396.
Generation and analysis of expressed sequence tags from a cDNA library of the fruiting body of Ganoderma lucidum.
- Luo H, Sun C, Song J, Lan J, Li Y, Li X, Chen S.
- Chin Med. 2010 Mar 16;5:9. doi: 10.1186/1749-8546-5-9.
- PMCID: PMC2848221
Luo H, et al.

Chin Med. 2010.

PMCID: PMC2848221

BACKGROUND: Little genomic or trancriptomic information on Ganoderma lucidum (Lingzhi) is known. This study aims to discover the transcripts involved in secondary metabolite biosynthesis and developmental regulation of G. lucidum using an expressed sequence t …

BACKGROUND: Little genomic or trancriptomic information on Ganoderma lucidum (Lingzhi) is known. This study aims to discover t …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Generation and analysis of expressed sequence tags from a cDNA library of the fruiting body of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
397.
Biochemical and Pharmacological aspects of Ganoderma lucidum: Exponent from the in vivo and computational investigations.
- Hossen SMM, Yusuf ATM, Emon NU, Alam N, Sami SA, Polash SH, Nur MA, Mitra S, Uddin MH, Emran TB.
- Biochem Biophys Rep. 2022 Nov 7;32:101371. doi: 10.1016/j.bbrep.2022.101371.
- PMCID: PMC9650014
Hossen SMM, et al.

Biochem Biophys Rep. 2022.

PMCID: PMC9650014

Ganoderma lucidum is known as lingzhi mushroom, which is said to have medicinal properties by the local residents. ...The antidepressant, anxiolytic, and sedative properties of the methanol extracts of G. lucidum (MEGL) were assessed using the forced swim tes …

Ganoderma lucidum is known as lingzhi mushroom, which is said to have medicinal properties by the local residents. ...The anti …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Biochemical and Pharmacological aspects of Ganoderma lucidum : Exponent from the in vivo and computational investigations.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
398.
Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides.
- Wei B, Zhang R, Zhai J, Zhu J, Yang F, Yue D, Liu X, Lu C, Sun X.
- J Immunol Res. 2018 May 20;2018:2906494. doi: 10.1155/2018/2906494.
- PMCID: PMC5985119
Wei B, et al.

J Immunol Res. 2018.

PMCID: PMC5985119

BACKGROUND: Ganoderma lucidum polysaccharides (GLP) has anti-inflammatory and immunomodulatory effects. ...

BACKGROUND: Ganoderma lucidum polysaccharides (GLP) has anti-inflammatory and immunomodulatory effects. ...
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
399.
Exploring the Protective and Reparative Mechanisms of G. lucidum Polysaccharides Against H(2)O(2)-Induced Oxidative Stress in Human Skin Fibroblasts.
- Shi X, Cheng W, Wang Q, Zhang J, Wang C, Li M, Zhao D, Wang D, An Q.
- Clin Cosmet Investig Dermatol. 2021 Oct 14;14:1481-1496. doi: 10.2147/CCID.S334527.
- PMCID: PMC8525518
Shi X, et al.

Clin Cosmet Investig Dermatol. 2021.

PMCID: PMC8525518

BACKGROUND: Ganoderma lucidum (G. lucidum) is one of China's traditional medicinal materials. G. lucidum polysaccharide has a wide range of promising pharmacological applications. However, there are many kinds of G. lucidum and they contain diff …

BACKGROUND: Ganoderma lucidum (G. lucidum) is one of China's traditional medicinal materials. G. lucidum polysac …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Exploring the Protective and Reparative Mechanisms of G. lucidum Polysaccharides Against H(2)O(2)-Induced Oxidative Stress in Human Skin Fibroblasts.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
400.
Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial.
- Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X.
- Evid Based Complement Alternat Med. 2011 Dec 10;2012:809614. doi: 10.1155/2012/809614.
- PMCID: PMC3236089
Zhao H, et al.

Evid Based Complement Alternat Med. 2011.

PMCID: PMC3236089

The aim of this study was to investigate the effectiveness of spore powder of Ganoderma lucidum for cancer-related fatigue in breast cancer patients undergoing endocrine therapy. ...This pilot study suggests that spore powder of Ganoderma lucidum may h …

The aim of this study was to investigate the effectiveness of spore powder of Ganoderma lucidum for cancer-related fatigue in …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Participant-reported outcomes, clinical biomarkers, and safety/tolerability. Open article.
- Why might this paper be useful to readers? Provides early human data; interpret with caution and check study size and endpoints. Open article.

Page 41

401.
Antiprotozoal activity of Boesenbergia rotunda (L.) Mansf and Ganoderma lucidum (Fr.) Kart extracts against Blastocystis hominis.
- Kaewjai C, Tonsomboon A, Pawiwongchai J, Prommano AO.
- Vet World. 2023 Jan 28;16(1):187-193. doi: 10.14202/vetworld.2023.187-193.
- PMCID: PMC9967722
Kaewjai C, et al.

Vet World. 2023.

PMCID: PMC9967722

This study aimed to determine the antiprotozoal activity of Boesenbergia rotunda (L.) Mansf and Ganoderma lucidum (Fr.) Kart extracts against B. hominis. MATERIALS AND METHODS: Antiprotozoal activity of B. rotunda and G. lucidum extracts against B. hominis su …

This study aimed to determine the antiprotozoal activity of Boesenbergia rotunda (L.) Mansf and Ganoderma lucidum (Fr.) Kart e …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antiprotozoal activity of Boesenbergia rotunda (L.) Mansf and Ganoderma lucidum (Fr.) Kart extracts against Blastocystis hominis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
402.
The Addition of Reishi and Lion's Mane Mushroom Powder to Pasta Influences the Content of Bioactive Compounds and the Antioxidant, Potential Anti-Inflammatory, and Anticancer Properties of Pasta.
- Szydłowska-Tutaj M, Szymanowska U, Tutaj K, Domagała D, Złotek U.
- Antioxidants (Basel). 2023 Mar 17;12(3):738. doi: 10.3390/antiox12030738.
- PMCID: PMC10044984
Szydłowska-Tutaj M, et al.

Antioxidants (Basel). 2023.

PMCID: PMC10044984

The influence of a 2.5% and 5% addition of dried Reishi and Lion's Mane mushrooms on the content of bioactive compounds and some pro-health properties of pasta was studied. ...In conclusion, the results suggest that Reishi and Lion's Mane mushroom powder can be used …

The influence of a 2.5% and 5% addition of dried Reishi and Lion's Mane mushrooms on the content of bioactive compounds and some pro- …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The Addition of Reishi and Lion's Mane Mushroom Powder to Pasta Influences the Content of Bioactive Compounds and the Antioxidant, Potential Anti-Inflammatory, and Anticancer Properties of Pasta.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
403.
Antifungal-demelanizing properties and RAW264.7 macrophages stimulation of glucan sulfate from the mycelium of the mushroom Ganoderma lucidum.
- Wan-Mohtar WAAQI, Viegelmann C, Klaus A, Lim SAH.
- Food Sci Biotechnol. 2017 Feb 28;26(1):159-165. doi: 10.1007/s10068-017-0021-6.
- PMCID: PMC6049470
Wan-Mohtar WAAQI, et al.

Food Sci Biotechnol. 2017.

PMCID: PMC6049470

Underutilized mycelium of Ganoderma lucidum BCCM 31549 has been a significant source of a glucan sulfate (GS) possessing therapeutic activities. ...The results highlight a novel bifunctional property of mycelial GS from G. lucidum....

Underutilized mycelium of Ganoderma lucidum BCCM 31549 has been a significant source of a glucan sulfate (GS) possessing thera …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antifungal-demelanizing properties and RAW264.7 macrophages stimulation of glucan sulfate from the mycelium of the mushroom Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
404.
Microbial communities and soil chemical features associated with commercial production of the medicinal mushroom Ganoderma lingzhi in soil.
- Ke LQ, Li PD, Xu JP, Wang QS, Wang LL, Wen HP.
- Sci Rep. 2019 Nov 1;9(1):15839. doi: 10.1038/s41598-019-52368-2.
- PMCID: PMC6825212
Ke LQ, et al.

Sci Rep. 2019.

PMCID: PMC6825212

Here in this study, we analyzed the production of the medicinal mushroom Ganoderma lingzhi and the associated soil microbial communities and soil chemical features over 24 months from April 2015 to April 2017. ...

Here in this study, we analyzed the production of the medicinal mushroom Ganoderma lingzhi and the associated soil microbial communit …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Microbial communities and soil chemical features associated with commercial production of the medicinal mushroom Ganoderma lingzhi in soil.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
405.
Ganoderma spore powder contains little triterpenoids.
- Liu MT, Chen LX, Zhao J, Li SP.
- Chin Med. 2020 Oct 12;15:111. doi: 10.1186/s13020-020-00391-1.
- PMCID: PMC7552346
Liu MT, et al.

Chin Med. 2020.

PMCID: PMC7552346

BACKGROUND: Ganoderma spore is a minuscule germ cell ejected from Ganoderma gills during its growth maturity period, it has been considered with high exploitable potential in health-care products manufacture. METHODS: After testing sporoderm-broken rate, the triterp …

BACKGROUND: Ganoderma spore is a minuscule germ cell ejected from Ganoderma gills during its growth maturity period, it has be …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma spore powder contains little triterpenoids.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
406.
Research progress of Ganoderma lucidum polysaccharide in prevention and treatment of Atherosclerosis.
- Ma Y, Han J, Wang K, Han H, Hu Y, Li H, Wu S, Zhang L.
- Heliyon. 2024 Jun 19;10(12):e33307. doi: 10.1016/j.heliyon.2024.e33307.
- PMCID: PMC11253544
Ma Y, et al.

Heliyon. 2024.

PMCID: PMC11253544

As such, traditional Chinese medicine (TCM) has been widely used recently due to its stable therapeutic effect and high safety. Ganoderma lucidum polysaccharides (GLP) are the main active ingredients of Ganoderma lucidum, a Chinese herbal medicine. ...

As such, traditional Chinese medicine (TCM) has been widely used recently due to its stable therapeutic effect and high safety. Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Research progress of Ganoderma lucidum polysaccharide in prevention and treatment of Atherosclerosis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
407.
Ganoderma lucidum Polysaccharides Induce Macrophage-Like Differentiation in Human Leukemia THP-1 Cells via Caspase and p53 Activation.
- Hsu JW, Huang HC, Chen ST, Wong CH, Juan HF.
- Evid Based Complement Alternat Med. 2011 Jan 4;2011:358717. doi: 10.1093/ecam/nep107.
- PMCID: PMC3135330
Hsu JW, et al.

Evid Based Complement Alternat Med. 2011.

PMCID: PMC3135330

In our previous study, we found that fucose-containing polysaccharide fraction F3 extracted from Ganoderma lucidum can bring about cytokine secretion and cell death in human leukemia THP-1 cells. ...

In our previous study, we found that fucose-containing polysaccharide fraction F3 extracted from Ganoderma lucidum can bring a …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Polysaccharides Induce Macrophage-Like Differentiation in Human Leukemia THP-1 Cells via Caspase and p53 Activation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
408.
Ganoderma lucidum extract (GLE) impairs breast cancer stem cells by targeting the STAT3 pathway.
- Rios-Fuller TJ, Ortiz-Soto G, Lacourt-Ventura M, Maldonado-Martinez G, Cubano LA, Schneider RJ, Martinez-Montemayor MM.
- Oncotarget. 2018 Nov 13;9(89):35907-35921. doi: 10.18632/oncotarget.26294.
- PMCID: PMC6267592
Rios-Fuller TJ, et al.

Oncotarget. 2018.

PMCID: PMC6267592

The signal transducer and activator of transcription 3 (STAT3) pathway participates in the development and progression of BCSCs, but its role in TNBC remains unclear. Here, we report that Ganoderma lucidum extract (GLE), a medicinal mushroom with anticancer activity …

The signal transducer and activator of transcription 3 (STAT3) pathway participates in the development and progression of BCSCs, but its rol …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum extract (GLE) impairs breast cancer stem cells by targeting the STAT3 pathway.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
409.
Chemical composition, antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts.
- Veljović S, Veljović M, Nikićević N, Despotović S, Radulović S, Nikšić M, Filipović L.
- J Food Sci Technol. 2017 Mar 10;54(5):1312-1320. doi: 10.1007/s13197-017-2559-y.
- PMCID: PMC5380636
Veljović S, et al.

J Food Sci Technol. 2017.

PMCID: PMC5380636

The content of phenolic compounds (TPC) and glucans, as well as the effectiveness of antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts were determined and compared. The content of glucans (total, alpha- and beta-) …

The content of phenolic compounds (TPC) and glucans, as well as the effectiveness of antiproliferative and antioxidant activity of different …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Chemical composition, antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
410.
Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology.
- Guggenheim AG, Wright KM, Zwickey HL.
- Integr Med (Encinitas). 2014 Feb;13(1):32-44.
- PMCID: PMC4684115
Guggenheim AG, et al.

Integr Med (Encinitas). 2014.

PMCID: PMC4684115

This review discusses the immunological roles of 5 major mushrooms in oncology: Agaricus blazei, Cordyceps sinensis, Grifola frondosa, Ganoderma lucidum, and Trametes versicolor. These mushrooms were selected based on the body of research performed on mushroom immun …

This review discusses the immunological roles of 5 major mushrooms in oncology: Agaricus blazei, Cordyceps sinensis, Grifola frondosa, Ga …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 42

411.
Polysaccharides from sporoderm-removed spores of Ganoderma lucidum induce apoptosis in human gastric cancer cells via disruption of autophagic flux.
- Zhong J, Fang L, Chen R, Xu J, Guo D, Guo C, Guo C, Chen J, Chen C, Wang X.
- Oncol Lett. 2021 Mar 29;21(5):425. doi: 10.3892/ol.2021.12686.
- PMCID: PMC8025153
Zhong J, et al.

Oncol Lett. 2021.

PMCID: PMC8025153

The sporoderm-broken spores of Ganoderma lucidum (G. lucidum) polysaccharide (BSGLP) have been demonstrated to inhibit carcinogenesis in several types of cancer. However, to the best of our knowledge, the anticancer effects of polysaccharides extracted from t …

The sporoderm-broken spores of Ganoderma lucidum (G. lucidum) polysaccharide (BSGLP) have been demonstrated to inhibit …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Polysaccharides from sporoderm-removed spores of Ganoderma lucidum induce apoptosis in human gastric cancer cells via disruption of autophagic flux.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
412.
Novel Insights into the Mechanism Underlying High Polysaccharide Yield in Submerged Culture of Ganoderma lucidum Revealed by Transcriptome and Proteome Analyses.
- Wang Q, Xu M, Zhao L, Chen L, Ding Z.
- Microorganisms. 2023 Mar 17;11(3):772. doi: 10.3390/microorganisms11030772.
- PMCID: PMC10055881
Wang Q, et al.

Microorganisms. 2023.

PMCID: PMC10055881

Polysaccharides are crucial dietary supplements and traditional pharmacological components of Ganoderma lucidum; however, the mechanisms responsible for high polysaccharide yields in G. lucidum remain unclear. ...Our findings provide new insights into the mec …

Polysaccharides are crucial dietary supplements and traditional pharmacological components of Ganoderma lucidum; however, the …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Novel Insights into the Mechanism Underlying High Polysaccharide Yield in Submerged Culture of Ganoderma lucidum Revealed by Transcriptome and Proteome Analyses.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
413.
Screening Immunoactive Compounds of Ganoderma lucidum Spores by Mass Spectrometry Molecular Networking Combined With in vivo Zebrafish Assays.
- Li Z, Shi Y, Zhang X, Xu J, Wang H, Zhao L, Wang Y.
- Front Pharmacol. 2020 Mar 18;11:287. doi: 10.3389/fphar.2020.00287.
- PMCID: PMC7093641
Li Z, et al.

Front Pharmacol. 2020.

PMCID: PMC7093641

Ganoderma lucidum is a well-known herbal remedy widely used for treating various chronic diseases. Traditionally, the fruiting body is regarded as the medicinal part of this fungus, while recently, the therapeutic potentials of Ganoderma lucidum spore …

Ganoderma lucidum is a well-known herbal remedy widely used for treating various chronic diseases. Traditionally, the fruiting …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Screening Immunoactive Compounds of Ganoderma lucidum Spores by Mass Spectrometry Molecular Networking Combined With in vivo Zebrafish Assays.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
414.
Breeding a new Ganoderma lucidum strain with increased contents of individual ganoderic acids by mono-mono crossing of genetically modified monokaryons.
- Zhou DX, Kong XM, Huang XM, Li N, Feng N, Xu JW.
- Front Microbiol. 2024 May 30;15:1410368. doi: 10.3389/fmicb.2024.1410368.
- PMCID: PMC11169689
Zhou DX, et al.

Front Microbiol. 2024.

PMCID: PMC11169689

Ganoderic acids (GAs) are major functional components of Ganoderma lucidum. The study aimed to breed a new G. lucidum strain with increased contents of individual GAs. ...In summary, we developed a new G. lucidum strain with higher contents of individu …

Ganoderic acids (GAs) are major functional components of Ganoderma lucidum. The study aimed to breed a new G. lucidum s …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Breeding a new Ganoderma lucidum strain with increased contents of individual ganoderic acids by mono-mono crossing of genetically modified monokaryons.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
415.
Green Synthesis of Ganoderma Lucidum-Mediated Silver Nanoparticles and its Microbial Activity against Oral Pathogenic Microbes: An In Vitro Study.
- Parameswari BD, Rajakumar M, Hariharan A, Kumar S, Mohamed K, Ballal S.
- J Pharm Bioallied Sci. 2024 Apr 16;16(Suppl 2):S1456-S1460. doi: 10.4103/jpbs.jpbs_933_23.
- PMCID: PMC11174218
Parameswari BD, et al.

J Pharm Bioallied Sci. 2024.

PMCID: PMC11174218

More than 200 active ingredients, including water-soluble, organic-soluble, and volatile chemicals, are found in Ganoderma. The main components are polysaccharides, adenosine, and terpenoids, each of which has exceptional therapeutic properties. This article explains the s …

More than 200 active ingredients, including water-soluble, organic-soluble, and volatile chemicals, are found in Ganoderma. The main …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Green Synthesis of Ganoderma Lucidum -Mediated Silver Nanoparticles and its Microbial Activity against Oral Pathogenic Microbes: An In Vitro Study.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
416.
CD8(+) T Cell-Mediated Therapeutic Antitumor Effect of an Herbal Mixture Containing Ganoderma lucidum.
- Takaku S, Shimizu M, Morita R.
- Evid Based Complement Alternat Med. 2023 Apr 28;2023:9630816. doi: 10.1155/2023/9630816.
- PMCID: PMC10162866
Takaku S, et al.

Evid Based Complement Alternat Med. 2023.

PMCID: PMC10162866

In this study, we determined whether oral administration of an herbal mixture containing Ganoderma lucidum (WTMCGEP; Wisteria floribunda, Trapae fructus, Myristica fragrans, Coicis semen, Ganoderma lucidum, Elfvingia applanata, and Punica granatum), an …

In this study, we determined whether oral administration of an herbal mixture containing Ganoderma lucidum (WTMCGEP; Wisteria …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: CD8(+) T Cell-Mediated Therapeutic Antitumor Effect of an Herbal Mixture Containing Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
417.
Polysaccharide peptide isolated from grass-cultured Ganoderma lucidum induces anti-proliferative and pro-apoptotic effects in the human U251 glioma cell line.
- Wang C, Lin D, Chen Q, Lin S, Shi S, Chen C.
- Oncol Lett. 2018 Jan 19;15(4):4330-4336. doi: 10.3892/ol.2018.7823.
- PMCID: PMC5835855
Wang C, et al.

Oncol Lett. 2018.

PMCID: PMC5835855

The Ganoderma lucidum (G. lucidum) mushroom is one of the most extensively studied functional foods, known for its numerous health benefits, including the inhibition of tumor cell growth. The present study assessed the anti-proliferative and pro-apoptotic act …

The Ganoderma lucidum (G. lucidum) mushroom is one of the most extensively studied functional foods, known for its nume …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Polysaccharide peptide isolated from grass-cultured Ganoderma lucidum induces anti-proliferative and pro-apoptotic effects in the human U251 glioma cell line.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
418.
Modulation of Lipoprotein Cholesterol Levels in Plasmodium berghei Malarial Infection by Crude Aqueous Extract of Ganoderma lucidum.
- Oluba OM, Olusola AO, Eidangbe GO, Babatola LJ, Onyeneke EC.
- Cholesterol. 2012 Jul 25;2012:536396. doi: 10.1155/2012/536396.
- PMCID: PMC3410371
Oluba OM, et al.

Cholesterol. 2012.

PMCID: PMC3410371

In this study, attempt is made to establish changes in serum and liver lipoprotein cholesterols accompanying Plasmodium berghei malarial infection in mice treated with aqueous extract of Ganoderma lucidum at 100, 250, and 500 mg/kg body weight in comparison with 15 …

In this study, attempt is made to establish changes in serum and liver lipoprotein cholesterols accompanying Plasmodium berghei malarial inf …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Modulation of Lipoprotein Cholesterol Levels in Plasmodium berghei Malarial Infection by Crude Aqueous Extract of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
419.
Effects of sporoderm-broken spores of Ganoderma lucidum on growth performance, antioxidant function and immune response of broilers.
- Liu T, Zhou J, Li W, Rong X, Gao Y, Zhao L, Fan Y, Zhang J, Ji C, Ma Q.
- Anim Nutr. 2019 Dec 23;6(1):39-46. doi: 10.1016/j.aninu.2019.11.005.
- PMCID: PMC7082644
Liu T, et al.

Anim Nutr. 2019.

PMCID: PMC7082644

This study was conducted to evaluate the effects of sporoderm-broken spores of Ganoderma lucidum (SSGL), a traditional Chinese medicinal herb, on growth performance, antioxidant ability, and immunity of broilers. ...

This study was conducted to evaluate the effects of sporoderm-broken spores of Ganoderma lucidum (SSGL), a traditional Chinese …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effects of sporoderm-broken spores of Ganoderma lucidum on growth performance, antioxidant function and immune response of broilers.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
420.
Ganoderma Lucidum Protects Rat Brain Tissue Against Trauma-Induced Oxidative Stress.
- Özevren H, İrtegün S, Deveci E, Aşır F, Pektanç G, Deveci Ş.
- Korean J Neurotrauma. 2017 Oct 31;13(2):76-84. doi: 10.13004/kjnt.2017.13.2.76.
- PMCID: PMC5702762
Özevren H, et al.

Korean J Neurotrauma. 2017.

PMCID: PMC5702762

This study aims to investigate the protective influence of antioxidant Ganoderma lucidum (G. lucidum) polysaccharides (GLPs) on brain injury in brain-traumatized rats. ...Groups were categorized as control, G. lucidum, trauma, trauma+ G. lucidum …

This study aims to investigate the protective influence of antioxidant Ganoderma lucidum (G. lucidum) polysaccharides ( …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma Lucidum Protects Rat Brain Tissue Against Trauma-Induced Oxidative Stress.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 43

421.
Pharmacokinetic, Metabolomic, and Stability Assessment of Ganoderic Acid H Based Triterpenoid Enriched Fraction of Ganoderma lucidum P. Karst.
- Ansari MHR, Khan W, Parveen R, Saher S, Ahmad S.
- Metabolites. 2022 Jan 21;12(2):97. doi: 10.3390/metabo12020097.
- PMCID: PMC8876931
Ansari MHR, et al.

Metabolites. 2022.

PMCID: PMC8876931

Ganoderma lucidum P. karst is an edible fungus that is used in traditional medicine and contains triterpenoids as the major phytoconstituents. ...Preparation of triterpenoid enriched fraction (TEF) from Ganoderma lucidum. (2). Major triterpenoid in TEF …

Ganoderma lucidum P. karst is an edible fungus that is used in traditional medicine and contains triterpenoids as the major ph …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Pharmacokinetic, Metabolomic, and Stability Assessment of Ganoderic Acid H Based Triterpenoid Enriched Fraction of Ganoderma lucidum P. Karst.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Broad molecular profiling and pathway/statistical analyses. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
422.
G. lucidum triterpenes restores intestinal flora balance in non-hepatitis B virus-related hepatocellular carcinoma: evidence of 16S rRNA sequencing and network pharmacology analysis.
- Xiong W, Yang C, Xia J, Wang W, Li N.
- Front Pharmacol. 2023 Sep 18;14:1197418. doi: 10.3389/fphar.2023.1197418.
- PMCID: PMC10544910
Xiong W, et al.

Front Pharmacol. 2023.

PMCID: PMC10544910

Background: Ganoderma lucidum (G. lucidum) is a popular traditional remedy medicine used in Asia to promote health and longevity, which has also been highlighted for anti-cancer effects. ...Conclusion: Therefore, Ganosporelactone B, the active ingredient of G …

Background: Ganoderma lucidum (G. lucidum) is a popular traditional remedy medicine used in Asia to promote health and …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: G. lucidum triterpenes restores intestinal flora balance in non-hepatitis B virus-related hepatocellular carcinoma: evidence of 16S rRNA sequencing and network pharmacology analysis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
423.
Wild Mushrooms: A Potential Source of Nutritional and Antioxidant Attributes with Acceptable Toxicity.
- Sharif S, Shahid M, Mushtaq M, Akram S, Rashid A.
- Prev Nutr Food Sci. 2017 Jun 30;22(2):124-130. doi: 10.3746/pnf.2017.22.2.124.
- PMCID: PMC5503421
Sharif S, et al.

Prev Nutr Food Sci. 2017.

PMCID: PMC5503421

This paper describes in detail proximate composition, nutritional profile, phytochemical constituents, antioxidant activities, antimicrobial potential, and antihemolytic activity (towards human erythrocytes) of various fractions of wild Ganoderma lucidum. Proximate …

This paper describes in detail proximate composition, nutritional profile, phytochemical constituents, antioxidant activities, antimicrobial …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Wild Mushrooms: A Potential Source of Nutritional and Antioxidant Attributes with Acceptable Toxicity.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
424.
Ganoderma lucidum Effects on Mood and Health-Related Quality of Life in Women with Fibromyalgia.
- Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D.
- Healthcare (Basel). 2020 Nov 30;8(4):520. doi: 10.3390/healthcare8040520.
- PMCID: PMC7712001
Pazzi F, et al.

Healthcare (Basel). 2020.

PMCID: PMC7712001

It is associated with several secondary symptoms such as psychological and pain-specific distress, which can directly impact daily functioning and quality of life, like anxiety and depression. The Ganoderma lucidum (GL) mushroom seems to be able to improve fibromyal …

It is associated with several secondary symptoms such as psychological and pain-specific distress, which can directly impact daily functioni …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Effects on Mood and Health-Related Quality of Life in Women with Fibromyalgia.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Quality/authentication methods study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Analytical validation (specificity/sensitivity), reference standards, and mislabeling rates. Open article.
- Why might this paper be useful to readers? Useful for quality control, sourcing, and preventing adulteration. Open article.
425.
Alterations in Growth and Morphology of Ganoderma lucidum and Volvariella volvaceae in Response to Nanoparticle Supplementation.
- Singh S, Kuca K, Kalia A.
- Mycobiology. 2020 Aug 27;48(5):383-391. doi: 10.1080/12298093.2020.1809613.
- PMCID: PMC7580762
Singh S, et al.

Mycobiology. 2020.

PMCID: PMC7580762

The present investigation explores the effect of in vitro supplementation of TiO(2), silica and silver NPs on radial growth and ultrastructural changes in the hyphae and spores of two mushroom genera, Ganoderma lucidum and Volvariella volvaceae. A concentration depe …

The present investigation explores the effect of in vitro supplementation of TiO(2), silica and silver NPs on radial growth and ultrastructu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Alterations in Growth and Morphology of Ganoderma lucidum and Volvariella volvaceae in Response to Nanoparticle Supplementation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
426.
Ganoderma lucidum-Mediated Green Synthesis of Silver Nanoparticles with Antimicrobial Activity.
- Constantin M, Răut I, Suica-Bunghez R, Firinca C, Radu N, Gurban AM, Preda S, Alexandrescu E, Doni M, Jecu L.
- Materials (Basel). 2023 Jun 8;16(12):4261. doi: 10.3390/ma16124261.
- PMCID: PMC10302571
Constantin M, et al.

Materials (Basel). 2023.

PMCID: PMC10302571

Nanoparticles can be synthesized by algae, bacteria, fungi, and plant extracts. Ganoderma lucidum is a commonly used medicinal mushroom with distinctive biological properties, such as antibacterial, antifungal, antioxidant, anti-inflammatory, anticancer, etc. In thi …

Nanoparticles can be synthesized by algae, bacteria, fungi, and plant extracts. Ganoderma lucidum is a commonly used medicinal …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum -Mediated Green Synthesis of Silver Nanoparticles with Antimicrobial Activity.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
427.
Improving Training Condition Assessment in Endurance Cyclists: Effects of Ganoderma lucidum and Ophiocordyceps sinensis Dietary Supplementation.
- Rossi P, Buonocore D, Altobelli E, Brandalise F, Cesaroni V, Iozzi D, Savino E, Marzatico F.
- Evid Based Complement Alternat Med. 2014 Apr 1;2014:979613. doi: 10.1155/2014/979613.
- PMCID: PMC3995149
Rossi P, et al.

Evid Based Complement Alternat Med. 2014.

PMCID: PMC3995149

We report the effects of a brief 3-month trial of two fungal supplements, Ganoderma lucidum and Cordyceps sinensis (3 capsules of O. sinensis and 2 capsules of G. lucidum per day), in 7 healthy male volunteers, aged between 30 and 40 years, who are all amateu …

We report the effects of a brief 3-month trial of two fungal supplements, Ganoderma lucidum and Cordyceps sinensis (3 capsules …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Improving Training Condition Assessment in Endurance Cyclists: Effects of Ganoderma lucidum and Ophiocordyceps sinensis Dietary Supplementation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
428.
Ganoderma lucidum enhances carboplatin chemotherapy effect by inhibiting the DNA damage response pathway and stemness.
- Suárez-Arroyo IJ, Acevedo-Díaz A, Ríos-Fuller TJ, Ortiz-Soto G, Vallejo-Calzada R, Reyes-Chea J, Maldonado-Martínez G, Schneider RJ, Martínez-Montemayor MM.
- Am J Cancer Res. 2022 Mar 15;12(3):1282-1294.
- PMCID: PMC8984902
Suárez-Arroyo IJ, et al.

Am J Cancer Res. 2022.

PMCID: PMC8984902

Because studies show that medicinal mushroom Ganoderma lucidum (GLE) sensitizes cancer cells to radiation and other drugs; herein, we aimed to investigate the therapeutic potential of GLE, alone or in combination with carboplatin in breast cancer models. ...

Because studies show that medicinal mushroom Ganoderma lucidum (GLE) sensitizes cancer cells to radiation and other drugs; her …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum enhances carboplatin chemotherapy effect by inhibiting the DNA damage response pathway and stemness.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
429.
Transcriptome and metabolome analyses reveal transcription factors regulating ganoderic acid biosynthesis in Ganoderma lucidum development.
- Meng L, Zhou R, Lin J, Zang X, Wang Q, Wang P, Wang L, Li Z, Wang W.
- Front Microbiol. 2022 Aug 4;13:956421. doi: 10.3389/fmicb.2022.956421.
- PMCID: PMC9386254
Meng L, et al.

Front Microbiol. 2022.

PMCID: PMC9386254

Ganoderma lucidum is an important medicinal fungus in Asian countries. Ganoderic acid (GA) is the major variety of bioactive and medicative components in G. lucidum. ...The analysis of predicted occurrences of DNA-binding domains revealed a set of 53 potentia …

Ganoderma lucidum is an important medicinal fungus in Asian countries. Ganoderic acid (GA) is the major variety of bioactive a …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Transcriptome and metabolome analyses reveal transcription factors regulating ganoderic acid biosynthesis in Ganoderma lucidum development.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
430.
Improved ganoderic acids production in Ganoderma lucidum by wood decaying components.
- Hu Y, Ahmed S, Li J, Luo B, Gao Z, Zhang Q, Li X, Hu X.
- Sci Rep. 2017 Apr 19;7:46623. doi: 10.1038/srep46623.
- PMCID: PMC5395960
Hu Y, et al.

Sci Rep. 2017.

PMCID: PMC5395960

Ganoderma lucidum is a legendary Traditional Chinese Medicine (TCM) over a few thousands of years and one kind of its major active components are Ganoderic acids (GAs). ...Our data indicated that MCC and D-galactose might be further industrialized for higher GAs pro …

Ganoderma lucidum is a legendary Traditional Chinese Medicine (TCM) over a few thousands of years and one kind of its major ac …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Improved ganoderic acids production in Ganoderma lucidum by wood decaying components.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 44

431.
Ganoderma lucidum inspired silver nanoparticles and its biomedical applications with special reference to drug resistant Escherichia coli isolates from CAUTI.
- Al-Ansari MM, Dhasarathan P, Ranjitsingh AJA, Al-Humaid LA.
- Saudi J Biol Sci. 2020 Sep 10;27(11):2993-3002. doi: 10.1016/j.sjbs.2020.09.008.
- PMCID: PMC7569111
Al-Ansari MM, et al.

Saudi J Biol Sci. 2020.

PMCID: PMC7569111

Fungal bioactive compounds and their nanoparticles were reported with the potential biomedical application. A medicinal mushroom Ganoderma lucidum was reported as a repository of rich medicinal properties. In the current study, silver nanoparticles were synthesized …

Fungal bioactive compounds and their nanoparticles were reported with the potential biomedical application. A medicinal mushroom Ganoderm …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum inspired silver nanoparticles and its biomedical applications with special reference to drug resistant Escherichia coli isolates from CAUTI.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
432.
Apoptosis induced by 9,11-dehydroergosterol peroxide from Ganoderma Lucidum mycelium in human malignant melanoma cells is Mcl-1 dependent.
- Zheng L, Wong YS, Shao M, Huang S, Wang F, Chen J.
- Mol Med Rep. 2018 May 17;18(1):938-944. doi: 10.3892/mmr.2018.9035.
- PMCID: PMC6059726
Zheng L, et al.

Mol Med Rep. 2018.

PMCID: PMC6059726

In the present study, the steroid from Ganoderma lucidum was purified on a submerged culture, and its antitumor mechanisms on A375 human malignant melanoma cells was investigated by MTT, flow cytometry and western blotting. ...The present study also suggests that my …

In the present study, the steroid from Ganoderma lucidum was purified on a submerged culture, and its antitumor mechanisms on …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Apoptosis induced by 9,11-dehydroergosterol peroxide from Ganoderma Lucidum mycelium in human malignant melanoma cells is Mcl-1 dependent.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
433.
From agro-waste to tool: biotechnological characterization and application of Ganoderma lucidum E47 laccase in dye decolorization.
- Palazzolo MA, Postemsky PD, Kurina-Sanz M.
- 3 Biotech. 2019 May 16;9(6):213. doi: 10.1007/s13205-019-1744-2.
- PMCID: PMC6522593
Palazzolo MA, et al.

3 Biotech. 2019.

PMCID: PMC6522593

The culture of fungal species from agro-waste allows for the sustainable preparation of valuable biotechnological products and contributes to establish the Circular Economy concept. The Ganoderma lucidum species is well known as producer of laccases (EC 1.10.3.2), w …

The culture of fungal species from agro-waste allows for the sustainable preparation of valuable biotechnological products and contributes t …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: From agro-waste to tool: biotechnological characterization and application of Ganoderma lucidum E47 laccase in dye decolorization.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Relevant for eco‑friendly processing, waste upcycling, and industrial biocatalysis. Open article.
434.
Green Synthesis of ZnO Nanoparticles via Ganoderma Lucidum Extract: Structural and Functional Analysis in Polymer Composites.
- Can A, Kızılbey K.
- Gels. 2024 Sep 4;10(9):576. doi: 10.3390/gels10090576.
- PMCID: PMC11431147
Can A, et al.

Gels. 2024.

PMCID: PMC11431147

This study presents the green synthesis of zinc oxide (ZnO) nanoparticles (ZnNPs) using Ganoderma Lucidum mushroom extract, characterized by DLS, SEM, XRD, and FTIR spectroscopy analyses. ...This pioneering study demonstrates the potential of Ganoderma Luc …

This study presents the green synthesis of zinc oxide (ZnO) nanoparticles (ZnNPs) using Ganoderma Lucidum mushroom extract, ch …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Green Synthesis of ZnO Nanoparticles via Ganoderma Lucidum Extract: Structural and Functional Analysis in Polymer Composites.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
435.
Ganoderma lucidum polysaccharides counteract inhibition on CD71 and FasL expression by culture supernatant of B16F10 cells upon lymphocyte activation.
- Sun LX, Lin ZB, Duan XS, Lu J, Ge ZH, Li M, Xing EH, Lan TF, Jiang MM, Yang N, Li WD.
- Exp Ther Med. 2013 Jan 29;5(4):1117-1122. doi: 10.3892/etm.2013.931.
- PMCID: PMC3628224
Sun LX, et al.

Exp Ther Med. 2013.

PMCID: PMC3628224

A potential component with this effect is Ganoderma lucidum polysaccharides (Gl-PS). In this study, Gl-PS was used on lymphocytes incubating with culture supernatant of B16F10 melanoma cells (B16F10-CS) in the presence of phytohemagglutinin. ...

A potential component with this effect is Ganoderma lucidum polysaccharides (Gl-PS). In this study, Gl-PS was used on lymphocy …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum polysaccharides counteract inhibition on CD71 and FasL expression by culture supernatant of B16F10 cells upon lymphocyte activation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
436.
Manganese affects the growth and metabolism of Ganoderma lucidum based on LC-MS analysis.
- Zhang B, Zhou J, Li Q, Gan B, Peng W, Zhang X, Tan W, Jiang L, Li X.
- PeerJ. 2019 May 1;7:e6846. doi: 10.7717/peerj.6846.
- PMCID: PMC6500383
Zhang B, et al.

PeerJ. 2019.

PMCID: PMC6500383

BACKGROUND: As a metal-enriched edible fungus, Ganoderma lucidum is capable of adsorbing manganese effectively. And the manganese ion is demonstrated to play an important role in the synthesis of manganese peroxidase (Mnp) and other physiological activities during G …

BACKGROUND: As a metal-enriched edible fungus, Ganoderma lucidum is capable of adsorbing manganese effectively. And the mangan …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Manganese affects the growth and metabolism of Ganoderma lucidum based on LC-MS analysis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
437.
ReishiMax inhibits mTORC1/2 by activating AMPK and inhibiting IGFR/PI3K/Rheb in tumor cells.
- Sohretoglu D, Zhang C, Luo J, Huang S.
- Signal Transduct Target Ther. 2019 Jun 28;4:21. doi: 10.1038/s41392-019-0056-7.
- PMCID: PMC6799808
Sohretoglu D, et al.

Signal Transduct Target Ther. 2019.

PMCID: PMC6799808

Ganoderma lucidum (G. lucidum) extracts, as dietary supplements, have been found to exert potent anticancer activity, which is attributed to the presence of polysaccharides and triterpenes. However, the molecular mechanism underlying the anticancer action of …

Ganoderma lucidum (G. lucidum) extracts, as dietary supplements, have been found to exert potent anticancer activity, w …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: ReishiMax inhibits mTORC1/2 by activating AMPK and inhibiting IGFR/PI3K/Rheb in tumor cells.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
438.
Modulatory effect of Ganoderma lucidum on expression of xenobiotic enzymes, oxidant-antioxidant and hormonal status in 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats.
- Deepalakshmi K, Mirunalini S.
- Pharmacogn Mag. 2013 Apr;9(34):167-75. doi: 10.4103/0973-1296.111286.
- PMCID: PMC3680858
Deepalakshmi K, et al.

Pharmacogn Mag. 2013.

PMCID: PMC3680858

BACKGROUND: Mushrooms are an important natural source represents a major and untapped potent pharmaceutical product. Ganoderma lucidum (G. lucidum) an important medicinal mushroom has been shown to contain high amount of antioxidant. ...Therefore, the dietary …

BACKGROUND: Mushrooms are an important natural source represents a major and untapped potent pharmaceutical product. Ganoderma luc …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Modulatory effect of Ganoderma lucidum on expression of xenobiotic enzymes, oxidant-antioxidant and hormonal status in 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
439.
Hyperproduction of exopolysaccharides by submerged mycelial culture of Ganoderma lucidum using a solid seed grown in fine-powder of wheat bran and in vitro evaluation of the antioxidant activity of the exopolysaccharides produced.
- Liu SR, Zhang WR.
- Food Sci Biotechnol. 2018 Feb 28;27(4):1129-1136. doi: 10.1007/s10068-018-0343-z.
- PMCID: PMC6085248
Liu SR, et al.

Food Sci Biotechnol. 2018.

PMCID: PMC6085248

To facilitate Ganoderma lucidum submerged culture and obtain high productivity, a fine powder of wheat bran was used to grow the fungus for solid-state fermentation and as solid seed for its submerged cultures. ...The developed solid seed can serve as a ready-to-use …

To facilitate Ganoderma lucidum submerged culture and obtain high productivity, a fine powder of wheat bran was used to grow t …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Hyperproduction of exopolysaccharides by submerged mycelial culture of Ganoderma lucidum using a solid seed grown in fine-powder of wheat bran and in vitro evaluation of the antioxidant activity of the exopolysaccharides produced.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
440.
Reconstruction and Analysis of a Genome-Scale Metabolic Model of Ganoderma lucidum for Improved Extracellular Polysaccharide Production.
- Ma Z, Ye C, Deng W, Xu M, Wang Q, Liu G, Wang F, Liu L, Xu Z, Shi G, Ding Z.
- Front Microbiol. 2018 Dec 11;9:3076. doi: 10.3389/fmicb.2018.03076.
- PMCID: PMC6298397
Ma Z, et al.

Front Microbiol. 2018.

PMCID: PMC6298397

In this study, we reconstructed for the first time a genome-scale metabolic model (GSMM) of Ganoderma lucidum strain CGMCC5.26, termed model iZBM1060, containing 1060 genes, 1202 metabolites, and 1404 reactions. ...Model iZBM1060 provides a useful platform for regul …

In this study, we reconstructed for the first time a genome-scale metabolic model (GSMM) of Ganoderma lucidum strain CGMCC5.26 …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Reconstruction and Analysis of a Genome-Scale Metabolic Model of Ganoderma lucidum for Improved Extracellular Polysaccharide Production.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.

Page 45

441.
Acrylamide Content of Experimental Flatbreads Prepared from Potato, Quinoa, and Wheat Flours with Added Fruit and Vegetable Peels and Mushroom Powders.
- Crawford LM, Kahlon TS, Wang SC, Friedman M.
- Foods. 2019 Jun 26;8(7):228. doi: 10.3390/foods8070228.
- PMCID: PMC6678822
Crawford LM, et al.

Foods. 2019.

PMCID: PMC6678822

To further enhance the functionality of flatbreads, we have developed, in this work, new experimental flatbreads using potato, quinoa, and wheat flours supplemented with peel powders prepared from commercial nonorganic and organic fruits and vegetables (apples, cherry tomatoes, m …

To further enhance the functionality of flatbreads, we have developed, in this work, new experimental flatbreads using potato, quinoa, and w …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Acrylamide Content of Experimental Flatbreads Prepared from Potato, Quinoa, and Wheat Flours with Added Fruit and Vegetable Peels and Mushroom Powders.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
442.
Sporoderm-broken spore powder of Ganoderma lucidum ameliorate obesity and inflammation process in high-fat diet-induced obese mice.
- Zhong B, Li FL, Zhao JY, Fu Y, Peng C.
- Food Nutr Res. 2022 Oct 12;66. doi: 10.29219/fnr.v66.8745.
- PMCID: PMC9602201
Zhong B, et al.

Food Nutr Res. 2022.

PMCID: PMC9602201

OBJECTIVE: This study examined the anti-obesity and anti-inflammatory effects of sporoderm-broken spore powder of Ganoderma lucidum (SSPL) against obese mice fed with a high-fat diet. METHODS: Four groups of C57BL/6J mice were randomly assigned to the following diet …

OBJECTIVE: This study examined the anti-obesity and anti-inflammatory effects of sporoderm-broken spore powder of Ganoderma lucidu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Sporoderm-broken spore powder of Ganoderma lucidum ameliorate obesity and inflammation process in high-fat diet-induced obese mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
443.
Immunostimulatory effects of a subcritical water extract of Ganoderma.
- Hattori K, Takagi H, Ogata Y, Yamada T, Horiba H, Fukata K, Sakaida T, Yashiro Y, Hasegawa S, Tanaka H.
- Biomed Rep. 2022 Nov 9;18(1):1. doi: 10.3892/br.2022.1583.
- PMCID: PMC9756285
Hattori K, et al.

Biomed Rep. 2022.

PMCID: PMC9756285

Ganoderma, a medicinal mushroom with various physiological activities, has been extensively investigated regarding its effectiveness. ...These results were not obtained in experiments using hot water extract of Ganoderma lucidum and Ganoderma sinense. …

Ganoderma, a medicinal mushroom with various physiological activities, has been extensively investigated regarding its effectiveness. …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Immunostimulatory effects of a subcritical water extract of Ganoderma .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
444.
Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway.
- Zhao X, Zhou D, Liu Y, Li C, Zhao X, Li Y, Li W.
- Mol Med Rep. 2017 Oct 26;17(1):147-157. doi: 10.3892/mmr.2017.7904.
- PMCID: PMC5780085
Zhao X, et al.

Mol Med Rep. 2017.

PMCID: PMC5780085

At present, the molecular mechanisms of growth and migration in human prostate cancer have not been completely elucidated. Studies have demonstrated that Ganoderma lucidum polysaccharides (GLP) can inhibit cancer. Therefore the present study investigated the effect …

At present, the molecular mechanisms of growth and migration in human prostate cancer have not been completely elucidated. Studies have demo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
445.
Polysaccharides of Sporoderm-Broken Spore of Ganoderma lucidum Modulate Adaptive Immune Function via Gut Microbiota Regulation.
- Su L, Li D, Su J, Zhang E, Chen S, Zheng C, Luo T, Li M, Chen X, Huang G, Xie Y, Li S.
- Evid Based Complement Alternat Med. 2021 Mar 23;2021:8842062. doi: 10.1155/2021/8842062.
- PMCID: PMC8009716
Su L, et al.

Evid Based Complement Alternat Med. 2021.

PMCID: PMC8009716

Ganoderma lucidum (Leyss.Fr.) Karst is one of the well-known medicinal macrofungi all over the world, and mounting researches have focused on the polysaccharides derived from the spores of G. lucidum. In the present study, BALB/c mice (n = 8-10) were administ …

Ganoderma lucidum (Leyss.Fr.) Karst is one of the well-known medicinal macrofungi all over the world, and mounting researches …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Polysaccharides of Sporoderm-Broken Spore of Ganoderma lucidum Modulate Adaptive Immune Function via Gut Microbiota Regulation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
446.
Optimization of submerged culture conditions involving a developed fine powder solid seed for exopolysaccharide production by the medicinal mushroom Ganoderma lucidum.
- Liu SR, Zhang WR.
- Food Sci Biotechnol. 2018 Dec 12;28(4):1135-1145. doi: 10.1007/s10068-018-0536-5.
- PMCID: PMC6595012
Liu SR, et al.

Food Sci Biotechnol. 2018.

PMCID: PMC6595012

To facilitate Ganoderma lucidum submerged cultivation and achieve high productivity, four fine powder solid substrates incorporated with different nitrogen-rich supplements were utilized to grow the fungus and as solid seed for its submerged culture. ...The develope …

To facilitate Ganoderma lucidum submerged cultivation and achieve high productivity, four fine powder solid substrates incorpo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Optimization of submerged culture conditions involving a developed fine powder solid seed for exopolysaccharide production by the medicinal mushroom Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
447.
Optimization of chemical conditions for metabolites production by Ganoderma lucidum using response surface methodology and investigation of antimicrobial as well as anticancer activities.
- Tajik A, Samadlouie HR, Salek Farrokhi A, Ghasemi A.
- Front Microbiol. 2024 Jan 22;14:1280405. doi: 10.3389/fmicb.2023.1280405.
- PMCID: PMC10839005
Tajik A, et al.

Front Microbiol. 2024.

PMCID: PMC10839005

Ganoderma lucidum (G. lucidum) is a medicinal mushroom that is known for its ability to produce compounds with physiological effects on human health. ...In addition, the IC50 levels of shell and stem of G. lucidum were 465.3 and 485.7 mug/mL, respectiv …

Ganoderma lucidum (G. lucidum) is a medicinal mushroom that is known for its ability to produce compounds with physiolo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Optimization of chemical conditions for metabolites production by Ganoderma lucidum using response surface methodology and investigation of antimicrobial as well as anticancer activities.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
448.
Development of an Efficient Strategy to Improve Extracellular Polysaccharide Production of Ganoderma lucidum Using L-Phenylalanine as an Enhancer.
- Ma Z, Xu M, Wang Q, Wang F, Zheng H, Gu Z, Li Y, Shi G, Ding Z.
- Front Microbiol. 2019 Oct 15;10:2306. doi: 10.3389/fmicb.2019.02306.
- PMCID: PMC6804554
Ma Z, et al.

Front Microbiol. 2019.

PMCID: PMC6804554

Ganoderma lucidum has been a well-known species of basidiomycetes for a long time, and has been widely applied in the fields of food and medicine. Based on the simulation results of model iZBM1060 in our previous research, the effect of L-phenylalanine on G. luci …

Ganoderma lucidum has been a well-known species of basidiomycetes for a long time, and has been widely applied in the fields o …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Development of an Efficient Strategy to Improve Extracellular Polysaccharide Production of Ganoderma lucidum Using L-Phenylalanine as an Enhancer.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
449.
Recombinant Ganoderma lucidum Immunomodulatory Protein Improves the Treatment for Chemotherapy-Induced Neutropenia.
- Lei X, Zhi C, Huang W, Sun X, Gao W, Yin X, Zhang X, Liang C, Zhang H, Sun F.
- Front Pharmacol. 2020 Jun 26;11:956. doi: 10.3389/fphar.2020.00956.
- PMCID: PMC7333219
Lei X, et al.

Front Pharmacol. 2020.

PMCID: PMC7333219

Ganoderma lucidum, also known as LINGZHI, has a long tradition of use in folk medicine of the Far East, which is documented in the oldest Chinese pharmacopoeia, declaring it a superior medicine. LINGZHI-8 (LZ-8) is an immunoregulatory fungal protein isolated from th …

Ganoderma lucidum, also known as LINGZHI, has a long tradition of use in folk medicine of the Far East, which is documented in …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Recombinant Ganoderma lucidum Immunomodulatory Protein Improves the Treatment for Chemotherapy-Induced Neutropenia.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
450.
Recent Advances in the Use of Ganoderma lucidum and Coriolus versicolor Mushrooms to Enhance the Anticancer Efficacy of EGFR-Targeted Drugs in Lung Cancer.
- Zhang H, Wang L, Chan YW, Cho WC, Zuo Z, To KKW.
- Pharmaceutics. 2025 Jul 15;17(7):917. doi: 10.3390/pharmaceutics17070917.
- PMCID: PMC12298319
Zhang H, et al.

Pharmaceutics. 2025.

PMCID: PMC12298319

In Asian countries, the concomitant use of Western medicine and traditional Chinese medicine (TCM) is very common. Ganoderma lucidum (Lingzhi) and Coriolus versicolor (Yunzhi) are popular TCMs that are widely consumed by cancer patients to enhance anticancer efficac …

In Asian countries, the concomitant use of Western medicine and traditional Chinese medicine (TCM) is very common. Ganoderma lucid …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Recent Advances in the Use of Ganoderma lucidum and Coriolus versicolor Mushrooms to Enhance the Anticancer Efficacy of EGFR-Targeted Drugs in Lung Cancer.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 46

451.
Ganoderma lucidum fruiting body extracts inhibit colorectal cancer by inducing apoptosis, autophagy, and G0/G1 phase cell cycle arrest in vitro and in vivo.
- Liu X, Xu Y, Li Y, Pan Y, Sun Z, Zhao S, Hou Y.
- Am J Transl Res. 2020 Jun 15;12(6):2675-2684.
- PMCID: PMC7344060
Liu X, et al.

Am J Transl Res. 2020.

PMCID: PMC7344060

Although previous studies have found that Ganoderma lucidum extracts have the ability to directly resist tumor proliferation and reduce metastasis and invasion, the effect of the extracts of Ganoderma lucidum fruiting body (GLE) on cancer is not clarif …

Although previous studies have found that Ganoderma lucidum extracts have the ability to directly resist tumor proliferation a …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum fruiting body extracts inhibit colorectal cancer by inducing apoptosis, autophagy, and G0/G1 phase cell cycle arrest in vitro and in vivo.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
452.
Do Ganoderma Species Represent Novel Sources of Phenolic Based Antimicrobial Agents?
- Rašeta M, Mišković J, Čapelja E, Zapora E, Petrović Fabijan A, Knežević P, Karaman M.
- Molecules. 2023 Apr 6;28(7):3264. doi: 10.3390/molecules28073264.
- PMCID: PMC10096548
Rašeta M, et al.

Molecules. 2023.

PMCID: PMC10096548

Ganoderma species have been recognized as potential antimicrobial (AM) agents and have been used in traditional Chinese medicine (TCM) for a long time. The aim of this study is to examine the AM potential of autochthonous Ganoderma species (G. applanatum, G. luci …

Ganoderma species have been recognized as potential antimicrobial (AM) agents and have been used in traditional Chinese medicine (TCM …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Do Ganoderma Species Represent Novel Sources of Phenolic Based Antimicrobial Agents?. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
453.
Ganoderma lucidum polysaccharides supplementation attenuates exercise-induced oxidative stress in skeletal muscle of mice.
- Zhonghui Z, Xiaowei Z, Fang F.
- Saudi J Biol Sci. 2013 Apr 23;21(2):119-23. doi: 10.1016/j.sjbs.2013.04.004.
- PMCID: PMC3942859
Zhonghui Z, et al.

Saudi J Biol Sci. 2013.

PMCID: PMC3942859

The present study was designed to determine the effects of Ganoderma lucidum polysaccharides (GL-PS) on exhaustive exercise-induced oxidative stress in skeletal muscle tissues of mice. ...

The present study was designed to determine the effects of Ganoderma lucidum polysaccharides (GL-PS) on exhaustive exercise-in …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum polysaccharides supplementation attenuates exercise-induced oxidative stress in skeletal muscle of mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
454.
A Comprehensive Review of Herbal Supplements Used for Persistent Symptoms Attributed to Lyme Disease.
- Thompson A, Hynicka LM, Shere-Wolfe KD.
- Integr Med (Encinitas). 2023 Mar;22(1):30-38.
- PMCID: PMC10124234
Thompson A, et al.

Integr Med (Encinitas). 2023.

PMCID: PMC10124234

The search used the keywords for 18 herbal compounds: (1) andrographis (Andrographis paniculate), (2) astragalus (Astragalus propinquus), (3) berberine, (4) cat's claw bark (Uncaria tomentosa), (5) cordyceps (Cordyceps sinensis), (6) cryptolepis (Cryptolepis sanguinolenta), (7) C …

The search used the keywords for 18 herbal compounds: (1) andrographis (Andrographis paniculate), (2) astragalus (Astragalus propinquus), (3 …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A Comprehensive Review of Herbal Supplements Used for Persistent Symptoms Attributed to Lyme Disease.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
455.
Ganoderma lucidum and Robinia pseudoacacia Flower Extract Complex Alleviates Kidney Inflammation and Fibrosis by Modulating Oxidative Stress.
- Kim S, Kim J, Kim JL, Park MR, Park KW, Chung KW.
- Antioxidants (Basel). 2025 Mar 28;14(4):409. doi: 10.3390/antiox14040409.
- PMCID: PMC12024243
Kim S, et al.

Antioxidants (Basel). 2025.

PMCID: PMC12024243

This study aimed to investigate the effects of a Ganoderma lucidum and Robinia pseudoacacia flower extract complex (NEPROBIN) through in vitro and in vivo experiments. ...

This study aimed to investigate the effects of a Ganoderma lucidum and Robinia pseudoacacia flower extract complex (NEPROBIN) …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum and Robinia pseudoacacia Flower Extract Complex Alleviates Kidney Inflammation and Fibrosis by Modulating Oxidative Stress.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
456.
An Efficient CRISPR/Cas9 Genome Editing System for a Ganoderma lucidum Cultivated Strain by Ribonucleoprotein Method.
- Tan Y, Yu X, Zhang Z, Tian J, Feng N, Tang C, Zou G, Zhang J.
- J Fungi (Basel). 2023 Dec 5;9(12):1170. doi: 10.3390/jof9121170.
- PMCID: PMC10745038
Tan Y, et al.

J Fungi (Basel). 2023.

PMCID: PMC10745038

In this study, we developed and optimized an RNP-mediated CRISPR/Cas9 genome editing system for the monokaryotic strain L1 from the Ganoderma lucidum cultivar 'Hunong No. 1'. On selective media containing 5-fluoroorotic acid (5-FOA), the targeting efficiency of the …

In this study, we developed and optimized an RNP-mediated CRISPR/Cas9 genome editing system for the monokaryotic strain L1 from the Ganod …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: An Efficient CRISPR/Cas9 Genome Editing System for a Ganoderma lucidum Cultivated Strain by Ribonucleoprotein Method.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
457.
ZnO and Ag NP-decorated ZnO nanoflowers: green synthesis using Ganoderma lucidum aqueous extract and characterization.
- Smirnov O, Dzhagan V, Kovalenko M, Gudymenko O, Dzhagan V, Mazur N, Isaieva O, Maksimenko Z, Kondratenko S, Skoryk M, Yukhymchuk V.
- RSC Adv. 2023 Jan 3;13(1):756-763. doi: 10.1039/d2ra05834k.
- PMCID: PMC9809204
Smirnov O, et al.

RSC Adv. 2023.

PMCID: PMC9809204

ZnO NPs with a flower-like morphology were synthesized by an affordable colloidal route, using an aqueous extract of Ganoderma lucidum as a reducing agent and stabilizer. Each individual "flower" has a large effective surface, which is preserved when the particles a …

ZnO NPs with a flower-like morphology were synthesized by an affordable colloidal route, using an aqueous extract of Ganoderma luc …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: ZnO and Ag NP-decorated ZnO nanoflowers: green synthesis using Ganoderma lucidum aqueous extract and characterization.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
458.
Polysaccharide prediction in Ganoderma lucidum fruiting body by hyperspectral imaging.
- Liu Y, Long Y, Liu H, Lan Y, Long T, Kuang R, Wang Y, Zhao J.
- Food Chem X. 2021 Dec 29;13:100199. doi: 10.1016/j.fochx.2021.100199.
- PMCID: PMC9039882
Liu Y, et al.

Food Chem X. 2021.

PMCID: PMC9039882

Ganoderma lucidum polysaccharide plays a vital role in improving human immunity and anti-oxidation. ...This study indicates that HSI can quickly and nondestructive detect the polysaccharide content of Ganoderma lucidum, provide guidance for the cultiva …

Ganoderma lucidum polysaccharide plays a vital role in improving human immunity and anti-oxidation. ...This study indicates th …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Polysaccharide prediction in Ganoderma lucidum fruiting body by hyperspectral imaging.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
459.
Ganoderma Lucidum polysaccharides protect against MPP(+) and rotenone-induced apoptosis in primary dopaminergic cell cultures through inhibiting oxidative stress.
- Guo SS, Cui XL, Rausch WD.
- Am J Neurodegener Dis. 2016 Jun 1;5(2):131-44.
- PMCID: PMC4913221
Guo SS, et al.

Am J Neurodegener Dis. 2016.

PMCID: PMC4913221

Polysaccharides are the main active constituents from Ganoderma lucidum which is characterized with anti-oxidant, antitumor and immunostimulant properties. In the present study, primary dopaminergic cell cultures prepared from embryonic mouse mesencephala were used …

Polysaccharides are the main active constituents from Ganoderma lucidum which is characterized with anti-oxidant, antitumor an …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma Lucidum polysaccharides protect against MPP(+) and rotenone-induced apoptosis in primary dopaminergic cell cultures through inhibiting oxidative stress.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
460.
Integrated Transcriptomics and Nontargeted Metabolomics Analysis Reveal Key Metabolic Pathways in Ganoderma lucidum in Response to Ethylene.
- Meng L, Zhou R, Lin J, Wang Q, Wang P, Wang W, Wang L, Li Z.
- J Fungi (Basel). 2022 Apr 28;8(5):456. doi: 10.3390/jof8050456.
- PMCID: PMC9146657
Meng L, et al.

J Fungi (Basel). 2022.

PMCID: PMC9146657

Ganoderic acid (GA) is an important secondary metabolite of Ganoderma lucidum with a diverse array of pharmacological properties. In this study, we found that exogenous ethylene increased the production of endogenous ethylene and ganoderic acid in G. lucidum. …

Ganoderic acid (GA) is an important secondary metabolite of Ganoderma lucidum with a diverse array of pharmacological properti …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Integrated Transcriptomics and Nontargeted Metabolomics Analysis Reveal Key Metabolic Pathways in Ganoderma lucidum in Response to Ethylene.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Maps pathways and components that can guide future lab and clinical research. Open article.

Page 47

461.
Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2/PI3K/Akt Signaling Pathway.
- Kuo HP, Hsu SC, Ou CC, Li JW, Tseng HH, Chuang TC, Liu JY, Chen SJ, Su MH, Cheng YC, Chou WY, Kao MC.
- Evid Based Complement Alternat Med. 2013 Apr 7;2013:219472. doi: 10.1155/2013/219472.
- PMCID: PMC3638576
Kuo HP, et al.

Evid Based Complement Alternat Med. 2013.

PMCID: PMC3638576

Ganoderma, also known as Lingzhi or Reishi, has been used for medicinal purposes in Asian countries for centuries. ...In this study, we investigated the molecular mechanisms by which Ganoderma tsugae (GT), one of the most common species of Ganoderma, i …

Ganoderma, also known as Lingzhi or Reishi, has been used for medicinal purposes in Asian countries for centuries. ...In this …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2/PI3K/Akt Signaling Pathway.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
462.
Ganoderma Lucidum Polysaccharides Enhance the Abscopal Effect of Photothermal Therapy in Hepatoma-Bearing Mice Through Immunomodulatory, Anti-Proliferative, Pro-Apoptotic and Anti-Angiogenic.
- Xia QH, Lu CT, Tong MQ, Yue M, Chen R, Zhuge DL, Yao Q, Xu HL, Zhao YZ.
- Front Pharmacol. 2021 Jul 6;12:648708. doi: 10.3389/fphar.2021.648708.
- PMCID: PMC8290260
Xia QH, et al.

Front Pharmacol. 2021.

PMCID: PMC8290260

PTT induces the release of tumor-associated antigens by ablating tumor and Ganoderma lucidum polysaccharides (GLP) enhance the antitumor immunity. Results showed that Indocyanine Green (ICG) was successfully encapsulated into SF-Gel. ...

PTT induces the release of tumor-associated antigens by ablating tumor and Ganoderma lucidum polysaccharides (GLP) enhance the …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma Lucidum Polysaccharides Enhance the Abscopal Effect of Photothermal Therapy in Hepatoma-Bearing Mice Through Immunomodulatory, Anti-Proliferative, Pro-Apoptotic and Anti-Angiogenic.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
463.
Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer.
- Gariboldi MB, Marras E, Ferrario N, Vivona V, Prini P, Vignati F, Perletti G.
- Int J Mol Sci. 2023 Jun 14;24(12):10120. doi: 10.3390/ijms241210120.
- PMCID: PMC10299416
Gariboldi MB, et al.

Int J Mol Sci. 2023.

PMCID: PMC10299416

In particular, the following mushrooms have been considered: Agaricus bisporus, Antrodia cinnamomea, Cordyceps sinensis, Cordyceps militaris, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, Lentinula edodes, and Pleurotus ostreatus. We also report insights …

In particular, the following mushrooms have been considered: Agaricus bisporus, Antrodia cinnamomea, Cordyceps sinensis, Cordyceps militaris …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
464.
Network pharmacology-based analysis of Resinacein S against non-alcoholic fatty liver disease by modulating lipid metabolism.
- Mao FF, Gao SS, Huang YJ, Zhou N, Feng JK, Liu ZH, Zhang YQ, Yuan LY, Wei G, Cheng SQ.
- Front Nutr. 2023 Feb 14;10:1076569. doi: 10.3389/fnut.2023.1076569.
- PMCID: PMC9971728
Mao FF, et al.

Front Nutr. 2023.

PMCID: PMC9971728

BACKGROUND: Ganoderma lucidum is reportedly the best source of traditional natural bioactive constituents. Ganoderma triterpenoids (GTs) have been verified as an alternative adjuvant for treating leukemia, cancer, hepatitis and diabetes. ...

BACKGROUND: Ganoderma lucidum is reportedly the best source of traditional natural bioactive constituents. Ganoderma tr …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Network pharmacology-based analysis of Resinacein S against non-alcoholic fatty liver disease by modulating lipid metabolism.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
465.
Anticancer Activity of Ganoderic Acid DM: Current Status and Future Perspective.
- Bryant JM, Bouchard M, Haque A.
- J Clin Cell Immunol. Author manuscript. 2017 Dec 12;8(6):535. doi: 10.4172/2155-9899.1000535.
- PMCID: PMC5795599
Bryant JM, et al.

J Clin Cell Immunol. Author manuscript. 2017.

PMCID: PMC5795599

Ganoderma lucidum is a mushroom that has a long history of medicinal use in the Far East countries as this mushroom is revered for its supposed miracle cures and life improving properties. ...The main category of biologically active compounds produced in the G. l …

Ganoderma lucidum is a mushroom that has a long history of medicinal use in the Far East countries as this mushroom is revered …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Anticancer Activity of Ganoderic Acid DM: Current Status and Future Perspective.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
466.
Gllac7 Is Induced by Agricultural and Forestry Residues and Exhibits Allelic Expression Bias in Ganoderma lucidum.
- Wang L, Ding X, Huang Q, Hu B, Liang L, Wang Q.
- Front Microbiol. 2022 Jun 30;13:890686. doi: 10.3389/fmicb.2022.890686.
- PMCID: PMC9279560
Wang L, et al.

Front Microbiol. 2022.

PMCID: PMC9279560

Ganoderma lucidum has a wide carbon spectrum, while the expression profile of key genes relevant to carbon metabolism on different carbon sources has been seldom studied. Here, the transcriptomes of G. lucidum mycelia cultured on each of 19 carbon sources wer …

Ganoderma lucidum has a wide carbon spectrum, while the expression profile of key genes relevant to carbon metabolism on diffe …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Gllac7 Is Induced by Agricultural and Forestry Residues and Exhibits Allelic Expression Bias in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
467.
Ethanol Extract of Ganoderma lucidum Augments Cellular Anti-oxidant Defense through Activation of Nrf2/HO-1.
- Lee YH, Kim JH, Song CH, Jang KJ, Kim CH, Kang JS, Choi YH, Yoon HM.
- J Pharmacopuncture. 2016 Mar;19(1):59-69. doi: 10.3831/KPI.2016.19.008.
- PMCID: PMC4887753
Lee YH, et al.

J Pharmacopuncture. 2016.

PMCID: PMC4887753

OBJECTIVES: The mushroom Ganoderma lucidum has been widely used as a traditional herbal medicine for many years. ...The present study investigated the cytoprotective effect of ethanol extract of Ganoderma lucidum (EGL) against oxidative stress (hydroge …

OBJECTIVES: The mushroom Ganoderma lucidum has been widely used as a traditional herbal medicine for many years. ...The presen …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ethanol Extract of Ganoderma lucidum Augments Cellular Anti-oxidant Defense through Activation of Nrf2/HO-1.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
468.
Ganoderma lucidum Combined with the EGFR Tyrosine Kinase Inhibitor, Erlotinib Synergize to Reduce Inflammatory Breast Cancer Progression.
- Suárez-Arroyo IJ, Rios-Fuller TJ, Feliz-Mosquea YR, Lacourt-Ventura M, Leal-Alviarez DJ, Maldonado-Martinez G, Cubano LA, Martínez-Montemayor MM.
- J Cancer. 2016 Feb 5;7(5):500-11. doi: 10.7150/jca.13599.
- PMCID: PMC4780125
Suárez-Arroyo IJ, et al.

J Cancer. 2016.

PMCID: PMC4780125

Here, we investigate the therapeutic potential of Ganoderma lucidum extract (GLE) in breast cancer, focusing on the regulation of the EGFR signaling cascade when treated with the EGFR TKI, Erlotinib. ...

Here, we investigate the therapeutic potential of Ganoderma lucidum extract (GLE) in breast cancer, focusing on the regulation …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Combined with the EGFR Tyrosine Kinase Inhibitor, Erlotinib Synergize to Reduce Inflammatory Breast Cancer Progression.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
469.
Ganoderma lucidum Polysaccharides Prevent Palmitic Acid-Evoked Apoptosis and Autophagy in Intestinal Porcine Epithelial Cell Line via Restoration of Mitochondrial Function and Regulation of MAPK and AMPK/Akt/mTOR Signaling Pathway.
- Liang Z, Yuan Z, Guo J, Wu J, Yi J, Deng J, Shan Y.
- Int J Mol Sci. 2019 Jan 23;20(3):478. doi: 10.3390/ijms20030478.
- PMCID: PMC6387170
Liang Z, et al.

Int J Mol Sci. 2019.

PMCID: PMC6387170

Ganoderma lucidum polysaccharide (GLP) extracted from Ganoderma lucidum (Leyss. ex Fr.) ...

Ganoderma lucidum polysaccharide (GLP) extracted from Ganoderma lucidum (Leyss. ex Fr.) ...
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Polysaccharides Prevent Palmitic Acid-Evoked Apoptosis and Autophagy in Intestinal Porcine Epithelial Cell Line via Restoration of Mitochondrial Function and Regulation of MAPK and AMPK/Akt/mTOR Signaling Pathway.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
470.
Root-Knot Disease Suppression in Eggplant Based on Three Growth Ages of Ganoderma lucidum.
- Fatima S, Khan F, Asif M, Alotaibi SS, Islam K, Shariq M, Khan A, Ikram M, Ahmad F, Khan TA, Meena R, Siddiqui MA.
- Microorganisms. 2022 May 23;10(5):1068. doi: 10.3390/microorganisms10051068.
- PMCID: PMC9144836
Fatima S, et al.

Microorganisms. 2022.

PMCID: PMC9144836

This investigation presents a novel finding showing the effect of culture filtrates (CFs) of macrofungi, Ganoderma lucidum, against Meloidogyne incognita evaluated in vitro and in planta. To determine the nematicidal activity, juveniles of M. incognita were exposed …

This investigation presents a novel finding showing the effect of culture filtrates (CFs) of macrofungi, Ganoderma lucidum, ag …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Root-Knot Disease Suppression in Eggplant Based on Three Growth Ages of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 48

471.
Neurite outgrowth stimulatory effects of culinary-medicinal mushrooms and their toxicity assessment using differentiating Neuro-2a and embryonic fibroblast BALB/3T3.
- Phan CW, David P, Naidu M, Wong KH, Sabaratnam V.
- BMC Complement Altern Med. 2013 Oct 11;13:261. doi: 10.1186/1472-6882-13-261.
- PMCID: PMC3852280
Phan CW, et al.

BMC Complement Altern Med. 2013.

PMCID: PMC3852280

In vitro cytotoxicity was investigated by using mouse embryonic fibroblast (BALB/3T3) and N2a cells for any embryo- and neuro-toxic effects; respectively. RESULTS: Aqueous extracts of Ganoderma lucidum, Lignosus rhinocerotis, Pleurotus giganteus and Grifola frondosa …

In vitro cytotoxicity was investigated by using mouse embryonic fibroblast (BALB/3T3) and N2a cells for any embryo- and neuro-toxic effects; …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Neurite outgrowth stimulatory effects of culinary-medicinal mushrooms and their toxicity assessment using differentiating Neuro-2a and embryonic fibroblast BALB/3T3.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
472.
Hypouricemic Effect of Submerged Culture of Ganoderma lucidum in Potassium Oxonate-Induced Hyperuricemic Rats.
- Huang CH, Chen TY, Tsai GJ.
- Metabolites. 2022 Jun 16;12(6):553. doi: 10.3390/metabo12060553.
- PMCID: PMC9227023
Huang CH, et al.

Metabolites. 2022.

PMCID: PMC9227023

The objective of this study was to investigate the hypouricemic effects of submerged culture of Ganoderma lucidum. The lyophilized powder of mycelium (GM) and extracellular polysaccharides (GP) of the G. lucidum submerged culture were prepared. ...These resul …

The objective of this study was to investigate the hypouricemic effects of submerged culture of Ganoderma lucidum. The lyophil …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Hypouricemic Effect of Submerged Culture of Ganoderma lucidum in Potassium Oxonate-Induced Hyperuricemic Rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
473.
Water Extract of Sporoderm-Broken Spores of Ganoderma lucidum Induces Osteosarcoma Apoptosis and Restricts Autophagic Flux.
- Zhang W, Lei Z, Meng J, Li G, Zhang Y, He J, Yan W.
- Onco Targets Ther. 2019 Dec 31;12:11651-11665. doi: 10.2147/OTT.S226850.
- PMCID: PMC6942530
Zhang W, et al.

Onco Targets Ther. 2019.

PMCID: PMC6942530

PURPOSE: Osteosarcoma (OS) is a malignant bone tumor with easy metastasis and poor prognosis. Ganoderma lucidum (G. lucidum), a traditional Chinese medicine, was reported playing a critical role in suppressing multiple tumor progress. So we wanted to investig …

PURPOSE: Osteosarcoma (OS) is a malignant bone tumor with easy metastasis and poor prognosis. Ganoderma lucidum (G. lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Water Extract of Sporoderm-Broken Spores of Ganoderma lucidum Induces Osteosarcoma Apoptosis and Restricts Autophagic Flux.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
474.
Indian medicinal mushrooms as a source of antioxidant and antitumor agents.
- A Ajith T, K Janardhanan K.
- J Clin Biochem Nutr. 2007 May;40(3):157-62. doi: 10.3164/jcbn.40.157.
- PMCID: PMC2275760
A Ajith T, et al.

J Clin Biochem Nutr. 2007.

PMCID: PMC2275760

Medicinal mushrooms occurring in South India namely Ganoderma lucidum, Phellinus rimosus, Pleurotus florida and Pleurotus pulmonaris possessed profound antioxidant and antitumor activities. ...

Medicinal mushrooms occurring in South India namely Ganoderma lucidum, Phellinus rimosus, Pleurotus florida and Pleurotus pulm …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Indian medicinal mushrooms as a source of antioxidant and antitumor agents.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
475.
Comparative Mitogenomics Provides Valuable Insights for the Phylogeny and New DNA Barcodes of Ganoderma.
- Chen TQ, Yang C, Xu XL, Yang L, He HQ, Weng MT, Ying ZH, Shi XK, Ding MG.
- J Fungi (Basel). 2024 Nov 5;10(11):769. doi: 10.3390/jof10110769.
- PMCID: PMC11595954
Chen TQ, et al.

J Fungi (Basel). 2024.

PMCID: PMC11595954

Herein, four novel mitogenomes of commonly cultivated Ganoderma (G. leucocontextum H4, G. lucidum G6, G. sinense MZ96 and G. tsugae SS) were de novo assembled and given detail functional annotations. ...And finally, we found that the atp9 and nad4L were the most rel …

Herein, four novel mitogenomes of commonly cultivated Ganoderma (G. leucocontextum H4, G. lucidum G6, G. sinense MZ96 and G. t …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Comparative Mitogenomics Provides Valuable Insights for the Phylogeny and New DNA Barcodes of Ganoderma .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Maps pathways and components that can guide future lab and clinical research. Open article.
476.
Long-Term Administration of Triterpenoids From Ganoderma lucidum Mitigates Age-Associated Brain Physiological Decline via Regulating Sphingolipid Metabolism and Enhancing Autophagy in Mice.
- Zeng M, Qi L, Guo Y, Zhu X, Tang X, Yong T, Xie Y, Wu Q, Zhang M, Chen D.
- Front Aging Neurosci. 2021 May 6;13:628860. doi: 10.3389/fnagi.2021.628860.
- PMCID: PMC8134542
Zeng M, et al.

Front Aging Neurosci. 2021.

PMCID: PMC8134542

In this study, long-term administration of triterpenoids of Ganoderma lucidum (TGL) can mitigate brain physiological decline in normal aging mice. In addition, the age-associated pathological features, including cataract formation, hair loss, and skin relaxation, br …

In this study, long-term administration of triterpenoids of Ganoderma lucidum (TGL) can mitigate brain physiological decline i …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Long-Term Administration of Triterpenoids From Ganoderma lucidum Mitigates Age-Associated Brain Physiological Decline via Regulating Sphingolipid Metabolism and Enhancing Autophagy in Mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
477.
Ganoderma lucidum ethanol extract inhibits the inflammatory response by suppressing the NF-kappaB and toll-like receptor pathways in lipopolysaccharide-stimulated BV2 microglial cells.
- Yoon HM, Jang KJ, Han MS, Jeong JW, Kim GY, Lee JH, Choi YH.
- Exp Ther Med. 2013 Jan 15;5(3):957-963. doi: 10.3892/etm.2013.895.
- PMCID: PMC3570243
Yoon HM, et al.

Exp Ther Med. 2013.

PMCID: PMC3570243

Ganoderma lucidum is a traditional Oriental medicine that has been widely used as a tonic to promote longevity and health in Korea and other Asian countries. ...In this study, we evaluated the inhibitory effects of G. lucidum ethanol extract (EGL) on the prod …

Ganoderma lucidum is a traditional Oriental medicine that has been widely used as a tonic to promote longevity and health in K …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum ethanol extract inhibits the inflammatory response by suppressing the NF-kappaB and toll-like receptor pathways in lipopolysaccharide-stimulated BV2 microglial cells.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
478.
Ganoderma tsuage promotes pain sensitivity in aging mice.
- Yang KN, Lin CY, Li WN, Tang CM, Pradhan J, Chao MW, Tseng CY.
- Sci Rep. 2024 May 21;14(1):11536. doi: 10.1038/s41598-024-61499-0.
- PMCID: PMC11109092
Yang KN, et al.

Sci Rep. 2024.

PMCID: PMC11109092

Health food is a geriatric healthcare choice for the elderly with Ganoderma tsuage (GT), a Reishi type, as the main product in the market. GT contains polysaccharides, triterpenoids, adenosine, immunoregulatory proteins, and other components, including anticancer, b …

Health food is a geriatric healthcare choice for the elderly with Ganoderma tsuage (GT), a Reishi type, as the main product in …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma tsuage promotes pain sensitivity in aging mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
479.
Mushroom beta-Glucan Recovered from Antler-Type Fruiting Body of Ganoderma lucidum by Enzymatic Process and Its Potential Biological Activities for Cosmeceutical Applications.
- Vaithanomsat P, Boonlum N, Chaiyana W, Tima S, Anuchapreeda S, Trakunjae C, Apiwatanapiwat W, Janchai P, Boondaeng A, Nimitkeatkai H, Jarerat A.
- Polymers (Basel). 2022 Oct 7;14(19):4202. doi: 10.3390/polym14194202.
- PMCID: PMC9573635
Vaithanomsat P, et al.

Polymers (Basel). 2022.

PMCID: PMC9573635

This research applied a process for recovering beta-glucan (BG) from the antler-type fruiting body of Ganoderma lucidum as well as tested the biological activities related to cosmeceutical applications. ...These findings provided new insights into the potential appl …

This research applied a process for recovering beta-glucan (BG) from the antler-type fruiting body of Ganoderma lucidum as wel …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Mushroom beta-Glucan Recovered from Antler-Type Fruiting Body of Ganoderma lucidum by Enzymatic Process and Its Potential Biological Activities for Cosmeceutical Applications.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
480.
Inter and intraspecific genetic diversity (RAPD) among three most frequent species of macrofungi (Ganoderma lucidum, Leucoagricus sp. and Lentinus sp.) of Tropical forest of Central India.
- Dwivedi S, Singh S, Chauhan UK, Tiwari MK.
- J Genet Eng Biotechnol. 2017 Dec 2;16(1):133-141. doi: 10.1016/j.jgeb.2017.11.008.
- PMCID: PMC6296601
Dwivedi S, et al.

J Genet Eng Biotechnol. 2017.

PMCID: PMC6296601

In present study seven RAPD primers were used to access the diversity within and among twelve populations of three mushroom species Ganoderma lucidum, leucoagaricus sp. and Lentinus sp. Total of 111 bands were scored by 7 RAPD primers in 30 accessions of three mushr …

In present study seven RAPD primers were used to access the diversity within and among twelve populations of three mushroom species Ganod …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Inter and intraspecific genetic diversity (RAPD) among three most frequent species of macrofungi ( Ganoderma lucidum , Leucoagricus sp. and Lentinus sp.) of Tropical forest of Central India.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 49

481.
Bioactivity and Mycochemical Profile of Extracts from Mycelial Cultures of Ganoderma spp.
- Sułkowska-Ziaja K, Zengin G, Gunia-Krzyżak A, Popiół J, Szewczyk A, Jaszek M, Rogalski J, Muszyńska B.
- Molecules. 2022 Jan 3;27(1):275. doi: 10.3390/molecules27010275.
- PMCID: PMC8746335
Sułkowska-Ziaja K, et al.

Molecules. 2022.

PMCID: PMC8746335

The present study aims to assess the biosynthetic potential of mycelial cultures of six Ganoderma species: G. adspersum, G. applanatum, G. carnosum, G. lucidum, G. pfeifferi, and G. resinaceum. ...The total content of indole compounds in the extracts ranged …

The present study aims to assess the biosynthetic potential of mycelial cultures of six Ganoderma species: G. adspersum, G.  …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Bioactivity and Mycochemical Profile of Extracts from Mycelial Cultures of Ganoderma spp.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
482.
Target proteins of ganoderic acid DM provides clues to various pharmacological mechanisms.
- Liu J, Shimizu K, Tanaka A, Shinobu W, Ohnuki K, Nakamura T, Kondo R.
- Sci Rep. 2012 Nov 30;2:905. doi: 10.1038/srep00905.
- PMCID: PMC3510465
Liu J, et al.

Sci Rep. 2012.

PMCID: PMC3510465

Ganoderma fungus (Ganodermataceae) is a multifunctional medicinal mushroom and has been traditionally used for the treatment of various types of disease. ...

Ganoderma fungus (Ganodermataceae) is a multifunctional medicinal mushroom and has been traditionally used for the treatment of vario …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Target proteins of ganoderic acid DM provides clues to various pharmacological mechanisms.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
483.
Ganoderma lucidum spore extract improves sleep disturbances in a rat model of sporadic Alzheimer's disease.
- Qin Y, Zhao Y, Hu X, Chen X, Jiang YP, Jin XJ, Li G, Li ZH, Yang JH, Zhang GL, Cui SY, Zhang YH.
- Front Pharmacol. 2024 Apr 24;15:1390294. doi: 10.3389/fphar.2024.1390294.
- PMCID: PMC11076761
Qin Y, et al.

Front Pharmacol. 2024.

PMCID: PMC11076761

Introduction: Ganoderma lucidum (G. lucidum, Lingzhi) has long been listed as a premium tonic that can be used to improve restlessness, insomnia, and forgetfulness. We previously reported that a rat model of sporadic Alzheimer's disease (sAD) that was induced …

Introduction: Ganoderma lucidum (G. lucidum, Lingzhi) has long been listed as a premium tonic that can be used to impro …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum spore extract improves sleep disturbances in a rat model of sporadic Alzheimer's disease.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
484.
Ganoderma: A Cancer Immunotherapy Review.
- Cao Y, Xu X, Liu S, Huang L, Gu J.
- Front Pharmacol. 2018 Oct 25;9:1217. doi: 10.3389/fphar.2018.01217.
- PMCID: PMC6209820
Cao Y, et al.

Front Pharmacol. 2018.

PMCID: PMC6209820

Ganoderma is a significant source of natural fungal medicines and has been used for the treatment of various diseases for many years. ...This review provides guidance for future research into the role of Ganoderma in cancer immunotherapy....

Ganoderma is a significant source of natural fungal medicines and has been used for the treatment of various diseases for many years. …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma : A Cancer Immunotherapy Review.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
485.
Senolytic effect of triterpenoid complex from Ganoderma lucidum on adriamycin-induced senescent human hepatocellular carcinoma cells model in vitro and in vivo.
- Abdelmoaty AAA, Chen J, Zhang K, Wu C, Li Y, Li P, Xu J.
- Front Pharmacol. 2024 Sep 19;15:1422363. doi: 10.3389/fphar.2024.1422363.
- PMCID: PMC11447279
Abdelmoaty AAA, et al.

Front Pharmacol. 2024.

PMCID: PMC11447279

BACKGROUND: Ganoderma lucidum (G. lucidum) is a famous medicinal mushroom that has been reported to prevent and treat a variety of diseases. Different extractions from G. lucidum have been used to manage age-related diseases, including cancer. Neverthe …

BACKGROUND: Ganoderma lucidum (G. lucidum) is a famous medicinal mushroom that has been reported to prevent and treat a …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Senolytic effect of triterpenoid complex from Ganoderma lucidum on adriamycin-induced senescent human hepatocellular carcinoma cells model in vitro and in vivo.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
486.
Management of Combined Therapy (Ceritinib, A. cinnamomea, G. lucidum, and Photobiomodulation) in Advanced Non-Small-Cell Lung Cancer: A Case Report.
- Su CT, Wu JH.
- Life (Basel). 2022 Jun 9;12(6):862. doi: 10.3390/life12060862.
- PMCID: PMC9228003
Su CT, et al.

Life (Basel). 2022.

PMCID: PMC9228003

Here, we report a patient with advanced NSCLC who received combined therapy, including ceritinib, photobiomodulation (PBM), ACGL (Antrodia cinnamomea (A. cinnamomea), and Ganoderma lucidum (G. lucidum)). Based on combined therapy, suitable doses of A. cinnamo …

Here, we report a patient with advanced NSCLC who received combined therapy, including ceritinib, photobiomodulation (PBM), ACGL (Antrodia c …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Management of Combined Therapy (Ceritinib, A. cinnamomea, G. lucidum , and Photobiomodulation) in Advanced Non-Small-Cell Lung Cancer: A Case Report.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
487.
The medicinal mushroom Ganoderma lucidum prevents lung tumorigenesis induced by tobacco smoke carcinogens.
- Shahid A, Chen M, Yeung S, Parsa C, Orlando R, Huang Y.
- Front Pharmacol. 2023 Sep 6;14:1244150. doi: 10.3389/fphar.2023.1244150.
- PMCID: PMC10516555
Shahid A, et al.

Front Pharmacol. 2023.

PMCID: PMC10516555

Ganoderma lucidum (GL), commonly known as "Lingzhi", is a well-known medicinal mushroom with antioxidant and anti-cancer activity. ...

Ganoderma lucidum (GL), commonly known as "Lingzhi", is a well-known medicinal mushroom with antioxidant and anti-cancer activ …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The medicinal mushroom Ganoderma lucidum prevents lung tumorigenesis induced by tobacco smoke carcinogens.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
488.
Network Pharmacology and Experimental Validation Reveal Ganodermanontriol Modulates Pneumonia via TNF/NF-κB/MAPKs Signaling Pathway.
- Deng S, Zhong D, Dong Y, Qian Y, Wang B, Hu M, Liu M, Tan K, Zhang C, Tang H.
- Food Sci Nutr. 2025 Mar 25;13(4):e70123. doi: 10.1002/fsn3.70123.
- PMCID: PMC11936839
Deng S, et al.

Food Sci Nutr. 2025.

PMCID: PMC11936839

Ganoderma lucidum (Leyss. ex Fr.) Karst, commonly known as Lingzhi, has long been employed in traditional Chinese medicine for its medicinal properties, particularly in alleviating respiratory issues like cough and asthma. ...Despite its widespread use, the effectiv …

Ganoderma lucidum (Leyss. ex Fr.) Karst, commonly known as Lingzhi, has long been employed in traditional Chinese medicine for …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Network Pharmacology and Experimental Validation Reveal Ganodermanontriol Modulates Pneumonia via TNF/NF-κB/MAPKs Signaling Pathway.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
489.
Traditional uses, chemical components and pharmacological activities of the genus Ganoderma P. Karst.: a review.
- Wang L, Li JQ, Zhang J, Li ZM, Liu HG, Wang YZ.
- RSC Adv. 2020 Nov 18;10(69):42084-42097. doi: 10.1039/d0ra07219b.
- PMCID: PMC9057998
Wang L, et al.

RSC Adv. 2020.

PMCID: PMC9057998

In recent years, some natural products isolated from the fungi of the genus Ganoderma have been found to have anti-tumor, liver protection, anti-inflammatory, immune regulation, anti-oxidation, anti-viral, anti-hyperglycemic and anti-hyperlipidemic effects. ...The triterpe …

In recent years, some natural products isolated from the fungi of the genus Ganoderma have been found to have anti-tumor, liver prote …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Traditional uses, chemical components and pharmacological activities of the genus Ganoderma P. Karst.: a review.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
490.
Advancement of Microwave-Assisted Biosynthesis for Preparing Au Nanoparticles Using Ganoderma lucidum Extract and Evaluation of Their Catalytic Reduction of 4-Nitrophenol.
- Nguyen VP, Le Trung H, Nguyen TH, Hoang D, Tran TH.
- ACS Omega. 2021 Nov 17;6(47):32198-32207. doi: 10.1021/acsomega.1c05033.
- PMCID: PMC8638019
Nguyen VP, et al.

ACS Omega. 2021.

PMCID: PMC8638019

This study describes the biosynthesis of gold nanoparticles (AuNPs) using the extract of Ganoderma lucidum in the buffer zone of Bach Ma National Park, Vietnam, as a reducing and protecting agent using microwave-assisted synthesis. ...

This study describes the biosynthesis of gold nanoparticles (AuNPs) using the extract of Ganoderma lucidum in the buffer zone …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Advancement of Microwave-Assisted Biosynthesis for Preparing Au Nanoparticles Using Ganoderma lucidum Extract and Evaluation of Their Catalytic Reduction of 4-Nitrophenol.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 50

491.
Interaction of Ganoderma triterpenes with doxorubicin and proteomic characterization of the possible molecular targets of Ganoderma triterpenes.
- Yue QX, Xie FB, Guan SH, Ma C, Yang M, Jiang BH, Liu X, Guo DA.
- Cancer Sci. 2008 Apr 16;99(7):1461-70. doi: 10.1111/j.1349-7006.2008.00824.x.
- PMCID: PMC11159042
Yue QX, et al.

Cancer Sci. 2008.

PMCID: PMC11159042

Triterpenes are the main components with cytotoxicity in Ganoderma lucidum, which is used popularly as a complementary treatment for cancer therapy in traditional Chinese medicine. To investigate the possible interaction between chemotherapeutic agents and triterpen …

Triterpenes are the main components with cytotoxicity in Ganoderma lucidum, which is used popularly as a complementary treatme …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Interaction of Ganoderma triterpenes with doxorubicin and proteomic characterization of the possible molecular targets of Ganoderma triterpenes.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Broad molecular profiling and pathway/statistical analyses. Open article.
- Why might this paper be useful to readers? Maps pathways and components that can guide future lab and clinical research. Open article.
492.
A Review of Ganoderma Triterpenoids and Their Bioactivities.
- Galappaththi MCA, Patabendige NM, Premarathne BM, Hapuarachchi KK, Tibpromma S, Dai DQ, Suwannarach N, Rapior S, Karunarathna SC.
- Biomolecules. 2022 Dec 22;13(1):24. doi: 10.3390/biom13010024.
- PMCID: PMC9856212
Galappaththi MCA, et al.

Biomolecules. 2022.

PMCID: PMC9856212

For centuries, Ganoderma has been used as a traditional medicine in Asian countries to prevent and treat various diseases. Numerous publications are stating that Ganoderma species have a variety of beneficial medicinal properties, and investigations on different met …

For centuries, Ganoderma has been used as a traditional medicine in Asian countries to prevent and treat various diseases. Numerous p …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A Review of Ganoderma Triterpenoids and Their Bioactivities.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
493.
Neuroprotective effect of pretreatment with ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus.
- Zhang W, Zhang Q, Deng W, Li Y, Xing G, Shi X, Du Y.
- Neural Regen Res. 2014 Aug 1;9(15):1446-52. doi: 10.4103/1673-5374.139461.
- PMCID: PMC4192946
Zhang W, et al.

Neural Regen Res. 2014.

PMCID: PMC4192946

This study aimed to investigate the protective effects and mechanisms of pretreatment with ganoderma lucidum (by intragastric administration) in cerebral ischemia/reperfusion injury in rats. ...These results suggest that pretreatment with ganoderma lucidum …

This study aimed to investigate the protective effects and mechanisms of pretreatment with ganoderma lucidum (by intragastric …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Neuroprotective effect of pretreatment with ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
494.
The Versatile Functions of G. Lucidum Polysaccharides and G. Lucidum Triterpenes in Cancer Radiotherapy and Chemotherapy.
- Xu J, Chen F, Wang G, Liu B, Song H, Ma T.
- Cancer Manag Res. 2021 Aug 17;13:6507-6516. doi: 10.2147/CMAR.S319732.
- PMCID: PMC8380140
Xu J, et al.

Cancer Manag Res. 2021.

PMCID: PMC8380140

G. lucidum has a long history of thousands of years in China and is closely related with the lives of the Chinese people. ...At present, many cancer research studies have reported the G. lucidum polysaccharides (GLPs) and G. lucidum triterpenes (GLTs) as the …

G. lucidum has a long history of thousands of years in China and is closely related with the lives of the Chinese people. ...At prese …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The Versatile Functions of G. Lucidum Polysaccharides and G. Lucidum Triterpenes in Cancer Radiotherapy and Chemotherapy.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
495.
Neuroprotective effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis.
- Sun XZ, Liao Y, Li W, Guo LM.
- Neural Regen Res. 2017 Jun;12(6):953-958. doi: 10.4103/1673-5374.208590.
- PMCID: PMC5514871
Sun XZ, et al.

Neural Regen Res. 2017.

PMCID: PMC5514871

Ganoderma lucidum polysaccharides have protective effects against apoptosis in neurons exposed to ischemia/reperfusion injury, but the mechanisms are unclear. ...In these cells, ganoderma lucidum polysaccharides remarkably suppressed H(2)O(2)-induced a …

Ganoderma lucidum polysaccharides have protective effects against apoptosis in neurons exposed to ischemia/reperfusion injury, …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Neuroprotective effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
496.
Exploring the health benefits of Ganoderma: antimicrobial properties and mechanisms of action.
- Karunarathna SC, Patabendige NM, Hapuarachchi KK, Promputtha I.
- Front Cell Infect Microbiol. 2025 Jul 18;15:1535246. doi: 10.3389/fcimb.2025.1535246.
- PMCID: PMC12313647
Karunarathna SC, et al.

Front Cell Infect Microbiol. 2025.

PMCID: PMC12313647

Ganoderma, a well-known medicinal mushroom, has garnered attention for its broad therapeutic properties, particularly its potent antimicrobial activities. This review focuses on the mechanisms of action and bioactive compounds responsible for the ability of Ganoderma …

Ganoderma, a well-known medicinal mushroom, has garnered attention for its broad therapeutic properties, particularly its potent anti …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Exploring the health benefits of Ganoderma : antimicrobial properties and mechanisms of action.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
497.
Study on Differences of Metabolites among Different Ganoderma Species with Comprehensive Metabolomics.
- Khadbaatar S, Bao H, Gao X, Huo H.
- J Fungi (Basel). 2024 Jul 27;10(8):524. doi: 10.3390/jof10080524.
- PMCID: PMC11355880
Khadbaatar S, et al.

J Fungi (Basel). 2024.

PMCID: PMC11355880

In traditional Chinese medicine, Ganoderma is a kind of edible and medicinal mushroom, which is widely used because of its significant pharmacological activity. ...This study provides new insights and a theoretical basis for the development and utilization of the genus …

In traditional Chinese medicine, Ganoderma is a kind of edible and medicinal mushroom, which is widely used because of its significan …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Study on Differences of Metabolites among Different Ganoderma Species with Comprehensive Metabolomics.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Broad molecular profiling and pathway/statistical analyses. Open article.
- Why might this paper be useful to readers? Maps pathways and components that can guide future lab and clinical research. Open article.
498.
The anti-fatigue and sleep-aiding effects vary significantly among different recipes containing Ganoderma lucidum extracts.
- Li K, Liu W, Wu C, Wang L, Huang Y, Li Y, Zheng H, Shang Y, Zhang L, Chen Z.
- Heliyon. 2024 May 8;10(10):e30907. doi: 10.1016/j.heliyon.2024.e30907.
- PMCID: PMC11103526
Li K, et al.

Heliyon. 2024.

PMCID: PMC11103526

AIMS: This study aims to delve into the anti-fatigue and sleep-aiding effects of various formulations containing Ganoderma lucidum extracts. MATERIALS AND METHODS: PGB [incorporating Ganoderma lucidum extract (GE), broken Ganoderma lucidum …

AIMS: This study aims to delve into the anti-fatigue and sleep-aiding effects of various formulations containing Ganoderma lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The anti-fatigue and sleep-aiding effects vary significantly among different recipes containing Ganoderma lucidum extracts.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
499.
Ganoderma spp.: A Promising Adjuvant Treatment for Breast Cancer.
- Suárez-Arroyo IJ, Loperena-Alvarez Y, Rosario-Acevedo R, Martínez-Montemayor MM.
- Medicines (Basel). 2017 Mar 15;4(1):15. doi: 10.3390/medicines4010015.
- PMCID: PMC5533290
Suárez-Arroyo IJ, et al.

Medicines (Basel). 2017.

PMCID: PMC5533290

Ganoderma anticancer effects are attributed to its efficacy in reducing cancer cell survival and growth, as well as by its chemosensitizing role. In vitro and in vivo studies have been conducted in various cancer cells and animal models; however, in this review, we focus o …

Ganoderma anticancer effects are attributed to its efficacy in reducing cancer cell survival and growth, as well as by its chemosensi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma spp.: A Promising Adjuvant Treatment for Breast Cancer.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
500.
The effects of freeze-dried Ganoderma lucidum mycelia on a recurrent oral ulceration rat model.
- Xie L, Zhong X, Liu D, Liu L, Xia Z.
- BMC Complement Altern Med. 2017 Dec 1;17(1):511. doi: 10.1186/s12906-017-2021-8.
- PMCID: PMC5709989
Xie L, et al.

BMC Complement Altern Med. 2017.

PMCID: PMC5709989

BACKGROUND: Conventional scientific studies had supported the use of polysaccharides and beta-glucans from a number of fungi, including Ganoderma lucidum for the treatment of recurrent oral ulceration (ROU). Our aim of the present study was to evaluate whether freez …

BACKGROUND: Conventional scientific studies had supported the use of polysaccharides and beta-glucans from a number of fungi, including G …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The effects of freeze-dried Ganoderma lucidum mycelia on a recurrent oral ulceration rat model.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 51

501.
Coriolus Versicolor and Ganoderma Lucidum Related Natural Products as an Adjunct Therapy for Cancers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Zhong L, Yan P, Lam WC, Yao L, Bian Z.
- Front Pharmacol. 2019 Jul 3;10:703. doi: 10.3389/fphar.2019.00703.
- PMCID: PMC6616310
Zhong L, et al.

Front Pharmacol. 2019.

PMCID: PMC6616310

Background: Cancer incidence and mortality rates keep rising globally. Coriolus versicolor and Ganoderma lucidum related natural products are commonly applied as a complementary therapeutic option for different stages and types of cancers. ...Conclusion: In this met …

Background: Cancer incidence and mortality rates keep rising globally. Coriolus versicolor and Ganoderma lucidum related natur …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Coriolus Versicolor and Ganoderma Lucidum Related Natural Products as an Adjunct Therapy for Cancers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Participant-reported outcomes, clinical biomarkers, and safety/tolerability. Open article.
- Why might this paper be useful to readers? Provides early human data; interpret with caution and check study size and endpoints. Open article.
502.
Elucidating "lucidum": Distinguishing the diverse laccate Ganoderma species of the United States.
- Loyd AL, Barnes CW, Held BW, Schink MJ, Smith ME, Smith JA, Blanchette RA.
- PLoS One. 2018 Jul 18;13(7):e0199738. doi: 10.1371/journal.pone.0199738.
- PMCID: PMC6051579
Loyd AL, et al.

PLoS One. 2018.

PMCID: PMC6051579

For the past century, many studies of Ganoderma in North America and other regions of the world have used the name G. lucidum sensu lato for any laccate (shiny or varnished) Ganoderma species growing on hardwood trees or substrates. ...These collections appea …

For the past century, many studies of Ganoderma in North America and other regions of the world have used the name G. lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Elucidating " lucidum ": Distinguishing the diverse laccate Ganoderma species of the United States.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
503.
Sporoderm-removed Ganoderma lucidum spores ameliorated early depression-like behavior in a rat model of sporadic Alzheimer's disease.
- Zhao Y, Qin Y, Hu X, Chen X, Jiang YP, Jin XJ, Li G, Li ZH, Yang JH, Cui SY, Zhang YH.
- Front Pharmacol. 2024 Apr 24;15:1406127. doi: 10.3389/fphar.2024.1406127.
- PMCID: PMC11076787
Zhao Y, et al.

Front Pharmacol. 2024.

PMCID: PMC11076787

Introduction: Ganoderma lucidum: (G. lucidum, Lingzhi) is a medicinal and edible homologous traditional Chinese medicine that is used to treat various diseases, including Alzheimer's disease and mood disorders. We previously reported that the sporoderm-remove …

Introduction: Ganoderma lucidum: (G. lucidum, Lingzhi) is a medicinal and edible homologous traditional Chinese medicin …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Sporoderm-removed Ganoderma lucidum spores ameliorated early depression-like behavior in a rat model of sporadic Alzheimer's disease.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
504.
A comprehensive review of the structure elucidation and biological activity of triterpenoids from Ganoderma spp.
- Xia Q, Zhang H, Sun X, Zhao H, Wu L, Zhu D, Yang G, Shao Y, Zhang X, Mao X, Zhang L, She G.
- Molecules. 2014 Oct 30;19(11):17478-535. doi: 10.3390/molecules191117478.
- PMCID: PMC6271249
Xia Q, et al.

Molecules. 2014.

PMCID: PMC6271249

Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, a traditional Chinese medicine, popularly used for complementary cancer therapy. ...This paper compiles 316 naturally occurring triterpenes from Ganoderma based on th …

Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, a traditional Chinese medicine, p …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A comprehensive review of the structure elucidation and biological activity of triterpenoids from Ganoderma spp.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
505.
Extraction, Structural Characterization, and Immunomodulatory Activity of a High Molecular Weight Polysaccharide From Ganoderma lucidum.
- Liu G, Zhang J, Kan Q, Song M, Hou T, An S, Lin H, Chen H, Hu L, Xiao J, Chen Y, Cao Y.
- Front Nutr. 2022 Mar 25;9:846080. doi: 10.3389/fnut.2022.846080.
- PMCID: PMC8990850
Liu G, et al.

Front Nutr. 2022.

PMCID: PMC8990850

Ganoderma lucidum polysaccharides (GLP) exhibited excellent immunomodulatory activity. Unfortunately, the structure and immunomodulatory activity of GLP are still unclear. ...

Ganoderma lucidum polysaccharides (GLP) exhibited excellent immunomodulatory activity. Unfortunately, the structure and immuno …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Extraction, Structural Characterization, and Immunomodulatory Activity of a High Molecular Weight Polysaccharide From Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
506.
Fortification of Chinese Steamed Bread Through Broken Ganoderma lucidum Spore Powder Incorporation: Effects on Physicochemical and Quality Properties.
- Chen J, Cheng D, Luo S, Hu Y, Liu C, Guo X, Yu X, Zhang L, Wu J.
- Foods. 2025 Apr 21;14(8):1433. doi: 10.3390/foods14081433.
- PMCID: PMC12027355
Chen J, et al.

Foods. 2025.

PMCID: PMC12027355

Broken Ganoderma lucidum spore powder (BGLSP) is abundant in nutrients and bioactive compounds, rendering it a suitable functional raw material for food applications. ...

Broken Ganoderma lucidum spore powder (BGLSP) is abundant in nutrients and bioactive compounds, rendering it a suitable functi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Fortification of Chinese Steamed Bread Through Broken Ganoderma lucidum Spore Powder Incorporation: Effects on Physicochemical and Quality Properties.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Useful for quality control, sourcing, and preventing adulteration. Open article.
507.
Ganoderma lucidum Pharmacopuncture for the Treatment of Acute Gastric Ulcers in Rats.
- Park JH, Jang KJ, Kim CH, Lee YH, Lee SJ, Kim BH, Yoon HM.
- J Pharmacopuncture. 2014 Sep;17(3):40-9. doi: 10.3831/KPI.2014.17.025.
- PMCID: PMC4332011
Park JH, et al.

J Pharmacopuncture. 2014.

PMCID: PMC4332011

The basic physiopathology of a gastric ulcer results from an imbalance between some endogenous aggressive and cytoprotective factors. This study examined whether Ganoderma lucidum pharmacopuncture (GLP) would provide protection against acute gastric ulcers in rats. …

The basic physiopathology of a gastric ulcer results from an imbalance between some endogenous aggressive and cytoprotective factors. This s …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Pharmacopuncture for the Treatment of Acute Gastric Ulcers in Rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
508.
Potentiation of neuritogenic activity of medicinal mushrooms in rat pheochromocytoma cells.
- Ling-Sing Seow S, Naidu M, David P, Wong KH, Sabaratnam V.
- BMC Complement Altern Med. 2013 Jul 4;13:157. doi: 10.1186/1472-6882-13-157.
- PMCID: PMC3720279
Ling-Sing Seow S, et al.

BMC Complement Altern Med. 2013.

PMCID: PMC3720279

METHODS: Cytotoxic effects of aqueous extracts of three medicinal mushrooms basidiocarps, Ganoderma lucidum, Ganoderma neo-japonicum and Grifola frondosa towards rat pheochromocytoma (PC-12) cells were determined by 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltet …

METHODS: Cytotoxic effects of aqueous extracts of three medicinal mushrooms basidiocarps, Ganoderma lucidum, Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Potentiation of neuritogenic activity of medicinal mushrooms in rat pheochromocytoma cells.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
509.
Evaluation of Bioactive Compounds, Antioxidant Activity, and Anticancer Potential of Wild Ganoderma lucidum Extracts from High-Altitude Regions of Nepal.
- Thapa I, Pandey A, Tiwari S, Awal SC.
- Curr Issues Mol Biol. 2025 Aug 5;47(8):624. doi: 10.3390/cimb47080624.
- PMCID: PMC12384079
Thapa I, et al.

Curr Issues Mol Biol. 2025.

PMCID: PMC12384079

Wild Ganoderma lucidum from Nepal's high-altitude regions was studied to identify key bioactive compounds and assess the influence of solvent type-water, ethanol, methanol, and acetone-on extraction efficiency and biological activity. ...These findings demonstrate t …

Wild Ganoderma lucidum from Nepal's high-altitude regions was studied to identify key bioactive compounds and assess the influ …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Evaluation of Bioactive Compounds, Antioxidant Activity, and Anticancer Potential of Wild Ganoderma lucidum Extracts from High-Altitude Regions of Nepal.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
510.
Synergistic Cytotoxic Effects of Ganoderma lucidum and Bacillus Calmette Guerin on Premalignant Urothelial HUC-PC Cells and Its Regulation on Proinflammatory Cytokine Secretion.
- Yuen JW, Gohel MD, Ng CF.
- Evid Based Complement Alternat Med. 2012 Aug 28;2012:147896. doi: 10.1155/2012/147896.
- PMCID: PMC3434421
Yuen JW, et al.

Evid Based Complement Alternat Med. 2012.

PMCID: PMC3434421

To address the issues of efficacy and safety, an ethanol extract of Ganoderma lucidum (GLe) was evaluated for its interaction with BCG. In a model of premalignant human uroepithelial cells (HUC-PC), GLe exerted immediate cytotoxic effects while BCG showed a delayed …

To address the issues of efficacy and safety, an ethanol extract of Ganoderma lucidum (GLe) was evaluated for its interaction …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Synergistic Cytotoxic Effects of Ganoderma lucidum and Bacillus Calmette Guerin on Premalignant Urothelial HUC-PC Cells and Its Regulation on Proinflammatory Cytokine Secretion.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 52

511.
Intranasal administration of Ganoderma lucidum-derived exosome-like nanovesicles ameliorates cognitive impairment by reducing inflammation in a mouse model of Alzheimer's disease.
- Mi X, Ruan X, Lin R, Huang S, Cai P, Chen X, Liao J, Dai X.
- Front Pharmacol. 2025 Jul 4;16:1572771. doi: 10.3389/fphar.2025.1572771.
- PMCID: PMC12271231
Mi X, et al.

Front Pharmacol. 2025.

PMCID: PMC12271231

Currently, there is currently still a lack of effective therapeutic drugs for AD. Ganoderma lucidum (G. lucidum) is abundant in active ingredients that harbor anti-inflammatory properties in both central nervous system and the periphery. We attempted to deter …

Currently, there is currently still a lack of effective therapeutic drugs for AD. Ganoderma lucidum (G. lucidum) is abu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Intranasal administration of Ganoderma lucidum -derived exosome-like nanovesicles ameliorates cognitive impairment by reducing inflammation in a mouse model of Alzheimer's disease.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
512.
Apoptotic and Immune Restoration Effects of Ganoderic Acids Define a New Prospective for Complementary Treatment of Cancer.
- Radwan FF, Perez JM, Haque A.
- J Clin Cell Immunol. Author manuscript. 2011 Dec 11;S3:4. doi: 10.4172/2155-9899.S3-004.
- PMCID: PMC3546526
Radwan FF, et al.

J Clin Cell Immunol. Author manuscript. 2011.

PMCID: PMC3546526

One attractive source of antitumor products is the Ganoderma lucidum mushroom, which has been used for centuries as an herbal medicine for the prevention and treatment of a variety of diseases, including cancer, and has been shown to improve immune function. ...

One attractive source of antitumor products is the Ganoderma lucidum mushroom, which has been used for centuries as an herbal …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Apoptotic and Immune Restoration Effects of Ganoderic Acids Define a New Prospective for Complementary Treatment of Cancer.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
513.
Exploring Edible Mushrooms for Diabetes: Unveiling Their Role in Prevention and Treatment.
- Shamim MZ, Mishra AK, Kausar T, Mahanta S, Sarma B, Kumar V, Mishra PK, Panda J, Baek KH, Mohanta YK.
- Molecules. 2023 Mar 21;28(6):2837. doi: 10.3390/molecules28062837.
- PMCID: PMC10058372
Shamim MZ, et al.

Molecules. 2023.

PMCID: PMC10058372

Hypoglycaemic effects have been observed in investigations on Agaricussu brufescens, Agaricus bisporus, Cordyceps sinensis, Inonotus obliqus, Coprinus comatus, Ganoderma lucidum, Phellinus linteus, Pleurotus spp., Poria cocos, and Sparassis crispa. ...

Hypoglycaemic effects have been observed in investigations on Agaricussu brufescens, Agaricus bisporus, Cordyceps sinensis, Inonotus obliqus …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Exploring Edible Mushrooms for Diabetes: Unveiling Their Role in Prevention and Treatment.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
514.
Anticancer activity of Amauroderma rude.
- Jiao C, Xie YZ, Yang X, Li H, Li XM, Pan HH, Cai MH, Zhong HM, Yang BB.
- PLoS One. 2013 Jun 20;8(6):e66504. doi: 10.1371/journal.pone.0066504.
- PMCID: PMC3688780
Jiao C, et al.

PLoS One. 2013.

PMCID: PMC3688780

We compared the anti-cancer activity of Amauroderma rude and Ganoderma lucidum, the most well-known medicinal mushrooms with anti-cancer activity and found that Amauroderma rude had significantly higher activity in killing cancer cells than Ganoderma lucid …

We compared the anti-cancer activity of Amauroderma rude and Ganoderma lucidum, the most well-known medicinal mushrooms with a …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Anticancer activity of Amauroderma rude.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
515.
Bibliometric, taxonomic, and medicinal perspectives of Ganoderma neo-japonicum Imazeki: A mini review.
- Lau MF, Phan CW, Sabaratnam V, Kuppusamy UR.
- Mycology. 2024 Jan 21;15(3):360-373. doi: 10.1080/21501203.2024.2302028.
- PMCID: PMC11376291
Lau MF, et al.

Mycology. 2024.

PMCID: PMC11376291

Ganoderma, a traditional medicine in Asian countries, has been used to prevent and treat various ailments for centuries. Ganoderma neo-japonicum (synonym Ganoderma bambusicola), also known as purple Lingzhi, is a species that is currently underutilised when c …

Ganoderma, a traditional medicine in Asian countries, has been used to prevent and treat various ailments for centuries. Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Bibliometric, taxonomic, and medicinal perspectives of Ganoderma neo-japonicum Imazeki: A mini review.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
516.
Integrating transcriptomics, metabolomics, and network pharmacology to investigate multi-target effects of sporoderm-broken spores of Ganoderma lucidum on improving HFD-induced diabetic nephropathy rats.
- Hu L, Yu L, Cao Z, Wang Y, Zhu C, Li Y, Yin J, Ma Z, He X, Zhang Y, Huang W, Guan Y, Chen Y, Li X, Chen X.
- J Pharm Anal. 2024 Sep 19;14(12):101105. doi: 10.1016/j.jpha.2024.101105.
- PMCID: PMC11750267
Hu L, et al.

J Pharm Anal. 2024.

PMCID: PMC11750267

Diabetes mellitus (DM) is a major metabolic disease endangering global health, with diabetic nephropathy (DN) as a primary complication lacking curative therapy. Sporoderm-broken spores of Ganoderma lucidum (GLP), an herbal medicine, has been used for the treatment …

Diabetes mellitus (DM) is a major metabolic disease endangering global health, with diabetic nephropathy (DN) as a primary complication lack …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Integrating transcriptomics, metabolomics, and network pharmacology to investigate multi-target effects of sporoderm-broken spores of Ganoderma lucidum on improving HFD-induced diabetic nephropathy rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Maps pathways and components that can guide future lab and clinical research. Open article.
517.
Distributions of Lanostene-Derived Triterpenoids and Glucan Content in the Fruiting Bodies of the Australian Ganoderma Species.
- De Oliveira Campos A, Harrison MD, Marshall DL, Strong PJ.
- J Fungi (Basel). 2024 Oct 18;10(10):723. doi: 10.3390/jof10100723.
- PMCID: PMC11509325
De Oliveira Campos A, et al.

J Fungi (Basel). 2024.

PMCID: PMC11509325

Lanostene-derived triterpenoids and beta-glucans are important metabolites in Ganoderma mushrooms associated with benefits to human health. The medicinal value of the Australian Ganoderma species remains unclear, with no data on triterpenoid distribution or glucan c …

Lanostene-derived triterpenoids and beta-glucans are important metabolites in Ganoderma mushrooms associated with benefits to human h …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Distributions of Lanostene-Derived Triterpenoids and Glucan Content in the Fruiting Bodies of the Australian Ganoderma Species.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
518.
Integrated metabolomic, transcriptomic and network analysis elucidates therapeutic mechanisms of Ganoderma lucidum spore oil against granulomatous pulmonary nodules.
- Liu Y, Xu W, Wang K, You Z, Chen X, Ti H, Liang X, Cao L, Cai H, Liu J, Yang Z.
- Front Pharmacol. 2025 Jun 10;16:1612043. doi: 10.3389/fphar.2025.1612043.
- PMCID: PMC12185471
Liu Y, et al.

Front Pharmacol. 2025.

PMCID: PMC12185471

Interventions based on medicinal plants approaches are pivotal for prevention and treatment. Ganoderma lucidum (GL) is a traditional botanical drug to treat inflammatory ailments. The spores of this fungus demonstrate distinct influences on immune response regulatio …

Interventions based on medicinal plants approaches are pivotal for prevention and treatment. Ganoderma lucidum (GL) is a tradi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Integrated metabolomic, transcriptomic and network analysis elucidates therapeutic mechanisms of Ganoderma lucidum spore oil against granulomatous pulmonary nodules.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Maps pathways and components that can guide future lab and clinical research. Open article.
519.
Applied modern biotechnology for cultivation of Ganoderma and development of their products.
- Zhou XW, Su KQ, Zhang YM.
- Appl Microbiol Biotechnol. 2011 Dec 15;93(3):941-63. doi: 10.1007/s00253-011-3780-7.
- PMCID: PMC7080118
Zhou XW, et al.

Appl Microbiol Biotechnol. 2011.

PMCID: PMC7080118

In order to analyze the current status of Ganoderma products, the detailed process of cultivation of Ganoderma spp. and development of their products are restated in this review article. These include the breeding, cultivating, extracting bioactive component, and pr …

In order to analyze the current status of Ganoderma products, the detailed process of cultivation of Ganoderma spp. and develo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Applied modern biotechnology for cultivation of Ganoderma and development of their products.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
520.
In vitro evaluation of the synergistic antioxidant and anti-inflammatory activities of the combined extracts from Malaysian Ganoderma lucidum and Egyptian Chlorella vulgaris.
- Abu-Serie MM, Habashy NH, Attia WE.
- BMC Complement Altern Med. 2018 May 10;18(1):154. doi: 10.1186/s12906-018-2218-5.
- PMCID: PMC5946467
Abu-Serie MM, et al.

BMC Complement Altern Med. 2018.

PMCID: PMC5946467

METHODS: This study evaluated the functional constituents, antioxidant and anti-inflammatory activities of Malaysian Ganoderma lucidum aqueous extract (GLE) and Egyptian Chlorella vulgaris ethanolic extract (CVE). ...

METHODS: This study evaluated the functional constituents, antioxidant and anti-inflammatory activities of Malaysian Ganoderma luc …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: In vitro evaluation of the synergistic antioxidant and anti-inflammatory activities of the combined extracts from Malaysian Ganoderma lucidum and Egyptian Chlorella vulgaris.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 53

521.
Antihepatoma and liver protective potentials of ganoderma lucidum ( ling zhi) fermented in a medium containing black soybean ( hei dou) and astragalus membranaceus ( sheng huang qi).
- Su ZY, Sun Hwang L, Chiang BH, Sheen LY.
- J Tradit Complement Med. 2013 Apr;3(2):110-8. doi: 10.4103/2225-4110.110415.
- PMCID: PMC3924974
Su ZY, et al.

J Tradit Complement Med. 2013.

PMCID: PMC3924974

The antihepatoma activity and liver protective function of the fermentation products (5 L fermenator) of Ganoderma lucidum (GL; Ling Zhi) cultivated in a medium containing black soybean (BS; Hei Dou) and Astragalus membranaceus (AM; Sheng Huang Qi) at different ferm …

The antihepatoma activity and liver protective function of the fermentation products (5 L fermenator) of Ganoderma lucidum (GL …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antihepatoma and liver protective potentials of ganoderma lucidum ( ling zhi) fermented in a medium containing black soybean ( hei dou) and astragalus membranaceus ( sheng huang qi).. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
522.
Effects of Oleic Acid Addition Methods on the Metabolic Flux Distribution of Ganoderic Acids R, S and T's Biosynthesis.
- Yan MQ, Su XW, Liu YF, Tang CH, Tang QJ, Zhou S, Tan Y, Liu LP, Zhang JS, Feng J.
- J Fungi (Basel). 2022 Jun 9;8(6):615. doi: 10.3390/jof8060615.
- PMCID: PMC9225475
Yan MQ, et al.

J Fungi (Basel). 2022.

PMCID: PMC9225475

The effects of oleic acid addition methods on the metabolic flux distribution of ganoderic acids R, S and T's biosynthesis from Ganoderma lucidum were investigated. The results showed that adding filter-sterilized oleic acid in the process of submerged fermentation …

The effects of oleic acid addition methods on the metabolic flux distribution of ganoderic acids R, S and T's biosynthesis from Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effects of Oleic Acid Addition Methods on the Metabolic Flux Distribution of Ganoderic Acids R, S and T's Biosynthesis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
523.
Identification of commercial Ganoderma (Lingzhi) species by ITS2 sequences.
- Liao B, Chen X, Han J, Dan Y, Wang L, Jiao W, Song J, Chen S.
- Chin Med. 2015 Aug 19;10:22. doi: 10.1186/s13020-015-0056-7.
- PMCID: PMC4543481
Liao B, et al.

Chin Med. 2015.

PMCID: PMC4543481

SNP(s) and RNA secondary structure of ITS2 were analyzed and compared among closely related Ganoderma species. RESULTS: G. lucidum cultivated in China was different from those cultivated in Europe. "Chizhi" (G. lucidum) and "Zizhi" (G. sinense) were clustered …

SNP(s) and RNA secondary structure of ITS2 were analyzed and compared among closely related Ganoderma species. RESULTS: G. lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Identification of commercial Ganoderma (Lingzhi) species by ITS2 sequences.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
524.
Recent Advances in the Preparation, Structure, and Biological Activities of beta-Glucan from Ganoderma Species: A Review.
- Zhang H, Zhang J, Liu Y, Tang C.
- Foods. 2023 Aug 7;12(15):2975. doi: 10.3390/foods12152975.
- PMCID: PMC10419088
Zhang H, et al.

Foods. 2023.

PMCID: PMC10419088

Ganoderma has served as a valuable food supplement and medicinal ingredient with outstanding active compounds that are essential for human protection against chronic diseases. Modern pharmacology studies have proven that Ganoderma beta-d-glucan exhibits versatile bi …

Ganoderma has served as a valuable food supplement and medicinal ingredient with outstanding active compounds that are essential for …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Recent Advances in the Preparation, Structure, and Biological Activities of beta-Glucan from Ganoderma Species: A Review.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
525.
Taxonomy of Ganoderma lucidum from Korea Based on rDNA and Partial beta-Tubulin Gene Sequence Analysis.
- Park YJ, Kwon OC, Son ES, Yoon DE, Han W, Yoo YB, Lee CS.
- Mycobiology. 2012 Mar 31;40(1):71-5. doi: 10.5941/MYCO.2012.40.1.071.
- PMCID: PMC3385146
Park YJ, et al.

Mycobiology. 2012.

PMCID: PMC3385146

In the present study, a phylogenetic analysis was undertaken based on the internal transcribed spacer (ITS) rDNA and partial beta-tubulin gene sequence of the Ganoderma species. The size of the ITS rDNA regions from different Ganoderma species varied from 625 to 673 …

In the present study, a phylogenetic analysis was undertaken based on the internal transcribed spacer (ITS) rDNA and partial beta-tubulin ge …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Taxonomy of Ganoderma lucidum from Korea Based on rDNA and Partial beta-Tubulin Gene Sequence Analysis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
526.
Inhibitory effect of polysaccharides extracted from Changbai Mountain Ganoderma lucidum on periodontal inflammation.
- Chen Z, Qin W, Lin H, Liu Y, Tian Y, Zhao X, Ding T, Wang Y, Mao T, Li J, Shen Y.
- Heliyon. 2023 Jan 28;9(2):e13205. doi: 10.1016/j.heliyon.2023.e13205.
- PMCID: PMC9939615
Chen Z, et al.

Heliyon. 2023.

PMCID: PMC9939615

As the main bioactive substance of Ganoderma lucidum, Ganoderma lucidum polysaccharide (GLP) has anti-inflammatory, antibacterial, and other biological activities. Studies have shown that GLP can regulate the expression of multiple inflammatory cytokin …

As the main bioactive substance of Ganoderma lucidum, Ganoderma lucidum polysaccharide (GLP) has anti-inflammato …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Inhibitory effect of polysaccharides extracted from Changbai Mountain Ganoderma lucidum on periodontal inflammation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
527.
Mechanistic and Functional Studies on the Microbial Induction of Wolfiporia cocos Liquid Fermentation Products.
- Yang Z, Su C, Xu Z, Liu Y, Chen J, Wu X.
- Foods. 2024 May 18;13(10):1578. doi: 10.3390/foods13101578.
- PMCID: PMC11121235
Yang Z, et al.

Foods. 2024.

PMCID: PMC11121235

Three edible mushroom co-fermentation systems were established, among which the Wolfiporia cocos-Ganoderma lucidum co-fermentation system significantly increased the mycelial biomass of the system by 57.71% compared to Wolfiporia cocos alone and 91.22% compared to < …

Three edible mushroom co-fermentation systems were established, among which the Wolfiporia cocos-Ganoderma lucidum co-fermenta …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Mechanistic and Functional Studies on the Microbial Induction of Wolfiporia cocos Liquid Fermentation Products.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
528.
Comparative Mitogenomic Analysis Reveals Intraspecific, Interspecific Variations and Genetic Diversity of Medical Fungus Ganoderma.
- Li Q, Zhang T, Li L, Bao Z, Tu W, Xiang P, Wu Q, Li P, Cao M, Huang W.
- J Fungi (Basel). 2022 Jul 26;8(8):781. doi: 10.3390/jof8080781.
- PMCID: PMC9394262
Li Q, et al.

J Fungi (Basel). 2022.

PMCID: PMC9394262

In this study, we sequenced and assembled four Ganoderma complete mitogenomes, including G. subamboinense s118, G. lucidum s37, G. lingzhi s62, and G. lingzhi s74. ...Frequent intron loss/gain events were detected within and between Ganoderma species. The mit …

In this study, we sequenced and assembled four Ganoderma complete mitogenomes, including G. subamboinense s118, G. lucidum s37 …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Comparative Mitogenomic Analysis Reveals Intraspecific, Interspecific Variations and Genetic Diversity of Medical Fungus Ganoderma .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Maps pathways and components that can guide future lab and clinical research. Open article.
529.
AOX Affects the Synthesis of Polysaccharides by Regulating the Reactive Oxygen Species in Ganoderma lucidum.
- Zhu R, Zhang L, Wu L, Liu J, Zhang J, Li J, Song K, Han P.
- Foods. 2025 Feb 27;14(5):826. doi: 10.3390/foods14050826.
- PMCID: PMC11898911
Zhu R, et al.

Foods. 2025.

PMCID: PMC11898911

These findings highlight the significant role of AOX-derived ROS in regulating polysaccharide synthesis and accumulation in Ganoderma lucidum....

These findings highlight the significant role of AOX-derived ROS in regulating polysaccharide synthesis and accumulation in Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: AOX Affects the Synthesis of Polysaccharides by Regulating the Reactive Oxygen Species in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
530.
Ganoderma lucidum spore oil alleviates psychological stress-evoked tumor progression by enhancing FcgammaR-mediated macrophage phagocytosis.
- Li DD, Li ZX, Zhou YF, Jin L, Liang WL, Xu WD, Luo X, Xiao GD, Chen QJ, Xie T, Xu H, Liu Y, Cai HF, Cao YF, Sun WY, Li YF, Liang L, Liu JY, Wu YP, He RR.
- Chin Med. 2025 Jul 14;20(1):111. doi: 10.1186/s13020-025-01168-0.
- PMCID: PMC12257750
Li DD, et al.

Chin Med. 2025.

PMCID: PMC12257750

BACKGROUND: Ganoderma lucidum (G. lucidum), has been documented as a medicinal herb in classical texts and officially recognized in both Eastern and Western pharmacopeias. G. lucidum spore oil (GLSO), a lipid substance extracted from sporoderm-broken s …

BACKGROUND: Ganoderma lucidum (G. lucidum), has been documented as a medicinal herb in classical texts and officially r …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum spore oil alleviates psychological stress-evoked tumor progression by enhancing FcgammaR-mediated macrophage phagocytosis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 54

531.
Volatile Composition and Sensory Profiles of a Shiraz Wine Product Made with Pre- and Post-Fermentation Additions of Ganoderma lucidum Extract.
- Nguyen ANH, Capone DL, Johnson TE, Jeffery DW, Danner L, Bastian SEP.
- Foods. 2019 Nov 1;8(11):538. doi: 10.3390/foods8110538.
- PMCID: PMC6915547
Nguyen ANH, et al.

Foods. 2019.

PMCID: PMC6915547

Novel Shiraz red wine products enriched with Ganoderma lucidum (GL) extract, a traditional Asian medicinal mushroom, were developed and characterized. ...

Novel Shiraz red wine products enriched with Ganoderma lucidum (GL) extract, a traditional Asian medicinal mushroom, were deve …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Volatile Composition and Sensory Profiles of a Shiraz Wine Product Made with Pre- and Post-Fermentation Additions of Ganoderma lucidum Extract.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
532.
Potentials of Natural Antioxidants in Reducing Inflammation and Oxidative Stress in Chronic Kidney Disease.
- Lee OYA, Wong ANN, Ho CY, Tse KW, Chan AZ, Leung GP, Kwan YW, Yeung MHY.
- Antioxidants (Basel). 2024 Jun 20;13(6):751. doi: 10.3390/antiox13060751.
- PMCID: PMC11201162
Lee OYA, et al.

Antioxidants (Basel). 2024.

PMCID: PMC11201162

Notably, lactoferrin, Boerhaavia diffusa, Amauroderma rugosum, and Ganoderma lucidum are known for their anti-inflammatory and antioxidant properties and may support kidney function preservation. ...

Notably, lactoferrin, Boerhaavia diffusa, Amauroderma rugosum, and Ganoderma lucidum are known for their anti-inflammatory and …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Potentials of Natural Antioxidants in Reducing Inflammation and Oxidative Stress in Chronic Kidney Disease.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
533.
Impact of Ganoderma lucidum fermentation on the nutritional composition, structural characterization, metabolites, and antioxidant activity of Soybean, sweet potato and Zanthoxylum pericarpium residues.
- Cen Q, Fan J, Zhang R, Chen H, Hui F, Li J, Zeng X, Qin L.
- Food Chem X. 2023 Dec 16;21:101078. doi: 10.1016/j.fochx.2023.101078.
- PMCID: PMC10776642
Cen Q, et al.

Food Chem X. 2023.

PMCID: PMC10776642

This study aimed to investigate the effects of Ganoderma lucidum (GL) fermentation on the nutritional components, structural characterization, metabolites, and antioxidant activity of soybean residue (SR), sweet potato residue (SPR), and zanthoxylum pericarpium resi …

This study aimed to investigate the effects of Ganoderma lucidum (GL) fermentation on the nutritional components, structural c …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Impact of Ganoderma lucidum fermentation on the nutritional composition, structural characterization, metabolites, and antioxidant activity of Soybean, sweet potato and Zanthoxylum pericarpium residues.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
534.
Ganoderma lucidum Polysaccharide Peptide Alleviates Cyclophosphamide-Induced Male Reproductive Injury by Reducing Oxidative Stress and Apoptosis.
- Zhang H, Li N, Zhang Y, Xu Y, Lu F, Lin D, Lin S, Li M, Yang B.
- Biomedicines. 2024 Jul 23;12(8):1632. doi: 10.3390/biomedicines12081632.
- PMCID: PMC11351902
Zhang H, et al.

Biomedicines. 2024.

PMCID: PMC11351902

It is crucial to discover safe and effective treatments to prevent male reproductive injury caused by chemotherapy. The Ganoderma lucidum polysaccharide peptide (GLPP) has multiple pharmacological activities. ...

It is crucial to discover safe and effective treatments to prevent male reproductive injury caused by chemotherapy. The Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Polysaccharide Peptide Alleviates Cyclophosphamide-Induced Male Reproductive Injury by Reducing Oxidative Stress and Apoptosis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
535.
A flow-injection mass spectrometry fingerprinting scaffold for feature selection and quantitation of Cordyceps and Ganoderma extracts in beverage: a predictive artificial neural network modelling strategy.
- Lim CW, Tai SH, Chan SH.
- AMB Express. 2012 Aug 13;2(1):43. doi: 10.1186/2191-0855-2-43.
- PMCID: PMC3442979
Lim CW, et al.

AMB Express. 2012.

PMCID: PMC3442979

In this study, we described a scaffold (proof-of-concept) adapted from spectroscopy to quantify Cordyceps sinensis and Ganoderma lucidum in a popular Cordyceps sinensis /Ganoderma lucidum -enriched health beverage by utilizing flow-injection/mass spect …

In this study, we described a scaffold (proof-of-concept) adapted from spectroscopy to quantify Cordyceps sinensis and Ganoderma l …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A flow-injection mass spectrometry fingerprinting scaffold for feature selection and quantitation of Cordyceps and Ganoderma extracts in beverage: a predictive artificial neural network modelling strategy.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
536.
The multifaceted effects of polysaccharides isolated from Dendrobium huoshanense on immune functions with the induction of interleukin-1 receptor antagonist (IL-1ra) in monocytes.
- Lin J, Chang YJ, Yang WB, Yu AL, Wong CH.
- PLoS One. 2014 Apr 4;9(4):e94040. doi: 10.1371/journal.pone.0094040.
- PMCID: PMC3976396
Lin J, et al.

PLoS One. 2014.

PMCID: PMC3976396

Finally, we observed that IL-1ra level induced by DH-PS was significantly higher than that by F3, a polysaccharide extract isolated from another popular Chinese herbal medicine, Ganoderma lucidum. These results indicated that DH-PS might have potential applications …

Finally, we observed that IL-1ra level induced by DH-PS was significantly higher than that by F3, a polysaccharide extract isolated from ano …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The multifaceted effects of polysaccharides isolated from Dendrobium huoshanense on immune functions with the induction of interleukin-1 receptor antagonist (IL-1ra) in monocytes.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
537.
Diversity and effects of competitive Trichoderma species in Ganoderma lucidum-cultivated soils.
- Wang Y, Zeng L, Wu J, Jiang H, Mei L.
- Front Microbiol. 2022 Dec 8;13:1067822. doi: 10.3389/fmicb.2022.1067822.
- PMCID: PMC9772278
Wang Y, et al.

Front Microbiol. 2022.

PMCID: PMC9772278

Ganoderma lucidum (GL) is a well-known medicinal mushroom that has been extensively cultivated. ...

Ganoderma lucidum (GL) is a well-known medicinal mushroom that has been extensively cultivated. ...
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Diversity and effects of competitive Trichoderma species in Ganoderma lucidum -cultivated soils.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
538.
Medicinal Mushrooms in Metastatic Breast Cancer: What Is Their Therapeutic Potential as Adjuvant in Clinical Settings?
- De Luca F, Roda E, Rossi P, Bottone MG.
- Curr Issues Mol Biol. 2024 Jul 17;46(7):7577-7591. doi: 10.3390/cimb46070450.
- PMCID: PMC11276109
De Luca F, et al.

Curr Issues Mol Biol. 2024.

PMCID: PMC11276109

Among the group of most promising MMs are Lentinula edodes, Grifola frondosa, Ganoderma lucidum, Ophiocordyceps sinensis and Agaricus blazei, which are already employed in conventional cancer protocols in Asia and China. ...

Among the group of most promising MMs are Lentinula edodes, Grifola frondosa, Ganoderma lucidum, Ophiocordyceps sinensis and A …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Medicinal Mushrooms in Metastatic Breast Cancer: What Is Their Therapeutic Potential as Adjuvant in Clinical Settings?. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
539.
Quality Difference Study of Six Varieties of Ganoderma lucidum with Different Origins.
- Lu J, Qin JZ, Chen P, Chen X, Zhang YZ, Zhao SJ.
- Front Pharmacol. 2012 Apr 9;3:57. doi: 10.3389/fphar.2012.00057.
- PMCID: PMC3321521
Lu J, et al.

Front Pharmacol. 2012.

PMCID: PMC3321521

The quality difference of six varieties Ganoderma lucidum with different origins was investigated in this study by comparing the contents of ganoderic acid A and B, polysaccharide, and triterpenoids. The contents of ganoderic acid A and B in G. lucidum were a …

The quality difference of six varieties Ganoderma lucidum with different origins was investigated in this study by comparing t …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Quality Difference Study of Six Varieties of Ganoderma lucidum with Different Origins.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Quality/authentication methods study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Analytical validation (specificity/sensitivity), reference standards, and mislabeling rates. Open article.
- Why might this paper be useful to readers? Useful for quality control, sourcing, and preventing adulteration. Open article.
540.
A concise review of mushrooms antiviral and immunomodulatory properties that may combat against COVID-19.
- Arunachalam K, Sasidharan SP, Yang X.
- Food Chem Adv. 2022 Mar 2;1:100023. doi: 10.1016/j.focha.2022.100023.
- PMCID: PMC8887958
Arunachalam K, et al.

Food Chem Adv. 2022.

PMCID: PMC8887958

In this review of the literature we foucsed popular mushrooms such as Agaricus subrufescens Peck, Agaricus blazei Murill, Cordyceps sinensis (Berk.) Sacc., Ganoderma lucidum (Curtis.) P. Karst., Grifola frondosa (Dicks.) Gray, Hericium erinaceus (Bull.) ...

In this review of the literature we foucsed popular mushrooms such as Agaricus subrufescens Peck, Agaricus blazei Murill, Cordyceps sinensis …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A concise review of mushrooms antiviral and immunomodulatory properties that may combat against COVID-19.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 55

541.
Effects of Environmental and Nutritional Conditions on Mycelium Growth of Three Basidiomycota.
- Schoder KA, Krümpel J, Müller J, Lemmer A.
- Mycobiology. 2024 Apr 25;52(2):124-134. doi: 10.1080/12298093.2024.2341492.
- PMCID: PMC11057518
Schoder KA, et al.

Mycobiology. 2024.

PMCID: PMC11057518

Further, the influence of the initial substrate characteristics on hyphae expansion was determined. Fungal isolates of Ganoderma lucidum, Pleurotus ostreatus, and Trametes versicolor were cultivated for seven days on substrate mixtures consisting of various proporti …

Further, the influence of the initial substrate characteristics on hyphae expansion was determined. Fungal isolates of Ganoderma l …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effects of Environmental and Nutritional Conditions on Mycelium Growth of Three Basidiomycota.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
542.
Non-destructive analysis of Ganoderma lucidum composition using hyperspectral imaging and machine learning.
- Ran J, Xu H, Wang Z, Zhang W, Bai X.
- Front Chem. 2025 Feb 26;13:1534216. doi: 10.3389/fchem.2025.1534216.
- PMCID: PMC11897918
Ran J, et al.

Front Chem. 2025.

PMCID: PMC11897918

BACKGROUND: Ganoderma lucidum is a widely used medicinal fungus whose quality is influenced by various factors, making traditional chemical detection methods complex and economically challenging. ...CONCLUSION: This integration of hyperspectral imaging and machine l …

BACKGROUND: Ganoderma lucidum is a widely used medicinal fungus whose quality is influenced by various factors, making traditi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Non-destructive analysis of Ganoderma lucidum composition using hyperspectral imaging and machine learning.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
543.
Antitumor and Immunomodulatory Effects of Polysaccharides from Broken-Spore of Ganoderma lucidum.
- Wang PY, Zhu XL, Lin ZB.
- Front Pharmacol. 2012 Jul 13;3:135. doi: 10.3389/fphar.2012.00135.
- PMCID: PMC3395810
Wang PY, et al.

Front Pharmacol. 2012.

PMCID: PMC3395810
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antitumor and Immunomodulatory Effects of Polysaccharides from Broken-Spore of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
544.
Molecular Identification and Characterization of Five Ganoderma Species from the Lower Volta River Basin of Ghana Based on Nuclear Ribosomal DNA (nrDNA) Sequences.
- Adotey G, Alolga RN, Quarcoo A, Yerenkyi P, Otu P, Anang AK, Okine LKN, Gbewonyo WSK, Holliday JC, Lombardi VC.
- J Fungi (Basel). 2023 Dec 21;10(1):6. doi: 10.3390/jof10010006.
- PMCID: PMC10817336
Adotey G, et al.

J Fungi (Basel). 2023.

PMCID: PMC10817336

Ganoderma is a genus of biomedical fungus that is used in the development of numerous health products throughout the world. ...Blastn search and sequence analysis revealed that the sample we coded as Ganoderma LVRB-2 belongs to G. mbrekobenum, whereas Ganoderma …

Ganoderma is a genus of biomedical fungus that is used in the development of numerous health products throughout the world. ...Blastn …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Molecular Identification and Characterization of Five Ganoderma Species from the Lower Volta River Basin of Ghana Based on Nuclear Ribosomal DNA (nrDNA) Sequences.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
545.
Volatile Composition, Colour, and Sensory Quality of Spirit-Based Beverages Enriched with Medicinal Fungus Ganoderma lucidum and Herbal Extract.
- Veljović SP, Tomić NS, Belović MM, Nikićević NJ, Vukosavljević PV, Nikšić MP, Tešević VV.
- Food Technol Biotechnol. 2019 Sep;57(3):408-417. doi: 10.17113/ftb.57.03.19.6106.
- PMCID: PMC6902298
Veljović SP, et al.

Food Technol Biotechnol. 2019.

PMCID: PMC6902298

The multicomponent mixtures consisting of herbs and fungi are commonly used for the production of alcoholic beverages with potential health-promoting effects in many Asian countries. The medicinal fungus Ganoderma lucidum is one of the most important fungi used for …

The multicomponent mixtures consisting of herbs and fungi are commonly used for the production of alcoholic beverages with potential health- …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Volatile Composition, Colour, and Sensory Quality of Spirit-Based Beverages Enriched with Medicinal Fungus Ganoderma lucidum and Herbal Extract.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Quality/authentication methods study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Analytical validation (specificity/sensitivity), reference standards, and mislabeling rates. Open article.
- Why might this paper be useful to readers? Useful for quality control, sourcing, and preventing adulteration. Open article.
546.
Mechanistic Insights Into Ganoderma Lucidum for Diabetes Treatment via Network Pharmacology and Validation.
- Guo S, Yang L, Zhou J, Luo W, Nie B, Zhong X, Liu D, Kang X.
- Diabetes Metab Syndr Obes. 2025 Apr 23;18:1263-1284. doi: 10.2147/DMSO.S500955.
- PMCID: PMC12034255
Guo S, et al.

Diabetes Metab Syndr Obes. 2025.

PMCID: PMC12034255

PURPOSE: There is an urgent need to develop antidiabetic medications with minimal side effects and low toxicity. Ganoderma lucidum, a food-medicine homologous in China, has been used to treat diabetes. ...The predicted key targets were verified via qRT-PCR in PA-ind …

PURPOSE: There is an urgent need to develop antidiabetic medications with minimal side effects and low toxicity. Ganoderma lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Mechanistic Insights Into Ganoderma Lucidum for Diabetes Treatment via Network Pharmacology and Validation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
547.
The Protective Effects of Ganoderma lucidum Active Peptide GLP4 on Lung Injury Induced by Cadmium Poisoning in Mice.
- Zhu S, Wang X, Liu G.
- Toxics. 2024 May 22;12(6):378. doi: 10.3390/toxics12060378.
- PMCID: PMC11209525
Zhu S, et al.

Toxics. 2024.

PMCID: PMC11209525

Ganoderma lucidum active peptide GLP4 is a natural protein with dual antioxidant activities derived from the mycelium of Ganoderma lucidum. ...The findings suggest that GLP4 reduces cadmium-induced lung injury in mice by inhibiting the activation of th …

Ganoderma lucidum active peptide GLP4 is a natural protein with dual antioxidant activities derived from the mycelium of Ga …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The Protective Effects of Ganoderma lucidum Active Peptide GLP4 on Lung Injury Induced by Cadmium Poisoning in Mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
548.
Hypoglicemic and Hypolipedimic Effects of Ganoderma lucidum in Streptozotocin-Induced Diabetic Rats.
- Bach EE, Hi EMB, Martins AMC, Nascimento PAM, Wadt NSY.
- Medicines (Basel). 2018 Jul 28;5(3):78. doi: 10.3390/medicines5030078.
- PMCID: PMC6163537
Bach EE, et al.

Medicines (Basel). 2018.

PMCID: PMC6163537

Background:Ganoderma lucidum (Leyss. Ex. Fr) Karst is a basidiomycete mushroom that has been used for many years as a food supplement and medicine. In Brazil, National Health Surveillance Agency (ANVISA) classified Ganoderma lucidum as a nutraceutical …

Background:Ganoderma lucidum (Leyss. Ex. Fr) Karst is a basidiomycete mushroom that has been used for many years as a food sup …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Hypoglicemic and Hypolipedimic Effects of Ganoderma lucidum in Streptozotocin-Induced Diabetic Rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
549.
Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus.
- Vitak T, Yurkiv B, Wasser S, Nevo E, Sybirna N.
- World J Diabetes. 2017 May 15;8(5):187-201. doi: 10.4239/wjd.v8.i5.187.
- PMCID: PMC5437617
Vitak T, et al.

World J Diabetes. 2017.

PMCID: PMC5437617

Our investigations show pronounced hypoglycemic and anti-anemic action of submerged cultivated mycelium powder of medicinal mushrooms Agaricus brasiliensis (A. brasiliensis) and Ganoderma lucidum (G. lucidum) on streptozotocin-induced DM in rats. Also, we sho …

Our investigations show pronounced hypoglycemic and anti-anemic action of submerged cultivated mycelium powder of medicinal mushrooms Agaric …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
550.
Ganoderma lucidum and Auricularia polytricha Mushrooms Protect against Carbofuran-Induced Toxicity in Rats.
- Hossen MS, Billah Prince MM, Tanvir EM, Chowdhury MAZ, Rahman MA, Alam F, Paul S, Saha M, Ali MY, Bhoumik NC, Karim N, Gan SH, Khalil MI.
- Evid Based Complement Alternat Med. 2018 May 15;2018:6254929. doi: 10.1155/2018/6254929.
- PMCID: PMC5976964
Hossen MS, et al.

Evid Based Complement Alternat Med. 2018.

PMCID: PMC5976964

The current study aimed to investigate the ameliorative effects of two types of mushrooms, Ganoderma lucidum (GL) and Auricularia polytricha (AP), against carbofuran- (CF) induced toxicity in rats. ...

The current study aimed to investigate the ameliorative effects of two types of mushrooms, Ganoderma lucidum (GL) and Auricula …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum and Auricularia polytricha Mushrooms Protect against Carbofuran-Induced Toxicity in Rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 56

551.
Antioxidant and Anti-Inflammatory Activity and Cytotoxicity of Ethanol Extracts from Rhynchosia nulubilis Cultivated with Ganoderma lucidum Mycelium.
- Park MH, Kim M.
- Prev Nutr Food Sci. 2018 Dec 31;23(4):326-334. doi: 10.3746/pnf.2018.23.4.326.
- PMCID: PMC6342532
Park MH, et al.

Prev Nutr Food Sci. 2018.

PMCID: PMC6342532

In this study, in order to verify the use of mycelium as a new functional material, Rhynchosia nulubilis was cultivated with Ganoderma lucidum mycelium, and the biological activity of the culture extract was evaluated. ...These results demonstrated that increased to …

In this study, in order to verify the use of mycelium as a new functional material, Rhynchosia nulubilis was cultivated with Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antioxidant and Anti-Inflammatory Activity and Cytotoxicity of Ethanol Extracts from Rhynchosia nulubilis Cultivated with Ganoderma lucidum Mycelium.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
552.
Bioreactor-grown exo- and endo-beta-glucan from Malaysian Ganoderma lucidum: An in vitro and in vivo study for potential antidiabetic treatment.
- Abdullah NR, Mohd Nasir MH, Azizan NH, Wan-Mohtar WAAQI, Sharif F.
- Front Bioeng Biotechnol. 2022 Aug 25;10:960320. doi: 10.3389/fbioe.2022.960320.
- PMCID: PMC9452895
Abdullah NR, et al.

Front Bioeng Biotechnol. 2022.

PMCID: PMC9452895

This study aims to identify the roles of exo-beta-glucan (EPS-BG) and endo-beta-glucan (ENS-BG) extracted from Ganoderma lucidum (GL) in inhibiting the alpha-glucosidase enzyme, a target mechanism for postprandial hyperglycaemia regulation. ...

This study aims to identify the roles of exo-beta-glucan (EPS-BG) and endo-beta-glucan (ENS-BG) extracted from Ganoderma lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Bioreactor-grown exo- and endo-beta-glucan from Malaysian Ganoderma lucidum : An in vitro and in vivo study for potential antidiabetic treatment.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
553.
Gene Editing in Ganoderma lucidum: Development, Challenges, and Future Prospects.
- He S, Liu Y, Zhang Z, Cai M, Hao Y, Hu H.
- J Fungi (Basel). 2025 Apr 14;11(4):310. doi: 10.3390/jof11040310.
- PMCID: PMC12029067
He S, et al.

J Fungi (Basel). 2025.

PMCID: PMC12029067

We mainly introduce the development of gene-editing technology, the application of clustered regularly interspaced short palindromic repeat/Cas9 (CRISPR/Cas9) in Ganoderma lucidum breeding, the current challenges and optimization strategies in the use of gene-editin …

We mainly introduce the development of gene-editing technology, the application of clustered regularly interspaced short palindromic repeat/ …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Gene Editing in Ganoderma lucidum : Development, Challenges, and Future Prospects.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
554.
Amylase-assisted extraction alters nutritional and physicochemical properties of polysaccharides and saponins isolated from Ganoderma spp.
- Chen BJ, Liu Y, Yang K, Li X, Dong X, Guan Y, Ismail A, Khoo HE.
- Food Chem X. 2023 Sep 29;20:100913. doi: 10.1016/j.fochx.2023.100913.
- PMCID: PMC10740064
Chen BJ, et al.

Food Chem X. 2023.

PMCID: PMC10740064

This study aimed to evaluate the efficacy of amylase in hydrolyzing complex carbohydrates of different parts of Ganoderma spp. The aqueous extracts of the Ganoderma samples were analyzed for their selected nutritional composition and physicochemical properties. ...T …

This study aimed to evaluate the efficacy of amylase in hydrolyzing complex carbohydrates of different parts of Ganoderma spp. The aq …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Amylase-assisted extraction alters nutritional and physicochemical properties of polysaccharides and saponins isolated from Ganoderma spp.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
555.
Chemical characterization and encapsulation of Ganoderma pfeifferi extract with cytotoxic properties.
- Šťastný J, Morellá-Aucejo Á, Skala T, Bernardos A, Maršík P, Lérida-Viso A, Matějka J, Mascellani Bergo A, Marcos MD, Martínez-Máñez R, Jablonský I, Klouček P.
- Front Pharmacol. 2025 Jan 23;16:1526502. doi: 10.3389/fphar.2025.1526502.
- PMCID: PMC11799868
Šťastný J, et al.

Front Pharmacol. 2025.

PMCID: PMC11799868

Mushrooms of the genus Ganoderma are known for diverse biological activities, demonstrated both traditionally and experimentally. ...This study investigated the cytotoxic properties of Ganoderma species methanolic extracts against the HeLa cancer cell line. Notably, …

Mushrooms of the genus Ganoderma are known for diverse biological activities, demonstrated both traditionally and experimentally. ... …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Chemical characterization and encapsulation of Ganoderma pfeifferi extract with cytotoxic properties.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
556.
Evaluation of the phytochemical, bioactive compounds and descriptive sensory of encapsulated lingzhi (Ganoderma lucidum) extracts with combined wall materials for masking effect on the perception of off-flavour and bitterness.
- Chuensun T, Chewonarin T, Laopajon W, Samakradhamrongthai RS, Chaisan W, Utama-Ang N.
- Heliyon. 2024 Nov 2;10(21):e40094. doi: 10.1016/j.heliyon.2024.e40094.
- PMCID: PMC11570458
Chuensun T, et al.

Heliyon. 2024.

PMCID: PMC11570458

Lingzhi mushroom (Ganoderma lucidum) is known as a medicinal mushroom that can be utilized in various functional foods available in the market, including powders, dietary supplements, and tea. ...

Lingzhi mushroom (Ganoderma lucidum) is known as a medicinal mushroom that can be utilized in various functional foods availab …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Evaluation of the phytochemical, bioactive compounds and descriptive sensory of encapsulated lingzhi ( Ganoderma lucidum ) extracts with combined wall materials for masking effect on the perception of off-flavour and bitterness.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
557.
Ganoderma lucidum (Curtis) P. Karst. Immunomodulatory Protein Has the Potential to Improve the Prognosis of Breast Cancer Through the Regulation of Key Prognosis-Related Genes.
- Zuo Z, Wen R, Jing S, Chen X, Liu R, Xue J, Zhang L, Li Q.
- Pharmaceuticals (Basel). 2024 Dec 16;17(12):1695. doi: 10.3390/ph17121695.
- PMCID: PMC11677753
Zuo Z, et al.

Pharmaceuticals (Basel). 2024.

PMCID: PMC11677753

Although luminal A breast cancer (LumA) has a relatively better prognosis, it still has a persistent pattern of recurrence. Ganoderma lucidum (Curtis) P. Karst. is a kind of traditional Chinese medicine and has antitumor effects. In this study, we aimed to identify …

Although luminal A breast cancer (LumA) has a relatively better prognosis, it still has a persistent pattern of recurrence. Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum (Curtis) P. Karst. Immunomodulatory Protein Has the Potential to Improve the Prognosis of Breast Cancer Through the Regulation of Key Prognosis-Related Genes.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
558.
Characterisation and Hypolipidaemic Effects of Tlayudas, Widely Consumed Tortillas, Containing Ganoderma lucidum Extracts on an In Vivo Model of Hypercholesterolaemia.
- Preciado Iñiga G, Martínez-Carrera D, Meneses ME, Sánchez M, Argumedo A, Bonilla M, Castillo I, Petlacalco B, Morales A, Fernández N, Martínez W, Antonio-Bautista J, Sánchez-Tapia M, Coutiño-Hernández D, Torres N, Tovar AR, Leal-Lara H.
- Int J Food Sci. 2025 Jul 29;2025:8096060. doi: 10.1155/ijfo/8096060.
- PMCID: PMC12324917
Preciado Iñiga G, et al.

Int J Food Sci. 2025.

PMCID: PMC12324917

We developed new functional food products from tlayudas (T) containing standardised hydroalcoholic extracts (T + Gl-1 and T + Gl-2) of the medicinal mushroom Ganoderma lucidum (Gl) from Mexico. These products were characterised through physicochemical and sensory pr …

We developed new functional food products from tlayudas (T) containing standardised hydroalcoholic extracts (T + Gl-1 and T + Gl-2) of the m …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Characterisation and Hypolipidaemic Effects of Tlayudas, Widely Consumed Tortillas, Containing Ganoderma lucidum Extracts on an In Vivo Model of Hypercholesterolaemia.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
559.
Production of Ganodiesel from the biomass of Ganoderma lucidum in air-L-shaped bioreactor (ALSB).
- Lim TC, Ilham Z, Wan-Mohtar WAAQI.
- Heliyon. 2024 Jul 29;10(15):e35170. doi: 10.1016/j.heliyon.2024.e35170.
- PMCID: PMC11334811
Lim TC, et al.

Heliyon. 2024.

PMCID: PMC11334811

Shake flask results showed 8.33 g/L of biomass and 2.17 % of lipid, while the ALSB system produced 5.32 g/L of biomass and 2.35 % lipid. The obtained Ganoderma lucidum mycelial lipid underwent acid-catalysed transesterification to produce biodiesel, which was subjec …

Shake flask results showed 8.33 g/L of biomass and 2.17 % of lipid, while the ALSB system produced 5.32 g/L of biomass and 2.35 % lipid. The …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Production of Ganodiesel from the biomass of Ganoderma lucidum in air-L-shaped bioreactor (ALSB).. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
560.
Fucose-containing fraction of Ling-Zhi enhances lipid rafts-dependent ubiquitination of TGFβ receptor degradation and attenuates breast cancer tumorigenesis.
- Tsao SM, Hsu HY.
- Sci Rep. 2016 Nov 10;6:36563. doi: 10.1038/srep36563.
- PMCID: PMC5103195
Tsao SM, et al.

Sci Rep. 2016.

PMCID: PMC5103195

Ganoderma lucidum exerts antitumor activity, but the mechanism of G. lucidum polysaccharides on cancer is unclear. ...

Ganoderma lucidum exerts antitumor activity, but the mechanism of G. lucidum polysaccharides on cancer is unclear. ...
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Fucose-containing fraction of Ling-Zhi enhances lipid rafts-dependent ubiquitination of TGFβ receptor degradation and attenuates breast cancer tumorigenesis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 57

561.
Network Pharmacology and Bioinformatics Study of Six Medicinal Food Homologous Plants Against Colorectal Cancer.
- Zhao X, Xiu J, Yang H, Han W, Jin Y.
- Int J Mol Sci. 2025 Jan 23;26(3):930. doi: 10.3390/ijms26030930.
- PMCID: PMC11817456
Zhao X, et al.

Int J Mol Sci. 2025.

PMCID: PMC11817456

Integrating network pharmacological analysis and bioinformatic techniques, this study systematically investigated the molecular mechanisms of six medicinal food homologous plants (Astragalus membranaceus, Ganoderma lucidum, Dioscorea opposite, Curcuma longa, Glycyrr …

Integrating network pharmacological analysis and bioinformatic techniques, this study systematically investigated the molecular mechanisms o …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Network Pharmacology and Bioinformatics Study of Six Medicinal Food Homologous Plants Against Colorectal Cancer.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Broad molecular profiling and pathway/statistical analyses. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
562.
Effects of hot-water extracts from Ganoderma lucidum residues and solid-state fermentation residues on prebiotic and immune-stimulatory activities in vitro and the powdered residues used as broiler feed additives in vivo.
- Liu YH, Lin YS, Lin KL, Lu YL, Chen CH, Chien MY, Shang HF, Lin SY, Hou WC.
- Bot Stud. 2015 Jul 4;56(1):17. doi: 10.1186/s40529-015-0097-3.
- PMCID: PMC5432903
Liu YH, et al.

Bot Stud. 2015.

PMCID: PMC5432903

BACKGROUND: Large amounts of Ganoderma lucidum (GL) commercial products are provided in the worldwide market such as powders, tea bags, or capsules as dietary supplements which contained triterpenoids and/or polysaccharides. ...

BACKGROUND: Large amounts of Ganoderma lucidum (GL) commercial products are provided in the worldwide market such as powders, …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effects of hot-water extracts from Ganoderma lucidum residues and solid-state fermentation residues on prebiotic and immune-stimulatory activities in vitro and the powdered residues used as broiler feed additives in vivo.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
563.
Anticancer effect of triterpenes from Ganoderma lucidum in human prostate cancer cells.
- Qu L, Li S, Zhuo Y, Chen J, Qin X, Guo G.
- Oncol Lett. 2017 Oct 9;14(6):7467-7472. doi: 10.3892/ol.2017.7153.
- PMCID: PMC5755215
Qu L, et al.

Oncol Lett. 2017.

PMCID: PMC5755215

Ganoderma lucidum, within the Polyporaceae family of Basidiomycota, is a popular traditional remedy medicine used in Asia to promote health and longevity. Compounds extracted from G. lucidum have revealed anticancer, antioxidant and liver protective effects. …

Ganoderma lucidum, within the Polyporaceae family of Basidiomycota, is a popular traditional remedy medicine used in Asia to p …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Anticancer effect of triterpenes from Ganoderma lucidum in human prostate cancer cells.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
564.
Medicinal Mushrooms in Colon Cancer Therapy: Mechanisms of Action of Bioactive Compounds and Therapeutic Potential.
- Bentharavithana J, Islam T, Xu B.
- Int J Mol Sci. 2025 May 31;26(11):5304. doi: 10.3390/ijms26115304.
- PMCID: PMC12154085
Bentharavithana J, et al.

Int J Mol Sci. 2025.

PMCID: PMC12154085

Medicinal mushrooms such as Lentinus edodes, Phellinus linteus, Ganoderma lucidum, Inonotus obliquus, Pleurotus ostreatus, Hericium erinaceus, Pleurotus eryngii, Gloeostereum incarnatum, and Termitomyces heimii are emerging as promising candidates, not only because …

Medicinal mushrooms such as Lentinus edodes, Phellinus linteus, Ganoderma lucidum, Inonotus obliquus, Pleurotus ostreatus, Her …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Medicinal Mushrooms in Colon Cancer Therapy: Mechanisms of Action of Bioactive Compounds and Therapeutic Potential.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
565.
Evidence for Effective Inhibitory Actions on Hyperpolarization-Activated Cation Current Caused by Ganoderma Triterpenoids, the Main Active Constitutents of Ganoderma Spores.
- Chang WT, Gao ZH, Lo YC, Wu SN.
- Molecules. 2019 Nov 22;24(23):4256. doi: 10.3390/molecules24234256.
- PMCID: PMC6930560
Chang WT, et al.

Molecules. 2019.

PMCID: PMC6930560

The triterpenoid fraction of Ganoderma (Ganoderma triterpenoids, GTs) has been increasingly demonstrated to provide effective antioxidant, neuroprotective or cardioprotective activities. ...

The triterpenoid fraction of Ganoderma (Ganoderma triterpenoids, GTs) has been increasingly demonstrated to provide effective …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Evidence for Effective Inhibitory Actions on Hyperpolarization-Activated Cation Current Caused by Ganoderma Triterpenoids, the Main Active Constitutents of Ganoderma Spores.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
566.
A Review of Ganoderma lucidum Polysaccharide: Preparations, Structures, Physicochemical Properties and Application.
- Zhong Y, Tan P, Lin H, Zhang D, Chen X, Pang J, Mu R.
- Foods. 2024 Aug 24;13(17):2665. doi: 10.3390/foods13172665.
- PMCID: PMC11395056
Zhong Y, et al.

Foods. 2024.

PMCID: PMC11395056

Ganoderma lucidum (GL) is a kind of edible fungus with various functions and a precious medicinal material with a long history. Ganoderma lucidum polysaccharide (GLP) is one of the main bioactive substances in GL, with anti-tumor, anti-oxidation, anti- …

Ganoderma lucidum (GL) is a kind of edible fungus with various functions and a precious medicinal material with a long history …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A Review of Ganoderma lucidum Polysaccharide: Preparations, Structures, Physicochemical Properties and Application.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
567.
Ganoderma tuberculosum Liquid Culture With Vineyard Pruning Extracts for Bioactive Composite Production With Antiproliferative Activity.
- Angulo-Sanchez LT, Cruz-Félix MC, Vidal-Gutiérrez M, Torres-Moreno H, Muñoz-Bernal ÓA, Álvarez-Parrilla E, Robles-Zepeda RE, Álvarez-Bajo O, Gutiérrez A, Esqueda M.
- Adv Pharmacol Pharm Sci. 2024 Oct 24;2024:5245451. doi: 10.1155/2024/5245451.
- PMCID: PMC11527534
Angulo-Sanchez LT, et al.

Adv Pharmacol Pharm Sci. 2024.

PMCID: PMC11527534

Elicitors are used to increase Ganoderma bioactive composite production. This study aims to evaluate the antiproliferative activity of ethanolic extracts from mycelium of Ganoderma tuberculosum (G. tuberculosum) grown in a liquid medium with vineyard pruning waste ( …

Elicitors are used to increase Ganoderma bioactive composite production. This study aims to evaluate the antiproliferative activity o …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma tuberculosum Liquid Culture With Vineyard Pruning Extracts for Bioactive Composite Production With Antiproliferative Activity.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
568.
Pancreatic cancer cell apoptosis is induced by a proteoglycan extracted from Ganoderma lucidum.
- Wu X, Jiang L, Zhang Z, He Y, Teng Y, Li J, Yuan S, Pan Y, Liang H, Yang H, Zhou P.
- Oncol Lett. 2020 Nov 12;21(1):34. doi: 10.3892/ol.2020.12295.
- PMCID: PMC7693130
Wu X, et al.

Oncol Lett. 2020.

PMCID: PMC7693130

The Traditional Chinese Medicine, Ganoderma lucidum, has been widely used for its immunity-related and anti-cancer effects. Fudan-Yueyang-Ganoderma lucidum (FYGL) is a proteoglycan, extracted from Ganoderma lucidum, that has shown safe an …

The Traditional Chinese Medicine, Ganoderma lucidum, has been widely used for its immunity-related and anti-cancer effects. Fu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Pancreatic cancer cell apoptosis is induced by a proteoglycan extracted from Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
569.
Sensory and Chemical Drivers of Wine Consumers' Preference for a New Shiraz Wine Product Containing Ganoderma lucidum Extract as a Novel Ingredient.
- Nguyen ANH, Johnson TE, Jeffery DW, Capone DL, Danner L, Bastian SEP.
- Foods. 2020 Feb 20;9(2):224. doi: 10.3390/foods9020224.
- PMCID: PMC7074515
Nguyen ANH, et al.

Foods. 2020.

PMCID: PMC7074515

This study explored wine consumers' preferences towards a novel Australian Shiraz wine product containing Ganoderma lucidum (GL). Wine consumers (n = 124) were asked to complete a questionnaire and participate in a blind tasting of six GL wine products (differing in …

This study explored wine consumers' preferences towards a novel Australian Shiraz wine product containing Ganoderma lucidum (G …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Sensory and Chemical Drivers of Wine Consumers' Preference for a New Shiraz Wine Product Containing Ganoderma lucidum Extract as a Novel Ingredient.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
570.
Exploring the Bioactive Mycocompounds (Fungal Compounds) of Selected Medicinal Mushrooms and Their Potentials against HPV Infection and Associated Cancer in Humans.
- Rokos T, Pribulova T, Kozubik E, Biringer K, Holubekova V, Kudela E.
- Life (Basel). 2023 Jan 16;13(1):244. doi: 10.3390/life13010244.
- PMCID: PMC9861011
Rokos T, et al.

Life (Basel). 2023.

PMCID: PMC9861011

Coriolus versicolor extract itself, and also its combination with another medicinal mushroom, Ganoderma lucidum, leads to improved HPV clearance in HPV cervical or oral-positive patients. ...

Coriolus versicolor extract itself, and also its combination with another medicinal mushroom, Ganoderma lucidum, leads to impr …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Exploring the Bioactive Mycocompounds (Fungal Compounds) of Selected Medicinal Mushrooms and Their Potentials against HPV Infection and Associated Cancer in Humans.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 58

571.
Anti-Staphylococcus aureus potential of compounds from Ganoderma sp.: A comprehensive molecular docking and simulation approaches.
- Nguyen TTT, Nguyen TTT, Nguyen HD, Nguyen TK, Pham PTV, Tran LTT, Pham HKT, Truong PCH, Tran LT, Tran MH.
- Heliyon. 2024 Mar 26;10(7):e28118. doi: 10.1016/j.heliyon.2024.e28118.
- PMCID: PMC11002548
Nguyen TTT, et al.

Heliyon. 2024.

PMCID: PMC11002548

Interestingly, ganosinoside A showed the greatest affinity for the protein clumping factor A, a result validated by molecular dynamic simulation. Additionally, three natural Ganoderma sp. Strains as Ganoderma lingzhi VNKKK1903, Ganoderma lingzhi VNKK1905A2, a …

Interestingly, ganosinoside A showed the greatest affinity for the protein clumping factor A, a result validated by molecular dynamic simula …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Anti-Staphylococcus aureus potential of compounds from Ganoderma sp.: A comprehensive molecular docking and simulation approaches.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
572.
Extracts of Polypore Mushroom Mycelia Reduce Viruses in Honey Bees.
- Stamets PE, Naeger NL, Evans JD, Han JO, Hopkins BK, Lopez D, Moershel HM, Nally R, Sumerlin D, Taylor AW, Carris LM, Sheppard WS.
- Sci Rep. 2018 Oct 4;8(1):13936. doi: 10.1038/s41598-018-32194-8.
- PMCID: PMC6172205
Stamets PE, et al.

Sci Rep. 2018.

PMCID: PMC6172205

We tested extracts from the mycelium of multiple polypore fungal species known to have antiviral properties. Extracts from amadou (Fomes) and reishi (Ganoderma) fungi reduced the levels of honey bee deformed wing virus (DWV) and Lake Sinai virus (LSV) in a dose-depe …

We tested extracts from the mycelium of multiple polypore fungal species known to have antiviral properties. Extracts from amadou (Fomes) an …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Extracts of Polypore Mushroom Mycelia Reduce Viruses in Honey Bees.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
573.
Current and future perspective on antimicrobial and anti-parasitic activities of Ganoderma sp.: an update.
- Basnet BB, Liu L, Bao L, Liu H.
- Mycology. 2017 May 24;8(2):111-124. doi: 10.1080/21501203.2017.1324529.
- PMCID: PMC6059132
Basnet BB, et al.

Mycology. 2017.

PMCID: PMC6059132

Medicinal mushroom Ganoderma sp. is considered to be a key source for the production of therapeutic agents. ...In this review, we aim to summarise all the antimicrobial and anti-parasitic works on Ganoderma sp. displayed on web of science, google scholar and endnote …

Medicinal mushroom Ganoderma sp. is considered to be a key source for the production of therapeutic agents. ...In this review, we aim …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Current and future perspective on antimicrobial and anti-parasitic activities of Ganoderma sp.: an update.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
574.
Ganoderma lucidum polysaccharides attenuates pressure-overload-induced pathological cardiac hypertrophy.
- Zhen C, Wu X, Zhang J, Liu D, Li G, Yan Y, He X, Miao J, Song H, Yan Y, Zhang Y.
- Front Pharmacol. 2023 Mar 23;14:1127123. doi: 10.3389/fphar.2023.1127123.
- PMCID: PMC10076566
Zhen C, et al.

Front Pharmacol. 2023.

PMCID: PMC10076566

However, drug therapies that can reverse the maladaptive process and restore heart function are limited. Ganoderma lucidum polysaccharides (GLPs) are one of the main active components of G. lucidum (Ganoderma lucidum), and they have various phar …

However, drug therapies that can reverse the maladaptive process and restore heart function are limited. Ganoderma lucidum pol …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum polysaccharides attenuates pressure-overload-induced pathological cardiac hypertrophy.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
575.
Critical Review on the Anti-Tumor Activity of Bioactive Compounds from Edible and Medicinal Mushrooms over the Last Five Years.
- Górska-Jakubowska S, Wu Y, Turło J, Xu B.
- Nutrients. 2025 May 30;17(11):1887. doi: 10.3390/nu17111887.
- PMCID: PMC12157108
Górska-Jakubowska S, et al.

Nutrients. 2025.

PMCID: PMC12157108

In this review, we aim to analyze the anti-cancer effects of edible/medicinal mushrooms, including Schizophyllum commune, Trametes versicolor, Grifola frondosa, Ganoderma lucidum, Lentinula edodes, Laetiporus sulphureus, Boletus edulis, and Phellinus igniarius, as w …

In this review, we aim to analyze the anti-cancer effects of edible/medicinal mushrooms, including Schizophyllum commune, Trametes versicolo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Critical Review on the Anti-Tumor Activity of Bioactive Compounds from Edible and Medicinal Mushrooms over the Last Five Years.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
576.
Mid-Infrared Spectroscopic Study of Cultivating Medicinal Fungi Ganoderma: Composition, Development, and Strain Variability of Basidiocarps.
- Synytsya A, Bleha R, Skrynnikova A, Babayeva T, Čopíková J, Kvasnička F, Jablonsky I, Klouček P.
- J Fungi (Basel). 2023 Dec 28;10(1):23. doi: 10.3390/jof10010023.
- PMCID: PMC10817577
Synytsya A, et al.

J Fungi (Basel). 2023.

PMCID: PMC10817577

Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy was proposed for rapid, versatile, and non-invasive screening of Ganoderma basidiocarps to assess their potential for specific applications. Fifteen species and strains of this fungus were selec …

Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy was proposed for rapid, versatile, and non-invasive screening …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Mid-Infrared Spectroscopic Study of Cultivating Medicinal Fungi Ganoderma : Composition, Development, and Strain Variability of Basidiocarps.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
577.
UPLC-ESI-MS/MS-based widely targeted metabolomics reveals differences in metabolite composition among four Ganoderma species.
- Wei-Ye L, Hong-Bo G, Rui-Heng Y, Ai-Guo X, Jia-Chen Z, Zhao-Qian Y, Wen-Jun H, Xiao-Dan Y.
- Front Nutr. 2024 Mar 18;11:1335538. doi: 10.3389/fnut.2024.1335538.
- PMCID: PMC10982346
Wei-Ye L, et al.

Front Nutr. 2024.

PMCID: PMC10982346

The Chinese name "Lingzhi" refers to Ganoderma genus, which are increasingly used in the food and medical industries. Ganoderma species are often used interchangeably since the differences in their composition are not known. ...Our findings contribute to more target …

The Chinese name "Lingzhi" refers to Ganoderma genus, which are increasingly used in the food and medical industries. Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: UPLC-ESI-MS/MS-based widely targeted metabolomics reveals differences in metabolite composition among four Ganoderma species.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Broad molecular profiling and pathway/statistical analyses. Open article.
- Why might this paper be useful to readers? Maps pathways and components that can guide future lab and clinical research. Open article.
578.
An improved HPLC-DAD method for quantitative comparisons of triterpenes in Ganoderma lucidum and its five related species originating from Vietnam.
- Ha do T, Loan le T, Hung TM, Han le VN, Khoi NM, Dung le V, Min BS, Nguyen NP.
- Molecules. 2015 Jan 9;20(1):1059-77. doi: 10.3390/molecules20011059.
- PMCID: PMC6272446
Ha do T, et al.

Molecules. 2015.

PMCID: PMC6272446

An HPLC-DAD method for the quality control of wild and cultivated Ganoderma lucidum (Linhzhi) and related species samples was developed and validated. The quantitative determination of G. lucidum and its related species using 14 triterpene constituents, inclu …

An HPLC-DAD method for the quality control of wild and cultivated Ganoderma lucidum (Linhzhi) and related species samples was …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: An improved HPLC-DAD method for quantitative comparisons of triterpenes in Ganoderma lucidum and its five related species originating from Vietnam.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
579.
Development of a rapid and confirmatory method to identify ganoderic acids in ganoderma mushrooms.
- Qi Y, Zhao L, Sun HH.
- Front Pharmacol. 2012 May 7;3:85. doi: 10.3389/fphar.2012.00085.
- PMCID: PMC3345583
Qi Y, et al.

Front Pharmacol. 2012.

PMCID: PMC3345583

To examine the composition of lanostanoids in Ganoderma lucidum, we have developed a liquid chromatography-mass spectrometry (LC-MS) method by using the ganoderic acids isolated in our laboratory as reference standards. ...Subsequently, only the HPLC-UV method would …

To examine the composition of lanostanoids in Ganoderma lucidum, we have developed a liquid chromatography-mass spectrometry ( …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Development of a rapid and confirmatory method to identify ganoderic acids in ganoderma mushrooms.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
580.
Effect of Ganoderma lucidum hydroalcoholic extract on insulin release in rat-isolated pancreatic islets.
- Shafiee-Nick R, Parizadeh SM, Zokaei N, Ghorbani A.
- Avicenna J Phytomed. 2012 Fall;2(4):206-11.
- PMCID: PMC4075681
Shafiee-Nick R, et al.

Avicenna J Phytomed. 2012.

PMCID: PMC4075681

OBJECTIVE: Ganoderma Lucidum (G. Lucidum) has been suggested to increase serum insulin level. This study was undertaken to investigate its direct effect on the islets of Langerhans. ...CONCLUSION: Our results demonstrate that G. lucidum acts directly o …

OBJECTIVE: Ganoderma Lucidum (G. Lucidum) has been suggested to increase serum insulin level. This study was undertaken …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effect of Ganoderma lucidum hydroalcoholic extract on insulin release in rat-isolated pancreatic islets.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 59

581.
Feed-forward neural network assisted by discriminant analysis for the spectroscopic discriminantion of cracked spores Ganoderma lucidum: A prospective biotechnology production tool.
- Lim CW, Chan SH, Visconti A.
- AMB Express. 2011 Nov 15;1(1):40. doi: 10.1186/2191-0855-1-40.
- PMCID: PMC3240128
Lim CW, et al.

AMB Express. 2011.

PMCID: PMC3240128

A major problem for manufacturers of cracked spores Ganoderma lucidum, a traditional functional food/Chinese medicine (TCM), is to ensure that raw materials are consistent as received from the producer. To address this, a feed-forward artificial neural network (ANN) …

A major problem for manufacturers of cracked spores Ganoderma lucidum, a traditional functional food/Chinese medicine (TCM), i …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Feed-forward neural network assisted by discriminant analysis for the spectroscopic discriminantion of cracked spores Ganoderma lucidum : A prospective biotechnology production tool.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
582.
Safety Considerations for Natural Products with Adaptogenic and Immunomodulating Activities.
- Liang CJW, Woerdenbag HJ, Ekhart C, Vitalone A, van Hunsel FPAM.
- Pharmaceuticals (Basel). 2025 Aug 15;18(8):1208. doi: 10.3390/ph18081208.
- PMCID: PMC12389708
Liang CJW, et al.

Pharmaceuticals (Basel). 2025.

PMCID: PMC12389708

These include herbal remedies (e.g., Panax ginseng), fungi (e.g., Ganoderma lucidum), and animal-derived substances (e.g., propolis from Apis mellifera). ...However, the causality remained unclear due to insufficient data. Ganoderma lucidum, Viscum alb …

These include herbal remedies (e.g., Panax ginseng), fungi (e.g., Ganoderma lucidum), and animal-derived substances (e.g., pro …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Safety Considerations for Natural Products with Adaptogenic and Immunomodulating Activities.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
583.
Ganoderma lucidum Ethanol Extraction Promotes Dextran Sulphate Sodium Induced Colitis Recovery and Modulation in Microbiota.
- Li M, Yu L, Zhai Q, Liu B, Zhao J, Chen W, Tian F.
- Foods. 2022 Dec 13;11(24):4023. doi: 10.3390/foods11244023.
- PMCID: PMC9778072
Li M, et al.

Foods. 2022.

PMCID: PMC9778072

Popular edible mushrooms Ganoderma lucidum and Gloeostereum incarnatum can improve physical health as a prebiotic and positively alter intestinal microbiota. Our research investigated the prebiotic effects of Ganoderma lucidum and Gloeostereum incarnat …

Popular edible mushrooms Ganoderma lucidum and Gloeostereum incarnatum can improve physical health as a prebiotic and positive …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Ethanol Extraction Promotes Dextran Sulphate Sodium Induced Colitis Recovery and Modulation in Microbiota.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
584.
Polysaccharides-Rich Extract of Ganoderma lucidum (M.A. Curtis:Fr.) P. Karst Accelerates Wound Healing in Streptozotocin-Induced Diabetic Rats.
- Cheng PG, Phan CW, Sabaratnam V, Abdullah N, Abdulla MA, Kuppusamy UR.
- Evid Based Complement Alternat Med. 2013 Nov 24;2013:671252. doi: 10.1155/2013/671252.
- PMCID: PMC3857811
Cheng PG, et al.

Evid Based Complement Alternat Med. 2013.

PMCID: PMC3857811

Ganoderma lucidum (M.A. Curtis:Fr.) P. Karst is a popular medicinal mushroom. Scientific reports had shown that the wound healing effects of G. lucidum were partly attributed to its rich polysaccharides. ...In this study, we evaluated the wound healing activi …

Ganoderma lucidum (M.A. Curtis:Fr.) P. Karst is a popular medicinal mushroom. Scientific reports had shown that the wound heal …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Polysaccharides-Rich Extract of Ganoderma lucidum (M.A. Curtis:Fr.) P. Karst Accelerates Wound Healing in Streptozotocin-Induced Diabetic Rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
585.
Unraveling bioactive potential and production in Ganoderma lucidum through omics and machine learning modeling.
- Khanal S, Kumar A, Kumar P, Thakur P, Chander AM, Verma R, Tapwal A, Chauhan V, Kumar D, Kumar D.
- Chin Herb Med. 2025 May 19;17(3):414-427. doi: 10.1016/j.chmed.2025.05.003.
- PMCID: PMC12301918
Khanal S, et al.

Chin Herb Med. 2025.

PMCID: PMC12301918

Ganoderma lucidum, a medicinal mushroom renowned for its production of a diverse array of compounds, accounts for the pharmacological effects including anti-inflammatory, antioxidant, immunomodulatory, and anticancer characteristics. ...Recent advances in omics tech …

Ganoderma lucidum, a medicinal mushroom renowned for its production of a diverse array of compounds, accounts for the pharmaco …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Unraveling bioactive potential and production in Ganoderma lucidum through omics and machine learning modeling.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
586.
Hepatoprotective effect of crude polysaccharides extracted from Ganoderma lucidum against carbon tetrachloride-induced liver injury in mice.
- Susilo RJK, Winarni D, Husen SA, Hayaza S, Punnapayak H, Wahyuningsih SPA, Sajidah ES, Darmanto W.
- Vet World. 2019 Dec 17;12(12):1987-1991. doi: 10.14202/vetworld.2019.1987-1991.
- PMCID: PMC6989327
Susilo RJK, et al.

Vet World. 2019.

PMCID: PMC6989327

The study aimed to determine the hepatoprotective effect of crude polysaccharides extracted from Ganoderma lucidum against liver injury induced by carbon tetrachloride (CCl(4)). MATERIALS AND METHODS: Twenty-four male BALB/C mice were randomly divided into six group …

The study aimed to determine the hepatoprotective effect of crude polysaccharides extracted from Ganoderma lucidum against liv …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Hepatoprotective effect of crude polysaccharides extracted from Ganoderma lucidum against carbon tetrachloride-induced liver injury in mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
587.
Novel therapeutic role of Ganoderma Polysaccharides in a septic mouse model - The key role of macrophages.
- Xiong W, Xia J, Peng X, Tan Y, Chen W, Zhou M, Yang C, Wang W.
- Heliyon. 2024 Feb 20;10(5):e26732. doi: 10.1016/j.heliyon.2024.e26732.
- PMCID: PMC10915390
Xiong W, et al.

Heliyon. 2024.

PMCID: PMC10915390

Ganoderma lucidum polysaccharides (G. PS) have been recognized for their immune-modulating properties. ...

Ganoderma lucidum polysaccharides (G. PS) have been recognized for their immune-modulating properties. ...
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Novel therapeutic role of Ganoderma Polysaccharides in a septic mouse model - The key role of macrophages.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
588.
The Effect of Mushroom Extracts on Human Platelet and Blood Coagulation: In vitro Screening of Eight Edible Species.
- Poniedziałek B, Siwulski M, Wiater A, Komaniecka I, Komosa A, Gąsecka M, Magdziak Z, Mleczek M, Niedzielski P, Proch J, Ropacka-Lesiak M, Lesiak M, Henao E, Rzymski P.
- Nutrients. 2019 Dec 12;11(12):3040. doi: 10.3390/nu11123040.
- PMCID: PMC6950045
Poniedziałek B, et al.

Nutrients. 2019.

PMCID: PMC6950045

This study screened the in vitro antiplatelet and anticoagulant activities of hot water extracts of eight edible mushroom species (Agaricus bisporus, Auricularia auricularia-judae, Coprinus comatus, Ganoderma lucidum, Hericium erinaceus, Lentinula edodes, Pleurotus …

This study screened the in vitro antiplatelet and anticoagulant activities of hot water extracts of eight edible mushroom species (Agaricus …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The Effect of Mushroom Extracts on Human Platelet and Blood Coagulation: In vitro Screening of Eight Edible Species.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
589.
Metabolite profiling, antioxidant and anti-glycemic activities of Tartary buckwheat processed by solid-state fermentation(SSF)with Ganoderma lucidum.
- Zhang R, Cen Q, Hu W, Chen H, Hui F, Li J, Zeng X, Qin L.
- Food Chem X. 2024 Apr 10;22:101376. doi: 10.1016/j.fochx.2024.101376.
- PMCID: PMC11043823
Zhang R, et al.

Food Chem X. 2024.

PMCID: PMC11043823

The aim of this study was to investigate the effect of Ganoderma lucidum fermentation on antioxidant and anti-glycemic activities of Tartary buckwheat. ...This study demonstrates that the fermentation of Ganoderma lucidum provides a new idea to enhance …

The aim of this study was to investigate the effect of Ganoderma lucidum fermentation on antioxidant and anti-glycemic activit …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Metabolite profiling, antioxidant and anti-glycemic activities of Tartary buckwheat processed by solid-state fermentation(SSF)with Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
590.
Ganoderiol A-enriched extract suppresses migration and adhesion of MDA-MB-231 cells by inhibiting FAK-SRC-paxillin cascade pathway.
- Wu GS, Song YL, Yin ZQ, Guo JJ, Wang SP, Zhao WW, Chen XP, Zhang QW, Lu JJ, Wang YT.
- PLoS One. 2013 Oct 29;8(10):e76620. doi: 10.1371/journal.pone.0076620.
- PMCID: PMC3812178
Wu GS, et al.

PLoS One. 2013.

PMCID: PMC3812178

Cell adhesion, migration and invasion are critical steps for carcinogenesis and cancer metastasis. Ganoderma lucidum, also called Lingzhi in China, is a traditional Chinese medicine, which exhibits anti-proliferation, anti-inflammation and anti-metastasis properties …

Cell adhesion, migration and invasion are critical steps for carcinogenesis and cancer metastasis. Ganoderma lucidum, also cal …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderiol A-enriched extract suppresses migration and adhesion of MDA-MB-231 cells by inhibiting FAK-SRC-paxillin cascade pathway.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 60

591.
The solid-state fermentation of Artemisia capillaris leaves with Ganoderma lucidum enhances the anti-inflammatory effects in a model of atopic dermatitis.
- Son HU, Lee S, Heo JC, Lee SH.
- Int J Mol Med. 2017 Apr 7;39(5):1233-1241. doi: 10.3892/ijmm.2017.2945.
- PMCID: PMC5403521
Son HU, et al.

Int J Mol Med. 2017.

PMCID: PMC5403521

In this study, in order to enhance the bioactivity potential of the leaves of Artemisia by Ganoderma lucidum mycelium, we prepared aqueous samples of Artemisia capillaris (Ac) leaves, Ganoderma lucidum (Gl) and aqueous fractions produced by the solid f …

In this study, in order to enhance the bioactivity potential of the leaves of Artemisia by Ganoderma lucidum mycelium, we prep …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The solid-state fermentation of Artemisia capillaris leaves with Ganoderma lucidum enhances the anti-inflammatory effects in a model of atopic dermatitis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
592.
Antimetastatic Effects of Ganoderma lucidum Polysaccharide Peptide on B16-F10-luc-G5 Melanoma Mice With Sleep Fragmentation.
- Xian H, Li J, Zhang Y, Li D, Zhu Y, Li S, Tan Z, Lin Z, Li X, Pan Y.
- Front Pharmacol. 2021 Jul 8;12:650216. doi: 10.3389/fphar.2021.650216.
- PMCID: PMC8296642
Xian H, et al.

Front Pharmacol. 2021.

PMCID: PMC8296642

Ganoderma lucidum (Lingzhi) polysaccharide peptide (GL-pp) is a component of the globally acknowledged traditional Chinese medicine Ganoderma lucidum; Ganoderma lucidum is known for its sedative, hypnotic, immune regulatory, antitumor, an …

Ganoderma lucidum (Lingzhi) polysaccharide peptide (GL-pp) is a component of the globally acknowledged traditional Chinese med …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antimetastatic Effects of Ganoderma lucidum Polysaccharide Peptide on B16-F10-luc-G5 Melanoma Mice With Sleep Fragmentation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
593.
The morphology of Ganoderma lucidum mycelium in a repeated-batch fermentation for exopolysaccharide production.
- Wan-Mohtar WA, Ab Kadir S, Saari N.
- Biotechnol Rep (Amst). 2016 May 17;11:2-11. doi: 10.1016/j.btre.2016.05.005.
- PMCID: PMC5042302
Wan-Mohtar WA, et al.

Biotechnol Rep (Amst). 2016.

PMCID: PMC5042302

The morphology of Ganoderma lucidum BCCM 31549 mycelium in a repeated-batch fermentation (RBF) was studied for exopolysaccharide (EPS) production. ...The proposed strategy showed that the morphology of G. lucidum mycelium can withstand extended fermentation c …

The morphology of Ganoderma lucidum BCCM 31549 mycelium in a repeated-batch fermentation (RBF) was studied for exopolysacchari …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The morphology of Ganoderma lucidum mycelium in a repeated-batch fermentation for exopolysaccharide production.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
594.
How Different Molecular Markers Estimate the Diversity of European Species of the Ganoderma Genus.
- Pristas P, Beck T, Nosalova L, Gaperova S, Gaper J.
- J Fungi (Basel). 2023 Oct 17;9(10):1023. doi: 10.3390/jof9101023.
- PMCID: PMC10608015
Pristas P, et al.

J Fungi (Basel). 2023.

PMCID: PMC10608015

Based on published anatomical-morphological and ecological characteristics and phylogenetic evidence, six species of the Ganoderma genus are known to occur in Europe, namely, G. applanatum (Pers.) Pat., G. adspersum (Schulzer) Donk, G. pfeifferi Bres., G. resinaceum Boud., …

Based on published anatomical-morphological and ecological characteristics and phylogenetic evidence, six species of the Ganoderma ge …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: How Different Molecular Markers Estimate the Diversity of European Species of the Ganoderma Genus.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
595.
Harnessing mushrooms for poultry nutrition: Boosting health, immunity, and productivity.
- Salahuddin M, Balan V, Stamps KG, Abdel-Wareth AAA, Mohammadi M, Kim WK, Zhu W, Lohakare J.
- Poult Sci. 2025 Apr 28;104(8):105223. doi: 10.1016/j.psj.2025.105223.
- PMCID: PMC12166808
Salahuddin M, et al.

Poult Sci. 2025.

PMCID: PMC12166808

Medicinal mushrooms such as Lentinula edodes, Ganoderma lucidum, and Trametes versicolor further enhance antioxidant defense and gut microbial balance. ...

Medicinal mushrooms such as Lentinula edodes, Ganoderma lucidum, and Trametes versicolor further enhance antioxidant defense a …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Harnessing mushrooms for poultry nutrition: Boosting health, immunity, and productivity.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
596.
Triterpenoids from Ganoderma lucidum inhibit cytochrome P450 enzymes interfering with the metabolic process of specific clinical drugs.
- Li D, Lin Y, Lv X, Wu Y, Han C, Cao P, Zhang G, Leng A, Zhou J, Wang C.
- Front Pharmacol. 2024 Nov 15;15:1485209. doi: 10.3389/fphar.2024.1485209.
- PMCID: PMC11605156
Li D, et al.

Front Pharmacol. 2024.

PMCID: PMC11605156

BACKGROUND: Ganoderma lucidum (G. lucidum), which possesses various biological effects, has been widely used as traditional medicine and functional food in Asian countries, especially China. ...METHODS: Using the in vivo activity assay of CYPs, the inhibitory …

BACKGROUND: Ganoderma lucidum (G. lucidum), which possesses various biological effects, has been widely used as traditi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Triterpenoids from Ganoderma lucidum inhibit cytochrome P450 enzymes interfering with the metabolic process of specific clinical drugs.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
597.
Transcriptome profiling of transcription factors in Ganoderma lucidum in response to methyl jasmonate.
- Xu X, Zhu F, Zhu Y, Li Y, Zhou H, Chen S, Ruan J.
- Front Microbiol. 2022 Nov 24;13:1052377. doi: 10.3389/fmicb.2022.1052377.
- PMCID: PMC9730249
Xu X, et al.

Front Microbiol. 2022.

PMCID: PMC9730249

Ganoderma lucidum is a traditional Chinese medicine and its major active ingredients are ganoderma triterpenoids (GTs). ...This study provided useful information for a better understanding of the regulation of TFs involved in GT biosynthesis and fungal growth …

Ganoderma lucidum is a traditional Chinese medicine and its major active ingredients are ganoderma triterpenoids (GTs). …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Transcriptome profiling of transcription factors in Ganoderma lucidum in response to methyl jasmonate.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
598.
Practical Application of "About Herbs" Website: Herbs and Dietary Supplement Use in Oncology Settings.
- Hou YN, Deng G, Mao JJ.
- Cancer J. Author manuscript. 2019 Sep/Oct;25(5):357-366. doi: 10.1097/PPO.0000000000000403.
- PMCID: PMC6777855
Hou YN, et al.

Cancer J. Author manuscript. 2019.

PMCID: PMC6777855

The 10 most searched-for herbs/supplements of 2018 are chaga mushroom, turmeric, ashwagandha, reishi mushroom, graviola, Active Hexose-Correlated Compound, boswellia, dandelion, green tea, and Coriolus versicolor. ...

The 10 most searched-for herbs/supplements of 2018 are chaga mushroom, turmeric, ashwagandha, reishi mushroom, graviola, Active Hexos …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Practical Application of "About Herbs" Website: Herbs and Dietary Supplement Use in Oncology Settings.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
599.
ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK.
- Thyagarajan-Sahu A, Lane B, Sliva D.
- BMC Complement Altern Med. 2011 Sep 19;11:74. doi: 10.1186/1472-6882-11-74.
- PMCID: PMC3224355
Thyagarajan-Sahu A, et al.

BMC Complement Altern Med. 2011.

PMCID: PMC3224355

In the present study, we evaluated whether a dietary supplement ReishiMax (RM), containing triterpenes and polysaccharides extracted from medicinal mushroom Ganoderma lucidum, affects adipocyte differentiation and glucose uptake in 3T3-L1 cells. ...

In the present study, we evaluated whether a dietary supplement ReishiMax (RM), containing triterpenes and polysaccharides extracted from me …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
600.
Bioactive Compounds of Ganoderma boninense Inhibited Methicillin-Resistant Staphylococcus aureus Growth by Affecting Their Cell Membrane Permeability and Integrity.
- Chan YS, Chong KP.
- Molecules. 2022 Jan 27;27(3):838. doi: 10.3390/molecules27030838.
- PMCID: PMC8840476
Chan YS, et al.

Molecules. 2022.

PMCID: PMC8840476

Some species of Ganoderma, such as G. lucidum, are well-known as traditional Chinese medicine (TCM), and their pharmacological value was scientifically proven in modern days. ...

Some species of Ganoderma, such as G. lucidum, are well-known as traditional Chinese medicine (TCM), and their pharmacological …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Bioactive Compounds of Ganoderma boninense Inhibited Methicillin-Resistant Staphylococcus aureus Growth by Affecting Their Cell Membrane Permeability and Integrity.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 61

601.
Whole-genome assembly of Ganoderma leucocontextum (Ganodermataceae, Fungi) discovered from the Tibetan Plateau of China.
- Liu Y, Huang L, Hu H, Cai M, Liang X, Li X, Zhang Z, Xie Y, Xiao C, Chen S, Chen D, Yong T, Pan H, Gao X, Wu Q.
- G3 (Bethesda). 2021 Dec 8;11(12):jkab337. doi: 10.1093/g3journal/jkab337.
- PMCID: PMC8664445
Liu Y, et al.

G3 (Bethesda). 2021.

PMCID: PMC8664445

Ganoderma leucocontextum, a newly discovered species of Ganodermataceae in China, has diverse pharmacological activities. ...Furthermore, differences in functional genes of secondary metabolites (terpenoids) were analyzed between G. leucocontextum and Ganoderma l …

Ganoderma leucocontextum, a newly discovered species of Ganodermataceae in China, has diverse pharmacological activities. ...Furtherm …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Whole-genome assembly of Ganoderma leucocontextum (Ganodermataceae, Fungi) discovered from the Tibetan Plateau of China.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
602.
Adenosine-rich extract of Ganoderma lucidum: A safe and effective lipid-lowering substance.
- Li H, Du Y, Ji H, Yang Y, Xu C, Li Q, Ran L, Wu C, Zhou Q, Wu S.
- iScience. 2022 Sep 26;25(11):105214. doi: 10.1016/j.isci.2022.105214.
- PMCID: PMC9586985
Li H, et al.

iScience. 2022.

PMCID: PMC9586985

Ganoderma lucidum is a traditional Chinese medicine with a variety of active compounds and possesses adequate lipid-lowering and anti-atherosclerotic effects. ...Here, we evaluated the anti-hyperlipidemic effect of the adenosine extract from Ganoderma luci …

Ganoderma lucidum is a traditional Chinese medicine with a variety of active compounds and possesses adequate lipid-lowering a …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Adenosine-rich extract of Ganoderma lucidum : A safe and effective lipid-lowering substance.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
603.
Meroterpenoids From Ganoderma lucidum Mushrooms and Their Biological Roles in Insulin Resistance and Triple-Negative Breast Cancer.
- Zhang JJ, Wang DW, Cai D, Lu Q, Cheng YX.
- Front Chem. 2021 Nov 3;9:772740. doi: 10.3389/fchem.2021.772740.
- PMCID: PMC8595597
Zhang JJ, et al.

Front Chem. 2021.

PMCID: PMC8595597

Ganoderma fungi as popular raw materials of numerous functional foods have been extensively investigated. In this study, five pairs of meroterpenoid enantiomers beyond well-known triterpenoids and polysaccharides, dayaolingzhiols I-M (1-5), were characterized from Ganod …

Ganoderma fungi as popular raw materials of numerous functional foods have been extensively investigated. In this study, five pairs o …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Meroterpenoids From Ganoderma lucidum Mushrooms and Their Biological Roles in Insulin Resistance and Triple-Negative Breast Cancer.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
604.
Alcohol Extracts From Ganoderma lucidum Delay the Progress of Alzheimer's Disease by Regulating DNA Methylation in Rodents.
- Lai G, Guo Y, Chen D, Tang X, Shuai O, Yong T, Wang D, Xiao C, Zhou G, Xie Y, Yang BB, Wu Q.
- Front Pharmacol. 2019 Mar 26;10:272. doi: 10.3389/fphar.2019.00272.
- PMCID: PMC6444160
Lai G, et al.

Front Pharmacol. 2019.

PMCID: PMC6444160

In this study, the AD model rats were used to screen the main active extracts from the mushroom, Ganoderma lucidum, for anti-aging properties, and their effects on DNA methylation were evaluated. The results of evaluation of rats treated with 100 mg/kg/day of D-gala …

In this study, the AD model rats were used to screen the main active extracts from the mushroom, Ganoderma lucidum, for anti-a …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Alcohol Extracts From Ganoderma lucidum Delay the Progress of Alzheimer's Disease by Regulating DNA Methylation in Rodents.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
605.
Ganoderma (Ganodermataceae, Basidiomycota) Species from the Greater Mekong Subregion.
- Luangharn T, Karunarathna SC, Dutta AK, Paloi S, Promputtha I, Hyde KD, Xu J, Mortimer PE.
- J Fungi (Basel). 2021 Sep 30;7(10):819. doi: 10.3390/jof7100819.
- PMCID: PMC8541142
Luangharn T, et al.

J Fungi (Basel). 2021.

PMCID: PMC8541142

The cosmopolitan fungal genus Ganoderma is an important pathogen on arboreal plant hosts, particularly in tropical and temperate regions. ...Comprehensive descriptions, color photographs of macro- and micro-characteristics, the distribution of Ganoderma within the G …

The cosmopolitan fungal genus Ganoderma is an important pathogen on arboreal plant hosts, particularly in tropical and temperate regi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma (Ganodermataceae, Basidiomycota) Species from the Greater Mekong Subregion.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
606.
GlSwi6 Positively Regulates Cellulase and Xylanase Activities through Intracellular Ca(2+) Signaling in Ganoderma lucidum.
- Lian LD, Shi LY, Zhu J, Liu R, Shi L, Ren A, Yu HS, Zhao MW.
- J Fungi (Basel). 2022 Feb 14;8(2):187. doi: 10.3390/jof8020187.
- PMCID: PMC8877461
Lian LD, et al.

J Fungi (Basel). 2022.

PMCID: PMC8877461

Ganoderma lucidum is a white-rot fungus that produces a range of lignocellulolytic enzymes to decompose lignin and cellulose. ...As the downstream transcription factor of Slt2-MAPK, the function of Swi6 in G. lucidum has not been fully studied. In this study, …

Ganoderma lucidum is a white-rot fungus that produces a range of lignocellulolytic enzymes to decompose lignin and cellulose. …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: GlSwi6 Positively Regulates Cellulase and Xylanase Activities through Intracellular Ca(2+) Signaling in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
607.
Ganoderma lucidum polysaccharides reduce the severity of acute liver injury by improving the diversity and function of the gut microbiota.
- Zhang XT, Yang Y, Ji C, Fu Y, Pu X, Xu G.
- Heliyon. 2024 Aug 2;10(15):e35559. doi: 10.1016/j.heliyon.2024.e35559.
- PMCID: PMC11336721
Zhang XT, et al.

Heliyon. 2024.

PMCID: PMC11336721

Acute liver injury (ALI) is an abnormal liver function caused by oxidative stress, inflammation and other mechanisms.The interaction between intestine and liver plays an important role in ALI, and natural polysaccharides can participate in the regulation of ALI by regulating the …

Acute liver injury (ALI) is an abnormal liver function caused by oxidative stress, inflammation and other mechanisms.The interaction between …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum polysaccharides reduce the severity of acute liver injury by improving the diversity and function of the gut microbiota.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
608.
Triterpenoids from the spores of Ganoderma lucidum.
- Ma B, Ren W, Zhou Y, Ma J, Ruan Y, Wen CN.
- N Am J Med Sci. 2011 Nov;3(11):495-8. doi: 10.4297/najms.2011.3495.
- PMCID: PMC3271404
Ma B, et al.

N Am J Med Sci. 2011.

PMCID: PMC3271404

Recently a series of triterpenoids were isolated from ganoderma spores and have drawn the attention of chemists and pharmacists. The aim of this review is to summarize the triterpenoids and their bioactivities of ganoderma spores. ...Triterpenoids isolated from g …

Recently a series of triterpenoids were isolated from ganoderma spores and have drawn the attention of chemists and pharmacists. The …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Triterpenoids from the spores of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
609.
Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities.
- Abdullah N, Ismail SM, Aminudin N, Shuib AS, Lau BF.
- Evid Based Complement Alternat Med. 2011 Jun 18;2012:464238. doi: 10.1155/2012/464238.
- PMCID: PMC3118607
Abdullah N, et al.

Evid Based Complement Alternat Med. 2011.

PMCID: PMC3118607

Antioxidant potential of each mushroom species was calculated based on the average percentages relative to quercetin and summarized as Antioxidant Index (AI). Ganoderma lucidum (30.1%), Schizophyllum commune (27.6%), and Hericium erinaceus (17.7%) showed relatively …

Antioxidant potential of each mushroom species was calculated based on the average percentages relative to quercetin and summarized as Antio …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
610.
Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors.
- Zheng DS, Chen LS.
- Exp Ther Med. 2017 Aug 3;14(4):3273-3278. doi: 10.3892/etm.2017.4883.
- PMCID: PMC5585879
Zheng DS, et al.

Exp Ther Med. 2017.

PMCID: PMC5585879

To find effective agents for the inhibition of Epstein-Barr virus (EBV) infection, which is associated with NPC, a phytochemical investigation of Ganoderma lucidum was carried out in the present study. Five triterpenoids were identified, including ganoderic acid A ( …

To find effective agents for the inhibition of Epstein-Barr virus (EBV) infection, which is associated with NPC, a phytochemical investigati …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.

Page 62

611.
Determination of selenium-containing species, including nanoparticles, in selenium-enriched Lingzhi mushrooms.
- LeBlanc KL, Kumlung T, Suárez Priede A, Kumkrong P, Junvee T, Deawtong S, Bettmer J, Montes-Bayón M, Mester Z.
- Anal Bioanal Chem. 2023 Nov 21;416(11):2761-2772. doi: 10.1007/s00216-023-05031-9.
- PMCID: PMC11009765
LeBlanc KL, et al.

Anal Bioanal Chem. 2023.

PMCID: PMC11009765
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Determination of selenium-containing species, including nanoparticles, in selenium-enriched Lingzhi mushrooms.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
612.
Triterpenoids and Polysaccharide Fractions of Ganoderma tsugae Exert Different Effects on Antiallergic Activities.
- Chen ML, Hsieh CC, Chiang BL, Lin BF.
- Evid Based Complement Alternat Med. 2015 Apr 19;2015:754836. doi: 10.1155/2015/754836.
- PMCID: PMC4417579
Chen ML, et al.

Evid Based Complement Alternat Med. 2015.

PMCID: PMC4417579

This study was to investigate antiallergic effects of triterpenoids (Gt-TRE) and polysaccharide (Gt-PS) extracts from Ganoderma tsugae, using mast cell line RBL-2H3, T cell line EL4, primary T cells, and transfected RAW264.7 macrophage cells. ...These data suggested that t …

This study was to investigate antiallergic effects of triterpenoids (Gt-TRE) and polysaccharide (Gt-PS) extracts from Ganoderma tsuga …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Triterpenoids and Polysaccharide Fractions of Ganoderma tsugae Exert Different Effects on Antiallergic Activities.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
613.
Influence of Food Waste Compost on the Yield and Mineral Content of Ganoderma lucidum, Lentinula edodes, and Pholiota adipose Fruiting Bodies.
- Jo EY, Choi JY, Choi JW, Ahn JH.
- Mycobiology. 2013 Dec 19;41(4):210-3. doi: 10.5941/MYCO.2013.41.4.210.
- PMCID: PMC3905124
Jo EY, et al.

Mycobiology. 2013.

PMCID: PMC3905124

The objectives of this study were to evaluate applicability of food waste compost (FWC) as a substrate for cultivation of Ganoderma lucidum, Lentinula edodes, and Pholiota adipose, and to determine contents of Ca, Mg, Na, and K in fruiting bodies (FB). FB yield per …

The objectives of this study were to evaluate applicability of food waste compost (FWC) as a substrate for cultivation of Ganoderma < …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Influence of Food Waste Compost on the Yield and Mineral Content of Ganoderma lucidum , Lentinula edodes, and Pholiota adipose Fruiting Bodies.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
614.
A novel adjuvant Ling Zhi-8 enhances the efficacy of DNA cancer vaccine by activating dendritic cells.
- Lin CC, Yu YL, Shih CC, Liu KJ, Ou KL, Hong LZ, Chen JD, Chu CL.
- Cancer Immunol Immunother. 2011 Apr 17;60(7):1019-27. doi: 10.1007/s00262-011-1016-4.
- PMCID: PMC11029078
Lin CC, et al.

Cancer Immunol Immunother. 2011.

PMCID: PMC11029078

The immunostimulatory effect of a fungal immunomodulatory protein Ling Zhi-8 (LZ-8) isolated from Ganoderma lucidum has been reported. In this study, we tested the adjuvanticity of LZ-8 for HER-2/neu DNA vaccine against p185(neu) expressing tumor MBT-2 in mice. ...

The immunostimulatory effect of a fungal immunomodulatory protein Ling Zhi-8 (LZ-8) isolated from Ganoderma lucidum has been r …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A novel adjuvant Ling Zhi-8 enhances the efficacy of DNA cancer vaccine by activating dendritic cells.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
615.
Whole-Genome Sequencing and Transcriptome Analysis of Ganoderma lucidum Strain Yw-1-5 Provides New Insights into the Enhanced Effect of Tween80 on Exopolysaccharide Production.
- Wu T, Cai M, Hu H, Jiao C, Zhang Z, Liu Y, Chen J, Xiao C, Li X, Gao X, Chen S, Wu Q, Xie Y.
- J Fungi (Basel). 2022 Oct 14;8(10):1081. doi: 10.3390/jof8101081.
- PMCID: PMC9605614
Wu T, et al.

J Fungi (Basel). 2022.

PMCID: PMC9605614

Ganoderma lucidum is an important medicinal mushroom widely cultured in Asian countries. Exopolysaccharides are bioactive compounds of G. lucidum with health benefits. Limited exopolysaccharide content hinders its extraction from G. lucidum. ...

Ganoderma lucidum is an important medicinal mushroom widely cultured in Asian countries. Exopolysaccharides are bioactive comp …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Whole-Genome Sequencing and Transcriptome Analysis of Ganoderma lucidum Strain Yw-1-5 Provides New Insights into the Enhanced Effect of Tween80 on Exopolysaccharide Production.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
616.
Influence of Selenium Biofortification on the Growth and Bioactive Metabolites of Ganoderma lucidum.
- Xu M, Zhu S, Wang L, Wei Z, Zhao L, Shi G, Ding Z.
- Foods. 2021 Aug 12;10(8):1860. doi: 10.3390/foods10081860.
- PMCID: PMC8391904
Xu M, et al.

Foods. 2021.

PMCID: PMC8391904

Selenium biofortification of edible and medicinal mushrooms is an effective way to produce selenium-enriched food supplements. Ganoderma lucidum is the typical one with excellent biological activity. This study investigated G. lucidum growth and bioactive met …

Selenium biofortification of edible and medicinal mushrooms is an effective way to produce selenium-enriched food supplements. Ganoderma< …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Influence of Selenium Biofortification on the Growth and Bioactive Metabolites of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
617.
The Performance and Evolutionary Mechanism of Ganoderma lucidum in Enhancing Selenite Tolerance and Bioaccumulation.
- Xu M, Meng Q, Zhu S, Yu R, Chen L, Shi G, Wong KH, Fan D, Ding Z.
- J Fungi (Basel). 2024 Jun 8;10(6):415. doi: 10.3390/jof10060415.
- PMCID: PMC11205109
Xu M, et al.

J Fungi (Basel). 2024.

PMCID: PMC11205109

To obtain Se-accumulating fungi, we isolated selenite-tolerance-enhanced Ganoderma lucidum JNUSE-200 through adaptive evolution. METHODS: The molecular mechanism responsible for selenite tolerance and accumulation was explored in G. lucidum JNUSE-200 by compa …

To obtain Se-accumulating fungi, we isolated selenite-tolerance-enhanced Ganoderma lucidum JNUSE-200 through adaptive evolutio …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The Performance and Evolutionary Mechanism of Ganoderma lucidum in Enhancing Selenite Tolerance and Bioaccumulation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
618.
Gel-Based Purification and Biochemical Study of Laccase Isozymes from Ganoderma sp. and Its Role in Enhanced Cotton Callogenesis.
- Kumar A, Singh D, Sharma KK, Arora S, Singh AK, Gill SS, Singhal B.
- Front Microbiol. 2017 Apr 20;8:674. doi: 10.3389/fmicb.2017.00674.
- PMCID: PMC5397484
Kumar A, et al.

Front Microbiol. 2017.

PMCID: PMC5397484

Basidiomycetous fungi, Ganoderma lucidum MDU-7 and Ganoderma sp. kk-02 secreted multiple laccase isozymes under diverse growth condition. Aromatic compounds and metal salts were also found to regulate the differential expression of laccase isozymes from both …

Basidiomycetous fungi, Ganoderma lucidum MDU-7 and Ganoderma sp. kk-02 secreted multiple laccase isozymes under diverse …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Gel-Based Purification and Biochemical Study of Laccase Isozymes from Ganoderma sp. and Its Role in Enhanced Cotton Callogenesis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Relevant for eco‑friendly processing, waste upcycling, and industrial biocatalysis. Open article.
619.
Regulatory Effects of Ganoderma lucidum, Grifola frondosa, and American ginseng Extract Formulation on Gut Microbiota and Fecal Metabolomics in Mice.
- Zhang F, Huang W, Zhao L.
- Foods. 2023 Oct 17;12(20):3804. doi: 10.3390/foods12203804.
- PMCID: PMC10606397
Zhang F, et al.

Foods. 2023.

PMCID: PMC10606397

The bioactivities of Ganoderma lucidum, Grifola frondosa, and American ginseng have been extensively studied and documented. ...In this study, an immunocompromised mouse model was induced using cyclophosphamide, and Ganoderma lucidum, Grifola frondosa, …

The bioactivities of Ganoderma lucidum, Grifola frondosa, and American ginseng have been extensively studied and documented. . …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Regulatory Effects of Ganoderma lucidum , Grifola frondosa, and American ginseng Extract Formulation on Gut Microbiota and Fecal Metabolomics in Mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Maps pathways and components that can guide future lab and clinical research. Open article.
620.
Investigation of lignocellulolytic enzymes during different growth phases of Ganoderma lucidum strain G0119 using genomic, transcriptomic and secretomic analyses.
- Zhou S, Zhang J, Ma F, Tang C, Tang Q, Zhang X.
- PLoS One. 2018 May 31;13(5):e0198404. doi: 10.1371/journal.pone.0198404.
- PMCID: PMC5979026
Zhou S, et al.

PLoS One. 2018.

PMCID: PMC5979026

Ganoderma lucidum is a medicinal mushroom that is well known for its ability to enhance human health, and products made from this fungus have been highly profitable. ...This study provides insight into the changes in the lignocellulose degradation ability of G. l …

Ganoderma lucidum is a medicinal mushroom that is well known for its ability to enhance human health, and products made from t …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Investigation of lignocellulolytic enzymes during different growth phases of Ganoderma lucidum strain G0119 using genomic, transcriptomic and secretomic analyses.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Maps pathways and components that can guide future lab and clinical research. Open article.

Page 63

621.
Macromycete Edible Fungi as a Functional Poultry Feed Additive: Influence on Health, Welfare, Eggs, and Meat Quality-Review.
- Duda D, Jaszcza K, Bernaś E.
- Molecules. 2025 Aug 1;30(15):3241. doi: 10.3390/molecules30153241.
- PMCID: PMC12348625
Duda D, et al.

Molecules. 2025.

PMCID: PMC12348625

Species with strong health-promoting potential include Hericium erinaceus, Cordyceps militaris, Ganoderma lucidum, Pleurotus ostreatus, Flammulina velutipes, and Inonotus obliquus. These species contain many bioactive compounds, including beta-glucans, endo- and exo …

Species with strong health-promoting potential include Hericium erinaceus, Cordyceps militaris, Ganoderma lucidum, Pleurotus o …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Macromycete Edible Fungi as a Functional Poultry Feed Additive: Influence on Health, Welfare, Eggs, and Meat Quality-Review.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Analytical validation (specificity/sensitivity), reference standards, and mislabeling rates. Open article.
- Why might this paper be useful to readers? Useful for quality control, sourcing, and preventing adulteration. Open article.
622.
Attenuated Total Reflection-Fourier Transform Infrared Spectroscopy (ATR-FTIR) Combined with Chemometrics Methods for the Classification of Lingzhi Species.
- Wang YY, Li JQ, Liu HG, Wang YZ.
- Molecules. 2019 Jun 13;24(12):2210. doi: 10.3390/molecules24122210.
- PMCID: PMC6631843
Wang YY, et al.

Molecules. 2019.

PMCID: PMC6631843
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Attenuated Total Reflection-Fourier Transform Infrared Spectroscopy (ATR-FTIR) Combined with Chemometrics Methods for the Classification of Lingzhi Species.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
623.
Integrated Transcriptomic and Targeted Metabolomic Analysis Reveals the Key Genes Involved in Triterpenoid Biosynthesis of Ganoderma lucidum.
- Xu X, Li C, Wu F, Zhao S, Chen T, You H, Lin Y, Zou X.
- J Fungi (Basel). 2025 Jan 13;11(1):57. doi: 10.3390/jof11010057.
- PMCID: PMC11767136
Xu X, et al.

J Fungi (Basel). 2025.

PMCID: PMC11767136

Ganoderma lucidum is a traditional Chinese medicinal fungus, and ganoderma triterpenoids (GTs) are one of the main bioactive compounds. ...In addition, interestingly, some flavonoids and phenolic compounds, which have been reported in plants, were also detect …

Ganoderma lucidum is a traditional Chinese medicinal fungus, and ganoderma triterpenoids (GTs) are one of the main bioa …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Integrated Transcriptomic and Targeted Metabolomic Analysis Reveals the Key Genes Involved in Triterpenoid Biosynthesis of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
624.
Comparison of the healing effects of mesazaline and Ganoderma lucidum in acetic acid-induced colitis in rats.
- Özden H, Şahin Y, Kilitçi A, Karaca G, Gömeç M, Yildiz A, Uçar C.
- Ann Surg Treat Res. 2022 Jan 3;102(1):29-35. doi: 10.4174/astr.2022.102.1.29.
- PMCID: PMC8753384
Özden H, et al.

Ann Surg Treat Res. 2022.

PMCID: PMC8753384

Our study aimed to compare the protective effects of mesalazine and Ganoderma lucidum in acetic acid (AA)-induced colitis in rats. METHODS: Twenty-four rats were randomly grouped as colitis, mesalazine, G. lucidum, and combined (G. lucidum + mesalazine …

Our study aimed to compare the protective effects of mesalazine and Ganoderma lucidum in acetic acid (AA)-induced colitis in r …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Comparison of the healing effects of mesazaline and Ganoderma lucidum in acetic acid-induced colitis in rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
625.
Evaluation of the hypoglycaemic and antioxidant effects of submerged Ganoderma lucidum cultures in type 2 diabetic rats.
- Huang CH, Lin WK, Chang SH, Tsai GJ.
- Mycology. 2020 Mar 1;12(2):82-93. doi: 10.1080/21501203.2020.1733119.
- PMCID: PMC8128183
Huang CH, et al.

Mycology. 2020.

PMCID: PMC8128183

We aim to investigate the hypoglycaemic and antioxidant effects of submerged Ganoderma lucidum cultures and elucidate the potential mechanisms behind these effects using a type 2 diabetic rat model. ...Based on the hypoglycaemic and antioxidant effects of G. luci …

We aim to investigate the hypoglycaemic and antioxidant effects of submerged Ganoderma lucidum cultures and elucidate the pote …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Evaluation of the hypoglycaemic and antioxidant effects of submerged Ganoderma lucidum cultures in type 2 diabetic rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
626.
GGV formula attenuates CCl₄-induced hepatic injury in mice by modulating the gut microbiota and metabolites.
- Wang Y, Zhang Y, He Y, Zhang S, Huang B, Wang Y, Lin W, Xiao W, Zou Z, Cui G.
- Front Nutr. 2025 May 27;12:1564177. doi: 10.3389/fnut.2025.1564177.
- PMCID: PMC12148870
Wang Y, et al.

Front Nutr. 2025.

PMCID: PMC12148870

Although the individual hepatoprotective properties of glutathione, Ganoderma lucidum extract, and vitamin C are well-documented, their combined effects remain to be elucidated. ...

Although the individual hepatoprotective properties of glutathione, Ganoderma lucidum extract, and vitamin C are well-document …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: GGV formula attenuates CCl 4 -induced hepatic injury in mice by modulating the gut microbiota and metabolites.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
627.
Two-dimensional code enables visibly mapping herbal medicine chemome: an application in Ganoderma lucidum.
- Wang Q, Liu W, Peng B, Gong X, Shi J, Zhang K, Li B, Tu P, Li J, Jiang J, Zhao Y, Song Y.
- Chin Med. 2023 Jan 12;18(1):6. doi: 10.1186/s13020-022-00702-8.
- PMCID: PMC9837956
Wang Q, et al.

Chin Med. 2023.

PMCID: PMC9837956

METHODS: We here attempted to denote both MS[Formula: see text] and MS[Formula: see text] dataset of HM with a single 2D-code chart. Measurement of Ganoderma lucidum that is one of the most famous HMs with LC-MS/MS was employed to illustrate the "coding-decoding" wo …

METHODS: We here attempted to denote both MS[Formula: see text] and MS[Formula: see text] dataset of HM with a single 2D-code chart. Measure …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Two-dimensional code enables visibly mapping herbal medicine chemome: an application in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
628.
Ganoderma adspersum (Ganodermataceae): Investigation of Its Secondary Metabolites and the Antioxidant, Antimicrobial, and Cytotoxic Potential of Its Extracts.
- Chafouz R, Karavergou S, Tsiftsoglou OS, Maskovic P, Lazari D.
- Int J Mol Sci. 2023 Dec 30;25(1):516. doi: 10.3390/ijms25010516.
- PMCID: PMC10779304
Chafouz R, et al.

Int J Mol Sci. 2023.

PMCID: PMC10779304

Ganoderma is a genus of wood-degrading mushrooms with medicinal importance. Most Ganoderma species have been studied extensively for their secondary metabolites, biological activities, and ecological value. ...

Ganoderma is a genus of wood-degrading mushrooms with medicinal importance. Most Ganoderma species have been studied extensive …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma adspersum (Ganodermataceae): Investigation of Its Secondary Metabolites and the Antioxidant, Antimicrobial, and Cytotoxic Potential of Its Extracts.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
629.
Induction of apoptosis in the SW620 colon carcinoma cell line by triterpene-enriched extracts from Ganoderma lucidum through activation of caspase-3.
- Ji Z, Tang Q, Hao R, Zhang J, Pan Y.
- Oncol Lett. 2011 Mar 21;2(3):565-570. doi: 10.3892/ol.2011.275.
- PMCID: PMC3410455
Ji Z, et al.

Oncol Lett. 2011.

PMCID: PMC3410455

The medicinal mushroom Ganoderma lucidum (G. lucidum) has been used for the treatment of various diseases, and is known for the immune-enhancing activity of its polysaccharide. ...These findings suggest that the triterpenes contained in G. lucidum are …

The medicinal mushroom Ganoderma lucidum (G. lucidum) has been used for the treatment of various diseases, and is known …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Induction of apoptosis in the SW620 colon carcinoma cell line by triterpene-enriched extracts from Ganoderma lucidum through activation of caspase-3.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
630.
Genome-Wide Characterization and Comparative Analysis of MYB Transcription Factors in Ganoderma Species.
- Wang L, Huang Q, Zhang L, Wang Q, Liang L, Liao B.
- G3 (Bethesda). 2020 Aug 5;10(8):2653-2660. doi: 10.1534/g3.120.401372.
- PMCID: PMC7407476
Wang L, et al.

G3 (Bethesda). 2020.

PMCID: PMC7407476

However, less is known about the functions of MYBs in Ganoderma In this study, five medicinal macrofungi of genus Ganoderma were subjected to a genome-wide comparative analysis of MYB genes. ...This comprehensive and systematic study of MYB family members provides a …

However, less is known about the functions of MYBs in Ganoderma In this study, five medicinal macrofungi of genus Ganoderma we …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Genome-Wide Characterization and Comparative Analysis of MYB Transcription Factors in Ganoderma Species.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 64

631.
Analysis of Antioxidant and Anti-Inflammatory Activities of Solvent Fractions from Rhynchosia nulubilis Cultivated with Ganoderma lucidum Mycelium.
- Park M, Kim M.
- Prev Nutr Food Sci. 2017 Dec 31;22(4):365-371. doi: 10.3746/pnf.2017.22.4.365.
- PMCID: PMC5758102
Park M, et al.

Prev Nutr Food Sci. 2017.

PMCID: PMC5758102

In this study, the crude ethanol Rhynchosia nulubilis cultivated with Ganoderma lucidum mycelium (RNGM) extract was solvent fractionated with organic solvents such as n-hexane, chloroform, ethyl acetate, and water. ...Therefore, it is suggested that the ethyl acetat …

In this study, the crude ethanol Rhynchosia nulubilis cultivated with Ganoderma lucidum mycelium (RNGM) extract was solvent fr …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Analysis of Antioxidant and Anti-Inflammatory Activities of Solvent Fractions from Rhynchosia nulubilis Cultivated with Ganoderma lucidum Mycelium.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
632.
The Importance of Nitric Oxide as the Molecular Basis of the Hydrogen Gas Fumigation-Induced Alleviation of Cd Stress on Ganoderma lucidum.
- Abdalmegeed D, Zhao G, Cheng P, Bhat JA, Khattak WA, Ali MG, Alnadari F, Ali I, Ali Q, Korma SA, Mahmoud YA, Abd Elnabi MK, Cui W, Shen W.
- J Fungi (Basel). 2021 Dec 23;8(1):10. doi: 10.3390/jof8010010.
- PMCID: PMC8780922
Abdalmegeed D, et al.

J Fungi (Basel). 2021.

PMCID: PMC8780922

Whether or not hydrogen gas (H(2)) can reduce cadmium (Cd) toxicity in Ganoderma lucidum has remained largely unknown. Here, we report that Cd-induced growth inhibition in G. lucidum was significantly alleviated by H(2) fumigation or hydrogen-rich water (HRW) …

Whether or not hydrogen gas (H(2)) can reduce cadmium (Cd) toxicity in Ganoderma lucidum has remained largely unknown. Here, w …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The Importance of Nitric Oxide as the Molecular Basis of the Hydrogen Gas Fumigation-Induced Alleviation of Cd Stress on Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
633.
Oral Administration of Ganoderma lucidum to Lead-Exposed Rats Protects Erythrocytes against Hemolysis: Implicates to Anti-Anemia.
- Hossain S, Bhowmick S, Islam S, Rozario L, Jahan S, Hassan M, Sarkar M, Choudhury BK, Ahmed S, Shahjalal H.
- Evid Based Complement Alternat Med. 2015 Aug 2;2015:463703. doi: 10.1155/2015/463703.
- PMCID: PMC4537730
Hossain S, et al.

Evid Based Complement Alternat Med. 2015.

PMCID: PMC4537730

We studied the effect of chronic oral exposure to lead acetate (PbA) on the sensitivity of RBC to hemolysis and whether the sensitivity could be decreased by feeding the rats with extract of medicinal mushroom Ganoderma lucidum. Three groups of rats, control, PbA-ex …

We studied the effect of chronic oral exposure to lead acetate (PbA) on the sensitivity of RBC to hemolysis and whether the sensitivity coul …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Oral Administration of Ganoderma lucidum to Lead-Exposed Rats Protects Erythrocytes against Hemolysis: Implicates to Anti-Anemia.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
634.
Mushrooms of the Genus Ganoderma Used to Treat Diabetes and Insulin Resistance.
- Wińska K, Mączka W, Gabryelska K, Grabarczyk M.
- Molecules. 2019 Nov 11;24(22):4075. doi: 10.3390/molecules24224075.
- PMCID: PMC6891282
Wińska K, et al.

Molecules. 2019.

PMCID: PMC6891282

This minireview summarizes the perspectives, recent advances, and major challenges of medicinal mushrooms from Ganoderma genus with reference to their antidiabetic activity. The most active ingredients of those mushrooms are polysaccharides and triterpenoids. ...

This minireview summarizes the perspectives, recent advances, and major challenges of medicinal mushrooms from Ganoderma genus with r …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Mushrooms of the Genus Ganoderma Used to Treat Diabetes and Insulin Resistance.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
635.
Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety.
- Shaito A, Thuan DTB, Phu HT, Nguyen THD, Hasan H, Halabi S, Abdelhady S, Nasrallah GK, Eid AH, Pintus G.
- Front Pharmacol. 2020 Apr 7;11:422. doi: 10.3389/fphar.2020.00422.
- PMCID: PMC7155419
Shaito A, et al.

Front Pharmacol. 2020.

PMCID: PMC7155419

Further, data on the ethnopharmacological therapeutic potentials and medicinal properties against CVDs of four widely used plants, namely Ginseng, Ginkgo biloba, Ganoderma lucidum, and Gynostemma pentaphyllum, are gathered and reviewed. In particular, the employment …

Further, data on the ethnopharmacological therapeutic potentials and medicinal properties against CVDs of four widely used plants, namely Gi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
636.
Ornithine Decarboxylase-Mediated Production of Putrescine Influences Ganoderic Acid Biosynthesis by Regulating Reactive Oxygen Species in Ganoderma lucidum.
- Wu CG, Tian JL, Liu R, Cao PF, Zhang TJ, Ren A, Shi L, Zhao MW.
- Appl Environ Microbiol. 2017 Sep 29;83(20):e01289-17. doi: 10.1128/AEM.01289-17.
- PMCID: PMC5627001
Wu CG, et al.

Appl Environ Microbiol. 2017.

PMCID: PMC5627001

A homolog of the gene encoding ODC was cloned from Ganoderma lucidum In the ODC-silenced strains, the transcript levels of the ODC gene and the putrescine content were significantly decreased. ...In this study, a homolog of the gene encoding ODC was cloned in Gan …

A homolog of the gene encoding ODC was cloned from Ganoderma lucidum In the ODC-silenced strains, the transcript levels of the …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ornithine Decarboxylase-Mediated Production of Putrescine Influences Ganoderic Acid Biosynthesis by Regulating Reactive Oxygen Species in Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
637.
Anti-tumor and Anti-angiogenic Ergosterols from Ganoderma lucidum.
- Chen S, Yong T, Zhang Y, Su J, Jiao C, Xie Y.
- Front Chem. 2017 Oct 30;5:85. doi: 10.3389/fchem.2017.00085.
- PMCID: PMC5670154
Chen S, et al.

Front Chem. 2017.

PMCID: PMC5670154

This study was carried out to isolate chemical constituents from the lipid enriched fraction of Ganoderma lucidum extract and to evaluate their anti-proliferative effect on tumor cells and human umbilical vein endothelial cells (HUVECs). Ergosterol derivatives (1-14 …

This study was carried out to isolate chemical constituents from the lipid enriched fraction of Ganoderma lucidum extract and …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Anti-tumor and Anti-angiogenic Ergosterols from Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
638.
Ganoderma lucidum Immobilized on Wood Demonstrates High Persistence During the Removal of OPFRs in a Trickle-Bed Bioreactor.
- Tayar S, Villagra J, Gaju N, Martínez-Alonso M, Beltrán-Flores E, Sarrà M.
- J Fungi (Basel). 2025 Jan 22;11(2):85. doi: 10.3390/jof11020085.
- PMCID: PMC11856180
Tayar S, et al.

J Fungi (Basel). 2025.

PMCID: PMC11856180

This study addresses this issue by evaluating the bioremediation potential of white-rot fungi for the removal of two OPFRs: tris(2-chloroethyl) phosphate (TCEP) and tributyl phosphate (TBP). Three fungal species-Ganoderma lucidum, Trametes versicolor, and Phanerocha …

This study addresses this issue by evaluating the bioremediation potential of white-rot fungi for the removal of two OPFRs: tris(2-chloroeth …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Immobilized on Wood Demonstrates High Persistence During the Removal of OPFRs in a Trickle-Bed Bioreactor.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
639.
Evaluation of anti-microbial activity of spore powder of Ganoderma lucidum on clinical isolates of Prevotella intermedia: A pilot study.
- Nayak RN, Dixitraj PT, Nayak A, Bhat K.
- Contemp Clin Dent. 2015 Sep;6(Suppl 1):S248-52. doi: 10.4103/0976-237X.166834.
- PMCID: PMC4632230
Nayak RN, et al.

Contemp Clin Dent. 2015.

PMCID: PMC4632230

AIM: This study aimed at evaluating the anti-microbial activity of spore powder of Ganoderma lucidum on Prevotella intermedia isolated from subgingival plaque from chronic periodontitis patients. ...Eleven samples showed sensitivity at 4 mcg/ml, 8 samples showed sen …

AIM: This study aimed at evaluating the anti-microbial activity of spore powder of Ganoderma lucidum on Prevotella intermedia …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Evaluation of anti-microbial activity of spore powder of Ganoderma lucidum on clinical isolates of Prevotella intermedia: A pilot study.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Participant-reported outcomes, clinical biomarkers, and safety/tolerability. Open article.
- Why might this paper be useful to readers? Provides early human data; interpret with caution and check study size and endpoints. Open article.
640.
Evaluation of Two Different Treatments for Larch Logs as Substrates to Cultivate Ganoderma tsugae in the Forest.
- Xia L, Tan X, Wang P, Yang D, Zhang Y, Cui Y, Yu Y, Zhang W, Huang X, Wen J.
- Life (Basel). 2024 Dec 31;15(1):39. doi: 10.3390/life15010039.
- PMCID: PMC11766503
Xia L, et al.

Life (Basel). 2024.

PMCID: PMC11766503

Larch wood, a prevalent cultivation medium for Ganoderma tsugae, has yet to be scrutinized concerning the differential impacts of sterilized and non-sterilized substrates on the growth and development of this fungus. ...

Larch wood, a prevalent cultivation medium for Ganoderma tsugae, has yet to be scrutinized concerning the differential impacts of ste …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Evaluation of Two Different Treatments for Larch Logs as Substrates to Cultivate Ganoderma tsugae in the Forest.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 65

641.
Differentiation and grouping of isolates of the Ganoderma lucidum complex by random amplified polymorphic DNA-PCR compared with grouping on the basis of internal transcribed spacer sequences.
- Hseu RS, Wang HH, Wang HF, Moncalvo JM.
- Appl Environ Microbiol. 1996 Apr;62(4):1354-63. doi: 10.1128/aem.62.4.1354-1363.1996.
- PMCID: PMC167902
Hseu RS, et al.

Appl Environ Microbiol. 1996.

PMCID: PMC167902

Laccate polypores of the Ganoderma lucidum species complex are widespread white rot fungi of economic importance, but isolates cannot be identified by traditional taxonomic methods. ...The conclusion of this study is that ITS sequences can be used to identify isolat …

Laccate polypores of the Ganoderma lucidum species complex are widespread white rot fungi of economic importance, but isolates …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Differentiation and grouping of isolates of the Ganoderma lucidum complex by random amplified polymorphic DNA-PCR compared with grouping on the basis of internal transcribed spacer sequences.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
642.
Detection of Extracellular Enzyme Activities in Ganoderma neo-japonicum.
- Jo WS, Park HN, Cho DH, Yoo YB, Park SC.
- Mycobiology. 2011 Jun 16;39(2):118-20. doi: 10.4489/MYCO.2011.39.2.118.
- PMCID: PMC3385105
Jo WS, et al.

Mycobiology. 2011.

PMCID: PMC3385105

Two Ganoderma lucidum isolates showed moderate activity for avicelase; however, Ganoderma neo-japonicum showed the strongest activity. Moderate ligninase activity was only observed in Ganoderma neo-japonicum. In contrast, pectinase, amylase, protease, …

Two Ganoderma lucidum isolates showed moderate activity for avicelase; however, Ganoderma neo-japonicum showed the stro …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Detection of Extracellular Enzyme Activities in Ganoderma neo-japonicum.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
643.
Decoding and reprogramming of the biosynthetic networks of mushroom-derived bioactive type II ganoderic acids in yeast.
- Wang Q, Li Y, Zhang S, Yuan W, Du Z, Shi T, Chang Z, Zhai X, Lu Y, Wang M, Guo J, Zhong JJ, Xiao H.
- Cell Discov. 2025 Jul 8;11(1):61. doi: 10.1038/s41421-025-00812-1.
- PMCID: PMC12234687
Wang Q, et al.

Cell Discov. 2025.

PMCID: PMC12234687

Mushroom's specialized secondary metabolites possess important pharmacological activities, but their biosynthetic pathway elucidation is extremely challenging, not to mention reprogramming of their biosynthetic networks to target metabolites. By taking Ganoderma lucidum …

Mushroom's specialized secondary metabolites possess important pharmacological activities, but their biosynthetic pathway elucidation is ext …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Decoding and reprogramming of the biosynthetic networks of mushroom-derived bioactive type II ganoderic acids in yeast.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
644.
Removal of cyanobacterial harmful algal blooms (HABs) from contaminated local park lake using Ganoderma lucidum mycelial pellets.
- Mohd Hanafiah Z, Hafsari AR, Elango M, Ilham Z, Doni F, Wan Mohtar WHM, Gafforov Y, Wong YJ, Abdul Maulud KN, Ismail NH, Putera Mohd Yusof MY, Wan-Mohtar WAAQI.
- Heliyon. 2024 Dec 15;11(1):e41205. doi: 10.1016/j.heliyon.2024.e41205.
- PMCID: PMC11730225
Mohd Hanafiah Z, et al.

Heliyon. 2024.

PMCID: PMC11730225

This study investigated the effectiveness of the bio-flocculation approach using the Ganoderma lucidum fungus strain BGF4A1 to remove these harmful blooms, specifically targeting cyanobacterial species like Microcystis PCC-7914. ...Morphological analysis using field …

This study investigated the effectiveness of the bio-flocculation approach using the Ganoderma lucidum fungus strain BGF4A1 to …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Removal of cyanobacterial harmful algal blooms (HABs) from contaminated local park lake using Ganoderma lucidum mycelial pellets.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
645.
Structural characterization and hepatoprotective activity of an acidic polysaccharide from Ganoderma lucidum.
- Chen S, Guan X, Yong T, Gao X, Xiao C, Xie Y, Chen D, Hu H, Wu Q.
- Food Chem X. 2022 Jan 3;13:100204. doi: 10.1016/j.fochx.2022.100204.
- PMCID: PMC9039936
Chen S, et al.

Food Chem X. 2022.

PMCID: PMC9039936

In this study, Ganoderma lucidum crude polysaccharide (GLP) was found to have protective effect on liver damage in mice caused by restraint stress through improving oxidative status. ...The findings provided a theoretical basis for the potential application of G. …

In this study, Ganoderma lucidum crude polysaccharide (GLP) was found to have protective effect on liver damage in mice caused …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Structural characterization and hepatoprotective activity of an acidic polysaccharide from Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
646.
Characterisation of a New Fungal Immunomodulatory Protein from Tiger Milk mushroom, Lignosus rhinocerotis.
- Pushparajah V, Fatima A, Chong CH, Gambule TZ, Chan CJ, Ng ST, Tan CS, Fung SY, Lee SS, Tan NH, Lim RL.
- Sci Rep. 2016 Jul 27;6:30010. doi: 10.1038/srep30010.
- PMCID: PMC4962085
Pushparajah V, et al.

Sci Rep. 2016.

PMCID: PMC4962085

Here we report the cDNA of this new member (FIP-Lrh) with a homology range of 54-64% to FIPs from other mushroom species, the closest is with FIP-glu (LZ-8) (64%) from Ganoderma lucidum. The FIP-Lrh of 112 amino acids (12.59 kDa) has a relatively hydrophobic N-termi …

Here we report the cDNA of this new member (FIP-Lrh) with a homology range of 54-64% to FIPs from other mushroom species, the closest is wit …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Characterisation of a New Fungal Immunomodulatory Protein from Tiger Milk mushroom, Lignosus rhinocerotis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
647.
Effect of Food Waste Compost on the Antler-Type Fruiting Body Yield of Ganoderma lucidum.
- Jo EY, Cheon JL, Ahn JH.
- Mycobiology. 2013 Mar 28;41(1):42-6. doi: 10.5941/MYCO.2013.41.1.42.
- PMCID: PMC3627969
Jo EY, et al.

Mycobiology. 2013.

PMCID: PMC3627969

The effects of the composition of a mixture containing food waste compost (FWC), rice bran (RB), and oak sawdust (SD) on the antler-type fruiting body (FB) yield of Ganoderma lucidum were studied. Experiments were performed using 0 (control), 5, 10, 15, 20, 25, 30, …

The effects of the composition of a mixture containing food waste compost (FWC), rice bran (RB), and oak sawdust (SD) on the antler-type fru …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effect of Food Waste Compost on the Antler-Type Fruiting Body Yield of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
648.
LingZhi oligopeptides amino acid sequence analysis and anticancer potency evaluation.
- Liu J, Wang H, Luo Q, Qiu S, He Z, Liu Z, Yang L, Liu X, Sun X.
- RSC Adv. 2020 Feb 27;10(14):8377-8384. doi: 10.1039/c9ra10400c.
- PMCID: PMC9049989
Liu J, et al.

RSC Adv. 2020.

PMCID: PMC9049989

LingZhi (Ganoderma lucidum) has been used as a therapeutic agent for decades, but the antitumor potency of LingZhi oligopeptides (LZOs) was not well explored. ...

LingZhi (Ganoderma lucidum) has been used as a therapeutic agent for decades, but the antitumor potency of LingZhi oligopeptid …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: LingZhi oligopeptides amino acid sequence analysis and anticancer potency evaluation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
649.
Effect of Oral Coadministration of Ascorbic Acid with Ling Zhi Preparation on Pharmacokinetics of Ganoderic Acid A in Healthy Male Subjects: A Randomized Crossover Study.
- Tawasri P, Ampasavate C, Tharatha S, Chiranthanut N, Teekachunhatean S.
- Biomed Res Int. 2016 Sep 25;2016:2819862. doi: 10.1155/2016/2819862.
- PMCID: PMC5055913
Tawasri P, et al.

Biomed Res Int. 2016.

PMCID: PMC5055913
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effect of Oral Coadministration of Ascorbic Acid with Ling Zhi Preparation on Pharmacokinetics of Ganoderic Acid A in Healthy Male Subjects: A Randomized Crossover Study.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
650.
Early Preclinical Studies of Ergosterol Peroxide and Biological Evaluation of Its Derivatives.
- Ling T, Arroyo-Cruz LV, Smither WR, Seighman EK, Martínez-Montemayor MM, Rivas F.
- ACS Omega. 2024 Aug 19;9(35):37117-37127. doi: 10.1021/acsomega.4c04350.
- PMCID: PMC11375702
Ling T, et al.

ACS Omega. 2024.

PMCID: PMC11375702

Ganoderma lucidum is a medicinal mushroom that produces various pharmacological compounds, including triterpenoids. A major bioactive component of G. lucidum is ergosterol peroxide (EP), which is attributed to its anticancer effects. The current study focuses …

Ganoderma lucidum is a medicinal mushroom that produces various pharmacological compounds, including triterpenoids. A major bi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Early Preclinical Studies of Ergosterol Peroxide and Biological Evaluation of Its Derivatives.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 66

651.
A novel Ganoderma lucidum G0119 fermentation strategy for enhanced triterpenes production by statistical process optimization and addition of oleic acid.
- Feng J, Zhang JS, Feng N, Yan MQ, Yang Y, Jia W, Lin CC.
- Eng Life Sci. 2016 Nov 2;17(4):430-439. doi: 10.1002/elsc.201600071.
- PMCID: PMC6999601
Feng J, et al.

Eng Life Sci. 2016.

PMCID: PMC6999601

A novel enhanced triterpenes fermentation production process by Ganoderma lucidum G0119 with the addition of oleic acid in the medium has been developed and optimized. All of the six exogenous additives tested were found to exhibit stimulatory effect on mycelial gro …

A novel enhanced triterpenes fermentation production process by Ganoderma lucidum G0119 with the addition of oleic acid in the …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A novel Ganoderma lucidum G0119 fermentation strategy for enhanced triterpenes production by statistical process optimization and addition of oleic acid.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
652.
Optimizing a culture medium for biomass and phenolic compounds production using Ganoderma lucidum.
- Zárate-Chaves CA, Romero-Rodríguez MC, Niño-Arias FC, Robles-Camargo J, Linares-Linares M, Rodríguez-Bocanegra MX, Gutiérrez-Rojas I.
- Braz J Microbiol. 2013 May 17;44(1):215-23. doi: 10.1590/S1517-83822013005000032.
- PMCID: PMC3804202
Zárate-Chaves CA, et al.

Braz J Microbiol. 2013.

PMCID: PMC3804202

The present work was aimed at optimizing a culture medium for biomass production and phenolic compounds by using Ganoderma lucidum. The culture was optimized in two stages; a Plackett-Burman design was used in the first one for identifying key components in the medi …

The present work was aimed at optimizing a culture medium for biomass production and phenolic compounds by using Ganoderma lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Optimizing a culture medium for biomass and phenolic compounds production using Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
653.
Ganoderma lucidum culture supplement ameliorates dyslipidemia and reduces visceral fat accumulation in type 2 diabetic rats.
- Huang CH, Lin WK, Chang SH, Tsai GJ.
- Mycology. 2020 Mar 23;12(2):94-104. doi: 10.1080/21501203.2020.1740409.
- PMCID: PMC8128174
Huang CH, et al.

Mycology. 2020.

PMCID: PMC8128174

Diabetic rats were daily fed with a high-cholesterol diet containing 1% or 3% freeze-dried whole submerged G. lucidum culture or its mycelia for 5 weeks. Body weight, adipose tissue weight and plasma triglyceride levels were reduced, while high-density lipoprotein-choleste …

Diabetic rats were daily fed with a high-cholesterol diet containing 1% or 3% freeze-dried whole submerged G. lucidum culture or its …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum culture supplement ameliorates dyslipidemia and reduces visceral fat accumulation in type 2 diabetic rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
654.
The Effect of Mitochondria on Ganoderma lucidum Growth and Bioactive Components Based on Transcriptomics.
- Ye L, He X, Su C, Feng H, Meng G, Chen B, Wu X.
- J Fungi (Basel). 2022 Nov 9;8(11):1182. doi: 10.3390/jof8111182.
- PMCID: PMC9692720
Ye L, et al.

J Fungi (Basel). 2022.

PMCID: PMC9692720

In this study, the effect of mitochondria on Ganoderma lucidum morphology, yield, and main primary bioactive components was analyzed via structuring and comparing isonuclear alloplasmic strains. ...The above results further proved that mitochondria could affect the …

In this study, the effect of mitochondria on Ganoderma lucidum morphology, yield, and main primary bioactive components was an …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The Effect of Mitochondria on Ganoderma lucidum Growth and Bioactive Components Based on Transcriptomics.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Broad molecular profiling and pathway/statistical analyses. Open article.
- Why might this paper be useful to readers? Maps pathways and components that can guide future lab and clinical research. Open article.
655.
Fungal beta glucan protects radiation induced DNA damage in human lymphocytes.
- Pillai TG, Maurya DK, Salvi VP, Janardhanan KK, Nair CK.
- Ann Transl Med. 2014 Feb;2(2):13. doi: 10.3978/j.issn.2305-5839.2014.02.02.
- PMCID: PMC4202477
Pillai TG, et al.

Ann Transl Med. 2014.

PMCID: PMC4202477

BACKGROUND: Ganoderma lucidum (Ling Zhi), a basidiomycete white rot macrofungus has been used extensively for therapeutic use in China, Japan, Korea and other Asian countries for 2,000 years. ...The radioprotective properties of BG isolated from the macro fungi G …

BACKGROUND: Ganoderma lucidum (Ling Zhi), a basidiomycete white rot macrofungus has been used extensively for therapeutic use …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Fungal beta glucan protects radiation induced DNA damage in human lymphocytes.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
656.
Ganoderma lucidum Immune Modulator Protein rLZ-8 Could Prevent and Reverse Bone Loss in Glucocorticoids-Induced Osteoporosis Rat Model.
- Yang Y, Yu T, Tang H, Ren Z, Li Q, Jia J, Chen H, Fu J, Ding S, Hao Q, Xu D, Song L, Sun B, Sun F, Pei J.
- Front Pharmacol. 2020 May 19;11:731. doi: 10.3389/fphar.2020.00731.
- PMCID: PMC7248554
Yang Y, et al.

Front Pharmacol. 2020.

PMCID: PMC7248554
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Immune Modulator Protein rLZ-8 Could Prevent and Reverse Bone Loss in Glucocorticoids-Induced Osteoporosis Rat Model.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
657.
In vitro prebiotic activities of oligosaccharides from the by-products in Ganoderma lucidum spore polysaccharide extraction.
- Yang K, Zhang Y, Cai M, Guan R, Neng J, Pi X, Sun P.
- RSC Adv. 2020 Apr 14;10(25):14794-14802. doi: 10.1039/c9ra10798c.
- PMCID: PMC9052122
Yang K, et al.

RSC Adv. 2020.

PMCID: PMC9052122

Until recently, a variety of oligosaccharides from fruits, vegetables and mushrooms have demonstrated positive prebiotic effects. Ganoderma lucidum, a well-known traditional medicine and tonic in East Asia, has been utilized in the prevention and treatment of a broa …

Until recently, a variety of oligosaccharides from fruits, vegetables and mushrooms have demonstrated positive prebiotic effects. Ganoder …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: In vitro prebiotic activities of oligosaccharides from the by-products in Ganoderma lucidum spore polysaccharide extraction.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
658.
A global meta-analysis of ITS rDNA sequences from material belonging to the genus Ganoderma (Basidiomycota, Polyporales) including new data from selected taxa.
- Fryssouli V, Zervakis GI, Polemis E, Typas MA.
- MycoKeys. 2020 Dec 1;75:71-143. doi: 10.3897/mycokeys.75.59872.
- PMCID: PMC7723883
Fryssouli V, et al.

MycoKeys. 2020.

PMCID: PMC7723883

Ganoderma taxa segregated into five main lineages (Clades A to E). Clade A corresponds to the core of laccate species and includes G. shanxiense and three major well-supported clusters: Cluster A.1 ('G. lucidum sensu lato') consists of taxa from Eurasia and North Am …

Ganoderma taxa segregated into five main lineages (Clades A to E). Clade A corresponds to the core of laccate species and includes G. …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A global meta-analysis of ITS rDNA sequences from material belonging to the genus Ganoderma (Basidiomycota, Polyporales) including new data from selected taxa.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
659.
Mitigating Oxidative Stress and Promoting Cellular Longevity with Mushroom Extracts.
- Abdelkader ME, Mediatrice H, Lin D, Lin Z, Aggag SA.
- Foods. 2024 Dec 13;13(24):4028. doi: 10.3390/foods13244028.
- PMCID: PMC11727512
Abdelkader ME, et al.

Foods. 2024.

PMCID: PMC11727512

This study investigated the antioxidant and anti-aging properties of four medicinal and edible mushrooms: Ganoderma lucidum, Hericium erinaceus, Pleurotus ostreatus, and Agaricus bisporus. The antioxidant activity of mushroom extracts was evaluated using (DPPH-ABTS- …

This study investigated the antioxidant and anti-aging properties of four medicinal and edible mushrooms: Ganoderma lucidum, H …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Mitigating Oxidative Stress and Promoting Cellular Longevity with Mushroom Extracts.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
660.
Characterization of gamma-Cadinene Enzymes in Ganoderma lucidum and Ganoderma sinensis from Basidiomycetes Provides Insight into the Identification of Terpenoid Synthases.
- Cao R, Wu X, Wang Q, Qi P, Zhang Y, Wang L, Sun C.
- ACS Omega. 2022 Feb 16;7(8):7229-7239. doi: 10.1021/acsomega.1c06792.
- PMCID: PMC8892675
Cao R, et al.

ACS Omega. 2022.

PMCID: PMC8892675

Aided by bioinformatics analysis, three gamma-cadinene enzymes from Ganoderma lucidum and Ganoderma sinensis were accurately predicted and identified experimentally. ...

Aided by bioinformatics analysis, three gamma-cadinene enzymes from Ganoderma lucidum and Ganoderma sinensis were accur …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Characterization of gamma-Cadinene Enzymes in Ganoderma lucidum and Ganoderma sinensis from Basidiomycetes Provides Insight into the Identification of Terpenoid Synthases.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 67

661.
Antioxidant, antibacterial and DNA protective activities of protein extracts from Ganoderma lucidum.
- Sa-Ard P, Sarnthima R, Khammuang S, Kanchanarach W.
- J Food Sci Technol. 2014 Apr 21;52(5):2966-73. doi: 10.1007/s13197-014-1343-5.
- PMCID: PMC4397306
Sa-Ard P, et al.

J Food Sci Technol. 2014.

PMCID: PMC4397306

Crude proteins of cultured mycelia and fruiting bodies of Ganoderma lucidum were investigated for antioxidant, antibacterial and DNA protective activities. ...This protein extract was partial purified by Diethyl amino ethyl (DEAE)-Sepharose column and Sulfopropyl (S …

Crude proteins of cultured mycelia and fruiting bodies of Ganoderma lucidum were investigated for antioxidant, antibacterial a …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antioxidant, antibacterial and DNA protective activities of protein extracts from Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
662.
Therapeutic potential of Ganoderma lucidum polysaccharide peptide in Doxorubicin-induced nephropathy: modulation of renin-angiotensin system and proteinuria.
- Fang H, Lin D, Li X, Wang L, Yang T.
- Front Pharmacol. 2023 Sep 29;14:1287908. doi: 10.3389/fphar.2023.1287908.
- PMCID: PMC10570435
Fang H, et al.

Front Pharmacol. 2023.

PMCID: PMC10570435

To reduce renal RAS activation and proteinuria caused by DOX, this study evaluated the effectiveness of Ganoderma lucidum polysaccharide peptide (GL-PP), a new glycopeptide produced from Ganoderma lucidum grown on grass. ...

To reduce renal RAS activation and proteinuria caused by DOX, this study evaluated the effectiveness of Ganoderma lucidum poly …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Therapeutic potential of Ganoderma lucidum polysaccharide peptide in Doxorubicin-induced nephropathy: modulation of renin-angiotensin system and proteinuria.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
663.
Nontargeted metabolomics study and pharmacodynamic evaluation of bidirectional fermentation for Ganoderma lucidum with Marsdenia tenacissima.
- Li R, Zhang Z, Su X, Yu J, Lu L, Liu T.
- Front Pharmacol. 2022 Oct 26;13:1012063. doi: 10.3389/fphar.2022.1012063.
- PMCID: PMC9643841
Li R, et al.

Front Pharmacol. 2022.

PMCID: PMC9643841

This study aims to produce biotransformation products rich in pungent saponins by using Marsdenia tenacissima as a fermentation medium of Ganoderma lucidum. Non-targeted metabolomics analysis was carried out on the fermentation products after the optimization proces …

This study aims to produce biotransformation products rich in pungent saponins by using Marsdenia tenacissima as a fermentation medium of …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Nontargeted metabolomics study and pharmacodynamic evaluation of bidirectional fermentation for Ganoderma lucidum with Marsdenia tenacissima.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Broad molecular profiling and pathway/statistical analyses. Open article.
- Why might this paper be useful to readers? Maps pathways and components that can guide future lab and clinical research. Open article.
664.
Use of Herbal Drugs in Cardiovascular Disease- A Review.
- Kaur A, Kumar R.
- Curr Cardiol Rev. 2025;21(1):e1573403X323724. doi: 10.2174/011573403X323724240830075719.
- PMCID: PMC12060911
Kaur A, et al.

Curr Cardiol Rev. 2025.

PMCID: PMC12060911

Medicinal plants that are widely known for treating CVD include ginseng, Ginkgo biloba, ganoderma lucidum, gynostemma pentaphyllum, viridis amaranthus, etc. Plant sterol, flavonoids, polyphenols, sulphur compound and terpenoid are the active phytochemicals present i …

Medicinal plants that are widely known for treating CVD include ginseng, Ginkgo biloba, ganoderma lucidum, gynostemma pentaphy …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Use of Herbal Drugs in Cardiovascular Disease- A Review.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
665.
Triterpenoids of Ganoderma lucidum inhibited S180 sarcoma and H22 hepatoma in mice by regulating gut microbiota.
- Wang J, Pu J, Zhang Z, Feng Z, Han J, Su X, Shi L.
- Heliyon. 2023 Jun 7;9(6):e16682. doi: 10.1016/j.heliyon.2023.e16682.
- PMCID: PMC10360580
Wang J, et al.

Heliyon. 2023.

PMCID: PMC10360580

The study assessed the antitumor effect of triterpenoids of Ganoderma lucidum (TGL) on S180 and H22 tumor bearing mice. A triterpene compound, 2alpha, 3alpha, 23-trihydroxy-urs-12-en-28-oic acid, was successfully isolated and purified from G. lucidum. ...

The study assessed the antitumor effect of triterpenoids of Ganoderma lucidum (TGL) on S180 and H22 tumor bearing mice. A trit …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Triterpenoids of Ganoderma lucidum inhibited S180 sarcoma and H22 hepatoma in mice by regulating gut microbiota.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
666.
Assessment of Polysaccharides from Mycelia of genus Ganoderma by Mid-Infrared and Near-Infrared Spectroscopy.
- Ma Y, He H, Wu J, Wang C, Chao K, Huang Q.
- Sci Rep. 2018 Jan 8;8(1):10. doi: 10.1038/s41598-017-18422-7.
- PMCID: PMC5758644
Ma Y, et al.

Sci Rep. 2018.

PMCID: PMC5758644

Ganoderma lingzhi (G. lingzhi), G. sinense, G. applanatum, etc. belongs to the Ganoderma genus of polypore mushrooms which contain rich polysaccharides valuable for nutrition and positive medicinal effects. In order to evaluate polysaccharide content in Ganoderma …

Ganoderma lingzhi (G. lingzhi), G. sinense, G. applanatum, etc. belongs to the Ganoderma genus of polypore mushrooms which con …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Assessment of Polysaccharides from Mycelia of genus Ganoderma by Mid-Infrared and Near-Infrared Spectroscopy.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
667.
Inhibitory effect of plant essential oils on α-glucosidase.
- You Z, Li Y, Zhang K, Zheng X, Wong VKW, Liu W.
- Food Sci Biotechnol. 2022 Aug 9;31(12):1593-1602. doi: 10.1007/s10068-022-01145-5.
- PMCID: PMC9582169
You Z, et al.

Food Sci Biotechnol. 2022.

PMCID: PMC9582169

The further study revealed that the most potent EOs against alpha-glucosidase were chuan-xiong, fructus cnidii, sacha inchi, aloe, ganoderma lucidum spore and ginger with IC(50) values of 3.02, 2.88, 7.37, 5.06, 5.32 and 7.40 mug/mL. Moreover, the inhibitory mechani …

The further study revealed that the most potent EOs against alpha-glucosidase were chuan-xiong, fructus cnidii, sacha inchi, aloe, ganode …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Inhibitory effect of plant essential oils on α-glucosidase.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
668.
Water Quality Assessment and Decolourisation of Contaminated Ex-Mining Lake Water Using Bioreactor Dye-Eating Fungus (BioDeF) System: A Real Case Study.
- Hanafiah ZM, Azmi AR, Wan-Mohtar WAAQI, Olivito F, Golemme G, Ilham Z, Jamaludin AA, Razali N, Halim-Lim SA, Wan Mohtar WHM.
- Toxics. 2024 Jan 11;12(1):60. doi: 10.3390/toxics12010060.
- PMCID: PMC10818540
Hanafiah ZM, et al.

Toxics. 2024.

PMCID: PMC10818540

Due to population growth and development limits, former mining lakes are being converted to more lucrative land uses like those of recreational zones, agriculture, and livestock. The fungus Ganoderma lucidum has the potential to be utilised as a substitute or to per …

Due to population growth and development limits, former mining lakes are being converted to more lucrative land uses like those of recreatio …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Water Quality Assessment and Decolourisation of Contaminated Ex-Mining Lake Water Using Bioreactor Dye-Eating Fungus (BioDeF) System: A Real Case Study.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Quality/authentication methods study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Analytical validation (specificity/sensitivity), reference standards, and mislabeling rates. Open article.
- Why might this paper be useful to readers? Useful for quality control, sourcing, and preventing adulteration. Open article.
669.
Dynamic changes of nutrients, isoflavone composition and antioxidant activities during liquid-state fermentation of soybean embryo homogenate by Ganoderma lucidum.
- Kim GY, Kwon YS, Gebru YA, Kim YH, Kang DH, Kim MK, Choi HS.
- Food Chem X. 2025 Feb 14;26:102283. doi: 10.1016/j.fochx.2025.102283.
- PMCID: PMC11880717
Kim GY, et al.

Food Chem X. 2025.

PMCID: PMC11880717

This study aims to explore compositional changes of oligosaccharides, amino-type nitrogen, free amino acids volatile compounds, isoflavones, total phenol, total flavonoid, and antioxidant capacities during liquid-state fermentation (LSF) of soybean embryo homogenate (SEH) by G …

This study aims to explore compositional changes of oligosaccharides, amino-type nitrogen, free amino acids volatile compounds, isoflavones, …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Dynamic changes of nutrients, isoflavone composition and antioxidant activities during liquid-state fermentation of soybean embryo homogenate by Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
670.
Extracellular polysaccharides produced by Ganoderma formosanum stimulate macrophage activation via multiple pattern-recognition receptors.
- Wang CL, Lu CY, Pi CC, Zhuang YJ, Chu CL, Liu WH, Chen CJ.
- BMC Complement Altern Med. 2012 Aug 10;12:119. doi: 10.1186/1472-6882-12-119.
- PMCID: PMC3495220
Wang CL, et al.

BMC Complement Altern Med. 2012.

PMCID: PMC3495220

BACKGROUND: The fungus of Ganoderma is a traditional medicine in Asia with a variety of pharmacological functions including anti-cancer activities. ...

BACKGROUND: The fungus of Ganoderma is a traditional medicine in Asia with a variety of pharmacological functions including anti-canc …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Extracellular polysaccharides produced by Ganoderma formosanum stimulate macrophage activation via multiple pattern-recognition receptors.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.

Page 68

671.
Effects of fermentation by Ganoderma lucidum and Saccharomyces cerevisiae on rape pollen morphology and its wall.
- Zhang Z, Cao H, Chen C, Chen X, Wei Q, Zhao F.
- J Food Sci Technol. 2017 Sep 19;54(12):4026-4034. doi: 10.1007/s13197-017-2868-1.
- PMCID: PMC5643820
Zhang Z, et al.

J Food Sci Technol. 2017.

PMCID: PMC5643820

This study investigated the mechanism of wall rupture fermentation of the rape bee pollen by Ganoderma lucidum and Saccharomyces cerevisiae. The enzymatic activities and broken-wall ratios were determined, and the results suggested the involvement of cellulase, prot …

This study investigated the mechanism of wall rupture fermentation of the rape bee pollen by Ganoderma lucidum and Saccharomyc …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effects of fermentation by Ganoderma lucidum and Saccharomyces cerevisiae on rape pollen morphology and its wall.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
672.
Biodegradation and decolourization of textile dye wastewater using Ganoderma lucidum.
- Selvakumar S, Manivasagan R, Chinnappan K.
- 3 Biotech. 2012 Jun 13;3(1):71-79. doi: 10.1007/s13205-012-0073-5.
- PMCID: PMC3563749
Selvakumar S, et al.

3 Biotech. 2012.

PMCID: PMC3563749

In this work, treatment of textile dye wastewater was carried in a batch reactor using Ganoderma lucidum. The characteristics of textile dye wastewater were studied. The effect of process parameters like pH, temperature, agitation speed and dye wastewater concentrat …

In this work, treatment of textile dye wastewater was carried in a batch reactor using Ganoderma lucidum. The characteristics …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Biodegradation and decolourization of textile dye wastewater using Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Relevant for eco‑friendly processing, waste upcycling, and industrial biocatalysis. Open article.
673.
Evaluation of Total Phenolic Content, HPLC Analysis, and Antioxidant Potential of Three Local Varieties of Mushroom: A Comparative Study.
- Bristy AT, Islam T, Ahmed R, Hossain J, Reza HM, Jain P.
- Int J Food Sci. 2022 Oct 19;2022:3834936. doi: 10.1155/2022/3834936.
- PMCID: PMC9605836
Bristy AT, et al.

Int J Food Sci. 2022.

PMCID: PMC9605836

The present study is aimed to investigate the ethanolic extracts of three varieties of mushrooms, namely, G. lucidum, G. tropicum, and C. indica grown in Bangladesh for phenolic and flavonoid content and their antioxidant properties. ...The alpha-amylase inhibitory and ant …

The present study is aimed to investigate the ethanolic extracts of three varieties of mushrooms, namely, G. lucidum, G. tropicum, an …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Evaluation of Total Phenolic Content, HPLC Analysis, and Antioxidant Potential of Three Local Varieties of Mushroom: A Comparative Study.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
674.
Proteoglycan Extracted from Ganoderma lucidum Ameliorated Diabetes-Induced Muscle Atrophy via the AMPK/SIRT1 Pathway In Vivo and In Vitro.
- Li J, Zhang Y, Yu F, Pan Y, Zhang Z, He Y, Yang H, Zhou P.
- ACS Omega. 2023 Aug 8;8(33):30359-30373. doi: 10.1021/acsomega.3c03513.
- PMCID: PMC10448640
Li J, et al.

ACS Omega. 2023.

PMCID: PMC10448640

In this study, we demonstrated that FYGL (Fudan-Yueyang-G. lucidum), a proteoglycan extracted from Ganoderma lucidum, ameliorated muscle atrophy in rat and mouse models of diabetes. ...

In this study, we demonstrated that FYGL (Fudan-Yueyang-G. lucidum), a proteoglycan extracted from Ganoderma lucidum, a …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Proteoglycan Extracted from Ganoderma lucidum Ameliorated Diabetes-Induced Muscle Atrophy via the AMPK/SIRT1 Pathway In Vivo and In Vitro.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
675.
Mechanism Underlying Ganoderma lucidum Polysaccharide Biosynthesis Regulation by the beta-1,3-Glucosyltransferase Gene gl20535.
- Liu J, Xu M, Shen M, Li J, Chen L, Gu Z, Shi G, Ding Z.
- J Fungi (Basel). 2025 Jul 17;11(7):532. doi: 10.3390/jof11070532.
- PMCID: PMC12295571
Liu J, et al.

J Fungi (Basel). 2025.

PMCID: PMC12295571

Ganoderma lucidum polysaccharides (GLPs) are natural compounds with a broad spectrum of biological activities. beta-1,3-glucosyltransferase (GL20535) plays an important role in polysaccharide synthesis by catalyzing the transfer of UDP-glucose to extend sugar chains …

Ganoderma lucidum polysaccharides (GLPs) are natural compounds with a broad spectrum of biological activities. beta-1,3-glucos …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Mechanism Underlying Ganoderma lucidum Polysaccharide Biosynthesis Regulation by the beta-1,3-Glucosyltransferase Gene gl20535.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
676.
Antitumor effects and mechanisms of Ganoderma extracts and spores oil.
- Chen C, Li P, Li Y, Yao G, Xu JH.
- Oncol Lett. 2016 Aug 29;12(5):3571-3578. doi: 10.3892/ol.2016.5059.
- PMCID: PMC5104053
Chen C, et al.

Oncol Lett. 2016.

PMCID: PMC5104053

Ganoderma lucidum is a popular herbal medicine used in China to promote health. Modern studies have disclosed that the active ingredients of Ganoderma can exhibit several effects, including antitumor effects and immunomodulation. ...The half maximal inhibitor …

Ganoderma lucidum is a popular herbal medicine used in China to promote health. Modern studies have disclosed that the active …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antitumor effects and mechanisms of Ganoderma extracts and spores oil.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
677.
Effects of a Ganoderma lucidum Proteoglycan on Type 2 Diabetic Rats and the Recovery of Rat Pancreatic Islets.
- Yu F, Teng Y, Li J, Yang S, Zhang Z, He Y, Yang H, Ding CF, Zhou P.
- ACS Omega. 2023 May 5;8(19):17304-17316. doi: 10.1021/acsomega.3c02200.
- PMCID: PMC10193549
Yu F, et al.

ACS Omega. 2023.

PMCID: PMC10193549

A natural proteoglycan extracted from Ganoderma lucidum, namely, FYGL, has been demonstrated to be capable of ameliorating insulin resistance in previous work. ...

A natural proteoglycan extracted from Ganoderma lucidum, namely, FYGL, has been demonstrated to be capable of ameliorating ins …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effects of a Ganoderma lucidum Proteoglycan on Type 2 Diabetic Rats and the Recovery of Rat Pancreatic Islets.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
678.
The inhibitory effects of polysaccharide peptides (PsP) of Ganoderma lucidum against atherosclerosis in rats with dyslipidemia.
- Wihastuti TA, Heriansyah T.
- Heart Int. 2017 Apr 12;12(1):e1-e7. doi: 10.5301/heartint.5000234.
- PMCID: PMC5460693
Wihastuti TA, et al.

Heart Int. 2017.

PMCID: PMC5460693

OBJECTIVES: This study aims to report Ganoderma lucidum polysaccharide peptide (PsP) effects in atherogenic process by measuring H(2)O(2) level, IL-10 level, and EPC number in blood serum, and also intima-media thickness of aorta in dyslipidemia Wistar rat model by …

OBJECTIVES: This study aims to report Ganoderma lucidum polysaccharide peptide (PsP) effects in atherogenic process by measuri …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The inhibitory effects of polysaccharide peptides (PsP) of Ganoderma lucidum against atherosclerosis in rats with dyslipidemia.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
679.
Ganoderma lucidum driven fermentation of Rosa roxburghii pomace: Effects on noodle physicochemical properties, digestion, and gut microbiota.
- Liu M, Yan K, Yu S, Tan F, Hu W, Dai Z, Tie H, Zeng X.
- Food Chem X. 2024 Nov 17;24:102014. doi: 10.1016/j.fochx.2024.102014.
- PMCID: PMC11617704
Liu M, et al.

Food Chem X. 2024.

PMCID: PMC11617704

This study investigated the effects of Ganoderma lucidum fermented Rosa roxburghii pomace (FRRP) on noodle cooking characteristics, texture, structure, in vitro digestion, and fermentation. ...

This study investigated the effects of Ganoderma lucidum fermented Rosa roxburghii pomace (FRRP) on noodle cooking characteris …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum driven fermentation of Rosa roxburghii pomace: Effects on noodle physicochemical properties, digestion, and gut microbiota.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
680.
Experimental mixture design as a tool to optimize the growth of various Ganoderma species cultivated on media with different sugars.
- Goh YK, Marzuki NF, Tan SY, Tan SS, Tung HJ, Goh YK, Goh KJ.
- Mycology. 2016 Feb 16;7(1):36-44. doi: 10.1080/21501203.2015.1137985.
- PMCID: PMC6059077
Goh YK, et al.

Mycology. 2016.

PMCID: PMC6059077

The media were adjusted to either pH 5 or 8. Ganoderma isolates (two G. boninense from oil palm, one Ganoderma species from coconut palm, G. lingzhi, and G. australe from tower tree) grew faster at pH 8. Ganoderma lingzhi proliferated at the slowest rate comp …

The media were adjusted to either pH 5 or 8. Ganoderma isolates (two G. boninense from oil palm, one Ganoderma species from co …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Experimental mixture design as a tool to optimize the growth of various Ganoderma species cultivated on media with different sugars.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 69

681.
Identification of a laccase Glac15 from Ganoderma lucidum 77002 and its application in bioethanol production.
- Fang Z, Liu X, Chen L, Shen Y, Zhang X, Fang W, Wang X, Bao X, Xiao Y.
- Biotechnol Biofuels. 2015 Mar 31;8:54. doi: 10.1186/s13068-015-0235-x.
- PMCID: PMC4399389
Fang Z, et al.

Biotechnol Biofuels. 2015.

PMCID: PMC4399389

Therefore, it is necessary to identify new laccases with lower cost but higher activity to detoxify lignocellulosic hydrolysates and better efficiency to produce biofuels such as bioethanol. Laccases from Ganoderma lucidum represent proper candidates in processing o …

Therefore, it is necessary to identify new laccases with lower cost but higher activity to detoxify lignocellulosic hydrolysates and better …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Identification of a laccase Glac15 from Ganoderma lucidum 77002 and its application in bioethanol production.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Relevant for eco‑friendly processing, waste upcycling, and industrial biocatalysis. Open article.
682.
A Gene from Ganoderma lucidum with Similarity to nmrA of Filamentous Ascomycetes Contributes to Regulating AreA.
- Liu H, Qiao J, Shangguan J, Guo X, Xing Z, Zhou X, Zhao M, Zhu J.
- J Fungi (Basel). 2023 Apr 26;9(5):516. doi: 10.3390/jof9050516.
- PMCID: PMC10219401
Liu H, et al.

J Fungi (Basel). 2023.

PMCID: PMC10219401

Studies have shown that there are different ways to regulate AreA activity in yeast and filamentous ascomycetes, but in Basidiomycota, how AreA is regulated is unknown. Here, a gene from Ganoderma lucidum with similarity to nmrA of filamentous ascomycetes was identi …

Studies have shown that there are different ways to regulate AreA activity in yeast and filamentous ascomycetes, but in Basidiomycota, how A …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A Gene from Ganoderma lucidum with Similarity to nmrA of Filamentous Ascomycetes Contributes to Regulating AreA.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
683.
Ganoderic Acid A Prevented Osteoporosis by Modulating the PIK3CA/p-Akt/TWIST1 Signaling Pathway.
- Zhao J, Fan Y, Li H, Wang C, Fan S, Sun H, Liu M.
- Food Sci Nutr. 2025 Apr 14;13(4):e70177. doi: 10.1002/fsn3.70177.
- PMCID: PMC11997014
Zhao J, et al.

Food Sci Nutr. 2025.

PMCID: PMC11997014

Osteoporosis is a disorder of decreased bone mass, microarchitectural deterioration, and fragility fractures. Ganoderma lucidum has been reported to have a variety of pharmacological activities, including immune regulation, anti-inflammation, antioxidation, sedative …

Osteoporosis is a disorder of decreased bone mass, microarchitectural deterioration, and fragility fractures. Ganoderma lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderic Acid A Prevented Osteoporosis by Modulating the PIK3CA/p-Akt/TWIST1 Signaling Pathway.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
684.
Re-Examination of the Holotype of Ganoderma sichuanense (Ganodermataceae, Polyporales) and a Clarification of the Identity of Chinese Cultivated Lingzhi.
- Du Z, Li Y, Wang XC, Wang K, Yao YJ.
- J Fungi (Basel). 2023 Mar 5;9(3):323. doi: 10.3390/jof9030323.
- PMCID: PMC10051598
Du Z, et al.

J Fungi (Basel). 2023.

PMCID: PMC10051598

The widely cultivated Chinese Lingzhi is a famous fungus with significant medicinal and economic value, which has commonly been misidentified as Ganoderma lucidum for a long period of time. The scientific binomial of the fungus is always a hotly debated question tha …

The widely cultivated Chinese Lingzhi is a famous fungus with significant medicinal and economic value, which has commonly been misidentifie …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Re-Examination of the Holotype of Ganoderma sichuanense (Ganodermataceae, Polyporales) and a Clarification of the Identity of Chinese Cultivated Lingzhi.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
685.
Determination of nucleosides in Cordyceps sinensis and Ganoderma lucidum by high performance liquid chromatography method.
- Khan MS, Parveen R, Mishra K, Tulsawani R, Ahmad S.
- J Pharm Bioallied Sci. 2015 Oct-Dec;7(4):264-6. doi: 10.4103/0975-7406.168022.
- PMCID: PMC4678991
Khan MS, et al.

J Pharm Bioallied Sci. 2015.

PMCID: PMC4678991

BACKGROUND: Nucleosides are supportive in the regulation and modulation of various physiological processes in body, they acts as precursors in nucleic acid synthesis, enhance immune response, help in absorption of iron and influence the metabolism of fatty acids. Cordyceps sinens …

BACKGROUND: Nucleosides are supportive in the regulation and modulation of various physiological processes in body, they acts as precursors …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Determination of nucleosides in Cordyceps sinensis and Ganoderma lucidum by high performance liquid chromatography method.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
686.
Culture broth of Ganoderma lucidum exhibited antioxidant, antibacterial and alpha-amylase inhibitory activities.
- Sarnthima R, Khammaung S, Sa-Ard P.
- J Food Sci Technol. 2017 Sep 7;54(11):3724-3730. doi: 10.1007/s13197-017-2839-6.
- PMCID: PMC5629183
Sarnthima R, et al.

J Food Sci Technol. 2017.

PMCID: PMC5629183

Culture broth of Ganoderma lucidum was determined for antioxidant, antibacterial and alpha-amylase inhibitory activities. ...This study suggested that apart from the fruiting bodies and the mycelial of G. lucidum, its culture broth also had potential applicat …

Culture broth of Ganoderma lucidum was determined for antioxidant, antibacterial and alpha-amylase inhibitory activities. ...T …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Culture broth of Ganoderma lucidum exhibited antioxidant, antibacterial and alpha-amylase inhibitory activities.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
687.
Profiling of phytochemical and antioxidant activity of wild mushrooms: Evidence from the in vitro study and phytoconstituent's binding affinity to the human erythrocyte catalase and human glutathione reductase.
- Hossen SMM, Hossain MS, Yusuf ATM, Chaudhary P, Emon NU, Janmeda P.
- Food Sci Nutr. 2021 Nov 2;10(1):88-102. doi: 10.1002/fsn3.2650.
- PMCID: PMC8751451
Hossen SMM, et al.

Food Sci Nutr. 2021.

PMCID: PMC8751451

Again, the absorption, distribution, metabolism, elimination and toxicity (ADME/T) analysis has been determined by using online tools. Both Ganoderma lucidum (Curtis) Karst. and Ganoderma applanatum (Pers.) Pat. showed a significant (p < .001) increase in
…

Again, the absorption, distribution, metabolism, elimination and toxicity (ADME/T) analysis has been determined by using online tools. Both …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Profiling of phytochemical and antioxidant activity of wild mushrooms: Evidence from the in vitro study and phytoconstituent's binding affinity to the human erythrocyte catalase and human glutathione reductase.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
688.
Understanding the characteristic changes of retrogradation behavior and edible quality of brown rice modified with inhibiting retrogradation enzymes of Ganoderma lucidum.
- Cui M, Qiu K, Ma Y, Wang J, Zhao W, Zhang X.
- Curr Res Food Sci. 2024 Nov 15;9:100927. doi: 10.1016/j.crfs.2024.100927.
- PMCID: PMC11617885
Cui M, et al.

Curr Res Food Sci. 2024.

PMCID: PMC11617885

Enzymatic modification is considered as an effective manner to retard starch retrogradation by degrading starch to an appropriate extent. Ganoderma lucidum can secrete various hydrolytic enzymes related to starch hydrolysis, providing a theoretical basis and feasibi …

Enzymatic modification is considered as an effective manner to retard starch retrogradation by degrading starch to an appropriate extent. …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Understanding the characteristic changes of retrogradation behavior and edible quality of brown rice modified with inhibiting retrogradation enzymes of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Useful for quality control, sourcing, and preventing adulteration. Open article.
689.
Sporoderm-Broken Spores of Ganoderma lucidum Sensitizes Ovarian Cancer to Cisplatin by ROS/ERK Signaling and Attenuates Chemotherapy-Related Toxicity.
- Cen K, Chen M, He M, Li Z, Song Y, Liu P, Jiang Q, Xu S, Jia Y, Shen P.
- Front Pharmacol. 2022 Feb 21;13:826716. doi: 10.3389/fphar.2022.826716.
- PMCID: PMC8900012
Cen K, et al.

Front Pharmacol. 2022.

PMCID: PMC8900012

Although platinum-based chemotherapeutics such as cisplatin are the cornerstone of treatment for ovarian cancer, their clinical application is profoundly limited due to chemoresistance and severe adverse effects. Sporoderm-broken spores of Ganoderma lucidum (SBSGL) …

Although platinum-based chemotherapeutics such as cisplatin are the cornerstone of treatment for ovarian cancer, their clinical application …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Sporoderm-Broken Spores of Ganoderma lucidum Sensitizes Ovarian Cancer to Cisplatin by ROS/ERK Signaling and Attenuates Chemotherapy-Related Toxicity.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
690.
Manipulations of glucose/lipid metabolism and gut microbiota of resistant starch encapsulated Ganoderma lucidum spores in T2DM rats.
- Jiang Y, Zhang N, Zhou Y, Zhou Z, Bai Y, Strappe P, Blanchard C.
- Food Sci Biotechnol. 2021 Apr 24;30(5):755-764. doi: 10.1007/s10068-021-00908-w.
- PMCID: PMC8144259
Jiang Y, et al.

Food Sci Biotechnol. 2021.

PMCID: PMC8144259

Our team previously demonstrated that Ganoderma lucidum spores (GLS) and resistant starch (RS) had hypoglycemic effects separately on type 2 diabetic mellitus (T2DM) rats. ...

Our team previously demonstrated that Ganoderma lucidum spores (GLS) and resistant starch (RS) had hypoglycemic effects separa …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Manipulations of glucose/lipid metabolism and gut microbiota of resistant starch encapsulated Ganoderma lucidum spores in T2DM rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 70

691.
Interaction and Inhibition of a Ganoderma lucidum Proteoglycan on PTP1B Activity for Anti-diabetes.
- Yu F, Wang Y, Teng Y, Yang S, He Y, Zhang Z, Yang H, Ding CF, Zhou P.
- ACS Omega. 2021 Oct 27;6(44):29804-29813. doi: 10.1021/acsomega.1c04244.
- PMCID: PMC8582033
Yu F, et al.

ACS Omega. 2021.

PMCID: PMC8582033

A natural hyperbranched proteoglycan extracted from Ganoderma lucidum, namely, Fudan-Yueyang G. Lucidum (FYGL), was demonstrated capable of inhibiting the activity of PTP1B. ...

A natural hyperbranched proteoglycan extracted from Ganoderma lucidum, namely, Fudan-Yueyang G. Lucidum (FYGL), was dem …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Interaction and Inhibition of a Ganoderma lucidum Proteoglycan on PTP1B Activity for Anti-diabetes.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
692.
Novel Medicinal Mushroom Blend as a Promising Supplement in Integrative Oncology: A Multi-Tiered Study using 4T1 Triple-Negative Mouse Breast Cancer Model.
- Roda E, Luca F, Iorio CD, Ratto D, Siciliani S, Ferrari B, Cobelli F, Borsci G, Priori EC, Chinosi S, Ronchi A, Franco R, Di Francia R, Berretta M, Locatelli CA, Gregori A, Savino E, Bottone MG, Rossi P.
- Int J Mol Sci. 2020 May 14;21(10):3479. doi: 10.3390/ijms21103479.
- PMCID: PMC7279026
Roda E, et al.

Int J Mol Sci. 2020.

PMCID: PMC7279026

Mice were orally administered with Micotherapy U-care, consisting of a mixture of Agaricus blazei, Ophiocordyceps sinensis, Ganoderma lucidum, Grifola frondosa, and Lentinula edodes. The syngeneic tumor-bearing mice were generated by injecting 4T1 cells in both supp …

Mice were orally administered with Micotherapy U-care, consisting of a mixture of Agaricus blazei, Ophiocordyceps sinensis, Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Novel Medicinal Mushroom Blend as a Promising Supplement in Integrative Oncology: A Multi-Tiered Study using 4T1 Triple-Negative Mouse Breast Cancer Model.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
693.
A methyltransferase LaeA regulates ganoderic acid biosynthesis in Ganoderma lingzhi.
- Luo Q, Li N, Xu JW.
- Front Microbiol. 2022 Oct 14;13:1025983. doi: 10.3389/fmicb.2022.1025983.
- PMCID: PMC9614229
Luo Q, et al.

Front Microbiol. 2022.

PMCID: PMC9614229

In this study, the laeA gene was identified in the basidiomycete Ganoderma lingzhi and its function in regulating the biosynthesis of anti-tumor ganoderic acids was evaluated. ...These results demonstrate an essential role of LaeA in the regulation of ganoderic acid biosyn …

In this study, the laeA gene was identified in the basidiomycete Ganoderma lingzhi and its function in regulating the biosynthesis of …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A methyltransferase LaeA regulates ganoderic acid biosynthesis in Ganoderma lingzhi.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
694.
Study on the Structure and Bioactivity of Ganoderma lucidum Polysaccharides under Cassava Stalk Stress.
- Liu Y, Mai B, Li Z, Feng X, Chen Y, Lin L, Xia Q.
- J Fungi (Basel). 2023 Apr 26;9(5):514. doi: 10.3390/jof9050514.
- PMCID: PMC10219112
Liu Y, et al.

J Fungi (Basel). 2023.

PMCID: PMC10219112

Various carbon sources affect the growth of the G. lucidum fruiting body, and the cassava stalk is considered a promising carbon source for G. lucidum. ...This study provided essential data support for cassava stalk as a carbon source in G. lucidum cultivatio …

Various carbon sources affect the growth of the G. lucidum fruiting body, and the cassava stalk is considered a promising carbon sour …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Study on the Structure and Bioactivity of Ganoderma lucidum Polysaccharides under Cassava Stalk Stress.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
695.
Physicochemical characteristics of Ganoderma lucidum oligosaccharide and its regulatory effect on intestinal flora in vitro fermentation.
- Xia Q, Zhao Q, Zhu H, Cao Y, Yang K, Sun P, Cai M.
- Food Chem X. 2022 Aug 9;15:100421. doi: 10.1016/j.fochx.2022.100421.
- PMCID: PMC9532794
Xia Q, et al.

Food Chem X. 2022.

PMCID: PMC9532794

This study explored the structure characteristics of an oligosaccharide from Ganoderma lucidum (GLO) and its regulatory functions on intestinal flora fermentation in vitro. ...

This study explored the structure characteristics of an oligosaccharide from Ganoderma lucidum (GLO) and its regulatory functi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Physicochemical characteristics of Ganoderma lucidum oligosaccharide and its regulatory effect on intestinal flora in vitro fermentation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
696.
Bioconversion of ginsenosides in the american ginseng ( xi yang shen) extraction residue by fermentation with lingzhi ( ling zhi, ganoderma lucidum).
- Yang Hsu B, Hui Chen C, Jang Lu T, Sun Hwang L.
- J Tradit Complement Med. 2013 Apr;3(2):95-101. doi: 10.4103/2225-4110.110416.
- PMCID: PMC3924966
Yang Hsu B, et al.

J Tradit Complement Med. 2013.

PMCID: PMC3924966

The objective of this research was to convert ginsenosides in American ginseng ( Xi Yang Shen) extraction residue (AmR) by fermentation with lingzhi ( Ling Zhi, Ganoderma lucidum) and the fermentation products will be used for further hypoglycemic activity research. …

The objective of this research was to convert ginsenosides in American ginseng ( Xi Yang Shen) extraction residue (AmR) by fermentation with …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Bioconversion of ginsenosides in the american ginseng ( xi yang shen) extraction residue by fermentation with lingzhi ( ling zhi, ganoderma lucidum ).. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
697.
Anti-Amnesic Effect of Fermented Ganoderma lucidum Water Extracts by Lactic Acid Bacteria on Scopolamine-Induced Memory Impairment in Rats.
- Choi YJ, Yang HS, Jo JH, Lee SC, Park TY, Choi BS, Seo KS, Huh CK.
- Prev Nutr Food Sci. 2015 Jun 30;20(2):126-32. doi: 10.3746/pnf.2015.20.2.126.
- PMCID: PMC4500515
Choi YJ, et al.

Prev Nutr Food Sci. 2015.

PMCID: PMC4500515

This study investigated the anti-amnesic effect of fermented Ganoderma lucidum water extracts (GW) on scopolamine-induced memory impairment in rats. ...

This study investigated the anti-amnesic effect of fermented Ganoderma lucidum water extracts (GW) on scopolamine-induced memo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Anti-Amnesic Effect of Fermented Ganoderma lucidum Water Extracts by Lactic Acid Bacteria on Scopolamine-Induced Memory Impairment in Rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
698.
Humoral responses of broiler chickens challenged with NDV following supplemental treatment with extracts of Aloe vera, Alma millsoni, Ganoderma lucidum and Archachatina marginata.
- Ojiezeh TI, Eghafona N.
- Cent Eur J Immunol. 2015 Oct 15;40(3):300-6. doi: 10.5114/ceji.2015.54590.
- PMCID: PMC4655379
Ojiezeh TI, et al.

Cent Eur J Immunol. 2015.

PMCID: PMC4655379

Group A was supplemented with Aloe vera (AV) extract, group B was given Alma millsoni (AM) extract, group C was given Archachatina marginata (AMS) extract and group D was given Ganoderma lucidum (GL) extract, and group E was the control group. Extract concentrations …

Group A was supplemented with Aloe vera (AV) extract, group B was given Alma millsoni (AM) extract, group C was given Archachatina marginata …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Humoral responses of broiler chickens challenged with NDV following supplemental treatment with extracts of Aloe vera, Alma millsoni, Ganoderma lucidum and Archachatina marginata.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
699.
Glycosylation of Ganoderic Acid G by Bacillus Glycosyltransferases.
- Wu JY, Ding HY, Wang TY, Zhang YR, Chang TS.
- Int J Mol Sci. 2021 Sep 9;22(18):9744. doi: 10.3390/ijms22189744.
- PMCID: PMC8468440
Wu JY, et al.

Int J Mol Sci. 2021.

PMCID: PMC8468440

Ganoderma lucidum is a medicinal fungus abundant in triterpenoids, its primary bioactive components. Although numerous Ganoderma triterpenoids have already been identified, rare Ganoderma triterpenoid saponins were recently discovered. ...

Ganoderma lucidum is a medicinal fungus abundant in triterpenoids, its primary bioactive components. Although numerous Gano …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Glycosylation of Ganoderic Acid G by Bacillus Glycosyltransferases.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
700.
Ganoderma lucidum polysaccharide enhances radiosensitivity of hepatocellular carcinoma cell line HepG2 through Akt signaling pathway.
- Yu Y, Qian L, Du N, Liu Y, Zhao X, Zhang X.
- Exp Ther Med. 2017 Oct 18;14(6):5903-5907. doi: 10.3892/etm.2017.5340.
- PMCID: PMC5740818
Yu Y, et al.

Exp Ther Med. 2017.

PMCID: PMC5740818

Ganoderma lucidum polysaccharide (GLP) is a well-known traditional Chinese medicine, known for its anti-cancer and immunomodulatory properties. ...

Ganoderma lucidum polysaccharide (GLP) is a well-known traditional Chinese medicine, known for its anti-cancer and immunomodul …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum polysaccharide enhances radiosensitivity of hepatocellular carcinoma cell line HepG2 through Akt signaling pathway.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.

Page 71

701.
Aqueous-soluble components of sporoderm-removed Ganoderma lucidum spore powder promote ferroptosis in oral squamous cell carcinoma.
- Wu X, Wu Q, Wang Y, Liu Y, Li Z, Liu Q, Huang Z, Li M, Zhang B, Zhan Q.
- Chin J Cancer Res. 2023 Apr 30;35(2):176-190. doi: 10.21147/j.issn.1000-9604.2023.02.07.
- PMCID: PMC10167607
Wu X, et al.

Chin J Cancer Res. 2023.

PMCID: PMC10167607

Here we explored the tumor inhibition effects of Ganoderma lucidum (G. lucidum) on oral squamous cell carcinoma (OSCC). Specifically, we aimed to clarify the biological mechanism of components in the dietary, aqueous-soluble sporoderm-removed G. lucidum …

Here we explored the tumor inhibition effects of Ganoderma lucidum (G. lucidum) on oral squamous cell carcinoma (OSCC). …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Aqueous-soluble components of sporoderm-removed Ganoderma lucidum spore powder promote ferroptosis in oral squamous cell carcinoma.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
702.
Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids.
- Tong A, Wu W, Chen Z, Wen J, Jia R, Liu B, Cao H, Zhao C.
- Curr Res Food Sci. 2022 Dec 27;6:100427. doi: 10.1016/j.crfs.2022.100427.
- PMCID: PMC9826932
Tong A, et al.

Curr Res Food Sci. 2022.

PMCID: PMC9826932

Ganoderma lucidum triterpenoids (GP) have been reported to help prevent and improve hyperlipidemia. ...

Ganoderma lucidum triterpenoids (GP) have been reported to help prevent and improve hyperlipidemia. ...
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
703.
Lanostane Triterpenoids and Ergostane Steroids from Ganoderma luteomarginatum and Their Cytotoxicity.
- Ma Q, Zhang S, Yang L, Xie Q, Dai H, Yu Z, Zhao Y.
- Molecules. 2022 Oct 18;27(20):6989. doi: 10.3390/molecules27206989.
- PMCID: PMC9611895
Ma Q, et al.

Molecules. 2022.

PMCID: PMC9611895

Macrofungus Ganoderma luteomarginatum is one of the main species of Ganoderma fungi distributed in Hainan province of China, the fruiting bodies of which have been widely used in folk as a healthy food to prevent tumors. ...

Macrofungus Ganoderma luteomarginatum is one of the main species of Ganoderma fungi distributed in Hainan province of China, t …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Lanostane Triterpenoids and Ergostane Steroids from Ganoderma luteomarginatum and Their Cytotoxicity.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
704.
Evaluation of in vitro pharmacological activities of medicinal mushrooms in the context of dry eye disease.
- Areesanan A, Wasilewicz A, Nicolay S, Grienke U, Zimmermann-Klemd AM, Rollinger JM, Gründemann C.
- Front Pharmacol. 2025 Mar 5;16:1557359. doi: 10.3389/fphar.2025.1557359.
- PMCID: PMC11920184
Areesanan A, et al.

Front Pharmacol. 2025.

PMCID: PMC11920184

In this study, the in vitro anti-inflammatory potential and mycochemical composition of six polypore extracts derived from the fruit bodies of Fomes fomentarius (L.) Fr. (FF), Ganoderma lucidum (Fr.) P. Karst. (GL), Ganoderma tsugae Murrill (GT), Gloeophyllum …

In this study, the in vitro anti-inflammatory potential and mycochemical composition of six polypore extracts derived from the fruit bodies …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Evaluation of in vitro pharmacological activities of medicinal mushrooms in the context of dry eye disease.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
705.
Improved production of polysaccharides in Ganoderma lingzhi mycelia by plasma mutagenesis and rapid screening of mutated strains through infrared spectroscopy.
- Ma Y, Zhang Q, Zhang Q, He H, Chen Z, Zhao Y, Wei D, Kong M, Huang Q.
- PLoS One. 2018 Sep 21;13(9):e0204266. doi: 10.1371/journal.pone.0204266.
- PMCID: PMC6150529
Ma Y, et al.

PLoS One. 2018.

PMCID: PMC6150529

As a traditional Chinese medicine, Ganoderma lingzhi has attracted increasing attention for both scientific research and medical application. In this work, in order to improve the production of polysaccharides from an original wide-type (WT) strain (named "RWY-0") of Ga …

As a traditional Chinese medicine, Ganoderma lingzhi has attracted increasing attention for both scientific research and medical appl …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Improved production of polysaccharides in Ganoderma lingzhi mycelia by plasma mutagenesis and rapid screening of mutated strains through infrared spectroscopy.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
706.
Systematic network pharmacology and experimental validation reveal anti-glioma mechanisms of ganoderma lucidum via multi-target regulation.
- Mei X, Zhang J, Chen L, Wang F.
- Discov Oncol. 2025 Aug 4;16(1):1467. doi: 10.1007/s12672-025-03280-x.
- PMCID: PMC12321698
Mei X, et al.

Discov Oncol. 2025.

PMCID: PMC12321698

Traditional Chinese medicine (TCM) offers a promising avenue for discovering multi-target agents against complex diseases. Ganoderma lucidum (Lingzhi), a well-known medicinal fungus, has shown anti-tumor effects in several malignancies, but its molecular mechanisms …

Traditional Chinese medicine (TCM) offers a promising avenue for discovering multi-target agents against complex diseases. Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Systematic network pharmacology and experimental validation reveal anti-glioma mechanisms of ganoderma lucidum via multi-target regulation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
707.
Inflammatory modulation effect of glycopeptide from Ganoderma capense (Lloyd) Teng.
- Zhou Y, Chen S, Ding R, Yao W, Gao X.
- Mediators Inflamm. 2014 May 22;2014:691285. doi: 10.1155/2014/691285.
- PMCID: PMC4055584
Zhou Y, et al.

Mediators Inflamm. 2014.

PMCID: PMC4055584

Glycopeptide from Ganoderma capense (Lloyd) Teng (GCGP) injection is widely used in kinds of immune disorders, but little is known about the molecular mechanisms of how GCGP could interfere with immune cell function. ...

Glycopeptide from Ganoderma capense (Lloyd) Teng (GCGP) injection is widely used in kinds of immune disorders, but little is known ab …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Inflammatory modulation effect of glycopeptide from Ganoderma capense (Lloyd) Teng.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
708.
Exceedingly biocompatible and thin-layered reduced graphene oxide nanosheets using an eco-friendly mushroom extract strategy.
- Muthoosamy K, Bai RG, Abubakar IB, Sudheer SM, Lim HN, Loh HS, Huang NM, Chia CH, Manickam S.
- Int J Nanomedicine. 2015 Feb 20;10:1505-19. doi: 10.2147/IJN.S75213.
- PMCID: PMC4345939
Muthoosamy K, et al.

Int J Nanomedicine. 2015.

PMCID: PMC4345939

PURPOSE: A simple, one-pot strategy was used to synthesize reduced graphene oxide (RGO) nanosheets by utilizing an easily available over-the-counter medicinal and edible mushroom, Ganoderma lucidum. METHODS: The mushroom was boiled in hot water to liberate the polys …

PURPOSE: A simple, one-pot strategy was used to synthesize reduced graphene oxide (RGO) nanosheets by utilizing an easily available over-the …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Exceedingly biocompatible and thin-layered reduced graphene oxide nanosheets using an eco-friendly mushroom extract strategy.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
709.
Use of sawdust for production of ligninolytic enzymes by white-rot fungi and pharmaceutical removal.
- Hultberg M, Golovko O.
- Bioprocess Biosyst Eng. 2024 Mar 14;47(4):475-482. doi: 10.1007/s00449-024-02976-8.
- PMCID: PMC11003897
Hultberg M, et al.

Bioprocess Biosyst Eng. 2024.

PMCID: PMC11003897

We used pure sawdust colonized by Pleurotus ostreatus, Trametes versicolor, and Ganoderma lucidum for extraction of ligninolytic enzymes in aqueous suspension. Crude enzyme suspensions of the three fungi, with laccase activity range 12-43 U/L and manganese peroxidas …

We used pure sawdust colonized by Pleurotus ostreatus, Trametes versicolor, and Ganoderma lucidum for extraction of ligninolyt …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Use of sawdust for production of ligninolytic enzymes by white-rot fungi and pharmaceutical removal.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
710.
An update on plant derived anti-androgens.
- Grant P, Ramasamy S.
- Int J Endocrinol Metab. 2012 Apr 20;10(2):497-502. doi: 10.5812/ijem.3644.
- PMCID: PMC3693613
Grant P, et al.

Int J Endocrinol Metab. 2012.

PMCID: PMC3693613

We provide an overview and discussion of the use of anti-androgen medications in clinical practice and explore the increasing recognition of the benefits of plant-derived anti-androgens, for example, spearmint tea in the management of PCOS, for which some evidence about efficacy …

We provide an overview and discussion of the use of anti-androgen medications in clinical practice and explore the increasing recognition of …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: An update on plant derived anti-androgens.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 72

711.
Ganoderma lucidum extract attenuates corticotropin-releasing hormone-induced cellular senescence in human hair follicle cells.
- Lee S, Kim SY, Lee S, Jang S, Hwang ST, Kwon Y, Choi J, Kwon O.
- iScience. 2024 Apr 6;27(5):109675. doi: 10.1016/j.isci.2024.109675.
- PMCID: PMC11068553
Lee S, et al.

iScience. 2024.

PMCID: PMC11068553

Here, we investigated the impact of stress-induced senescence and evaluated the potential of Ganoderma lucidum (GL) extract in mitigating CRH-induced senescence in human hair follicle cells (hHFCs). ...

Here, we investigated the impact of stress-induced senescence and evaluated the potential of Ganoderma lucidum (GL) extract in …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum extract attenuates corticotropin-releasing hormone-induced cellular senescence in human hair follicle cells.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
712.
Modulation of energy metabolism and mitochondrial biogenesis by a novel proteoglycan from Ganoderma lucidum.
- Yang Z, Zhang Z, Zhao J, He Y, Yang H, Zhou P.
- RSC Adv. 2019 Jan 18;9(5):2591-2598. doi: 10.1039/c8ra09482a.
- PMCID: PMC9059857
Yang Z, et al.

RSC Adv. 2019.

PMCID: PMC9059857

In this study we first focused on the effects of a novel proteoglycan extracted from Ganoderma lucidum (FYGL) on mitochondrial biogenesis, because mitochondrial dysfunction is highly related to insulin resistance. ...

In this study we first focused on the effects of a novel proteoglycan extracted from Ganoderma lucidum (FYGL) on mitochondrial …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Modulation of energy metabolism and mitochondrial biogenesis by a novel proteoglycan from Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
713.
Research Progress on the Anticancer Activities and Mechanisms of Polysaccharides From Ganoderma.
- Wang M, Yu F.
- Front Pharmacol. 2022 Jul 5;13:891171. doi: 10.3389/fphar.2022.891171.
- PMCID: PMC9294232
Wang M, et al.

Front Pharmacol. 2022.

PMCID: PMC9294232

Accumulating evidence has verified the prominent anticancer properties of Ganoderma polysaccharides, suggesting that Ganoderma polysaccharides may be effective chemopreventive agents of natural origin. ...A more sophisticated understanding of the anticancer benefits …

Accumulating evidence has verified the prominent anticancer properties of Ganoderma polysaccharides, suggesting that Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Research Progress on the Anticancer Activities and Mechanisms of Polysaccharides From Ganoderma .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
714.
Effects of molecular weight on intestinal anti-inflammatory activities of beta-D-glucan from Ganoderma lucidum.
- Liu Y, Tang Q, Feng J, Liu J, Tang C, Yan M, Zhou S, Liu L, Zhou J, Zhang J.
- Front Nutr. 2022 Sep 29;9:1028727. doi: 10.3389/fnut.2022.1028727.
- PMCID: PMC9557179
Liu Y, et al.

Front Nutr. 2022.

PMCID: PMC9557179

To investigate the influence of molecular weight (M (w)) on the anti-inflammatory activity of beta-D-glucan from Ganoderma lucidum, ultrasonic irradiation was applied to treat the beta-D-glucan (GLP, 2.42 10(6) g/mol) solution to obtain two degraded fractions with m …

To investigate the influence of molecular weight (M (w)) on the anti-inflammatory activity of beta-D-glucan from Ganoderma lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effects of molecular weight on intestinal anti-inflammatory activities of beta-D-glucan from Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
715.
Enhanced active extracellular polysaccharide production from Ganoderma formosanum using computational modeling.
- Hsu KD, Wu SP, Lin SP, Lum CC, Cheng KC.
- J Food Drug Anal. 2017 Feb 16;25(4):804-811. doi: 10.1016/j.jfda.2016.12.006.
- PMCID: PMC9328880
Hsu KD, et al.

J Food Drug Anal. 2017.

PMCID: PMC9328880

Extracellular polysaccharide (EPS) is one of the major bioactive ingredients contributing to the health benefits of Ganoderma spp. In this study, response surface methodology was applied to determine the optimal culture conditions for EPS production of Ganoderma for …

Extracellular polysaccharide (EPS) is one of the major bioactive ingredients contributing to the health benefits of Ganoderma spp. In …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Enhanced active extracellular polysaccharide production from Ganoderma formosanum using computational modeling.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
716.
Study of Optimal Conditions to Grow Thai Ganoderma, Fruiting Test, Proximate and Their Alpha Glucosidase Inhibitory Activity.
- Wannasawang N, Luangharn T, Thawthong A, Charoensup R, Jaidee W, Tongdeesoontorn W, Hyde KD, Thongklang N.
- Life (Basel). 2023 Sep 9;13(9):1887. doi: 10.3390/life13091887.
- PMCID: PMC10532565
Wannasawang N, et al.

Life (Basel). 2023.

PMCID: PMC10532565

Ganoderma (Ganodermataceae) has a worldwide distribution and has been widely used in traditional medicines. ...All types of cereal grains can be used to promote the growth of the mycelia of Ganoderma species. Fruiting tests were performed. All strains of Ganoderm …

Ganoderma (Ganodermataceae) has a worldwide distribution and has been widely used in traditional medicines. ...All types of cereal gr …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Study of Optimal Conditions to Grow Thai Ganoderma , Fruiting Test, Proximate and Their Alpha Glucosidase Inhibitory Activity.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
717.
An Immunomodulatory Protein (Ling Zhi-8) from a Ganoderma lucidum Induced Acceleration of Wound Healing in Rat Liver Tissues after Monopolar Electrosurgery.
- Lin HJ, Chang YS, Lin LH, Haung CF, Wu CY, Ou KL.
- Evid Based Complement Alternat Med. 2014 May 5;2014:916531. doi: 10.1155/2014/916531.
- PMCID: PMC4026841
Lin HJ, et al.

Evid Based Complement Alternat Med. 2014.

PMCID: PMC4026841
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: An Immunomodulatory Protein (Ling Zhi-8) from a Ganoderma lucidum Induced Acceleration of Wound Healing in Rat Liver Tissues after Monopolar Electrosurgery.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
718.
Bioprospecting of Selected Species of Polypore Fungi from the Western Balkans.
- Kozarski M, Klaus A, Špirović-Trifunović B, Miletić S, Lazić V, Žižak Ž, Vunduk J.
- Molecules. 2024 Jan 8;29(2):314. doi: 10.3390/molecules29020314.
- PMCID: PMC10819588
Kozarski M, et al.

Molecules. 2024.

PMCID: PMC10819588

Fomitopsis pinicola had the strongest anti-tumor efficacy while Ganoderma lucidum demonstrated strong selectivity in anti-tumor effect in comparison to normal cells. ...

Fomitopsis pinicola had the strongest anti-tumor efficacy while Ganoderma lucidum demonstrated strong selectivity in anti-tumo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Bioprospecting of Selected Species of Polypore Fungi from the Western Balkans.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
719.
Effects of replacing fat by betaglucans from Ganoderma lucidum on batter and cake properties.
- Lindarte Artunduaga J, Gutiérrez LF.
- J Food Sci Technol. 2018 Dec 4;56(1):451-461. doi: 10.1007/s13197-018-3507-1.
- PMCID: PMC6342768
Lindarte Artunduaga J, et al.

J Food Sci Technol. 2018.

PMCID: PMC6342768

The aim of this study was to investigate the effects of replacing vegetable fat at different concentrations (20, 30, 40 and 50%) by betaglucans from Ganoderma lucidum (betaGGL), on the physical properties of cake batters, and on the quality of the resultant cakes. . …

The aim of this study was to investigate the effects of replacing vegetable fat at different concentrations (20, 30, 40 and 50%) by betagluc …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effects of replacing fat by betaglucans from Ganoderma lucidum on batter and cake properties.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
720.
Antrodia cinnamomea Formula Suppresses Prostate Cancer Progression via Immune Modulation and PD-1/PD-L1 Pathway Inhibition.
- Tsai MY, Lu CK, Shu LH, Liu HT, Wu YH, Lin YS, Yang YH, Shih WT, Lee IY, Wu YH, Wu CY.
- Int J Mol Sci. 2025 Mar 17;26(6):2684. doi: 10.3390/ijms26062684.
- PMCID: PMC11942070
Tsai MY, et al.

Int J Mol Sci. 2025.

PMCID: PMC11942070

This study investigated the therapeutic potential of the Antrodia cinnamomea formula (XIANZHIFANG formula, XZF), comprising Antrodia cinnamomea, Sanghuangporus sanghuang, Ganoderma lucidum, Ganoderma sinense, and Inonotus obliquus, in prostate cancer treatmen …

This study investigated the therapeutic potential of the Antrodia cinnamomea formula (XIANZHIFANG formula, XZF), comprising Antrodia cinnamo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antrodia cinnamomea Formula Suppresses Prostate Cancer Progression via Immune Modulation and PD-1/PD-L1 Pathway Inhibition.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 73

721.
Convenient synthesis of uncovered imprinted microspheres by Ganoderma lucidum spore-stabilized pickering emulsion polymerization and their enhanced recognition of spiramycin.
- Zhu Y, Teng H, Sun D, Jiang D, Yan Y.
- RSC Adv. 2019 Oct 29;9(60):34772-34783. doi: 10.1039/c9ra07745f.
- PMCID: PMC9074138
Zhu Y, et al.

RSC Adv. 2019.

PMCID: PMC9074138

And surprisingly the solid particles were absent on the surface of imprinted microspheres, which can be ascribed to the Ganoderma lucidum spores (GLS): they were firstly selected to be the stabilizers for the Pickering emulsion in this new strategy. ...

And surprisingly the solid particles were absent on the surface of imprinted microspheres, which can be ascribed to the Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Convenient synthesis of uncovered imprinted microspheres by Ganoderma lucidum spore-stabilized pickering emulsion polymerization and their enhanced recognition of spiramycin.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
722.
The innovation research on the extraction technology of ganoderma lucidum.
- Liang C.
- Front Pharmacol. 2012 Jun 18;3:79. doi: 10.3389/fphar.2012.00079.
- PMCID: PMC3376421
Liang C.

Front Pharmacol. 2012.

PMCID: PMC3376421
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The innovation research on the extraction technology of ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
723.
Molecular Pharmacological Interventions for Endometrial Cancer: A Comprehensive Review.
- Qin W, Qi Y, Li Q, Wang B, Wang J, Ge X, Li Y, Zhang X, Liu K.
- Drug Des Devel Ther. 2025 Aug 27;19:7381-7392. doi: 10.2147/DDDT.S524181.
- PMCID: PMC12399865
Qin W, et al.

Drug Des Devel Ther. 2025.

PMCID: PMC12399865

Additionally, we highlight the potential of natural compounds like curcumin, paclitaxel, and Ganoderma lucidum polysaccharides as adjunctive therapies, demonstrating efficacy in preclinical studies and early-phase clinical trials. ...

Additionally, we highlight the potential of natural compounds like curcumin, paclitaxel, and Ganoderma lucidum polysaccharides …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Molecular Pharmacological Interventions for Endometrial Cancer: A Comprehensive Review.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Participant-reported outcomes, clinical biomarkers, and safety/tolerability. Open article.
- Why might this paper be useful to readers? Provides early human data; interpret with caution and check study size and endpoints. Open article.
724.
Lucialdehyde B suppresses proliferation and induces mitochondria-dependent apoptosis in nasopharyngeal carcinoma CNE2 cells.
- Liu L, Yu Z, Chen J, Liu B, Wu C, Li Y, Xu J, Li P.
- Pharm Biol. 2023 Dec;61(1):918-926. doi: 10.1080/13880209.2023.2220754.
- PMCID: PMC10281419
Liu L, et al.

Pharm Biol. 2023.

PMCID: PMC10281419

CONTEXT: Lucialdehyde B (LB), an effective triterpenoid isolated from Ganoderma lucidum (Leyss. ex Fr.) Karst. (Polyproraceae), exerts cytotoxic activity against nasopharyngeal carcinoma CNE2 cells. ...

CONTEXT: Lucialdehyde B (LB), an effective triterpenoid isolated from Ganoderma lucidum (Leyss. ex Fr.) Karst. (Polyproraceae) …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Lucialdehyde B suppresses proliferation and induces mitochondria-dependent apoptosis in nasopharyngeal carcinoma CNE2 cells.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
725.
Linzhi (Ganoderma lucidum); evidence of its clinical usefulness in renal diseases.
- Joob B, Wiwanitkit V.
- J Nephropharmacol. 2015 Dec 27;5(1):9-10.
- PMCID: PMC5297513
Joob B, et al.

J Nephropharmacol. 2015.

PMCID: PMC5297513
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Linzhi ( Ganoderma lucidum ); evidence of its clinical usefulness in renal diseases.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
726.
Green synthesis of nanoparticles with extracellular and intracellular extracts of basidiomycetes.
- Vetchinkina E, Loshchinina E, Kupryashina M, Burov A, Pylaev T, Nikitina V.
- PeerJ. 2018 Jul 20;6:e5237. doi: 10.7717/peerj.5237.
- PMCID: PMC6055591
Vetchinkina E, et al.

PeerJ. 2018.

PMCID: PMC6055591

Au, Ag, Se, and Si nanoparticles were synthesized from aqueous solutions of HAuCl(4), AgNO(3), Na(2)SeO(3), and Na(2)SiO(3) with extra- and intracellular extracts from the xylotrophic basidiomycetes Pleurotus ostreatus, Lentinus edodes, Ganoderma lucidum, and Grifol …

Au, Ag, Se, and Si nanoparticles were synthesized from aqueous solutions of HAuCl(4), AgNO(3), Na(2)SeO(3), and Na(2)SiO(3) with extra- and …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Green synthesis of nanoparticles with extracellular and intracellular extracts of basidiomycetes.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
727.
Pellet diameter of Ganoderma lucidum in a repeated-batch fermentation for the trio total production of biomass-exopolysaccharide-endopolysaccharide and its anti-oral cancer beta-glucan response.
- Abdullah NR, Sharif F, Azizan NH, Hafidz IFM, Supramani S, Usuldin SRA, Ahmad R, Wan-Mohtar WAAQI.
- AIMS Microbiol. 2020 Oct 22;6(4):379-400. doi: 10.3934/microbiol.2020023.
- PMCID: PMC7755588
Abdullah NR, et al.

AIMS Microbiol. 2020.

PMCID: PMC7755588

The pellet morphology and diameter range (DR) of Ganoderma lucidum were observed in a repeated-batch fermentation (RBF) for the trio total production of biomass, exopolysaccharide (EPS) and endopolysaccharide (ENS). ...Meanwhile, 4 mg/L of BG gave negative cytotoxic …

The pellet morphology and diameter range (DR) of Ganoderma lucidum were observed in a repeated-batch fermentation (RBF) for th …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Pellet diameter of Ganoderma lucidum in a repeated-batch fermentation for the trio total production of biomass-exopolysaccharide-endopolysaccharide and its anti-oral cancer beta-glucan response.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
728.
The Effect of Mushroom Beta-Glucans from Solid Culture of Ganoderma lucidum on Inhibition of the Primary Tumor Metastasis.
- Chen SN, Chang CS, Hung MH, Chen S, Wang W, Tai CJ, Lu CL.
- Evid Based Complement Alternat Med. 2014 Apr 1;2014:252171. doi: 10.1155/2014/252171.
- PMCID: PMC3995106
Chen SN, et al.

Evid Based Complement Alternat Med. 2014.

PMCID: PMC3995106

This study evaluates the effect of mushroom beta-glucans (MBGS) derived from solid culture of Ganoderma lucidum on tumor inhibition by examining size of the primary tumor and rate of metastasis in Lewis lung carcinoma (LLC) bearing mice (C57BL/6), given oral adminis …

This study evaluates the effect of mushroom beta-glucans (MBGS) derived from solid culture of Ganoderma lucidum on tumor inhib …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The Effect of Mushroom Beta-Glucans from Solid Culture of Ganoderma lucidum on Inhibition of the Primary Tumor Metastasis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
729.
Structure-function insights of natural Ganoderma polysaccharides: advances in biosynthesis and functional food applications.
- Wu ZW, Zhao XF, Quan CX, Liu XC, Tao XY, Li YJ, Peng XR, Qiu MH.
- Nat Prod Bioprospect. 2025 Mar 4;15(1):15. doi: 10.1007/s13659-025-00496-w.
- PMCID: PMC11880470
Wu ZW, et al.

Nat Prod Bioprospect. 2025.

PMCID: PMC11880470

Ganoderma polysaccharides (GPs), derived from various species of the Ganoderma genus, exhibit diverse bioactivities, including immune modulation, anti-tumor effects, and gut microbiota regulation. ...

Ganoderma polysaccharides (GPs), derived from various species of the Ganoderma genus, exhibit diverse bioactivities, including …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Structure-function insights of natural Ganoderma polysaccharides: advances in biosynthesis and functional food applications.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
730.
Ganoderma lucidum Spore Powder Alleviates Metabolic-Associated Fatty Liver Disease by Improving Lipid Accumulation and Oxidative Stress via Autophagy.
- Zhang Y, Zhou J, Yang L, Xiao H, Liu D, Kang X.
- Antioxidants (Basel). 2024 Dec 9;13(12):1501. doi: 10.3390/antiox13121501.
- PMCID: PMC11673792
Zhang Y, et al.

Antioxidants (Basel). 2024.

PMCID: PMC11673792

Lipid accumulation and oxidative stress, which could be improved by autophagy, are the "hits" of metabolic-associated fatty liver disease (MAFLD). Ganoderma lucidum spore powder (GLSP) has the effect of improving liver function. However, there are few reports about …

Lipid accumulation and oxidative stress, which could be improved by autophagy, are the "hits" of metabolic-associated fatty liver disease (M …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Spore Powder Alleviates Metabolic-Associated Fatty Liver Disease by Improving Lipid Accumulation and Oxidative Stress via Autophagy.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 74

731.
Carbonized Ganoderma Lucidum/V(2)O(3) Composites as a Superior Cathode for High-Performance Aqueous Zinc-Ion Batteries.
- Zeng G, Li Z, Jiang S, Zhou W.
- Molecules. 2024 Aug 4;29(15):3688. doi: 10.3390/molecules29153688.
- PMCID: PMC11314629
Zeng G, et al.

Molecules. 2024.

PMCID: PMC11314629

In response to the suboptimal electrochemical performance of low-valence vanadium oxides, Ganoderma lucidum biomass-derived carbon@V(2)O(3) (V(2)O(3)@CGL) composites were prepared by evaporative self-assembly technology and high-temperature calcination. ...

In response to the suboptimal electrochemical performance of low-valence vanadium oxides, Ganoderma lucidum biomass-derived ca …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Carbonized Ganoderma Lucidum /V(2)O(3) Composites as a Superior Cathode for High-Performance Aqueous Zinc-Ion Batteries.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
732.
Apoptosis induction of colorectal cancer cells HTL-9 in vitro by the transformed products of soybean isoflavones by Ganoderma lucidum.
- Cui ML, Yang HY, He GQ.
- J Zhejiang Univ Sci B. 2017 Dec.;18(12):1101-1112. doi: 10.1631/jzus.B1700189.
- PMCID: PMC5742293
Cui ML, et al.

J Zhejiang Univ Sci B. 2017.

PMCID: PMC5742293

In this paper, we first studied the transformation of soybean isoflavones with the homogenized slurry of Ganoderma lucidum. The resultant transformed products (TSI) contained (703.21 4.35) mg/g of genistein, with transformed rates of 96.63% and 87.82% of daidzein an …

In this paper, we first studied the transformation of soybean isoflavones with the homogenized slurry of Ganoderma lucidum. Th …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Apoptosis induction of colorectal cancer cells HTL-9 in vitro by the transformed products of soybean isoflavones by Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
733.
Characterizations of Ganoderma species causing basal stem rot disease in coconut tree.
- Sajjan U, Hubballi M, Pandey AK, Devappa V, Maheswarappa HP.
- 3 Biotech. 2024 Mar 8;14(4):104. doi: 10.1007/s13205-023-03872-w.
- PMCID: PMC10923766
Sajjan U, et al.

3 Biotech. 2024.

PMCID: PMC10923766

The basal stem rot disease incidence ranged from 0 to 5% in Karnataka India during the year 2019-20. Twenty pathogenic isolates of Ganoderma sp varied with cultural characteristics and virulence on coconut seedlings of the variety Tipatur Tall. ...Two isolates viz., G(4) a …

The basal stem rot disease incidence ranged from 0 to 5% in Karnataka India during the year 2019-20. Twenty pathogenic isolates of Ganode …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Characterizations of Ganoderma species causing basal stem rot disease in coconut tree.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
734.
Ganoderma terpenoid extract exhibited anti-plasmodial activity by a mechanism involving reduction in erythrocyte and hepatic lipids in Plasmodium berghei infected mice.
- Oluba OM.
- Lipids Health Dis. 2019 Jan 12;18(1):12. doi: 10.1186/s12944-018-0951-x.
- PMCID: PMC6330487
Oluba OM.

Lipids Health Dis. 2019.

PMCID: PMC6330487

Bioactive components of Ganoderma lucidum has recently gained intense research attention due to their acclaimed nutritional and medicinal properties. Thus, the terpenoid extract from the fruit bodies of G. lucidum (GT) was evaluated for activity against Plasm …

Bioactive components of Ganoderma lucidum has recently gained intense research attention due to their acclaimed nutritional an …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma terpenoid extract exhibited anti-plasmodial activity by a mechanism involving reduction in erythrocyte and hepatic lipids in Plasmodium berghei infected mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
735.
Proteomic Research on the Antitumor Properties of Medicinal Mushrooms.
- Jakopovic B, Oršolić N, Jakopovich I.
- Molecules. 2021 Nov 5;26(21):6708. doi: 10.3390/molecules26216708.
- PMCID: PMC8588050
Jakopovic B, et al.

Molecules. 2021.

PMCID: PMC8588050

This review is focused on the current state of proteomic research into antitumor mechanisms of some of the most researched medicinal mushroom species, including Phellinus linteus, Ganoderma lucidum, Auricularia auricula, Agrocybe aegerita, Grifola frondosa, and Lent …

This review is focused on the current state of proteomic research into antitumor mechanisms of some of the most researched medicinal mushroo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Proteomic Research on the Antitumor Properties of Medicinal Mushrooms.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Broad molecular profiling and pathway/statistical analyses. Open article.
- Why might this paper be useful to readers? Maps pathways and components that can guide future lab and clinical research. Open article.
736.
Study of the Metabolite Changes in Ganoderma lucidum under Pineapple Leaf Residue Stress via LC-MS/MS Coupled with a Non-Targeted Metabolomics Approach.
- Liu Y, Qian Y, Wang C, He Y, Zhu C, Chen G, Lin L, Chen Y.
- Metabolites. 2023 Mar 28;13(4):487. doi: 10.3390/metabo13040487.
- PMCID: PMC10144527
Liu Y, et al.

Metabolites. 2023.

PMCID: PMC10144527

The effects of fermentation metabolites of G. lucidum under different pineapple leaf residue additions were separated and identified using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). ...These study results are considered instrumental in substant …

The effects of fermentation metabolites of G. lucidum under different pineapple leaf residue additions were separated and identified …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Study of the Metabolite Changes in Ganoderma lucidum under Pineapple Leaf Residue Stress via LC-MS/MS Coupled with a Non-Targeted Metabolomics Approach.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Broad molecular profiling and pathway/statistical analyses. Open article.
- Why might this paper be useful to readers? Maps pathways and components that can guide future lab and clinical research. Open article.
737.
Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation.
- Zhang R, Xu S, Cai Y, Zhou M, Zuo X, Chan P.
- Evid Based Complement Alternat Med. 2011 Jun 18;2011:156810. doi: 10.1093/ecam/nep075.
- PMCID: PMC3136196
Zhang R, et al.

Evid Based Complement Alternat Med. 2011.

PMCID: PMC3136196

The emerging evidence has supported that microglia may play key roles in the progressive neurodegeneration in PD and might be a promising therapeutic target. Ganoderma lucidum (GL), a traditional Chinese medicinal herb, has been shown potential neuroprotective effec …

The emerging evidence has supported that microglia may play key roles in the progressive neurodegeneration in PD and might be a promising th …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
738.
Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection.
- Jan JT, Cheng TR, Juang YP, Ma HH, Wu YT, Yang WB, Cheng CW, Chen X, Chou TH, Shie JJ, Cheng WC, Chein RJ, Mao SS, Liang PH, Ma C, Hung SC, Wong CH.
- Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2021579118. doi: 10.1073/pnas.2021579118.
- PMCID: PMC7865145
Jan JT, et al.

Proc Natl Acad Sci U S A. 2021.

PMCID: PMC7865145

Some of the active compounds identified in the screen were further tested in vivo, and it was found that mefloquine, nelfinavir, and extracts of Ganoderma lucidum (RF3), Perilla frutescens, and Mentha haplocalyx were effective in a challenge study using hamsters as …

Some of the active compounds identified in the screen were further tested in vivo, and it was found that mefloquine, nelfinavir, and extract …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
739.
Efficacy of complementary medicine for nonsteroidal anti-inflammatory drug-induced small intestinal injuries: A narrative review.
- Cho M, Bu Y, Park JW, Rahman H, Ko SJ.
- Medicine (Baltimore). 2021 Dec 3;100(48):e28005. doi: 10.1097/MD.0000000000028005.
- PMCID: PMC9191556
Cho M, et al.

Medicine (Baltimore). 2021.

PMCID: PMC9191556

Clinical and experimental studies on the effect of CAMs on NSIs were performed using 10 databases.Twenty-two studies (3 clinical and 19 in vivo experimental studies) were included in the final analysis involving 10 kinds of CAMs: bovine colostrum, Orengedokuto (coptis), muscovite …

Clinical and experimental studies on the effect of CAMs on NSIs were performed using 10 databases.Twenty-two studies (3 clinical and 19 in v …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Efficacy of complementary medicine for nonsteroidal anti-inflammatory drug-induced small intestinal injuries: A narrative review.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
740.
Lignin-modifying enzymes of the white rot basidiomycete Ganoderma lucidum.
- D'Souza TM, Merritt CS, Reddy CA.
- Appl Environ Microbiol. 1999 Dec;65(12):5307-13. doi: 10.1128/AEM.65.12.5307-5313.1999.
- PMCID: PMC91721
D'Souza TM, et al.

Appl Environ Microbiol. 1999.

PMCID: PMC91721

Ganoderma lucidum, a white rot basidiomycete widely distributed worldwide, was studied for the production of the lignin-modifying enzymes laccase, manganese-dependent peroxidase (MnP), and lignin peroxidase (LiP). ...No LiP activity was seen in any of the media test …

Ganoderma lucidum, a white rot basidiomycete widely distributed worldwide, was studied for the production of the lignin-modify …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Lignin-modifying enzymes of the white rot basidiomycete Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 75

741.
Spore Oil enhances the effect of cyclophosphamide inhibiting programmed death-1 and prolongs the survival of H22 tumor-bearing mice.
- Zhaojian J, Hongfei C, Cheng Y, Lin C, Wendong XU, Yaming H, Qin Z, Jing LI, Qin W, Juyan L.
- J Tradit Chin Med. 2024 Aug;44(4):652-659. doi: 10.19852/j.cnki.jtcm.2024.04.003.
- PMCID: PMC11337259
Zhaojian J, et al.

J Tradit Chin Med. 2024.

PMCID: PMC11337259

OBJECTIVE: To investigate the effect of Ganoderma Lucidum Spore Oil (GLSO) on the tumor growth and survival of H22 tumor-bearing mice treated with cyclophosphamide (CTX), and explore the underlying mechanism. ...

OBJECTIVE: To investigate the effect of Ganoderma Lucidum Spore Oil (GLSO) on the tumor growth and survival of H22 tumor-beari …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Spore Oil enhances the effect of cyclophosphamide inhibiting programmed death-1 and prolongs the survival of H22 tumor-bearing mice.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
742.
Pan-genomic characterization and structural variant analysis reveal insights into spore development and species diversity in Ganoderma.
- Yu H, Wang S, Wang L, Wu W, Xu W, Wu S, Li X, Xu W, Huang Z, Lin Y, Wang H.
- Microb Genom. 2024 Nov;10(11):001328. doi: 10.1099/mgen.0.001328.
- PMCID: PMC11897173
Yu H, et al.

Microb Genom. 2024.

PMCID: PMC11897173

Understanding the genomic diversity and functional implications of Ganoderma species is crucial for elucidating their evolutionary history and biotechnological potential. Here, we present the first pan-genomic analysis of Ganoderma spp., combining five newly sequenc …

Understanding the genomic diversity and functional implications of Ganoderma species is crucial for elucidating their evolutionary hi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Pan-genomic characterization and structural variant analysis reveal insights into spore development and species diversity in Ganoderma .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Broad molecular profiling and pathway/statistical analyses. Open article.
- Why might this paper be useful to readers? Maps pathways and components that can guide future lab and clinical research. Open article.
743.
Preparation and Characterization of Multilayer pH-Responsive Hydrogel Loaded Ganoderma lucidum Peptides.
- Liu R, Gan J, Du M, Kong X, Xu C, Lü Y, Cao S, Meng T, Wang B, Yu T.
- Foods. 2023 Mar 31;12(7):1481. doi: 10.3390/foods12071481.
- PMCID: PMC10094239
Liu R, et al.

Foods. 2023.

PMCID: PMC10094239

The composite hydrogels exhibited excellent pH sensitivity and Ganoderma lucidum peptides (GLP) loading capacity. The prepared hydrogels were characterized and evaluated. ...

The composite hydrogels exhibited excellent pH sensitivity and Ganoderma lucidum peptides (GLP) loading capacity. The prepared …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Preparation and Characterization of Multilayer pH-Responsive Hydrogel Loaded Ganoderma lucidum Peptides.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
744.
Triterpene-loaded microemulsion using Coix lacryma-jobi seed extract as oil phase for enhanced antitumor efficacy: preparation and in vivo evaluation.
- Qu D, He J, Liu C, Zhou J, Chen Y.
- Int J Nanomedicine. 2013 Dec 19;9:109-19. doi: 10.2147/IJN.S54796.
- PMCID: PMC3872217
Qu D, et al.

Int J Nanomedicine. 2013.

PMCID: PMC3872217

Ganoderma lucidum triterpene-loaded microemulsions (TMEs) using Coix lacryma-jobi (adlay) seed oil as oil phase were prepared, characterized, and evaluated for enhanced antitumor activity. ...

Ganoderma lucidum triterpene-loaded microemulsions (TMEs) using Coix lacryma-jobi (adlay) seed oil as oil phase were prepared, …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Triterpene-loaded microemulsion using Coix lacryma-jobi seed extract as oil phase for enhanced antitumor efficacy: preparation and in vivo evaluation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
745.
Impact of the fermentation broth of Ganoderma lucidum on the quality of Chinese steamed bread.
- Guowei Z, Lili W, Yufeng L, Hailei W.
- AMB Express. 2019 Aug 27;9(1):133. doi: 10.1186/s13568-019-0859-5.
- PMCID: PMC6712117
Guowei Z, et al.

AMB Express. 2019.

PMCID: PMC6712117

The potential of fermentation broth of Ganoderma lucidum (FB(G)) in improving the quality of Chinese steamed bread (CSB) was firstly evaluated. ...

The potential of fermentation broth of Ganoderma lucidum (FB(G)) in improving the quality of Chinese steamed bread (CSB) was f …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Impact of the fermentation broth of Ganoderma lucidum on the quality of Chinese steamed bread.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Quality/authentication methods study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Analytical validation (specificity/sensitivity), reference standards, and mislabeling rates. Open article.
- Why might this paper be useful to readers? Useful for quality control, sourcing, and preventing adulteration. Open article.
746.
Mushroom-Derived Novel Selenium Nanocomposites' Effects on Potato Plant Growth and Tuber Germination.
- Tsivileva OM, Perfileva AI.
- Molecules. 2022 Jul 11;27(14):4438. doi: 10.3390/molecules27144438.
- PMCID: PMC9321743
Tsivileva OM, et al.

Molecules. 2022.

PMCID: PMC9321743

Potato plants exposed to Se-bio-composite from Ganoderma lucidum SIE1303 experienced an increase in the potato vegetative biomass by up to 55% versus the control. ...

Potato plants exposed to Se-bio-composite from Ganoderma lucidum SIE1303 experienced an increase in the potato vegetative biom …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Mushroom-Derived Novel Selenium Nanocomposites' Effects on Potato Plant Growth and Tuber Germination.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
747.
Ganoderma lucidum and Professor Zhi-Bin Lin.
- Su DF, Zhu XL.
- Front Pharmacol. 2012 Mar 28;3:51. doi: 10.3389/fphar.2012.00051.
- PMCID: PMC3314231
Su DF, et al.

Front Pharmacol. 2012.

PMCID: PMC3314231
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum and Professor Zhi-Bin Lin.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
748.
Ganoderma lucidum Ameliorates Non-Alcoholic Steatosis by Upregulating Energy Metabolizing Enzymes in the Liver.
- Jung S, Son H, Hwang CE, Cho KM, Park SW, Kim HJ.
- J Clin Med. 2018 Jun 15;7(6):152. doi: 10.3390/jcm7060152.
- PMCID: PMC6025418
Jung S, et al.

J Clin Med. 2018.

PMCID: PMC6025418

In the present study, we investigated the molecular mechanism of Ganoderma lucidum (GL) against the development of non-alcoholic steatosis using in vivo and in vitro settings. ...

In the present study, we investigated the molecular mechanism of Ganoderma lucidum (GL) against the development of non-alcohol …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum Ameliorates Non-Alcoholic Steatosis by Upregulating Energy Metabolizing Enzymes in the Liver.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
749.
Phytochemical property and assessment of antidermatophytic activity of some selected wild macrofungi against pathogenic dermatophytes.
- Ogidi OC, Oyetayo VO.
- Mycology. 2016 Feb 22;7(1):9-14. doi: 10.1080/21501203.2016.1145608.
- PMCID: PMC6059083
Ogidi OC, et al.

Mycology. 2016.

PMCID: PMC6059083

The phytochemical property and inhibitory potential of petroleum ether and ethanol extracts of Lenzites quercina, Ganoderma lucidum and Rigidoporus ulmarius were assessed. Standard method was adopted to quantify the phytochemicals in the mushroom extracts. ...Extrac …

The phytochemical property and inhibitory potential of petroleum ether and ethanol extracts of Lenzites quercina, Ganoderma lucidu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Phytochemical property and assessment of antidermatophytic activity of some selected wild macrofungi against pathogenic dermatophytes.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
750.
Anti-lung cancer activity through enhancement of immunomodulation and induction of cell apoptosis of total triterpenes extracted from Ganoderma luncidum (Leyss. ex Fr.) Karst.
- Feng L, Yuan L, Du M, Chen Y, Zhang MH, Gu JF, He JJ, Wang Y, Cao W.
- Molecules. 2013 Aug 19;18(8):9966-81. doi: 10.3390/molecules18089966.
- PMCID: PMC6270046
Feng L, et al.

Molecules. 2013.

PMCID: PMC6270046

Ganoderma luncidum (Leyss. ex Fr.) Karst. (GLK) has been used traditionally for the prevention and treatment of cancers or tumors for a long time in Traditional Chinese Medicine. ...

Ganoderma luncidum (Leyss. ex Fr.) Karst. (GLK) has been used traditionally for the prevention and treatment of cancers or tumors for …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Anti-lung cancer activity through enhancement of immunomodulation and induction of cell apoptosis of total triterpenes extracted from Ganoderma luncidum (Leyss. ex Fr.) Karst.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 76

751.
Improved Production and Antitumor Properties of Triterpene Acids from Submerged Culture of Ganoderma lingzhi.
- Wang XL, Ding ZY, Liu GQ, Yang H, Zhou GY.
- Molecules. 2016 Oct 20;21(10):1395. doi: 10.3390/molecules21101395.
- PMCID: PMC6273529
Wang XL, et al.

Molecules. 2016.

PMCID: PMC6273529

Triterpene acids (TAs) are the major bioactive constituents in the medicinal fungus Ganoderma lingzhi. However, fermentative production of TAs has not been optimized for commercial use, and whether the TAs isolated from G. lingzhi submerged culture mycelia possess antitumo …

Triterpene acids (TAs) are the major bioactive constituents in the medicinal fungus Ganoderma lingzhi. However, fermentative producti …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Improved Production and Antitumor Properties of Triterpene Acids from Submerged Culture of Ganoderma lingzhi.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
752.
Polysaccharides from Basidiocarps of the Polypore Fungus Ganoderma resinaceum: Isolation and Structure.
- Bleha R, Třešnáková L, Sushytskyi L, Capek P, Čopíková J, Klouček P, Jablonský I, Synytsya A.
- Polymers (Basel). 2022 Jan 8;14(2):255. doi: 10.3390/polym14020255.
- PMCID: PMC8778809
Bleha R, et al.

Polymers (Basel). 2022.

PMCID: PMC8778809

In this study, we focused on the isolation and structural characterization of polysaccharides from a basidiocarp of polypore fungus Ganoderma resinaceum. Polysaccharide fractions were obtained by successive extractions with cold water at room temperature (20 C), hot water …

In this study, we focused on the isolation and structural characterization of polysaccharides from a basidiocarp of polypore fungus Ganod …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Polysaccharides from Basidiocarps of the Polypore Fungus Ganoderma resinaceum: Isolation and Structure.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
753.
Significant effects of Ganoderma lucidum polysaccharide on lipid metabolism in diabetes may be associated with the activation of the FAM3C-HSF1-CAM signaling pathway.
- Pan R, Lou J, Wei L.
- Exp Ther Med. 2021 Jun 2;22(2):820. doi: 10.3892/etm.2021.10252.
- PMCID: PMC8193219
Pan R, et al.

Exp Ther Med. 2021.

PMCID: PMC8193219

Type 2 diabetes (T2DM), one of the two main types of diabetes, is a long-term metabolic disease caused by heredity and environmental factors. It has been reported that Ganoderma lucidum polysaccharide (GLP) significantly decreased the concentration of blood glucose, …

Type 2 diabetes (T2DM), one of the two main types of diabetes, is a long-term metabolic disease caused by heredity and environmental factors …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Significant effects of Ganoderma lucidum polysaccharide on lipid metabolism in diabetes may be associated with the activation of the FAM3C-HSF1-CAM signaling pathway.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
754.
In vitro antitumor effects of methanolic extracts of three Ganoderema mushrooms.
- Toson EA, El-Fallal AA, Oransa MA, El-Gharabawy HM.
- Sci Rep. 2025 Jan 17;15(1):2274. doi: 10.1038/s41598-025-86162-0.
- PMCID: PMC11748650
Toson EA, et al.

Sci Rep. 2025.

PMCID: PMC11748650

Ganoderma mushrooms have a variety of pharmacological activities and may have antitumor effects. ...Additionally, Ganoderma australe and Ganoderma mbrekobenum decreased the viability of OEC cell line at an IC(50) of 328.29 and 271.56 g/ mL, respectively. ...

Ganoderma mushrooms have a variety of pharmacological activities and may have antitumor effects. ...Additionally, Ganoderma au …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: In vitro antitumor effects of methanolic extracts of three Ganoderema mushrooms.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
755.
Ganoderma lucidum polysaccharide extract inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation and function by inducing microRNA-125b.
- Li A, Shuai X, Jia Z, Li H, Liang X, Su D, Guo W.
- J Transl Med. 2015 Mar 26;13:100. doi: 10.1186/s12967-015-0465-5.
- PMCID: PMC4379953
Li A, et al.

J Transl Med. 2015.

PMCID: PMC4379953

BACKGROUND: Ganoderma lucidum polysaccharides (GLPS) have been used as traditional Chinese medicine for their properties of cancer prevention and immunomodulation. ...

BACKGROUND: Ganoderma lucidum polysaccharides (GLPS) have been used as traditional Chinese medicine for their properties of ca …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum polysaccharide extract inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation and function by inducing microRNA-125b.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
756.
Comparative studies of delignification caused by ganoderma species.
- Adaskaveg JE, Gilbertson RL, Blanchette RA.
- Appl Environ Microbiol. 1990 Jun;56(6):1932-43. doi: 10.1128/aem.56.6.1932-1943.1990.
- PMCID: PMC184533
Adaskaveg JE, et al.

Appl Environ Microbiol. 1990.

PMCID: PMC184533

Isolates of six species of Ganoderma in the G. lucidum complex were evaluated for their ability to decay wood of Quercus hypoleucoides A. ...Only Ganoderma sp. isolates JEA615 and JEA625 caused delignification, with JEA615 causing a lignin-to-glucose gram los …

Isolates of six species of Ganoderma in the G. lucidum complex were evaluated for their ability to decay wood of Quercus hypol …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Comparative studies of delignification caused by ganoderma species.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
757.
The Effects of the Substrate Length and Cultivation Time on the Physical and Mechanical Properties of Mycelium-Based Cushioning Materials from Salix psammophila and Peanut Straw.
- Song X, Chen S, Wu J, Cai Z, Zhang Y, Na R, Lv H, He C, Wu T, Wang X.
- Biomimetics (Basel). 2025 Jun 5;10(6):371. doi: 10.3390/biomimetics10060371.
- PMCID: PMC12191277
Song X, et al.

Biomimetics (Basel). 2025.

PMCID: PMC12191277

This study investigated the potential of using Salix psammophila and peanut straw as substrates for cultivating Pleurotus ostreatus and Ganoderma lucidum, respectively, to fabricate mycelium-based cushioning materials. The results demonstrated that the Pleurotus ost …

This study investigated the potential of using Salix psammophila and peanut straw as substrates for cultivating Pleurotus ostreatus and G …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The Effects of the Substrate Length and Cultivation Time on the Physical and Mechanical Properties of Mycelium-Based Cushioning Materials from Salix psammophila and Peanut Straw.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
758.
Chronic Treatment with a Water-Soluble Extract from the Culture Medium of Ganoderma lucidum Mycelia Prevents Apoptosis and Necroptosis in Hypoxia/Ischemia-Induced Injury of Type 2 Diabetic Mouse Brain.
- Xuan M, Okazaki M, Iwata N, Asano S, Kamiuchi S, Matsuzaki H, Sakamoto T, Miyano Y, Iizuka H, Hibino Y.
- Evid Based Complement Alternat Med. 2015 Apr 6;2015:865986. doi: 10.1155/2015/865986.
- PMCID: PMC4402482
Xuan M, et al.

Evid Based Complement Alternat Med. 2015.

PMCID: PMC4402482

On the basis of our previous study regarding a water-soluble extract from the culture medium of Ganoderma lucidum mycelia (designed as MAK), which exerts antioxidative and neuroprotective effects, the present study was conducted to evaluate the preventive effects of …

On the basis of our previous study regarding a water-soluble extract from the culture medium of Ganoderma lucidum mycelia (des …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Chronic Treatment with a Water-Soluble Extract from the Culture Medium of Ganoderma lucidum Mycelia Prevents Apoptosis and Necroptosis in Hypoxia/Ischemia-Induced Injury of Type 2 Diabetic Mouse Brain.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
759.
An In-Depth Study of Phytopathogenic Ganoderma: Pathogenicity, Advanced Detection Techniques, Control Strategies, and Sustainable Management.
- Karunarathna SC, Patabendige NM, Lu W, Asad S, Hapuarachchi KK.
- J Fungi (Basel). 2024 Jun 7;10(6):414. doi: 10.3390/jof10060414.
- PMCID: PMC11204718
Karunarathna SC, et al.

J Fungi (Basel). 2024.

PMCID: PMC11204718

Recent studies have quantified the economic impact of Ganoderma infections, revealing staggering yield losses ranging from 20% to 80% across various crops. ...This comprehensive analysis underscores the imperative for adopting an integrated approach to Ganoderma dis …

Recent studies have quantified the economic impact of Ganoderma infections, revealing staggering yield losses ranging from 20% to 80% …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: An In-Depth Study of Phytopathogenic Ganoderma : Pathogenicity, Advanced Detection Techniques, Control Strategies, and Sustainable Management.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
760.
The Protective Effects of Ganoderic Acids from Ganoderma lucidum Fruiting Body on Alcoholic Liver Injury and Intestinal Microflora Disturbance in Mice with Excessive Alcohol Intake.
- Cao YJ, Huang ZR, You SZ, Guo WL, Zhang F, Liu B, Lv XC, Lin ZX, Liu PH.
- Foods. 2022 Mar 25;11(7):949. doi: 10.3390/foods11070949.
- PMCID: PMC8997615
Cao YJ, et al.

Foods. 2022.

PMCID: PMC8997615

This study aimed to investigate the protective effects of ganoderic acids (GA) from Ganoderma lucidum against liver injury and intestinal microbial disorder in mice with excessive alcohol intake. ...

This study aimed to investigate the protective effects of ganoderic acids (GA) from Ganoderma lucidum against liver injury and …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The Protective Effects of Ganoderic Acids from Ganoderma lucidum Fruiting Body on Alcoholic Liver Injury and Intestinal Microflora Disturbance in Mice with Excessive Alcohol Intake.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 77

761.
Development and Characterization of Mycelium-Based Composite Using Agro-Industrial Waste and Ganoderma lucidum as Insulating Material.
- Jiménez-Obando G, Arcila JS, Tolosa-Correa RA, Valencia-Cardona YL, Montoya S.
- J Fungi (Basel). 2025 Jun 17;11(6):460. doi: 10.3390/jof11060460.
- PMCID: PMC12194127
Jiménez-Obando G, et al.

J Fungi (Basel). 2025.

PMCID: PMC12194127

This study focuses on developing an MBC based on abundant waste in Colombia, pith Arboloco (A) (Montanoa quadrangularis), a plant endemic to the Colombian-Venezuelan Andes with outstanding insulating properties, and natural fiber of Kikuyu grass (G) (Cenchrus clandestinus), utili …

This study focuses on developing an MBC based on abundant waste in Colombia, pith Arboloco (A) (Montanoa quadrangularis), a plant endemic to …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Development and Characterization of Mycelium-Based Composite Using Agro-Industrial Waste and Ganoderma lucidum as Insulating Material.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Participant-reported outcomes, clinical biomarkers, and safety/tolerability. Open article.
- Why might this paper be useful to readers? Provides early human data; interpret with caution and check study size and endpoints. Open article.
762.
Impact of malt concentration in solid substrate on mycelial growth and network connectivity in Ganoderma species.
- Nussbaum N, von Wyl T, Gandia A, Romanens E, Rühs PA, Fischer P.
- Sci Rep. 2023 Nov 29;13(1):21051. doi: 10.1038/s41598-023-48203-4.
- PMCID: PMC10687231
Nussbaum N, et al.

Sci Rep. 2023.

PMCID: PMC10687231

The effect of malt extract concentration in the growth medium on radial growth kinetics, morphology, mycelium network connectivity, and mechanical characteristics of mycelium from two Ganoderma species were investigated. While an evident pattern of radial growth rate enhan …

The effect of malt extract concentration in the growth medium on radial growth kinetics, morphology, mycelium network connectivity, and mech …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Impact of malt concentration in solid substrate on mycelial growth and network connectivity in Ganoderma species.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
763.
Whole-genome sequencing and comparative genomic analyses of the medicinal fungus Sanguinoderma infundibulare in Ganodermataceae.
- Fang Y, Wu D, Gao N, Lv M, Zhou M, Ma C, Sun Y, Cui B.
- G3 (Bethesda). 2024 Apr 3;14(4):jkae005. doi: 10.1093/g3journal/jkae005.
- PMCID: PMC10989896
Fang Y, et al.

G3 (Bethesda). 2024.

PMCID: PMC10989896

Comparative genomic analyses were conducted among S. infundibulare, Sanguinoderma rugosum, Ganoderma lucidum, and Ganoderma sinense to determine their intergeneric differences. The 4 species were found to share 4,011 orthogroups, and 24 specific gene families …

Comparative genomic analyses were conducted among S. infundibulare, Sanguinoderma rugosum, Ganoderma lucidum, and Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Whole-genome sequencing and comparative genomic analyses of the medicinal fungus Sanguinoderma infundibulare in Ganodermataceae.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Maps pathways and components that can guide future lab and clinical research. Open article.
764.
Evaluation of Conditions to Improve Biomass Production by Submerged Culture of Ganoderma sp.
- Rosales-López C, Vargas-López A, Monge-Artavia M, Rojas-Chaves M.
- Microorganisms. 2022 Jul 12;10(7):1404. doi: 10.3390/microorganisms10071404.
- PMCID: PMC9322093
Rosales-López C, et al.

Microorganisms. 2022.

PMCID: PMC9322093

In the present investigation, the conditions for in vitro submerged culture of a native strain of Ganoderma sp. were evaluated. Different culture medium ingredients, inoculum concentrations, inoculation methods, configuration, and airflows were evaluated to improve biomass …

In the present investigation, the conditions for in vitro submerged culture of a native strain of Ganoderma sp. were evaluated. Diffe …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Evaluation of Conditions to Improve Biomass Production by Submerged Culture of Ganoderma sp.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
765.
Anti-breast Cancer Enhancement of a Polysaccharide From Spore of Ganoderma lucidum With Paclitaxel: Suppression on Tumor Metabolism With Gut Microbiota Reshaping.
- Su J, Li D, Chen Q, Li M, Su L, Luo T, Liang D, Lai G, Shuai O, Jiao C, Wu Q, Xie Y, Zhou X.
- Front Microbiol. 2018 Dec 17;9:3099. doi: 10.3389/fmicb.2018.03099.
- PMCID: PMC6304348
Su J, et al.

Front Microbiol. 2018.

PMCID: PMC6304348

The present work explored the enhancement of a polysaccharide derived from spore of Ganoderma lucidum (SGP) with PTX in a murine 4T1-breast cancer model. Results showed that the combination of PTX and SGP displayed an improved tumor control, in which mRNA expression …

The present work explored the enhancement of a polysaccharide derived from spore of Ganoderma lucidum (SGP) with PTX in a muri …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Anti-breast Cancer Enhancement of a Polysaccharide From Spore of Ganoderma lucidum With Paclitaxel: Suppression on Tumor Metabolism With Gut Microbiota Reshaping.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
766.
Extracellular expression of a functional recombinant Ganoderma lucidium immunomodulatory protein by Bacillus subtilis and Lactococcus lactis.
- Yeh CM, Yeh CK, Hsu XY, Luo QM, Lin MY.
- Appl Environ Microbiol. 2007 Dec 21;74(4):1039-49. doi: 10.1128/AEM.01547-07.
- PMCID: PMC2258568
Yeh CM, et al.

Appl Environ Microbiol. 2007.

PMCID: PMC2258568

Bacillus subtilis and Lactococcus lactis are ideal hosts for the production of extracellular heterologous proteins of major commercial importance. A recombinant gene for the novel Ganoderma lucidium immunomodulatory protein LZ-8, recombinant LZ-8, was designed encoding the …

Bacillus subtilis and Lactococcus lactis are ideal hosts for the production of extracellular heterologous proteins of major commercial impor …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Extracellular expression of a functional recombinant Ganoderma lucidium immunomodulatory protein by Bacillus subtilis and Lactococcus lactis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
767.
Ganoderma Lucidum Pharmacopuncture for Teating Ethanol-induced Chronic Gastric Ulcers in Rats.
- Park JH, Jang KJ, Kim CH, Kim JH, Kim YK, Yoon HM.
- J Pharmacopuncture. 2015 Mar;18(1):72-8. doi: 10.3831/KPI.2015.18.008.
- PMCID: PMC4379478
Park JH, et al.

J Pharmacopuncture. 2015.

PMCID: PMC4379478

This study was accomplished to investigate the effect of Ganoderma lucidum pharmacopuncture (GLP) on chronic gastric ulcers in rats. METHODS: The rats were divided into 4 groups of 8 animals each: the normal, the control, the normal saline (NP) and the GLP groups. . …

This study was accomplished to investigate the effect of Ganoderma lucidum pharmacopuncture (GLP) on chronic gastric ulcers in …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma Lucidum Pharmacopuncture for Teating Ethanol-induced Chronic Gastric Ulcers in Rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
768.
Competitive antagonistic action of laccase between Trichoderma species and the newly identified wood pathogenic Ganoderma camelum.
- Umar A, Elshikh MS, Aljowaie RM, Hussein JM, Dufossé L, Wu C, Lu J.
- Front Microbiol. 2024 Sep 25;15:1408521. doi: 10.3389/fmicb.2024.1408521.
- PMCID: PMC11461316
Umar A, et al.

Front Microbiol. 2024.

PMCID: PMC11461316

Ganoderma, a well-known genus in the Ganodermataceae family, has caused the extinction of several tree species due to its pathogenicity. This study explored the pathogenic effect of a newly identified Ganoderma species on trees and its competitive efficiency against …

Ganoderma, a well-known genus in the Ganodermataceae family, has caused the extinction of several tree species due to its pathogenici …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Competitive antagonistic action of laccase between Trichoderma species and the newly identified wood pathogenic Ganoderma camelum.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Relevant for eco‑friendly processing, waste upcycling, and industrial biocatalysis. Open article.
769.
Synthesis, Application and Prospects of Carbon Dots as A Medicine Food Homology.
- Huang S, Ren H, Chen H, Wen N, Du L, Song C, Lv Y.
- Nanomaterials (Basel). 2025 Jun 11;15(12):906. doi: 10.3390/nano15120906.
- PMCID: PMC12196279
Huang S, et al.

Nanomaterials (Basel). 2025.

PMCID: PMC12196279

This review used ChatGPT 4.0 to collect background information related to carbon dots, focusing on the common rich medicinal and food resources such as Lycium barbarum, Chinese yam, honeysuckle, and Ganoderma lucidum. These carbon dots are synthesized by hydrotherma …

This review used ChatGPT 4.0 to collect background information related to carbon dots, focusing on the common rich medicinal and food resour …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Synthesis, Application and Prospects of Carbon Dots as A Medicine Food Homology.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
770.
Mushrooms as Nutritional Powerhouses: A Review of Their Bioactive Compounds, Health Benefits, and Value-Added Products.
- Singh A, Saini RK, Kumar A, Chawla P, Kaushik R.
- Foods. 2025 Feb 22;14(5):741. doi: 10.3390/foods14050741.
- PMCID: PMC11899115
Singh A, et al.

Foods. 2025.

PMCID: PMC11899115

Edible mushroom varieties such as Hericium erinaceus, Ganoderma sp., and Lentinula edodes are recognized as functional foods due to their remarkable potential for disease prevention and promotion of overall health and well-being. ...

Edible mushroom varieties such as Hericium erinaceus, Ganoderma sp., and Lentinula edodes are recognized as functional foods due to t …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Mushrooms as Nutritional Powerhouses: A Review of Their Bioactive Compounds, Health Benefits, and Value-Added Products.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 78

771.
Ganoderma Triterpenoids Exert Antiatherogenic Effects in Mice by Alleviating Disturbed Flow-Induced Oxidative Stress and Inflammation.
- Hsu PL, Lin YC, Ni H, Mo FE.
- Oxid Med Cell Longev. 2018 Apr 11;2018:3491703. doi: 10.1155/2018/3491703.
- PMCID: PMC5924996
Hsu PL, et al.

Oxid Med Cell Longev. 2018.

PMCID: PMC5924996

Ganoderma mushrooms, used in traditional Chinese medicine to promote health and longevity, have become widely accepted as herbal supplements. Ganoderma lucidum (GL), a commonly seen ganoderma species, is commercially cultivated under controlled conditi …

Ganoderma mushrooms, used in traditional Chinese medicine to promote health and longevity, have become widely accepted as herbal supp …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma Triterpenoids Exert Antiatherogenic Effects in Mice by Alleviating Disturbed Flow-Induced Oxidative Stress and Inflammation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
772.
The Protective Effect of Ganoderma lucidum Extract in Ultraviolet B-Induced Human Dermal Fibroblasts and Skin Equivalent Models.
- Lee SH, Lee ES, Bae IH, Kim SH, Park NH, Shim JS, Lee CS, Lee J.
- Ann Dermatol. 2020 Apr 24;32(3):251-254. doi: 10.5021/ad.2020.32.3.251.
- PMCID: PMC7992618
Lee SH, et al.

Ann Dermatol. 2020.

PMCID: PMC7992618
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The Protective Effect of Ganoderma lucidum Extract in Ultraviolet B-Induced Human Dermal Fibroblasts and Skin Equivalent Models.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
773.
Development of efficient strain of Ganoderma lucidum for biological stripping of cotton fabric dyed Reactive Blue 21.
- Latif Z, Shafique J, Summuna B, Lone B, Ur Rehman M, El-Sheikh MA, Hashim MJ, Vladulescu C, Shafique T.
- Saudi J Biol Sci. 2021 Sep 17;28(12):7550-7560. doi: 10.1016/j.sjbs.2021.09.038.
- PMCID: PMC8626342
Latif Z, et al.

Saudi J Biol Sci. 2021.

PMCID: PMC8626342

In this research work reactive blue 21 dye with 0.5, 2 and 4% shade strengths was used to dye cotton fabric. The Ganoderma lucidum fungal strains were mutated by UV mutagen, and five were selected for further processing. ...

In this research work reactive blue 21 dye with 0.5, 2 and 4% shade strengths was used to dye cotton fabric. The Ganoderma lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Development of efficient strain of Ganoderma lucidum for biological stripping of cotton fabric dyed Reactive Blue 21.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
774.
Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review.
- Jeitler M, Michalsen A, Frings D, Hübner M, Fischer M, Koppold-Liebscher DA, Murthy V, Kessler CS.
- Front Pharmacol. 2020 Nov 11;11:580656. doi: 10.3389/fphar.2020.580656.
- PMCID: PMC7794004
Jeitler M, et al.

Front Pharmacol. 2020.

PMCID: PMC7794004

The medicinal mushrooms investigated were Agaricus sylvaticus (two trials), Agaricus blazei murill (two trials), Antrodia cinnamomea (one trial), Coriolus versicolor (one trial) and Ganoderma lucidum (three trials); all were compared to placebo and administered oral …

The medicinal mushrooms investigated were Agaricus sylvaticus (two trials), Agaricus blazei murill (two trials), Antrodia cinnamomea (one tr …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
775.
Ultrasound-assisted extraction of neuroprotective antioxidants from Ganoderma lucidum.
- Cui J, Wang D, Liu Y, Zhang T, Liu Y, Cheng Y, Liu X.
- Ultrason Sonochem. 2025 Aug 25;121:107528. doi: 10.1016/j.ultsonch.2025.107528. Online ahead of print.
- PMCID: PMC12410444
Cui J, et al.

Ultrason Sonochem. 2025.

PMCID: PMC12410444

Ganoderma lucidum (GL), a traditional Chinese medicinal fungus, is rich in triterpenoids and phenols with antioxidant properties. ...

Ganoderma lucidum (GL), a traditional Chinese medicinal fungus, is rich in triterpenoids and phenols with antioxidant properti …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ultrasound-assisted extraction of neuroprotective antioxidants from Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
776.
Improvement of Saccharification and Delignification Efficiency of Trichoderma reesei Rut-C30 by Genetic Bioengineering.
- Gopalakrishnan RM, Manavalan T, Ramesh J, Thangavelu KP, Heese K.
- Microorganisms. 2020 Jan 23;8(2):159. doi: 10.3390/microorganisms8020159.
- PMCID: PMC7074786
Gopalakrishnan RM, et al.

Microorganisms. 2020.

PMCID: PMC7074786

In this study, we heterologously expressed the Ganoderma lucidum RMK1 versatile peroxidase gene (vp1) in the Rut-C30 strain of T. reesei. The expression of purified 6 His-tag-containing recombinant G. lucidum-derived protein (rVP1) was confirmed through weste …

In this study, we heterologously expressed the Ganoderma lucidum RMK1 versatile peroxidase gene (vp1) in the Rut-C30 strain of …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Improvement of Saccharification and Delignification Efficiency of Trichoderma reesei Rut-C30 by Genetic Bioengineering.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
777.
Ganoderic acid C2 exerts the pharmacological effects against cyclophosphamide-induced immunosuppression: a study involving molecular docking and experimental validation.
- Liu Y, Tan D, Cui H, Wang J.
- Sci Rep. 2023 Oct 18;13(1):17745. doi: 10.1038/s41598-023-44394-y.
- PMCID: PMC10584852
Liu Y, et al.

Sci Rep. 2023.

PMCID: PMC10584852

Triterpenoids, as the main active ingredient of Ganoderma lucidum fermented extract, exert multiple pharmacological activities, including immunomodulatory properties. ...Our findings lay a theoretical foundation for the in-depth development and utilization of Gan …

Triterpenoids, as the main active ingredient of Ganoderma lucidum fermented extract, exert multiple pharmacological activities …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderic acid C2 exerts the pharmacological effects against cyclophosphamide-induced immunosuppression: a study involving molecular docking and experimental validation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
778.
Ganoderan (GDN) Regulates The Growth, Motility And Apoptosis Of Non-Small Cell Lung Cancer Cells Through ERK Signaling Pathway In Vitro And In Vivo.
- Wang W, Gou X, Xue H, Liu K.
- Onco Targets Ther. 2019 Oct 25;12:8821-8832. doi: 10.2147/OTT.S221161.
- PMCID: PMC6821078
Wang W, et al.

Onco Targets Ther. 2019.

PMCID: PMC6821078

Ganoderan (GDN) is one of the components of Ganoderma lucidum polysaccharides. Ganoderan A (GDNA), Ganoderan B (GDNB) and Ganoderan C (GDNC) were three polysaccharides isolated from the Ganoderma lucidum fruiting body. ...

Ganoderan (GDN) is one of the components of Ganoderma lucidum polysaccharides. Ganoderan A (GDNA), Ganoderan B (GDNB) and Gano …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderan (GDN) Regulates The Growth, Motility And Apoptosis Of Non-Small Cell Lung Cancer Cells Through ERK Signaling Pathway In Vitro And In Vivo.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
779.
Nephroprotective Effects of Two Ganoderma Species Methanolic Extracts in an In Vitro Model of Cisplatin Induced Tubulotoxicity.
- Sinaeve S, Husson C, Antoine MH, Welti S, Stévigny C, Nortier J.
- J Fungi (Basel). 2022 Sep 24;8(10):1002. doi: 10.3390/jof8101002.
- PMCID: PMC9605180
Sinaeve S, et al.

J Fungi (Basel). 2022.

PMCID: PMC9605180

This study aims to identify new prophylactic properties with respect to medicinal mushrooms. Among five Ganoderma species, the methanolic extracts of Ganoderma tuberculosum Murill., Ganoderma parvigibbosum Welti & Courtec. (10 g/mL), and their association …

This study aims to identify new prophylactic properties with respect to medicinal mushrooms. Among five Ganoderma species, the methan …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Nephroprotective Effects of Two Ganoderma Species Methanolic Extracts in an In Vitro Model of Cisplatin Induced Tubulotoxicity.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
780.
Synthesis of Ganoderic Acids Loaded Zein-Chitosan Nanoparticles and Evaluation of Their Hepatoprotective Effect on Mice Given Excessive Alcohol.
- Cao Y, Yang Y, Liang Z, Guo W, Lv X, Ni L, Chen Y.
- Foods. 2024 Aug 29;13(17):2760. doi: 10.3390/foods13172760.
- PMCID: PMC11394847
Cao Y, et al.

Foods. 2024.

PMCID: PMC11394847

Ganoderma lucidum, used in East Asia for its health benefits, contains ganoderic acids (GA) which have various pharmacological activities but are limited by poor water solubility and low oral bioaccessibility. ...

Ganoderma lucidum, used in East Asia for its health benefits, contains ganoderic acids (GA) which have various pharmacological …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Synthesis of Ganoderic Acids Loaded Zein-Chitosan Nanoparticles and Evaluation of Their Hepatoprotective Effect on Mice Given Excessive Alcohol.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 79

781.
Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake.
- Guo WL, Cao YJ, You SZ, Wu Q, Zhang F, Han JZ, Lv XC, Rao PF, Ai LZ, Ni L.
- Curr Res Food Sci. 2022 Feb 24;5:515-530. doi: 10.1016/j.crfs.2022.02.013.
- PMCID: PMC8913248
Guo WL, et al.

Curr Res Food Sci. 2022.

PMCID: PMC8913248

Alcoholic liver injury is mainly caused by excessive alcohol consumption and has become a global public health problem threatening human health. It is well known that Ganoderma lucidum possesses various excellent beneficial effects on liver function and lipid metabo …

Alcoholic liver injury is mainly caused by excessive alcohol consumption and has become a global public health problem threatening human hea …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
782.
The reduction of aorta histopathological images through inhibition of reactive oxygen species formation in hypercholesterolemia rattus norvegicus treated with polysaccharide peptide of Ganoderma lucidum.
- Andri Wihastuti T, Sargowo D, Heriansyah T, Eka Aziza Y, Puspitarini D, Nur Iwana A, Astrida Evitasari L.
- Iran J Basic Med Sci. 2015 May;18(5):514-9.
- PMCID: PMC4475661
Andri Wihastuti T, et al.

Iran J Basic Med Sci. 2015.

PMCID: PMC4475661

One source of antioxidant, which has potential to be developed, is PsP from Ganoderma lucidum. This study aims to prove the effect of PsP in decreasing H2O2, PVAT, foam cells and atherosclerotic plaque. ...

One source of antioxidant, which has potential to be developed, is PsP from Ganoderma lucidum. This study aims to prove the ef …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The reduction of aorta histopathological images through inhibition of reactive oxygen species formation in hypercholesterolemia rattus norvegicus treated with polysaccharide peptide of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
783.
Mycelium-based biomaterials as smart devices for skin wound healing.
- Ruggeri M, Miele D, Contardi M, Vigani B, Boselli C, Icaro Cornaglia A, Rossi S, Suarato G, Athanassiou A, Sandri G.
- Front Bioeng Biotechnol. 2023 Aug 15;11:1225722. doi: 10.3389/fbioe.2023.1225722.
- PMCID: PMC10465301
Ruggeri M, et al.

Front Bioeng Biotechnol. 2023.

PMCID: PMC10465301

Introduction: Recently, mycelia of Ganoderma lucidum and Pleurotus ostreatus, edible fungi, have been characterized in vitro as self-growing biomaterials for tissue engineering since they are constituted of interconnected fibrous networks resembling the dermal colla …

Introduction: Recently, mycelia of Ganoderma lucidum and Pleurotus ostreatus, edible fungi, have been characterized in vitro a …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Mycelium-based biomaterials as smart devices for skin wound healing.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
784.
Ganoderma lucidum polysaccharide ameliorates cholesterol gallstone formation by modulating cholesterol and bile acid metabolism in an FXR-dependent manner.
- Huang D, Shen S, Zhuang Q, Ye X, Qian Y, Dong Z, Wan X.
- Chin Med. 2024 Jan 24;19(1):16. doi: 10.1186/s13020-024-00889-y.
- PMCID: PMC10809463
Huang D, et al.

Chin Med. 2024.

PMCID: PMC10809463

BACKGROUND: Cholesterol gallstone (CG) disease is a worldwide common disease characterized by cholesterol supersaturation in gallbladder bile. Ganoderma lucidum polysaccharide (GLP) has been shown to possess various beneficial effects against metabolic disorders. .. …

BACKGROUND: Cholesterol gallstone (CG) disease is a worldwide common disease characterized by cholesterol supersaturation in gallbladder bil …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum polysaccharide ameliorates cholesterol gallstone formation by modulating cholesterol and bile acid metabolism in an FXR-dependent manner.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
785.
Ganoderma applanatum mushroom provides new insights into the management of diabetes mellitus, hyperlipidemia, and hepatic degeneration: A comprehensive analysis.
- Hossain MS, Barua A, Tanim MAH, Hasan MS, Islam MJ, Hossain MR, Emon NU, Hossen SMM.
- Food Sci Nutr. 2021 Jun 24;9(8):4364-4374. doi: 10.1002/fsn3.2407.
- PMCID: PMC8358375
Hossain MS, et al.

Food Sci Nutr. 2021.

PMCID: PMC8358375

Besides, in silico screening of the compounds of Ganoderma applanatum has been incorporated thus to check the binding affinity of compounds and enzymes affinity. ...Nine days of oral feeding of MEGA and AEGA of Ganoderma applanatum resulted in a significant (p < …

Besides, in silico screening of the compounds of Ganoderma applanatum has been incorporated thus to check the binding affinity of com …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma applanatum mushroom provides new insights into the management of diabetes mellitus, hyperlipidemia, and hepatic degeneration: A comprehensive analysis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
786.
Anti-glycated and antiradical activities in vitro of polysaccharides from Ganoderma capense.
- Yan C, Kong F, Zhang D, Cui J.
- Pharmacogn Mag. 2013 Jan;9(33):23-7. doi: 10.4103/0973-1296.108132.
- PMCID: PMC3647389
Yan C, et al.

Pharmacogn Mag. 2013.

PMCID: PMC3647389

BACKGROUND: Ganoderma capense is a Ganoderma species and is widely used, especially in Asia, as a well-known medicinal mushroom for health-promoting effect and for treatment of chronic diseases, such as diabetes, aging, etc. ...

BACKGROUND: Ganoderma capense is a Ganoderma species and is widely used, especially in Asia, as a well-known medicinal mushroo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Anti-glycated and antiradical activities in vitro of polysaccharides from Ganoderma capense.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
787.
Ganoderma lucidum polysaccharide improves rat DSS-induced colitis by altering cecal microbiota and gene expression of colonic epithelial cells.
- Xie J, Liu Y, Chen B, Zhang G, Ou S, Luo J, Peng X.
- Food Nutr Res. 2019 Feb 12;63. doi: 10.29219/fnr.v63.1559.
- PMCID: PMC6387425
Xie J, et al.

Food Nutr Res. 2019.

PMCID: PMC6387425

As a result, it is still unclear whether there is an anti-colitis effect in Ganoderma lucidum polysaccharide (GLP), which is mainly composed of beta-glucan. Moreover, the association between GLP function and gut microbiota remains to be elucidated. ...

As a result, it is still unclear whether there is an anti-colitis effect in Ganoderma lucidum polysaccharide (GLP), which is m …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum polysaccharide improves rat DSS-induced colitis by altering cecal microbiota and gene expression of colonic epithelial cells.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
788.
Evaluation of the Use of Elicitors for the Production of Antioxidant Compounds in Liquid Cultures of Ganoderma curtisii from Costa Rica.
- Rosales-López C, Arce-Torres F, Monge-Artavia M, Rojas-Chaves M.
- Molecules. 2022 Jul 2;27(13):4265. doi: 10.3390/molecules27134265.
- PMCID: PMC9268739
Rosales-López C, et al.

Molecules. 2022.

PMCID: PMC9268739

In this research, the effects of different elicitors on the production of antioxidant secondary metabolites were evaluated in a strain of Ganoderma sp. The elicitors tested were pH changes in different growth phases of the fungus (pH 3, 5.5 and 8), different concentrations …

In this research, the effects of different elicitors on the production of antioxidant secondary metabolites were evaluated in a strain of …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Evaluation of the Use of Elicitors for the Production of Antioxidant Compounds in Liquid Cultures of Ganoderma curtisii from Costa Rica.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
789.
Inhibitory effects of Thai herbal extracts on the cytochrome P450 3A-mediated the metabolism of gefitinib, lapatinib and sorafenib.
- Rodseeda C, Yamanont P, Pinthong D, Korprasertthaworn P.
- Toxicol Rep. 2022 Oct 4;9:1846-1852. doi: 10.1016/j.toxrep.2022.10.004.
- PMCID: PMC9742957
Rodseeda C, et al.

Toxicol Rep. 2022.

PMCID: PMC9742957

The aim of this study was to determine the inhibitory effects of Andrographis paniculata, Curcuma zedoaria, Ganoderma lucidum, Murdannia loriformis and Ventilago denticulata extracts on the metabolism of gefitinib, lapatinib and sorafenib. ...Curcuma zedoaria extrac …

The aim of this study was to determine the inhibitory effects of Andrographis paniculata, Curcuma zedoaria, Ganoderma lucidum, …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Inhibitory effects of Thai herbal extracts on the cytochrome P450 3A-mediated the metabolism of gefitinib, lapatinib and sorafenib.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
790.
Growth Characteristics of Polyporales Mushrooms for the Mycelial Mat Formation.
- Bae B, Kim M, Kim S, Ro HS.
- Mycobiology. 2021 Apr 26;49(3):280-284. doi: 10.1080/12298093.2021.1911401.
- PMCID: PMC8259868
Bae B, et al.

Mycobiology. 2021.

PMCID: PMC8259868

Among the 64 strains of Polyporales, G. lucidum LBS5496GL was selected as the best candidate because it showed fast mycelial growth with high mycelial strength in both the sawdust-based solid medium and the potato dextrose liquid plate medium. ...The higher physical streng …

Among the 64 strains of Polyporales, G. lucidum LBS5496GL was selected as the best candidate because it showed fast mycelial growth w …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Growth Characteristics of Polyporales Mushrooms for the Mycelial Mat Formation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 80

791.
Effect and Mechanism of Ganoderma lucidum Spores on Alleviation of Diabetic Cardiomyopathy in a Pilot in vivo Study.
- Shaher F, Wang S, Qiu H, Hu Y, Zhang Y, Wang W, Al-Ward H, Abdulghani MAM, Baldi S, Zhou S.
- Diabetes Metab Syndr Obes. 2020 Dec 7;13:4809-4822. doi: 10.2147/DMSO.S281527.
- PMCID: PMC7736836
Shaher F, et al.

Diabetes Metab Syndr Obes. 2020.

PMCID: PMC7736836

BACKGROUND: Ganoderma lucidum spores (GLS) exhibit disease prevention properties, but no study has been carried out on the anti-diabetic cardiomyopathy property of GLS. ...

BACKGROUND: Ganoderma lucidum spores (GLS) exhibit disease prevention properties, but no study has been carried out on the ant …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effect and Mechanism of Ganoderma lucidum Spores on Alleviation of Diabetic Cardiomyopathy in a Pilot in vivo Study.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Participant-reported outcomes, clinical biomarkers, and safety/tolerability. Open article.
- Why might this paper be useful to readers? Provides early human data; interpret with caution and check study size and endpoints. Open article.
792.
Evaluation of cosmetic efficacy of lychee seed fermentation liquid.
- Yan Y, Fu H, Tang Y, Huang T, Zou X, Su N, Wang D, Wang C, Li M.
- Bioresour Bioprocess. 2024 Oct 31;11(1):104. doi: 10.1186/s40643-024-00818-9.
- PMCID: PMC11527852
Yan Y, et al.

Bioresour Bioprocess. 2024.

PMCID: PMC11527852

BACKGROUND: Lychee seeds were fermented by three kinds of bacteria (Lactobacillus plantarum, Saccharomyces cerevillus and ganoderma lucidum mycelium), and two effective strains were selected by two indexes of activity content and antioxidant, so as to further verify …

BACKGROUND: Lychee seeds were fermented by three kinds of bacteria (Lactobacillus plantarum, Saccharomyces cerevillus and ganoderma < …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Evaluation of cosmetic efficacy of lychee seed fermentation liquid.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
793.
Mixed Medicinal Mushroom Mycelia Attenuates Alzheimer's Disease Pathologies In Vitro and In Vivo.
- Jeong JH, Hong GL, Jeong YG, Lee NS, Kim DK, Park JY, Park M, Kim HM, Kim YE, Yoo YC, Han SY.
- Curr Issues Mol Biol. 2023 Aug 15;45(8):6775-6789. doi: 10.3390/cimb45080428.
- PMCID: PMC10453438
Jeong JH, et al.

Curr Issues Mol Biol. 2023.

PMCID: PMC10453438

Here, the aqueous extract of mixed medicinal mushroom mycelia (MMMM)-Phellinus linteus, Ganoderma lucidum, and Inonotus obliquus-cultivated on a barley medium was assessed for its anti-AD effects. ...

Here, the aqueous extract of mixed medicinal mushroom mycelia (MMMM)-Phellinus linteus, Ganoderma lucidum, and Inonotus obliqu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Mixed Medicinal Mushroom Mycelia Attenuates Alzheimer's Disease Pathologies In Vitro and In Vivo.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
794.
Erratum: Meroterpenoids From Ganoderma lucidum Mushrooms and Their Biological Roles in Insulin Resistance and Triple-Negative Breast Cancer.
- Frontiers Production Office.
- Front Chem. 2021 Dec 23;9:817898. doi: 10.3389/fchem.2021.817898.
- PMCID: PMC8753409
Frontiers Production Office.

Front Chem. 2021.

PMCID: PMC8753409
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Erratum: Meroterpenoids From Ganoderma lucidum Mushrooms and Their Biological Roles in Insulin Resistance and Triple-Negative Breast Cancer.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
795.
Ganoderma lucidum polysaccharide ameliorated diabetes mellitus-induced erectile dysfunction in rats by regulating fibrosis and the NOS/ERK/JNK pathway.
- Yao X, Yuan Y, Jing T, Ye S, Wang S, Xia D.
- Transl Androl Urol. 2022 Jul;11(7):982-995. doi: 10.21037/tau-22-428.
- PMCID: PMC9360518
Yao X, et al.

Transl Androl Urol. 2022.

PMCID: PMC9360518

This study aimed to explore the role and mechanism of Ganoderma lucidum polysaccharide (GLP) on DMED. METHODS: DMED was induced in the experimental rats [male 12-week-old Sprague-Dawley (SD) rats] by treatment with streptozotocin (60 mg/kg) and apomorphine (APO). .. …

This study aimed to explore the role and mechanism of Ganoderma lucidum polysaccharide (GLP) on DMED. METHODS: DMED was induce …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum polysaccharide ameliorated diabetes mellitus-induced erectile dysfunction in rats by regulating fibrosis and the NOS/ERK/JNK pathway.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
796.
Effect of Pd-Sensitization on Poisonous Chlorine Gas Detection Ability of TiO₂: Green Synthesis and Low-Temperature Operation.
- Ekar S, Nakate UT, Khollam YB, Shaikh SF, Mane RS, Rana AUHS, Palaniswami M.
- Sensors (Basel). 2022 May 31;22(11):4200. doi: 10.3390/s22114200.
- PMCID: PMC9185264
Ekar S, et al.

Sensors (Basel). 2022.

PMCID: PMC9185264

Ganoderma lucidum mushroom-mediated green synthesis of nanocrystalline titanium dioxide (TiO(2)) is explored via a low-temperature ( 70 C) wet chemical method. The role of Ganoderma lucidum mushroom extract in the reaction is to release the ganoderic a …

Ganoderma lucidum mushroom-mediated green synthesis of nanocrystalline titanium dioxide (TiO(2)) is explored via a low-tempera …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effect of Pd-Sensitization on Poisonous Chlorine Gas Detection Ability of TiO 2 : Green Synthesis and Low-Temperature Operation.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
797.
The Addition of Hot Water Extract of Juncao-Substrate Ganoderma lucidum Residue to Diets Enhances Growth Performance, Immune Function, and Intestinal Health in Broilers.
- Gao YY, Liu XP, Zhou YH, He JY, Di B, Zheng XY, Guo PT, Zhang J, Wang CK, Jin L.
- Animals (Basel). 2024 Oct 11;14(20):2926. doi: 10.3390/ani14202926.
- PMCID: PMC11503797
Gao YY, et al.

Animals (Basel). 2024.

PMCID: PMC11503797

The purpose of this experiment was to investigate the effects of Hot Water Extract of Juncao-substrate Ganoderma lucidum Residue (HWE-JGLR) on the immune function and intestinal health of yellow-feather broilers. ...

The purpose of this experiment was to investigate the effects of Hot Water Extract of Juncao-substrate Ganoderma lucidum Resid …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The Addition of Hot Water Extract of Juncao-Substrate Ganoderma lucidum Residue to Diets Enhances Growth Performance, Immune Function, and Intestinal Health in Broilers.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
798.
Preparation of Ganoderma Lucidum Bran-Based Biological Activated Carbon for Dual-Functional Adsorption and Detection of Copper Ions.
- Wang B, Lan J, Bo C, Gong B, Ou J.
- Materials (Basel). 2023 Jan 10;16(2):689. doi: 10.3390/ma16020689.
- PMCID: PMC9866797
Wang B, et al.

Materials (Basel). 2023.

PMCID: PMC9866797

In this paper, Ganoderma lucidum bran was explored as the precursor to fabricate biomass activated carbon. ...

In this paper, Ganoderma lucidum bran was explored as the precursor to fabricate biomass activated carbon. ...
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Preparation of Ganoderma Lucidum Bran-Based Biological Activated Carbon for Dual-Functional Adsorption and Detection of Copper Ions.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
799.
New Triterpenoid from Novel Triterpenoid 15-O-Glycosylation on Ganoderic Acid A by Intestinal Bacteria of Zebrafish.
- Chang TS, Chiang CM, Wang TY, Lee CH, Lee YW, Wu JY.
- Molecules. 2018 Sep 13;23(9):2345. doi: 10.3390/molecules23092345.
- PMCID: PMC6225395
Chang TS, et al.

Molecules. 2018.

PMCID: PMC6225395

Ganoderic acid A (GAA) is a major triterpenoid from the medicinal fungus Ganoderma lucidum. In studying the microbial biotransformation of GAA, dozens of intestinal bacteria were isolated from the excreta of zebrafish. ...The present study is the first to report the …

Ganoderic acid A (GAA) is a major triterpenoid from the medicinal fungus Ganoderma lucidum. In studying the microbial biotrans …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: New Triterpenoid from Novel Triterpenoid 15- O -Glycosylation on Ganoderic Acid A by Intestinal Bacteria of Zebrafish.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
800.
Widely Targeted Metabolomics Decodes Metabolic Remodeling and Functional Shifts in Ganoderma lucidum-Fermented Green Tea Infusion.
- Liu X, Ju Y, Wen S, Zeng H, Wang C, Jiang M, Tian B, Huang J, Liu Z.
- Foods. 2025 Aug 18;14(16):2855. doi: 10.3390/foods14162855.
- PMCID: PMC12385791
Liu X, et al.

Foods. 2025.

PMCID: PMC12385791

This study used a targeted metabolomics approach to examine changes in metabolites within green tea infusions fermented by G. lucidum (TFG) and evaluate the in vitro antioxidant and lipid-lowering properties of TFG. ...

This study used a targeted metabolomics approach to examine changes in metabolites within green tea infusions fermented by G. lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Widely Targeted Metabolomics Decodes Metabolic Remodeling and Functional Shifts in Ganoderma lucidum -Fermented Green Tea Infusion.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Broad molecular profiling and pathway/statistical analyses. Open article.
- Why might this paper be useful to readers? Maps pathways and components that can guide future lab and clinical research. Open article.

Page 81

801.
Ganoderma tsugae prevents cognitive impairment and attenuates oxidative damage in d-galactose-induced aging in the rat brain.
- Kuo HC, Tong SY, Chao MW, Tseng CY.
- PLoS One. 2022 Apr 7;17(4):e0266331. doi: 10.1371/journal.pone.0266331.
- PMCID: PMC8989198
Kuo HC, et al.

PLoS One. 2022.

PMCID: PMC8989198

The D-galactose (D-gal, 100 mg/kg/day)-induced aging Long-Evans rats were simultaneously orally administered a DMSO extract of Ganoderma tsugae (GTDE, 200 mug/kg/day) for 25 weeks to investigate the effects of GTDE on oxidative stress and memory deficits in the D-galactose …

The D-galactose (D-gal, 100 mg/kg/day)-induced aging Long-Evans rats were simultaneously orally administered a DMSO extract of Ganoderma< …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma tsugae prevents cognitive impairment and attenuates oxidative damage in d-galactose-induced aging in the rat brain.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
802.
Ganoderma lucidum extract, Lycopene, Sulforaphane, Royal Jelly and Resveratrol as a combination demonstrate antioxidant and anti-inflammatory effects in COVID-19.
- Emilija A, Marija P, Dragica Z, Kristina P, Katerina S, Kosta K, Dejan J.
- Free Radic Biol Med. 2022 Aug 11;189:29. doi: 10.1016/j.freeradbiomed.2022.06.129.
- PMCID: PMC9386034
Emilija A, et al.

Free Radic Biol Med. 2022.

PMCID: PMC9386034
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum extract, Lycopene, Sulforaphane, Royal Jelly and Resveratrol as a combination demonstrate antioxidant and anti-inflammatory effects in COVID-19.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
803.
Cytotoxic activity of Ganoderma weberianum-sichuanese isolated from the Lower Volta River Basin of Ghana against human prostate carcinoma (PC-3), leukemic T cell (Jurkat), and plasmacytoid dendritic cell (pDC)-derived acute leukemia (PMDC05) cell lines.
- Adotey G, Alolga RN, Quarcoo A, Gedel MA, Yerenkyi P, Otu P, Anang AK, Okine LKN, Gbewonyo WSK, Holliday JC, Lombardi VC.
- PLoS One. 2025 Jul 11;20(7):e0327087. doi: 10.1371/journal.pone.0327087.
- PMCID: PMC12250544
Adotey G, et al.

PLoS One. 2025.

PMCID: PMC12250544

Ganoderma is a genus of medically important fungus that contains at least 80 species, many of which have not been properly evaluated for their anticancer potential. This study was conducted to assess the cytotoxic activity of the mycelial biomass of Ganoderma weberi …

Ganoderma is a genus of medically important fungus that contains at least 80 species, many of which have not been properly evaluated …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Cytotoxic activity of Ganoderma weberianum-sichuanese isolated from the Lower Volta River Basin of Ghana against human prostate carcinoma (PC-3), leukemic T cell (Jurkat), and plasmacytoid dendritic cell (pDC)-derived acute leukemia (PMDC05) cell lines.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
804.
Ganoderma lucidum and Hypericum perforatum Exhibit Anti-Inflammatory, Antioxidant, and Anti-Androgen Effect in Rat Model of Experimental Polycystic Ovarian Syndrome.
- Okay G, Kırıcı P, Mavral N, Utkan Korun ZE, Annac E, Kaplan S.
- Med Princ Pract. 2024 Apr 10;33(4):1-7. doi: 10.1159/000538595. Online ahead of print.
- PMCID: PMC11324204
Okay G, et al.

Med Princ Pract. 2024.

PMCID: PMC11324204

OBJECTIVE: Chronic inflammation is considered to be of key importance in the pathogenesis of polycystic ovarian syndrome (PCOS). Ganoderma lucidum polysaccharide (GLP) and Hypericum perforatum (HP) have been reported to have anti-inflammatory and antioxidant activit …

OBJECTIVE: Chronic inflammation is considered to be of key importance in the pathogenesis of polycystic ovarian syndrome (PCOS). Ganoderm …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum and Hypericum perforatum Exhibit Anti-Inflammatory, Antioxidant, and Anti-Androgen Effect in Rat Model of Experimental Polycystic Ovarian Syndrome.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
805.
A review of botany, phytochemistry, pharmacology, and applications of the herb with the homology of medicine and food: Ligustrum lucidum W.T. Aiton.
- Chen L, Huang D, Jiang L, Yang J, Shi X, Wang R, Li W.
- Front Pharmacol. 2024 Jun 12;15:1330732. doi: 10.3389/fphar.2024.1330732.
- PMCID: PMC11199554
Chen L, et al.

Front Pharmacol. 2024.

PMCID: PMC11199554

Ligustrum lucidum W.T. Aiton is rich in nutritional components and a variety of bioactive ingredients. ...Ligustrum lucidum W.T. Aiton has rich plant resources. However, the application potential of it has not been fully exploited. ...

Ligustrum lucidum W.T. Aiton is rich in nutritional components and a variety of bioactive ingredients. ...Ligustrum lucidum W. …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A review of botany, phytochemistry, pharmacology, and applications of the herb with the homology of medicine and food: Ligustrum lucidum W.T. Aiton.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
806.
Ganoderma pfeifferi Bres. and Ganoderma resinaceum Boud. as Potential Therapeutic Agents: A Comparative Study on Antiproliferative and Lipid-Lowering Properties.
- Rašeta M, Kebert M, Mišković J, Kostić S, Kaišarević S, Stilinović N, Vukmirović S, Karaman M.
- J Fungi (Basel). 2024 Jul 19;10(7):501. doi: 10.3390/jof10070501.
- PMCID: PMC11277669
Rašeta M, et al.

J Fungi (Basel). 2024.

PMCID: PMC11277669

Medicinal mushrooms, especially Ganoderma species, hold immense promise for the production of a wide range of bioactive compounds with various effects. ...Further research and dietary assessments could help determine the full potential and applications of the two underexpl …

Medicinal mushrooms, especially Ganoderma species, hold immense promise for the production of a wide range of bioactive compounds wit …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma pfeifferi Bres. and Ganoderma resinaceum Boud. as Potential Therapeutic Agents: A Comparative Study on Antiproliferative and Lipid-Lowering Properties.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
807.
Protective effects of Ganoderma lucidum spores on estradiol benzoate-induced TEC apoptosis and compromised double-positive thymocyte development.
- Yang J, Pan H, Wang M, Li A, Zhang G, Fan X, Li Z.
- Front Pharmacol. 2024 Aug 16;15:1419881. doi: 10.3389/fphar.2024.1419881.
- PMCID: PMC11361955
Yang J, et al.

Front Pharmacol. 2024.

PMCID: PMC11361955

Numerous clinical and preclinical investigations have underscored the regulatory role of Ganoderma lucidum spores (GLS) in T cell development. However, the precise mechanisms underlying this regulation remain elusive. ...

Numerous clinical and preclinical investigations have underscored the regulatory role of Ganoderma lucidum spores (GLS) in T c …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Protective effects of Ganoderma lucidum spores on estradiol benzoate-induced TEC apoptosis and compromised double-positive thymocyte development.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
808.
Ganoderma formosanum polysaccharides attenuate Th2 inflammation and airway hyperresponsiveness in a murine model of allergic asthma.
- Pi CC, Wang HY, Lu CY, Lu FL, Chen CJ.
- Springerplus. 2014 Jun 12;3:297. doi: 10.1186/2193-1801-3-297.
- PMCID: PMC4072879
Pi CC, et al.

Springerplus. 2014.

PMCID: PMC4072879

Allergic asthma is an inflammatory disease of the airways mediated by Th2 immune responses and characterized by airway hyperresponsiveness (AHR). Fungi of the genus Ganoderma are basidiomycetes that have been used in traditional Asian medicine for centuries. We recently fo …

Allergic asthma is an inflammatory disease of the airways mediated by Th2 immune responses and characterized by airway hyperresponsiveness ( …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma formosanum polysaccharides attenuate Th2 inflammation and airway hyperresponsiveness in a murine model of allergic asthma.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
809.
Correction: Generation and Analysis of the Expressed Sequence Tags from the Mycelium of Ganoderma lucidum.
- Huang YH, Wu HY, Wu KM, Liu TT, Liou RF, Tsai SF, Shiao MS, Ho LT, Tzean SS, Yang UC.
- PLoS One. 2013 Sep 9;8(9):10.1371/annotation/d3ee6fb1-5239-4a09-b197-379d22f27163. doi: 10.1371/annotation/d3ee6fb1-5239-4a09-b197-379d22f27163.
- PMCID: PMC3776884
Huang YH, et al.

PLoS One. 2013.

PMCID: PMC3776884
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Correction: Generation and Analysis of the Expressed Sequence Tags from the Mycelium of Ganoderma lucidum .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
810.
Correction: Anti-Epileptic Effect of Ganoderma Lucidum Polysaccharides by Inhibition of Intracellular Calcium Accumulation and Stimulation of Expression of CaMKII alpha in Epileptic Hippocampal Neurons.
- The PLOS ONE Staff.
- PLoS One. 2014 Oct 10;9(10):e111295. doi: 10.1371/journal.pone.0111295.
- PMCID: PMC4193866
The PLOS ONE Staff.

PLoS One. 2014.

PMCID: PMC4193866
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Correction: Anti-Epileptic Effect of Ganoderma Lucidum Polysaccharides by Inhibition of Intracellular Calcium Accumulation and Stimulation of Expression of CaMKII alpha in Epileptic Hippocampal Neurons.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.

Page 82

811.
Oral Presentation Award Winner: Polysaccharide Peptide of Ganoderma lucidum Reduces Endothelial Injury in Stable Angina and High-risk Patients.
- Susilowati E, Sargowo D, Ovianti N.
- Eur Cardiol. 2021 Dec 14;16:e59. doi: 10.15420/ecr.2021.16.PO3.
- PMCID: PMC8785058
Susilowati E, et al.

Eur Cardiol. 2021.

PMCID: PMC8785058
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Oral Presentation Award Winner: Polysaccharide Peptide of Ganoderma lucidum Reduces Endothelial Injury in Stable Angina and High-risk Patients.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
812.
Erratum: Triterpenoids from Ganoderma lucidum inhibit cytochrome P450 enzymes interfering with the metabolic process of specific clinical drugs.
- Frontiers Production Office.
- Front Pharmacol. 2024 Dec 19;15:1539089. doi: 10.3389/fphar.2024.1539089.
- PMCID: PMC11693988
Frontiers Production Office.

Front Pharmacol. 2024.

PMCID: PMC11693988
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Erratum: Triterpenoids from Ganoderma lucidum inhibit cytochrome P450 enzymes interfering with the metabolic process of specific clinical drugs.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
813.
Optimization of mycelial growth and cultivation of wild Ganoderma sinense.
- Nguyen LT, Van Le V, Nguyen BTT, Nguyen HTT, Tran AD, Ngo NX.
- BioTechnologia (Pozn). 2023 Mar 27;104(1):65-74. doi: 10.5114/bta.2023.125087.
- PMCID: PMC10091450
Nguyen LT, et al.

BioTechnologia (Pozn). 2023.

PMCID: PMC10091450

Ganoderma sinense, a well-known medicinal macrofungus of Basidiomycetes, is widely used in traditional medicine for promoting health and longevity in East Asia. ...

Ganoderma sinense, a well-known medicinal macrofungus of Basidiomycetes, is widely used in traditional medicine for promoting health …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Optimization of mycelial growth and cultivation of wild Ganoderma sinense.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Extraction/process optimization. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Yield comparisons, parameter optimization, and scalability considerations. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
814.
Corrigendum: Anti-breast Cancer Enhancement of a Polysaccharide From Spore of Ganoderma lucidum With Paclitaxel: Suppression on Tumor Metabolism With Gut Microbiota Reshaping.
- Su J, Li D, Chen Q, Li M, Su L, Luo T, Liang D, Lai G, Shuai O, Jiao C, Wu Q, Xie Y, Zhou X.
- Front Microbiol. 2019 May 31;10:1224. doi: 10.3389/fmicb.2019.01224.
- PMCID: PMC6555303
Su J, et al.

Front Microbiol. 2019.

PMCID: PMC6555303
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Corrigendum: Anti-breast Cancer Enhancement of a Polysaccharide From Spore of Ganoderma lucidum With Paclitaxel: Suppression on Tumor Metabolism With Gut Microbiota Reshaping.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
815.
The comparative protective effects of ganoderma spores lipid and fish oil on N-methyl-N-nitrosourea-induced photoreceptor cell lesion in rats.
- Yang G, Xin-Guo D, Na L, Guang-Wei L, Chung PC.
- Evid Based Complement Alternat Med. 2011 May 18;2011:903261. doi: 10.1155/2011/903261.
- PMCID: PMC3108162
Yang G, et al.

Evid Based Complement Alternat Med. 2011.

PMCID: PMC3108162

Purpose. To compare Ganoderma spores lipid (GSL) and fish oil (FO) in inhibiting retinal photoreceptor cell lesions induced by N-methyl-N-nitrosourea (MNU) in rats. ...

Purpose. To compare Ganoderma spores lipid (GSL) and fish oil (FO) in inhibiting retinal photoreceptor cell lesions induced by N-meth …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The comparative protective effects of ganoderma spores lipid and fish oil on N-methyl-N-nitrosourea-induced photoreceptor cell lesion in rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
816.
Protective Effects of Amauroderma rugosum on Doxorubicin-Induced Cardiotoxicity through Suppressing Oxidative Stress, Mitochondrial Dysfunction, Apoptosis, and Activating Akt/mTOR and Nrf2/HO-1 Signaling Pathways.
- Li J, Cheng Y, Li R, Wu X, Zheng C, Shiu PH, Chan JC, Rangsinth P, Liu C, Leung SW, Lee SM, Zhang C, Fu C, Zhang J, Cheung TM, Leung GP.
- Oxid Med Cell Longev. 2022 Jun 1;2022:9266178. doi: 10.1155/2022/9266178.
- PMCID: PMC9177334
- Retraction in: Oxid Med Cell Longev. 2023 Dec 29;2023:9861059. doi: 10.1155/2023/9861059. PubMed Abstract
Li J, et al.

Oxid Med Cell Longev. 2022.

PMCID: PMC9177334

Retracted.

Natural products provide abundant resources to search for novel cardioprotective agents. Ganoderma lucidum (GL) is the most well-known edible mushroom within the Ganodermataceae family. ...

Natural products provide abundant resources to search for novel cardioprotective agents. Ganoderma lucidum (GL) is the most we …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Protective Effects of Amauroderma rugosum on Doxorubicin-Induced Cardiotoxicity through Suppressing Oxidative Stress, Mitochondrial Dysfunction, Apoptosis, and Activating Akt/mTOR and Nrf2/HO-1 Signaling Pathways.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
817.
The bHLH-zip transcription factor SREBP regulates triterpenoid and lipid metabolisms in the medicinal fungus Ganoderma lingzhi.
- Liu YN, Wu FY, Tian RY, Shi YX, Xu ZQ, Liu JY, Huang J, Xue FF, Liu BY, Liu GQ.
- Commun Biol. 2023 Jan 3;6(1):1. doi: 10.1038/s42003-022-04154-6.
- PMCID: PMC9810662
Liu YN, et al.

Commun Biol. 2023.

PMCID: PMC9810662

Ganoderic acids (GAs) are well recognized as important pharmacological components of the medicinal species belonging to the basidiomycete genus Ganoderma. However, transcription factors directly regulating the expression of GA biosynthesis genes remain poorly understood. H …

Ganoderic acids (GAs) are well recognized as important pharmacological components of the medicinal species belonging to the basidiomycete ge …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The bHLH-zip transcription factor SREBP regulates triterpenoid and lipid metabolisms in the medicinal fungus Ganoderma lingzhi.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
818.
Ganoderma lucidum bran-derived blue-emissive and green-emissive carbon dots for detection of copper ions.
- Wang B, Lan J, Ou J, Bo C, Gong B.
- RSC Adv. 2023 May 12;13(21):14506-14516. doi: 10.1039/d3ra02168h.
- PMCID: PMC10176043
Wang B, et al.

RSC Adv. 2023.

PMCID: PMC10176043

Ganoderma lucidum bran (GB) has a broad application prospect in the preparation of activated carbon, livestock feed, and biogas, but the preparation of carbon dots (CDs) from GB has never been reported. ...

Ganoderma lucidum bran (GB) has a broad application prospect in the preparation of activated carbon, livestock feed, and bioga …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma lucidum bran-derived blue-emissive and green-emissive carbon dots for detection of copper ions.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
819.
A Ganoderma-Derived Compound Exerts Inhibitory Effect Through Formyl Peptide Receptor 2.
- Wang H, Peng X, Ge Y, Zhang S, Wang Z, Fan Y, Huang W, Qiu M, Ye RD.
- Front Pharmacol. 2020 Mar 24;11:337. doi: 10.3389/fphar.2020.00337.
- PMCID: PMC7105723
Wang H, et al.

Front Pharmacol. 2020.

PMCID: PMC7105723

In order to search for potentially novel anti-inflammatory agents, we examined Ganoderma (Lingzhi), a Chinese medicinal herbs known for its anti-inflammatory effects, and found that compound 18 (C18) derived from Ganoderma cochlear could limit the inflammatory respo …

In order to search for potentially novel anti-inflammatory agents, we examined Ganoderma (Lingzhi), a Chinese medicinal herbs known f …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A Ganoderma -Derived Compound Exerts Inhibitory Effect Through Formyl Peptide Receptor 2.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
820.
Insoluble Dietary Fibers From By-Products of Edible Fungi Industry: Basic Structure, Physicochemical Properties, and Their Effects on Energy Intake.
- Tian B, Pan Y, Wang J, Cai M, Ye B, Yang K, Sun P.
- Front Nutr. 2022 Mar 10;9:851228. doi: 10.3389/fnut.2022.851228.
- PMCID: PMC8961438
Tian B, et al.

Front Nutr. 2022.

PMCID: PMC8961438

Among them, Hericium erinaceus is the softest without obvious granular texture, following Lentinus edodes, while Ganoderma lucidum and Grifola frondosa have a relatively hard texture. The yield of four kinds of IDF from high to low came from Ganoderma luci …

Among them, Hericium erinaceus is the softest without obvious granular texture, following Lentinus edodes, while Ganoderma lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Insoluble Dietary Fibers From By-Products of Edible Fungi Industry: Basic Structure, Physicochemical Properties, and Their Effects on Energy Intake.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 83

821.
Safety assessment of the fungal immunomodulatory protein from Ganoderma microsporum (GMI) derived from engineered Pichia pastoris: Genetic toxicology, a 13-week oral gavage toxicity study, and an embryo-fetal developmental toxicity study in Sprague-Dawley rats.
- Fu HY, Hseu RS.
- Toxicol Rep. 2022 May 26;9:1240-1254. doi: 10.1016/j.toxrep.2022.05.013.
- PMCID: PMC9742912
Fu HY, et al.

Toxicol Rep. 2022.

PMCID: PMC9742912

The 12.4 kDa fungal immunomodulatory protein from Ganoderma microsporum (GMI) has bioactivity in vitro and in vivo. This study assessed the safety of GMI derived from engineered Pichia pastoris in Sprague-Dawley rats as a dietary supplement and food ingredient by evaluatin …

The 12.4 kDa fungal immunomodulatory protein from Ganoderma microsporum (GMI) has bioactivity in vitro and in vivo. This study assess …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Safety assessment of the fungal immunomodulatory protein from Ganoderma microsporum (GMI) derived from engineered Pichia pastoris: Genetic toxicology, a 13-week oral gavage toxicity study, and an embryo-fetal developmental toxicity study in Sprague-Dawley rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
822.
202 Functional Properties of Ganoderma Lucidum (GL) Supplementation in Canine Nutrition.
- Kayser E, Osorio LMGM, de Godoy MRC.
- J Anim Sci. 2023 Nov 6;101(Suppl 3):107. doi: 10.1093/jas/skad281.130.
- PMCID: PMC10632978
Kayser E, et al.

J Anim Sci. 2023.

PMCID: PMC10632978

Ganoderma lucidum (GL) is a mushroom that has been widely used in Asia for its immunomodulatory and anti-inflammatory capacity. ...

Ganoderma lucidum (GL) is a mushroom that has been widely used in Asia for its immunomodulatory and anti-inflammatory capacity …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: 202 Functional Properties of Ganoderma Lucidum (GL) Supplementation in Canine Nutrition.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
823.
Insight into plant cell wall degradation and pathogenesis of Ganoderma boninense via comparative genome analysis.
- Ramzi AB, Che Me ML, Ruslan US, Baharum SN, Nor Muhammad NA.
- PeerJ. 2019 Dec 18;7:e8065. doi: 10.7717/peerj.8065.
- PMCID: PMC6927665
Ramzi AB, et al.

PeerJ. 2019.

PMCID: PMC6927665

Comparison of CAZymes from G. boninense NJ3 was made against G. lucidum, a well-studied model Ganoderma sp. and five selected pathogenic fungi for CAZymes characterization. ...RESULTS: G. boninense was enriched with CAZymes and CWDEs in a similar fashion to G. lu …

Comparison of CAZymes from G. boninense NJ3 was made against G. lucidum, a well-studied model Ganoderma sp. and five selected …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Insight into plant cell wall degradation and pathogenesis of Ganoderma boninense via comparative genome analysis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
824.
Natural Compounds and Health Benefits of Ganoderma capense.
- Liu L, Shi X, Jia L, Wang R, Liu C.
- Molecules. 2025 May 21;30(10):2250. doi: 10.3390/molecules30102250.
- PMCID: PMC12114035
Liu L, et al.

Molecules. 2025.

PMCID: PMC12114035

Ganoderma capense, a member of the Ganoderma genus within the Polyporaceae family, has long been recognized for its high nutritional value and extensive use in traditional medicine. ...

Ganoderma capense, a member of the Ganoderma genus within the Polyporaceae family, has long been recognized for its high nutri …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Natural Compounds and Health Benefits of Ganoderma capense.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
825.
[20(22)E]-Lanostane Triterpenes from the Fungus Ganoderma australe.
- Zhou L, Guo LL, Isaka M, Li ZH, Chen HP.
- J Fungi (Basel). 2022 May 12;8(5):503. doi: 10.3390/jof8050503.
- PMCID: PMC9145439
Zhou L, et al.

J Fungi (Basel). 2022.

PMCID: PMC9145439

Twelve new lanostane triterpenoids (1-5, 7-13) were isolated from the fruiting bodies of the fungus Ganoderma australe. The structures of the new compounds were elucidated by extensive 1D and 2D NMR, and HRESIMS spectroscopic analysis. All the triterpenes are featured by 2 …

Twelve new lanostane triterpenoids (1-5, 7-13) were isolated from the fruiting bodies of the fungus Ganoderma australe. The structure …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: [20(22)E]-Lanostane Triterpenes from the Fungus Ganoderma australe.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
826.
Historical and current perspectives on therapeutic potential of higher basidiomycetes: an overview.
- Varghese R, Dalvi YB, Lamrood PY, Shinde BP, Nair CKK.
- 3 Biotech. 2019 Sep 17;9(10):362. doi: 10.1007/s13205-019-1886-2.
- PMCID: PMC6749005
Varghese R, et al.

3 Biotech. 2019.

PMCID: PMC6749005

The present review provides historical importance as well as an updated information on pharmacologically relevant higher basidiomycetes belong to the genus Agaricus, Auricularia, Phellinus, Ganoderma, Pleurotus, Trametes and Lentinus and their biologically active secondary …

The present review provides historical importance as well as an updated information on pharmacologically relevant higher basidiomycetes belo …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Historical and current perspectives on therapeutic potential of higher basidiomycetes: an overview.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
827.
A New Species of Ganoderma (Ganodermataceae, Polyporales) from Southern China and Optimum Condition for Mycelia Production.
- Wei QL, Zheng HF, Shao YY, Rasheed U, Lin JT, Huang FC, Liu B.
- Mycobiology. 2024 Feb 21;52(1):58-67. doi: 10.1080/12298093.2024.2306012.
- PMCID: PMC10896125
Wei QL, et al.

Mycobiology. 2024.

PMCID: PMC10896125

The present study sought to propose Ganoderma guixiense sp. nov. as a new species based on phenotypic and genotypic evidence. ...

The present study sought to propose Ganoderma guixiense sp. nov. as a new species based on phenotypic and genotypic evidence. ...
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: A New Species of Ganoderma (Ganodermataceae, Polyporales) from Southern China and Optimum Condition for Mycelia Production.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
828.
Degradation of three aromatic dyes by white rot fungi and the production of ligninolytic enzymes.
- Jayasinghe C, Imtiaj A, Lee GW, Im KH, Hur H, Lee MW, Yang HS, Lee TS.
- Mycobiology. 2008 Jun 30;36(2):114-20. doi: 10.4489/MYCO.2008.36.2.114.
- PMCID: PMC3755234
Jayasinghe C, et al.

Mycobiology. 2008.

PMCID: PMC3755234

The results of this study revealed that Pycnoporus cinnabarinus, Pleurotus pulmonarius, Ganoderma lucidum, Trametes suaveolens, Stereum ostrea and Fomes fomentarius have the ability to efficiently degrade congo red on solid media. ...In addition, P. cinnabarinus, G. …

The results of this study revealed that Pycnoporus cinnabarinus, Pleurotus pulmonarius, Ganoderma lucidum, Trametes suaveolens …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Degradation of three aromatic dyes by white rot fungi and the production of ligninolytic enzymes.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
829.
Use of Zebrafish Embryo Assay to Evaluate Toxicity and Safety of Bioreactor-Grown Exopolysaccharides and Endopolysaccharides from European Ganoderma applanatum Mycelium for Future Aquaculture Applications.
- Wan-Mohtar WAAQI, Ilham Z, Jamaludin AA, Rowan N.
- Int J Mol Sci. 2021 Feb 7;22(4):1675. doi: 10.3390/ijms22041675.
- PMCID: PMC7914815
Wan-Mohtar WAAQI, et al.

Int J Mol Sci. 2021.

PMCID: PMC7914815

Natural mycelial exopolysaccharide (EPS) and endopolysaccharide (ENS) extracted from bioreactor-cultivated European Ganoderma applanatum mushrooms are of potential high commercial value for both food and adjacent biopharmaceutical industries. ...

Natural mycelial exopolysaccharide (EPS) and endopolysaccharide (ENS) extracted from bioreactor-cultivated European Ganoderma applana …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Use of Zebrafish Embryo Assay to Evaluate Toxicity and Safety of Bioreactor-Grown Exopolysaccharides and Endopolysaccharides from European Ganoderma applanatum Mycelium for Future Aquaculture Applications.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
830.
113 Immunological Effects of Ganoderma Lucidum Supplementation in Canine Nutrition.
- Kayser E, He F, Gomez LM, de Godoy MR.
- J Anim Sci. 2022 Sep 21;100(Suppl 3):53. doi: 10.1093/jas/skac247.103.
- PMCID: PMC9493504
Kayser E, et al.

J Anim Sci. 2022.

PMCID: PMC9493504

Ganoderma lucidum (GL) is a mushroom that has been widely used in Asia for its immunomodulatory, anti-inflammatory and anti-tumor capacity in humans. ...

Ganoderma lucidum (GL) is a mushroom that has been widely used in Asia for its immunomodulatory, anti-inflammatory and anti-tu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: 113 Immunological Effects of Ganoderma Lucidum Supplementation in Canine Nutrition.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 84

831.
Two Laminaria japonica Fermentation Broths Alleviate Oxidative Stress and Inflammatory Response Caused by UVB Damage: Photoprotective and Reparative Effects.
- Sun Q, Fang J, Wang Z, Song Z, Geng J, Wang D, Wang C, Li M.
- Mar Drugs. 2022 Oct 20;20(10):650. doi: 10.3390/md20100650.
- PMCID: PMC9605345
Sun Q, et al.

Mar Drugs. 2022.

PMCID: PMC9605345

We establish a UVB-induced damage model of human immortalized epidermal keratinocytes (HaCaT) to explore the protective and reparative effects of Laminaria japonica on UVB-damaged epidermal inflammation after fermentation by white Ganoderma lucidum (Curtis) P. Karst …

We establish a UVB-induced damage model of human immortalized epidermal keratinocytes (HaCaT) to explore the protective and reparative effec …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Two Laminaria japonica Fermentation Broths Alleviate Oxidative Stress and Inflammatory Response Caused by UVB Damage: Photoprotective and Reparative Effects.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
832.
Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design.
- Zhu Q, Bang TH, Ohnuki K, Sawai T, Sawai K, Shimizu K.
- Sci Rep. 2015 Aug 26;5:13194. doi: 10.1038/srep13194.
- PMCID: PMC4549708
Zhu Q, et al.

Sci Rep. 2015.

PMCID: PMC4549708

Thirty-one triterpenoids from the medicinal mushroom Ganoderma lingzhi were analyzed in an in vitro NA inhibition assay, leading to the discovery of ganoderic acid T-Q and TR as two inhibitors of H5N1 and H1N1 NAs. ...

Thirty-one triterpenoids from the medicinal mushroom Ganoderma lingzhi were analyzed in an in vitro NA inhibition assay, leading to t …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
833.
Green synthesis and antimicrobial activity of silver nanoparticles using wild medicinal mushroom Ganoderma applanatum (Pers.) Pat. from Similipal Biosphere Reserve, Odisha, India.
- Mohanta YK, Singdevsachan SK, Parida UK, Panda SK, Mohanta TK, Bae H.
- IET Nanobiotechnol. 2016 Aug;10(4):184-9. doi: 10.1049/iet-nbt.2015.0059.
- PMCID: PMC8675986
Mohanta YK, et al.

IET Nanobiotechnol. 2016.

PMCID: PMC8675986

In the present study, green synthesis and cost effective approach of silver nanoparticles using wild medicinal mushroom Ganoderma applanatum (Pers.) Pat. from Similipal Biosphere Reserve, Odisha, India is reported. ...

In the present study, green synthesis and cost effective approach of silver nanoparticles using wild medicinal mushroom Ganoderma app …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Green synthesis and antimicrobial activity of silver nanoparticles using wild medicinal mushroom Ganoderma applanatum (Pers.) Pat. from Similipal Biosphere Reserve, Odisha, India.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
834.
Effects of Ganoderma lucidum Powder on the Growth Performance, Immune Organ Weights, Cecal Microbiology, Serum Immunoglobulins, and Tibia Minerals of Broiler Chickens.
- Avain A, Azad MAK, García Y, García Y, Martínez Y.
- Vet Sci. 2024 Dec 22;11(12):675. doi: 10.3390/vetsci11120675.
- PMCID: PMC11680373
Avain A, et al.

Vet Sci. 2024.

PMCID: PMC11680373

The treatments consisted of a basal diet (control group), basal diet + 0.02% zinc bacitracin (AGP group), basal diet + 0.2% G. lucidum powder (GLP; 0.2% GLP group), and basal diet + 0.3% GLP (0.3% GLP group). The results showed that dietary 0.2% GLP supplementation increas …

The treatments consisted of a basal diet (control group), basal diet + 0.02% zinc bacitracin (AGP group), basal diet + 0.2% G. lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Effects of Ganoderma lucidum Powder on the Growth Performance, Immune Organ Weights, Cecal Microbiology, Serum Immunoglobulins, and Tibia Minerals of Broiler Chickens.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
835.
Ganoderic acid T improves the radiosensitivity of HeLa cells via converting apoptosis to necroptosis.
- Shao CS, Feng N, Zhou S, Zheng XX, Wang P, Zhang JS, Huang Q.
- Toxicol Res (Camb). 2021 May 13;10(3):531-541. doi: 10.1093/toxres/tfab030.
- PMCID: PMC8201584
Shao CS, et al.

Toxicol Res (Camb). 2021.

PMCID: PMC8201584

The use of natural substances derived from traditional Chinese medicine and natural plants as safe radiosensitizing adjuvants is a new trend for cancer radiotherapy. Ganoderma lucidum has been used as a traditional Chinese medicine with a history of more than 2000 y …

The use of natural substances derived from traditional Chinese medicine and natural plants as safe radiosensitizing adjuvants is a new trend …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderic acid T improves the radiosensitivity of HeLa cells via converting apoptosis to necroptosis.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
836.
Corrigendum: Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota.
- Chang CJ, Lin CS, Lu CC, Martel J, Ko YF, Ojcius DM, Tseng SF, Wu TR, Chen YM, Young JD, Lai HC.
- Nat Commun. 2017 Jul 11;8:16130. doi: 10.1038/ncomms16130.
- PMCID: PMC5508223
Chang CJ, et al.

Nat Commun. 2017.

PMCID: PMC5508223
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Corrigendum: Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
837.
Correction: Exploring the anti-cancer potential of Ganoderma Lucidum polysaccharides (GLPs) and their versatile role in enhancing drug delivery systems: a multifaceted approach to combat cancer.
- Gao X, Homayoonfal M.
- Cancer Cell Int. 2024 May 22;24(1):178. doi: 10.1186/s12935-024-03284-7.
- PMCID: PMC11112831
Gao X, et al.

Cancer Cell Int. 2024.

PMCID: PMC11112831
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Correction: Exploring the anti-cancer potential of Ganoderma Lucidum polysaccharides (GLPs) and their versatile role in enhancing drug delivery systems: a multifaceted approach to combat cancer.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
838.
Antidyslipidemic Potential of Water-Soluble Polysaccharides of Ganoderma applanatum in MACAPOS-2-Induced Obese Rats.
- Mfopa A, Mediesse FK, Mvongo C, Nkoubatchoundjwen S, Lum AA, Sobngwi E, Kamgang R, Boudjeko T.
- Evid Based Complement Alternat Med. 2021 Aug 18;2021:2452057. doi: 10.1155/2021/2452057.
- PMCID: PMC8390130
Mfopa A, et al.

Evid Based Complement Alternat Med. 2021.

PMCID: PMC8390130

Increased consumption of high-calorie foods leads to obesity usually associated with metabolic disorders including diabetes, hyperglycemia, and dyslipidemia. Ganoderma applanatum is a nonedible mushroom traditionally used in West Cameroon for the treatment of many diseases …

Increased consumption of high-calorie foods leads to obesity usually associated with metabolic disorders including diabetes, hyperglycemia, …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Antidyslipidemic Potential of Water-Soluble Polysaccharides of Ganoderma applanatum in MACAPOS-2-Induced Obese Rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
839.
Dietary Factors and Supplements Influencing Prostate Specific-Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials.
- Grammatikopoulou MG, Gkiouras K, Papageorgiou SΤ, Myrogiannis I, Mykoniatis I, Papamitsou T, Bogdanos DP, Goulis DG.
- Nutrients. 2020 Sep 29;12(10):2985. doi: 10.3390/nu12102985.
- PMCID: PMC7600271
Grammatikopoulou MG, et al.

Nutrients. 2020.

PMCID: PMC7600271

Several antioxidants, including lycopene, selenium, curcumin, coenzyme Q10, phytoestrogens (including isoflavones and flavonoids), green tea catechins, cernitin, vitamins (C, E, D) and multivitamins, medicinal mushrooms (Ganoderma lucidum), fruit extracts (saw palme …

Several antioxidants, including lycopene, selenium, curcumin, coenzyme Q10, phytoestrogens (including isoflavones and flavonoids), green tea …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Dietary Factors and Supplements Influencing Prostate Specific-Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Human clinical study (trial/pilot). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Provides early human data; interpret with caution and check study size and endpoints. Open article.
840.
Erratum: Polysaccharide Peptide (PsP) Ganoderma lucidum: A Potential Inducer For Vascular Repair In Type 2 Diabetes Mellitus Model [Corrigendum].
- [No authors listed]
- Vasc Health Risk Manag. 2019 Nov 5;15:517. doi: 10.2147/VHRM.S234754.
- PMCID: PMC6842898
[No authors listed]

Vasc Health Risk Manag. 2019.

PMCID: PMC6842898
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Erratum: Polysaccharide Peptide (PsP) Ganoderma lucidum : A Potential Inducer For Vascular Repair In Type 2 Diabetes Mellitus Model [Corrigendum].. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.

Page 85

841.
Features of the Formation of Sensitive Films Based on Mycelium of Higher Fungi for Surface and Plate Acoustic Waves Gas Sensors.
- Smirnov A, Anisimkin V, Krasnopolskaya L, Guliy O, Sinev I, Simakov V, Golyshkin A, Almyasheva N, Ageykin N, Kuznetsova I.
- Sensors (Basel). 2023 Feb 16;23(4):2216. doi: 10.3390/s23042216.
- PMCID: PMC9962002
Smirnov A, et al.

Sensors (Basel). 2023.

PMCID: PMC9962002

Two types of films based on mycelium of higher fungus Ganoderma lucidum (Curtis) P. Karst (G. lucidum) prepared by various methods were used as sensitive coatings. These films were based on G. lucidum mycelium ethanolic (48% v/v) homogenizate (MEGl) an …

Two types of films based on mycelium of higher fungus Ganoderma lucidum (Curtis) P. Karst (G. lucidum) prepared by vari …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Features of the Formation of Sensitive Films Based on Mycelium of Higher Fungi for Surface and Plate Acoustic Waves Gas Sensors.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
842.
Anticancer, antithrombotic, antityrosinase, and anti-α-glucosidase activities of selected wild and commercial mushrooms from Pakistan.
- Sharif S, Atta A, Huma T, Shah AA, Afzal G, Rashid S, Shahid M, Mustafa G.
- Food Sci Nutr. 2018 Sep 14;6(8):2170-2176. doi: 10.1002/fsn3.781.
- PMCID: PMC6261167
Sharif S, et al.

Food Sci Nutr. 2018.

PMCID: PMC6261167

They have also gained interest due to their medicinal properties, economic importance, and organoleptic merit. In this study, wild Ganoderma lucidum and four commercial mushrooms, that is, Pleurotus ostreatus, Volvariella volvacea, Hericium erinaceus, and Lentinus e …

They have also gained interest due to their medicinal properties, economic importance, and organoleptic merit. In this study, wild Ganode …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Anticancer, antithrombotic, antityrosinase, and anti-α-glucosidase activities of selected wild and commercial mushrooms from Pakistan.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
843.
Two-stage cultivation strategies for optimal production of Ganoderma pellets with potential application in the vegan food industry.
- Bibi S, Wang ZL, Lin C, Min SH, Cheng CY.
- J Food Sci Technol. 2023 Mar 17;60(6):1793-1802. doi: 10.1007/s13197-023-05719-x.
- PMCID: PMC10169959
Bibi S, et al.

J Food Sci Technol. 2023.

PMCID: PMC10169959

The vegan food industry is gaining popularity nowadays. Ganoderma sp. is mainly used in the health and food industries as a medicinal, edible mushroom with high nutritional potential. ...

The vegan food industry is gaining popularity nowadays. Ganoderma sp. is mainly used in the health and food industries as a medicinal …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Two-stage cultivation strategies for optimal production of Ganoderma pellets with potential application in the vegan food industry.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
844.
Two novel lanostane triterpenoids from Ganoderma sinense.
- Qiao Y, Zhang XM, Qiu MH.
- Molecules. 2007 Aug 23;12(8):2038-46. doi: 10.3390/12082038.
- PMCID: PMC6149161
Qiao Y, et al.

Molecules. 2007.

PMCID: PMC6149161
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Two novel lanostane triterpenoids from Ganoderma sinense.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
845.
Neuronal health - can culinary and medicinal mushrooms help?
- Sabaratnam V, Kah-Hui W, Naidu M, Rosie David P.
- J Tradit Complement Med. 2013 Jan;3(1):62-8. doi: 10.4103/2225-4110.106549.
- PMCID: PMC3924982
Sabaratnam V, et al.

J Tradit Complement Med. 2013.

PMCID: PMC3924982

Hericium erinaceus a culinary and medicinal mushroom is a well established candidate for brain and nerve health. Ganoderma lucidum, Grifola frondosa and Sarcodon scabrosus have been reported to have neurite outgrowth and neuronal health benefits. ...In the on-going …

Hericium erinaceus a culinary and medicinal mushroom is a well established candidate for brain and nerve health. Ganoderma lucidum …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Neuronal health - can culinary and medicinal mushrooms help?. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
846.
Ganoderma tsugae hepatoprotection against exhaustive exercise-induced liver injury in rats.
- Huang CC, Huang WC, Yang SC, Chan CC, Lin WT.
- Molecules. 2013 Jan 29;18(2):1741-54. doi: 10.3390/molecules18021741.
- PMCID: PMC6270576
Huang CC, et al.

Molecules. 2013.

PMCID: PMC6270576

Several studies have been shown that accelerated apoptosis is involved in post-exercise lymphocytopenia and tissue damage after high-intensity exercise. Ganoderma tsugae (GT) is one of the well-known medicinal mushrooms that possess various pharmacological functions. ...

Several studies have been shown that accelerated apoptosis is involved in post-exercise lymphocytopenia and tissue damage after high-intensi …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderma tsugae hepatoprotection against exhaustive exercise-induced liver injury in rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
847.
In silico Approach for Anti-Thrombosis Drug Discovery: P2Y₁R Structure-Based TCMs Screening.
- Yi F, Sun L, Xu LJ, Peng Y, Liu HB, He CN, Xiao PG.
- Front Pharmacol. 2017 Jan 9;7:531. doi: 10.3389/fphar.2016.00531.
- PMCID: PMC5220089
Yi F, et al.

Front Pharmacol. 2017.

PMCID: PMC5220089

These computational results suggested that licorice (Glycyrrhiza uralensis Fisch), cimicifugae (Cimicifuga foetida L.), and ganoderma (Ganoderma lucidum Karst) and their chemical constituents, which have not previously been widely used for anti-thrombosis, ma …

These computational results suggested that licorice (Glycyrrhiza uralensis Fisch), cimicifugae (Cimicifuga foetida L.), and ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: In silico Approach for Anti-Thrombosis Drug Discovery: P2Y 1 R Structure-Based TCMs Screening.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
848.
Investigating the cellular antioxidant and anti-inflammatory effects of the novel peptides in lingzhi mushrooms.
- Aursuwanna T, Noitang S, Sangtanoo P, Srimongkol P, Saisavoey T, Puthong S, Reamtong O, Karnchanatat A.
- Heliyon. 2022 Oct 13;8(10):e11067. doi: 10.1016/j.heliyon.2022.e11067.
- PMCID: PMC9593296
Aursuwanna T, et al.

Heliyon. 2022.

PMCID: PMC9593296

The lingzhi mushroom (Ganoderma lucidum) is well known for its medicinal properties and has long played a role in traditional oriental medicine due to its health-giving benefits and potential to extend life expectancy. ...

The lingzhi mushroom (Ganoderma lucidum) is well known for its medicinal properties and has long played a role in traditional …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Investigating the cellular antioxidant and anti-inflammatory effects of the novel peptides in lingzhi mushrooms.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
849.
Mycomedicine: A Unique Class of Natural Products with Potent Anti-tumour Bioactivities.
- Dai R, Liu M, Nik Nabil WN, Xi Z, Xu H.
- Molecules. 2021 Feb 19;26(4):1113. doi: 10.3390/molecules26041113.
- PMCID: PMC7923288
Dai R, et al.

Molecules. 2021.

PMCID: PMC7923288

As medicinal fungi and fungal metabolites can induce apoptosis or autophagy, enhance the immune response, and reduce metastatic potential, several types of mushrooms, such as Ganoderma lucidum and Grifola frondosa, have been extensively investigated, and anti-cancer …

As medicinal fungi and fungal metabolites can induce apoptosis or autophagy, enhance the immune response, and reduce metastatic potential, s …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Mycomedicine: A Unique Class of Natural Products with Potent Anti-tumour Bioactivities.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
850.
Enzymatic extract containing lignin peroxidase immobilized on carbon nanotubes: Potential biocatalyst in dye decolourization.
- Oliveira SF, da Luz JMR, Kasuya MCM, Ladeira LO, Correa Junior A.
- Saudi J Biol Sci. 2016 Mar 10;25(4):651-659. doi: 10.1016/j.sjbs.2016.02.018.
- PMCID: PMC5936880
Oliveira SF, et al.

Saudi J Biol Sci. 2016.

PMCID: PMC5936880

Two fungi isolates, Pleurotus ostreatus (PLO9) and Ganoderma lucidum (GRM117), produced the enzymatic extract by fermentation in the lignocellulosic residue, Jatropha curcas seed cake. ...

Two fungi isolates, Pleurotus ostreatus (PLO9) and Ganoderma lucidum (GRM117), produced the enzymatic extract by fermentation …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Enzymatic extract containing lignin peroxidase immobilized on carbon nanotubes: Potential biocatalyst in dye decolourization.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Relevant for eco‑friendly processing, waste upcycling, and industrial biocatalysis. Open article.

Page 86

851.
Characterization and fungicide sensitivity of Trichoderma species causing green mold of Ganoderma sichuanense in China.
- Li X, Sossah FL, Tuo Y, Hu J, Wei Q, Li S, Rong N, Wiafe-Kwagyan M, Li C, Zhang B, Li X, Li Y.
- Front Microbiol. 2023 Oct 19;14:1264699. doi: 10.3389/fmicb.2023.1264699.
- PMCID: PMC10620716
Li X, et al.

Front Microbiol. 2023.

PMCID: PMC10620716
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Characterization and fungicide sensitivity of Trichoderma species causing green mold of Ganoderma sichuanense in China.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
852.
Screening of tropical wood-rotting mushrooms for copper biosorption.
- Muraleedharan TR, Iyengar L, Venkobachar C.
- Appl Environ Microbiol. 1995 Sep;61(9):3507-8. doi: 10.1128/aem.61.9.3507-3508.1995.
- PMCID: PMC1388590
Muraleedharan TR, et al.

Appl Environ Microbiol. 1995.

PMCID: PMC1388590

Wide variation in Q(infmax) was observed among the species and ranged from 0.048 to 0.383 mmol per g of sorbent. The uptake capacity of Ganoderma lucidum, which exhibited the highest Q(infmax), was higher than those of other microbial biosorbents reported in the lit …

Wide variation in Q(infmax) was observed among the species and ranged from 0.048 to 0.383 mmol per g of sorbent. The uptake capacity of G …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Screening of tropical wood-rotting mushrooms for copper biosorption.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
853.
Enzymatic formation of compound-K from ginsenoside Rb1 by enzyme preparation from cultured mycelia of Armillaria mellea.
- Upadhyaya J, Kim MJ, Kim YH, Ko SR, Park HW, Kim MK.
- J Ginseng Res. 2015 Jun 4;40(2):105-12. doi: 10.1016/j.jgr.2015.05.007.
- PMCID: PMC4845050
Upadhyaya J, et al.

J Ginseng Res. 2015.

PMCID: PMC4845050

METHODS: Mycelia of Armillaria mellea, Ganoderma lucidum, Phellinus linteus, Elfvingia applanata, and Pleurotus ostreatus were cultivated in liquid media at 25 C for 2 wk. ...RESULTS: Among the mushrooms used in this study, the enzyme preparation from cultured mycel …

METHODS: Mycelia of Armillaria mellea, Ganoderma lucidum, Phellinus linteus, Elfvingia applanata, and Pleurotus ostreatus were …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Enzymatic formation of compound-K from ginsenoside Rb1 by enzyme preparation from cultured mycelia of Armillaria mellea.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
854.
Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma.
- Wang WJ, Wu YS, Chen S, Liu CF, Chen SN.
- Biomed Res Int. 2015 Jun 17;2015:604385. doi: 10.1155/2015/604385.
- PMCID: PMC4488085
Wang WJ, et al.

Biomed Res Int. 2015.

PMCID: PMC4488085

The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-gamma mRNA expression but significantly reduced COX-2 mRNA expression within the lung. For LLC tumor model, oral Ganoderma lucidum or Antrodia camphorata polysaccharides tr …

The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-gamma mRNA expression but significantly reduce …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
855.
Corrigendum to "Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake" [Curr. Res. Food Sci. 5(2022) 515-530].
- Guo WL, Cao YJ, You SZ, Wu Q, Zhang F, Han JZ, Lv XC, Rao PF, Ai LZ, Ni L.
- Curr Res Food Sci. 2022 Jul 14;5:1108-1109. doi: 10.1016/j.crfs.2022.07.001.
- PMCID: PMC9294490
Guo WL, et al.

Curr Res Food Sci. 2022.

PMCID: PMC9294490
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Corrigendum to "Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake" [Curr. Res. Food Sci. 5(2022) 515-530].. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
856.
Fungal Based Biopolymer Composites for Construction Materials.
- Răut I, Călin M, Vuluga Z, Oancea F, Paceagiu J, Radu N, Doni M, Alexandrescu E, Purcar V, Gurban AM, Petre I, Jecu L.
- Materials (Basel). 2021 May 28;14(11):2906. doi: 10.3390/ma14112906.
- PMCID: PMC8198279
Răut I, et al.

Materials (Basel). 2021.

PMCID: PMC8198279

Fungal based biopolymer composite was obtained after cultivation of Ganoderma lucidum macromycetes on a mixture including wheat straws and polypropylene embedded with spores from Bacillus amyloliquefaciens. ...

Fungal based biopolymer composite was obtained after cultivation of Ganoderma lucidum macromycetes on a mixture including whea …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Fungal Based Biopolymer Composites for Construction Materials.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
857.
Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.
- Ko KM, Leung HY.
- Chin Med. 2007 Mar 27;2:3. doi: 10.1186/1749-8546-2-3.
- PMCID: PMC1847515
Ko KM, et al.

Chin Med. 2007.

PMCID: PMC1847515

Chinese tonifying herbs such as herba cistanche, ganoderma and cordyceps, which possess antioxidant and/or immunomodulatory activities, can be useful in the prevention and treatment of age-related diseases. ...

Chinese tonifying herbs such as herba cistanche, ganoderma and cordyceps, which possess antioxidant and/or immunomodulatory activitie …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
858.
Comprehensive analysis of codon bias in 13 Ganoderma mitochondrial genomes.
- Wu P, Xiao W, Luo Y, Xiong Z, Chen X, He J, Sha A, Gui M, Li Q.
- Front Microbiol. 2023 May 4;14:1170790. doi: 10.3389/fmicb.2023.1170790.
- PMCID: PMC10192751
Wu P, et al.

Front Microbiol. 2023.

PMCID: PMC10192751

However, the specific attributes of codon usage in the mitochondrial genome of Ganoderma species remain unknown. METHODS: In this study, we investigated the codon bias of 12 mitochondrial core protein-coding genes (PCGs) in 9 Ganoderma species, including 13 Ganod …

However, the specific attributes of codon usage in the mitochondrial genome of Ganoderma species remain unknown. METHODS: In this stu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Comprehensive analysis of codon bias in 13 Ganoderma mitochondrial genomes.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
859.
Two cases of incidental Podostroma cornu-damae poisoning.
- Kim HN, Do HH, Seo JS, Kim HY.
- Clin Exp Emerg Med. 2016 Sep 30;3(3):186-189. doi: 10.15441/ceem.15.028.
- PMCID: PMC5065333
Kim HN, et al.

Clin Exp Emerg Med. 2016.

PMCID: PMC5065333

However, it can be easily mistaken for antler Ganoderma lucidum. In this case report, two patients made tea with the fungus and drank it over a 2-week period. ...

However, it can be easily mistaken for antler Ganoderma lucidum. In this case report, two patients made tea with the fungus an …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Two cases of incidental Podostroma cornu-damae poisoning.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
860.
Structure elucidation and immunomodulatory activity of a beta glucan from the fruiting bodies of Ganoderma sinense.
- Han XQ, Yue GL, Yue RQ, Dong CX, Chan CL, Ko CH, Cheung WS, Luo KW, Dai H, Wong CK, Leung PC, Han QB.
- PLoS One. 2014 Jul 11;9(7):e100380. doi: 10.1371/journal.pone.0100380.
- PMCID: PMC4094382
Han XQ, et al.

PLoS One. 2014.

PMCID: PMC4094382

A polysaccharide named GSP-2 with a molecular size of 32 kDa was isolated from the fruiting bodies of Ganoderma sinense. Its structure was well elucidated, by a combined utilization of chemical and spectroscopic techniques, to be a beta-glucan with a backbone of (1 4)- and …

A polysaccharide named GSP-2 with a molecular size of 32 kDa was isolated from the fruiting bodies of Ganoderma sinense. Its structur …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Structure elucidation and immunomodulatory activity of a beta glucan from the fruiting bodies of Ganoderma sinense.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 87

861.
Iron biofortification and availability in the mycelial biomass of edible and medicinal basidiomycetes cultivated in sugarcane molasses.
- Scheid SS, Faria MGI, Velasquez LG, do Valle JS, Gonçalves AC Jr, Dragunski DC, Colauto NB, Linde GA.
- Sci Rep. 2020 Jul 30;10(1):12875. doi: 10.1038/s41598-020-69699-0.
- PMCID: PMC7393360
Scheid SS, et al.

Sci Rep. 2020.

PMCID: PMC7393360

This study aimed to evaluate the in vitro iron bioaccumulation and availability in the mycelial biomass of edible and medicinal basidiomycetes grown in two distinct culture media. Lentinus crinitus, Ganoderma lucidum, Schizophyllum commune, Pleurotus ostreatus, Pleu …

This study aimed to evaluate the in vitro iron bioaccumulation and availability in the mycelial biomass of edible and medicinal basidiomycet …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Iron biofortification and availability in the mycelial biomass of edible and medicinal basidiomycetes cultivated in sugarcane molasses.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
862.
Enzymatic Glycosylation of Ganoderma Terpenoid via Bacterial Glycosyltransferases and Glycoside Hydrolases.
- Chang TS, Wu JY, Ding HY, Wang TY.
- Biomolecules. 2025 May 1;15(5):655. doi: 10.3390/biom15050655.
- PMCID: PMC12109177
Chang TS, et al.

Biomolecules. 2025.

PMCID: PMC12109177

This review explored the role of two primary enzyme classes-glycosyltransferases (GTs) and glycoside hydrolases (GHs, glycosidases)-in catalyzing the glycosylation of natural products, with a specific focus on Ganoderma triterpenoids. While GTs typically use activated suga …

This review explored the role of two primary enzyme classes-glycosyltransferases (GTs) and glycoside hydrolases (GHs, glycosidases)-in catal …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Enzymatic Glycosylation of Ganoderma Terpenoid via Bacterial Glycosyltransferases and Glycoside Hydrolases.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
863.
GSP-2, a polysaccharide extracted from Ganoderma sinense, is a novel toll-like receptor 4 agonist.
- Liu KS, Zhang C, Dong HL, Li KK, Han QB, Wan Y, Chen R, Yang F, Li HL, Ko CH, Han XQ.
- PLoS One. 2019 Aug 23;14(8):e0221636. doi: 10.1371/journal.pone.0221636.
- PMCID: PMC6707555
Liu KS, et al.

PLoS One. 2019.

PMCID: PMC6707555

Ganoderma sinense is a Chinese unique medicinal fungus that has been used in folk medicine for thousands of years. ...Previously we found that GSP-2, a new polysaccharide isolated from Ganoderma sinense, exerts an immunomodulatory effect in human peripheral blood mo …

Ganoderma sinense is a Chinese unique medicinal fungus that has been used in folk medicine for thousands of years. ...Previously we f …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: GSP-2, a polysaccharide extracted from Ganoderma sinense, is a novel toll-like receptor 4 agonist.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
864.
Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine.
- Lee KH, Morris-Natschke SL, Yang X, Huang R, Zhou T, Wu SF, Shi Q, Itokawa H.
- J Tradit Complement Med. 2012 Apr;2(2):84-95.
- PMCID: PMC3942920
Lee KH, et al.

J Tradit Complement Med. 2012.

PMCID: PMC3942920

This article will review selected herbal products used in traditional Chinese medicine, including medicinal mushrooms ( ba xi mo gu; Agaricus blazei, yun zhi; Coriolus versicolor, ling zhi; Ganoderma lucidum, xiang xun; shiitake, Lentinus edodes, niu zhang zhi; Taiw …

This article will review selected herbal products used in traditional Chinese medicine, including medicinal mushrooms ( ba xi mo gu; Agaricu …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
865.
Potato freeze-thaw solution enhances immune function and antitumor activity in vivo.
- Xu G, Shen J, Sun P, Niu Y, Zhao P, Tang P, Zhang J, Fei C, Bu L, Yue Z, Liu H, Wang Z, Yang L, Sun D.
- Oncol Lett. 2017 Sep 15;14(5):6129-6134. doi: 10.3892/ol.2017.6970.
- PMCID: PMC5661393
Xu G, et al.

Oncol Lett. 2017.

PMCID: PMC5661393

While mice injected with cyclophosphamide exhibited decreased counts of peripheral WBCs, treatment of the cyclophosphamide-injected mice with PFTS for 10 days significantly increased the number of peripheral WBCs and reversed WBC counts to the normal level, a comparable effect to …

While mice injected with cyclophosphamide exhibited decreased counts of peripheral WBCs, treatment of the cyclophosphamide-injected mice wit …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Potato freeze-thaw solution enhances immune function and antitumor activity in vivo .. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
866.
Optimized Synthesis of Small and Stable Silver Nanoparticles Using Intracellular and Extracellular Components of Fungi: An Alternative for Bacterial Inhibition.
- Murillo-Rábago EI, Vilchis-Nestor AR, Juarez-Moreno K, Garcia-Marin LE, Quester K, Castro-Longoria E.
- Antibiotics (Basel). 2022 Jun 14;11(6):800. doi: 10.3390/antibiotics11060800.
- PMCID: PMC9220004
Murillo-Rábago EI, et al.

Antibiotics (Basel). 2022.

PMCID: PMC9220004

In this work, we report optimized protocols for the production of AgNPs using extracts and supernatants of Trichoderma harzianum and Ganoderma sessile. AgNPs were characterized using UV-Vis spectroscopy and transmission electron microscopy, and the hydrodynamic diameter an …

In this work, we report optimized protocols for the production of AgNPs using extracts and supernatants of Trichoderma harzianum and Gano …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Optimized Synthesis of Small and Stable Silver Nanoparticles Using Intracellular and Extracellular Components of Fungi: An Alternative for Bacterial Inhibition.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
867.
Colon targeting in rats, dogs and IBD patients with species-independent film coatings.
- Ferraro F, Sonnleitner LM, Neut C, Mahieux S, Verin J, Siepmann J, Siepmann F.
- Int J Pharm X. 2024 Feb 8;7:100233. doi: 10.1016/j.ijpx.2024.100233.
- PMCID: PMC10876578
Ferraro F, et al.

Int J Pharm X. 2024.

PMCID: PMC10876578

Interestingly, extracts from aloe vera and reishi (a mushroom) showed a promising potential for colon targeting in all species....

Interestingly, extracts from aloe vera and reishi (a mushroom) showed a promising potential for colon targeting in all species....
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Colon targeting in rats, dogs and IBD patients with species-independent film coatings.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
868.
Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.
- Huang YL, Pai FS, Tsou YT, Mon HC, Hsu TL, Wu CY, Chou TY, Yang WB, Chen CH, Wong CH, Hsieh SL.
- J Biol Chem. 2015 Jul 13;290(35):21252-63. doi: 10.1074/jbc.M115.649814.
- PMCID: PMC4571857
Huang YL, et al.

J Biol Chem. 2015.

PMCID: PMC4571857

Moreover, CLEC18 bind polysaccharide in Ca(2+)-independent manner, and amino acid residues Ser/Arg(339) and Asp/Asn(421) in CTLD domain contribute to their differential binding abilities to polysaccharides isolated from Ganoderma lucidum (GLPS-F3). The Ser(339) (CLE …

Moreover, CLEC18 bind polysaccharide in Ca(2+)-independent manner, and amino acid residues Ser/Arg(339) and Asp/Asn(421) in CTLD domain cont …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
869.
The Sophora flavescens flavonoid compound trifolirhizin inhibits acetylcholine induced airway smooth muscle contraction.
- Yang N, Liang B, Srivastava K, Zeng J, Zhan J, Brown L, Sampson H, Goldfarb J, Emala C, Li XM.
- Phytochemistry. Author manuscript. 2013 Aug 27;95:259-267. doi: 10.1016/j.phytochem.2013.07.023.
- PMCID: PMC4118489
Yang N, et al.

Phytochemistry. Author manuscript. 2013.

PMCID: PMC4118489

ASHMI (Anti-asthma Herbal Medicine Intervention) is an aqueous extract of Ganoderma lucidum (Fr.) P. Karst (Ling Zhi), Sophora flavescens Aiton (Ku Shen) and Glycyrrhiza uralensis Fisch. ex DC (Gan Cao). ...It was found that S. flavescens, but not G. lucidum …

ASHMI (Anti-asthma Herbal Medicine Intervention) is an aqueous extract of Ganoderma lucidum (Fr.) P. Karst (Ling Zhi), Sophora …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: The Sophora flavescens flavonoid compound trifolirhizin inhibits acetylcholine induced airway smooth muscle contraction.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
870.
Natural Polysaccharides and Their Derivates: A Promising Natural Adjuvant for Tumor Immunotherapy.
- Li Y, Wang X, Ma X, Liu C, Wu J, Sun C.
- Front Pharmacol. 2021 Apr 14;12:621813. doi: 10.3389/fphar.2021.621813.
- PMCID: PMC8080043
Li Y, et al.

Front Pharmacol. 2021.

PMCID: PMC8080043

For a long time in the past, polysaccharides such as lentinan and Ganoderma lucidum glycopeptide have been used in clinic as adjuvant drugs to widely improve the immunity of the body. ...

For a long time in the past, polysaccharides such as lentinan and Ganoderma lucidum glycopeptide have been used in clinic as a …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Natural Polysaccharides and Their Derivates: A Promising Natural Adjuvant for Tumor Immunotherapy.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.

Page 88

871.
Phosphatidic acid directly activates mTOR and then regulates SREBP to promote ganoderic acid biosynthesis under heat stress in Ganoderma lingzhi.
- Liu YN, Chen YL, Zhang ZJ, Wu FY, Wang HJ, Wang XL, Liu GQ.
- Commun Biol. 2024 Nov 13;7(1):1503. doi: 10.1038/s42003-024-07225-y.
- PMCID: PMC11560937
Liu YN, et al.

Commun Biol. 2024.

PMCID: PMC11560937

Ganoderic acids (GAs), a class of secondary metabolites produced by the traditional medicinal mushroom Ganoderma, are a group of triterpenoids with superior biological activities. Heat stress (HS) is one of the most important environmental abiotic stresses. ...

Ganoderic acids (GAs), a class of secondary metabolites produced by the traditional medicinal mushroom Ganoderma, are a group of trit …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Phosphatidic acid directly activates mTOR and then regulates SREBP to promote ganoderic acid biosynthesis under heat stress in Ganoderma lingzhi.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
872.
Green synthesis of silver nanoparticles using Ganoderma neo-japonicum Imazeki: a potential cytotoxic agent against breast cancer cells.
- Gurunathan S, Raman J, Abd Malek SN, John PA, Vikineswary S.
- Int J Nanomedicine. 2013 Nov 15;8:4399-413. doi: 10.2147/IJN.S51881.
- PMCID: PMC3833323
Gurunathan S, et al.

Int J Nanomedicine. 2013.

PMCID: PMC3833323

The aim of our study was to determine the cytotoxic effects of biologically synthesized AgNPs using hot aqueous extracts of the mycelia of Ganoderma neo-japonicum Imazeki on MDA-MB-231 human breast cancer cells. METHODS: We developed a green method for the synthesis of wat …

The aim of our study was to determine the cytotoxic effects of biologically synthesized AgNPs using hot aqueous extracts of the mycelia of < …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Green synthesis of silver nanoparticles using Ganoderma neo-japonicum Imazeki: a potential cytotoxic agent against breast cancer cells.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Cell-based (in vitro) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Cell viability, signaling/gene expression, and functional assays. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
873.
Application progress of CRISPR/Cas9 genome-editing technology in edible fungi.
- Zhang Y, Chen S, Yang L, Zhang Q.
- Front Microbiol. 2023 May 25;14:1169884. doi: 10.3389/fmicb.2023.1169884.
- PMCID: PMC10248459
Zhang Y, et al.

Front Microbiol. 2023.

PMCID: PMC10248459

In this review, we briefly summarized the working mechanism of the CRISPR/Cas9 system and highlighted the application progress of CRISPR/Cas9-mediated genome-editing technology in edible fungi, including Agaricus bisporus, Ganoderma lucidum, Flammulina filiformis, U …

In this review, we briefly summarized the working mechanism of the CRISPR/Cas9 system and highlighted the application progress of CRISPR/Cas …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Application progress of CRISPR/Cas9 genome-editing technology in edible fungi.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Omics/profiling or bioinformatics study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
874.
Microwave-Assisted Biogenic Synthesis of Metal-Decorated Reduced Graphene Oxide and their Electrochemical Properties.
- Gannavarapu KP, Azizighannad S, Muthukumar V S, Mitra S, Dandamudi RB.
- ChemistrySelect. Author manuscript. 2018 Dec 17;3(47):13438-13441. doi: 10.1002/slct.201803420.
- PMCID: PMC6370324
Gannavarapu KP, et al.

ChemistrySelect. Author manuscript. 2018.

PMCID: PMC6370324

Herein we report a microwave assisted, fungal (Ganoderma lucidum) extract mediated synthesis of noble metal decorated reduced graphene oxide(r-GO). ...

Herein we report a microwave assisted, fungal (Ganoderma lucidum) extract mediated synthesis of noble metal decorated reduced …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Microwave-Assisted Biogenic Synthesis of Metal-Decorated Reduced Graphene Oxide and their Electrochemical Properties.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
875.
Plant polysaccharides influence tumor development based on epigenetics: a review.
- Li C, Hu Y, Yang H.
- Front Pharmacol. 2025 May 6;16:1588857. doi: 10.3389/fphar.2025.1588857.
- PMCID: PMC12089089
Li C, et al.

Front Pharmacol. 2025.

PMCID: PMC12089089

This review integrates evidences from multi-database (PubMed, Web of Science and CNKI, 2010-2025) to elucidate three core epigenetic mechanisms of plant polysaccharides (e.g., Astragalus and Ganoderma lucidum): 1) TET2-mediated DNA demethylation; 2) inhibition of hi …

This review integrates evidences from multi-database (PubMed, Web of Science and CNKI, 2010-2025) to elucidate three core epigenetic mechani …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Plant polysaccharides influence tumor development based on epigenetics: a review.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Review or meta-analysis. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
876.
LC/MS analysis of mushrooms provided new insights into dietary management of diabetes mellitus in rats.
- Hussein A, Ghonimy A, Jiang H, Qin G, El-Ashram S, Hussein S, Abd El-Razek I, El-Afifi T, Farouk MH.
- Food Sci Nutr. 2023 Jan 27;11(5):2321-2335. doi: 10.1002/fsn3.3236.
- PMCID: PMC10171545
Hussein A, et al.

Food Sci Nutr. 2023.

PMCID: PMC10171545

The effects of five different mushroom species (Ganoderma lucidum, GLM; Pleurotus ostreatus, POM; Pleurotus citrinopileatus, PCM; Lentinus edodes, LEM; or Hypsizigus marmoreus, HMM) on alloxan-induced diabetic rats were investigated in this study. ...

The effects of five different mushroom species (Ganoderma lucidum, GLM; Pleurotus ostreatus, POM; Pleurotus citrinopileatus, P …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: LC/MS analysis of mushrooms provided new insights into dietary management of diabetes mellitus in rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
877.
Basic Research of Material Properties of Mycelium-Based Composites.
- Vašatko H, Gosch L, Jauk J, Stavric M.
- Biomimetics (Basel). 2022 Apr 21;7(2):51. doi: 10.3390/biomimetics7020051.
- PMCID: PMC9150003
Vašatko H, et al.

Biomimetics (Basel). 2022.

PMCID: PMC9150003

The methodology includes evaluating several substrates, focused on beech sawdust, with two mycelium strains (Pleurotus ostreatus and Ganoderma lucidum), density calculations, compression tests, three-point flexural tests and capillary water absorption. ...

The methodology includes evaluating several substrates, focused on beech sawdust, with two mycelium strains (Pleurotus ostreatus and Gano …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Basic Research of Material Properties of Mycelium-Based Composites.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
878.
Mechanical properties of dense mycelium-bound composites under accelerated tropical weathering conditions.
- Chan XY, Saeidi N, Javadian A, Hebel DE, Gupta M.
- Sci Rep. 2021 Nov 11;11(1):22112. doi: 10.1038/s41598-021-01598-4.
- PMCID: PMC8586338
Chan XY, et al.

Sci Rep. 2021.

PMCID: PMC8586338

Here, we show how weathering conditions affect the DMC stress and elastic modulus. DMC was made using Ganoderma lucidum mycelium grown on a substrate of sawdust and empty fruit bunch. The DMC was then subjected to weathering under tropical conditions over 35 days an …

Here, we show how weathering conditions affect the DMC stress and elastic modulus. DMC was made using Ganoderma lucidum myceli …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Mechanical properties of dense mycelium-bound composites under accelerated tropical weathering conditions.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
879.
Ganoderic Acid DM: An Alternative Agent for the Treatment of Advanced Prostate Cancer.
- Johnson BM, Doonan BP, Radwan FF, Haque A.
- Open Prost Cancer J. Author manuscript. 2010 Jan 1;3:78-85. doi: 10.2174/1876822901003010078.
- PMCID: PMC4002166
Johnson BM, et al.

Open Prost Cancer J. Author manuscript. 2010.

PMCID: PMC4002166

In this review, we discuss one potential candidate, ganoderic acid, an extract from the Ganoderma lucidum mushroom that has been tested in multiple cancer models. Interestingly, ganoderic acid DM (GA-DM) has shown toxicity to both androgen-dependent and independent …

In this review, we discuss one potential candidate, ganoderic acid, an extract from the Ganoderma lucidum mushroom that has be …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Ganoderic Acid DM: An Alternative Agent for the Treatment of Advanced Prostate Cancer.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
880.
Phylogenetic analysis and morphology of Ganoderma multipileum, a Ganoderma species associated with dieback of the metropolitan woody plant Delonix regia (Boj. ex Hook.) Raf. in Vietnam.
- Nguyen TTT, Nguyen HD, Bui AT, Pham KHT, Van KTP, Tran LT, Tran MH.
- Sci Prog. 2023 Jul-Sep;106(3):368504231195503. doi: 10.1177/00368504231195503.
- PMCID: PMC10467396
Nguyen TTT, et al.

Sci Prog. 2023.

PMCID: PMC10467396

Ganoderma multipileum, a wood decay mushroom, was initially discovered and classified in Taiwan through the analysis of its morphology and the internal transcribed spacer (ITS) region of nuclear ribosomal DNA. ...Notably, scanning electron microscopy of the basidiospores r …

Ganoderma multipileum, a wood decay mushroom, was initially discovered and classified in Taiwan through the analysis of its morpholog …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Phylogenetic analysis and morphology of Ganoderma multipileum, a Ganoderma species associated with dieback of the metropolitan woody plant Delonix regia (Boj. ex Hook.) Raf. in Vietnam.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.

Page 89

881.
Single- and repeated-dose toxicities of aloe fermentation products in rats.
- Cho JH, Kim HK, Baik SO, Choi SY, Lee JY.
- Lab Anim Res. 2011 Sep 30;27(3):235-44. doi: 10.5625/lar.2011.27.3.235.
- PMCID: PMC3188731
Cho JH, et al.

Lab Anim Res. 2011.

PMCID: PMC3188731

In this study, aloe fermentation products were derived from mycelia from 3 mushrooms: Ganoderma lucidum (AG), Hericium erinaceum (AH), and Phellinus linteus (AP). Levels of aloin A and B increased with fermentation time. ...

In this study, aloe fermentation products were derived from mycelia from 3 mushrooms: Ganoderma lucidum (AG), Hericium erinace …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Single- and repeated-dose toxicities of aloe fermentation products in rats.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Animal (in vivo) study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Biomarkers, histology, behavior/physiology, and dose–response in animals. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
882.
Species diversity of Ganoderma (Ganodermataceae, Polyporales) with three new species and a key to Ganoderma in Yunnan Province, China.
- He J, Han X, Luo ZL, Li EX, Tang SM, Luo HM, Niu KY, Su XJ, Li SH.
- Front Microbiol. 2022 Oct 14;13:1035434. doi: 10.3389/fmicb.2022.1035434.
- PMCID: PMC9614375
He J, et al.

Front Microbiol. 2022.

PMCID: PMC9614375

Despite the importance of this fungus, the studies on the species diversity of Ganoderma in Yunnan Province, China (YPC) have poorly been carried out. During this study, opportunistic sampling was used to collect 21 specimens of Ganoderma from YPC. ...In addition, a …

Despite the importance of this fungus, the studies on the species diversity of Ganoderma in Yunnan Province, China (YPC) have poorly …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Species diversity of Ganoderma (Ganodermataceae, Polyporales) with three new species and a key to Ganoderma in Yunnan Province, China.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
883.
Isolation of laccase gene-specific sequences from white rot and brown rot fungi by PCR.
- D'Souza TM, Boominathan K, Reddy CA.
- Appl Environ Microbiol. 1996 Oct;62(10):3739-44. doi: 10.1128/aem.62.10.3739-3744.1996.
- PMCID: PMC168181
D'Souza TM, et al.

Appl Environ Microbiol. 1996.

PMCID: PMC168181

Computer searches of the databases identified the sequence of each of the PCR products analyzed as a laccase gene sequence, suggesting the specificity of the primers. PCR products of the white rot fungi Ganoderma lucidum, Phlebia brevispora, and Trametes versicolor …

Computer searches of the databases identified the sequence of each of the PCR products analyzed as a laccase gene sequence, suggesting the s …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Isolation of laccase gene-specific sequences from white rot and brown rot fungi by PCR.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Enzyme activity profiles, substrate specificity, and production conditions. Open article.
- Why might this paper be useful to readers? Relevant for eco‑friendly processing, waste upcycling, and industrial biocatalysis. Open article.
884.
CNS anti-depressant, anxiolytic and analgesic effects of Ganoderma applanatum (mushroom) along with ligand-receptor binding screening provide new insights: Multi-disciplinary approaches.
- Hossen SMM, Islam MJ, Hossain MR, Barua A, Uddin MG, Emon NU.
- Biochem Biophys Rep. 2021 Jul 9;27:101062. doi: 10.1016/j.bbrep.2021.101062.
- PMCID: PMC8278240
Hossen SMM, et al.

Biochem Biophys Rep. 2021.

PMCID: PMC8278240

This research was designed to evaluate the CNS depressant, anxiolytic, and analgesic action of aqueous and ethanol extract of Ganoderma applanatum, a valuable medicinal fungus used in multiple disorders belongs to Ganodermataceae family. ...

This research was designed to evaluate the CNS depressant, anxiolytic, and analgesic action of aqueous and ethanol extract of Ganoderma …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: CNS anti-depressant, anxiolytic and analgesic effects of Ganoderma applanatum (mushroom) along with ligand-receptor binding screening provide new insights: Multi-disciplinary approaches.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
885.
Growth Propagation of Liquid Spawn on Non-Woven Hemp Mats to Inform Digital Biofabrication of Mycelium-Based Composites.
- Biront A, Sillen M, Van Dijck P, Wurm J.
- Biomimetics (Basel). 2025 Jan 8;10(1):33. doi: 10.3390/biomimetics10010033.
- PMCID: PMC11762511
Biront A, et al.

Biomimetics (Basel). 2025.

PMCID: PMC11762511

This paper, part of a digital biofabrication framework, investigates the growth kinetics of Ganoderma lucidum and Pleurotus ostreatus on hemp non-woven mats, offering flexibility and mold-free fabrication using liquid inoculation. ...The experiment involved pre-cult …

This paper, part of a digital biofabrication framework, investigates the growth kinetics of Ganoderma lucidum and Pleurotus os …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Growth Propagation of Liquid Spawn on Non-Woven Hemp Mats to Inform Digital Biofabrication of Mycelium-Based Composites.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
886.
Anti-Adipogenic Lanostane-Type Triterpenoids from the Edible and Medicinal Mushroom Ganoderma applanatum.
- Peng XR, Wang Q, Su HG, Zhou L, Xiong WY, Qiu MH.
- J Fungi (Basel). 2022 Mar 22;8(4):331. doi: 10.3390/jof8040331.
- PMCID: PMC9028577
Peng XR, et al.

J Fungi (Basel). 2022.

PMCID: PMC9028577

Our previous research has shown that lanostane triterpenoids from Ganoderma applanatum exhibit significant anti-adipogenesis effects. In order to obtain more structurally diverse lanostane triterpenoids to establish a structure-activity relationship, we continued the study …

Our previous research has shown that lanostane triterpenoids from Ganoderma applanatum exhibit significant anti-adipogenesis effects. …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Anti-Adipogenic Lanostane-Type Triterpenoids from the Edible and Medicinal Mushroom Ganoderma applanatum.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Clarifies how specific mushroom compounds are produced, measured, or function in research settings. Open article.
887.
Additions to the knowledge of Ganoderma in Thailand: Ganoderma casuarinicola, a new record; and Ganoderma thailandicum sp. nov.
- Luangharn T, Karunarathna SC, Mortimer PE, Hyde KD, Xu J.
- MycoKeys. 2019 Oct 16;59:47-65. doi: 10.3897/mycokeys.59.36823.
- PMCID: PMC6811390
Luangharn T, et al.

MycoKeys. 2019.

PMCID: PMC6811390

Ganoderma is a cosmopolitan genus of mushrooms, which can cause root and butt rot diseases on many tree species. ...In this study, three Ganoderma strains were collected in tropical southern Thailand. Phylogenetic analyses of combined ITS, LSU, TEF1alpha and RPB2 se …

Ganoderma is a cosmopolitan genus of mushrooms, which can cause root and butt rot diseases on many tree species. ...In this study, th …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Additions to the knowledge of Ganoderma in Thailand: Ganoderma casuarinicola, a new record; and Ganoderma thailandicum sp. nov.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
888.
Potential of natural products and gut microbiome in tumor immunotherapy.
- Cao L, Wang X, Ma X, Xu M, Li J.
- Chin Med. 2024 Nov 20;19(1):161. doi: 10.1186/s13020-024-01032-7.
- PMCID: PMC11580227
Cao L, et al.

Chin Med. 2024.

PMCID: PMC11580227

Karst, Icariside I, Safflower yellow, Ganoderma lucidum, and Ginsenoside Rk3, and other Chinese native medicinal compound prescriptions to boost their efficacy of anti-tumor immunotherapy through the regulation of microbiota and microbiota metabolites. ...

Karst, Icariside I, Safflower yellow, Ganoderma lucidum, and Ginsenoside Rk3, and other Chinese native medicinal compound pres …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Potential of natural products and gut microbiome in tumor immunotherapy.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
889.
Natural Products in Renal-Associated Drug Discovery.
- Wruck W, Genfi AKA, Adjaye J.
- Antioxidants (Basel). 2023 Aug 11;12(8):1599. doi: 10.3390/antiox12081599.
- PMCID: PMC10451693
Wruck W, et al.

Antioxidants (Basel). 2023.

PMCID: PMC10451693

Additionally, we conducted a meta-analysis to identify gene signatures and associated biological processes perturbed in human and mouse cells treated with antioxidants such as epigallocatechin gallate (EGCG), the active ingredient in green tea, and the mushroom Ganoderma < …

Additionally, we conducted a meta-analysis to identify gene signatures and associated biological processes perturbed in human and mouse cell …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Natural Products in Renal-Associated Drug Discovery.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Research article (type not explicit in title). Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.
890.
Phorbol ester degradation in Jatropha seedcake using white rot fungi.
- Bose A, Keharia H.
- 3 Biotech. 2013 Sep 26;4(4):447-450. doi: 10.1007/s13205-013-0174-9.
- PMCID: PMC4145619
Bose A, et al.

3 Biotech. 2013.

PMCID: PMC4145619

All the white rot fungi tested exhibited degradation of phorbol ester during fermentation of JSC without adversely influencing the nutritional properties of the seedcake. Ganoderma lucidum and Trametes zonata were found to degrade phorbol ester in JSC to undetectabl …

All the white rot fungi tested exhibited degradation of phorbol ester during fermentation of JSC without adversely influencing the nutrition …
Quick FAQ for this paper (4 questions)
- What does this article investigate or review? From the title, it focuses on: Phorbol ester degradation in Jatropha seedcake using white rot fungi.. See the full text for detailed methods and results. Open article.
- What kind of study is it? Enzymology/bioprocessing study. Check the paper’s Methods for design and protocols. Open article.
- What outcomes or endpoints are typically reported? Outcomes and methods described in the paper’s Results/Methods sections. Open article.
- Why might this paper be useful to readers? Gives context for future research, product development, or cultivation/process decisions. Open article.