Cordyceps Research Database
Comprehensive Scientific Studies on Cordyceps sinensis
8+ peer-reviewed studies documenting Cordyceps' energy enhancement, immune support, and diabetes management benefits.
Studies at a Glance
Quick overview of all research studies - click any card to expand full details
Immunomodulatory Clinical Trial (2019)
Clinical TrialRandomized double-blind clinical trial demonstrating significant immunomodulatory effects in humans.
Diabetic Nephropathy Study (2021)
PharmacologyNetwork pharmacology analysis identifying multiple therapeutic targets for diabetic nephropathy treatment.
Type 2 Diabetes Treatment (2019)
Animal StudyPreserved renal function in Type 2 diabetic nephropathy mice with significant renal protection.
Immunomodulatory Effects Review (2024)
ReviewComprehensive review of Cordyceps polysaccharides immunomodulatory effects and mechanisms.
Galactoglucomannan Study (2023)
In Vitro/In VivoNew galactoglucomannan from Cordyceps cicadae with significant immunomodulatory activity.
Hypoxia Tolerance Study (2013)
In VitroIncreased hypoxia tolerance in human lung epithelial cells, enhancing oxygen utilization and cellular energy production.
Antioxidant and Hypoglycemic Effects (2018)
Animal StudySignificant antioxidant and hypoglycemic effects in Type 2 diabetes mice with enhanced energy metabolism.
Research Categories
Human Clinical Trials
Landmark human studies demonstrating Cordyceps' health benefits in real-world applications.
Immunomodulatory Clinical Trial (2019)
Randomized double-blind clinical trialKey Outcomes:
- Enhanced immune cell function
- Improved immune response markers
- Well-tolerated with no adverse effects
- Significant improvement over placebo
Citation: Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial. BMC Complementary and Alternative Medicine, 19(1), 6441223.
Diabetes Management Studies
Research demonstrating Cordyceps' benefits for diabetes and diabetic complications.
Diabetic Nephropathy Study (2021)
Network pharmacology studyKey Findings:
- Multiple molecular targets for diabetic nephropathy
- Renal protection mechanisms identified
- Anti-inflammatory effects
- Potential for kidney disease treatment
Citation: Based on Network Pharmacology Tools to Investigate the Molecular Mechanism of Cordyceps sinensis on the Treatment of Diabetic Nephropathy. Journal of Diabetes Research, 2021, 8891093.
Type 2 Diabetes Treatment (2019)
Animal studyKey Findings:
- Preserved renal function in diabetic mice
- Reduced kidney damage markers
- Anti-inflammatory effects
- Potential for diabetes complications
Citation: Cordyceps militaris Treatment Preserves Renal Function in Type 2 Diabetic Nephropathy Mice. Journal of Agricultural and Food Chemistry, 67(19), 5104498.
Immune System Studies
Research demonstrating Cordyceps' immune modulation and support mechanisms.
Immunomodulatory Effects Review (2024)
Comprehensive reviewKey Findings:
- Enhanced immune cell activation
- Improved immune response
- Anti-inflammatory effects
- Multiple immunomodulatory pathways
Citation: Cordyceps Polysaccharides: A Review of Their Immunomodulatory Effects. Frontiers in Immunology, 15, 11547421.
Galactoglucomannan Study (2023)
In vitro and in vivo studyKey Findings:
- New bioactive polysaccharide identified
- Enhanced immune cell function
- Anti-inflammatory properties
- Potential for immune support
Citation: A New Galactoglucomannan from the Mycelium of the Medicinal Parasitic Fungus Cordyceps cicadae and Its Immunomodulatory Activity In Vitro and In Vivo. International Journal of Biological Macromolecules, 2023, 10179787.
Energy Enhancement Studies
Research demonstrating Cordyceps' energy enhancement and athletic performance benefits.
Hypoxia Tolerance Study (2013)
In vitro studyKey Findings:
- Increased hypoxia tolerance
- Enhanced oxygen utilization
- Improved cellular energy production
- Potential for athletic performance
Citation: Cordyceps sinensis increases hypoxia tolerance by inducing heme oxygenase-1 and metallothionein via Nrf2 activation in human lung epithelial cells. American Journal of Chinese Medicine, 41(6), 3770031.
Antioxidant and Hypoglycemic Effects (2018)
Animal studyKey Findings:
- Enhanced antioxidant capacity
- Improved blood sugar regulation
- Increased energy metabolism
- Better glucose utilization
Citation: Antioxidant and Hypoglycemic Effects of Acidic-Extractable Polysaccharides from Cordyceps militaris on Type 2 Diabetes Mice. International Journal of Biological Macromolecules, 120, 6286747.
Research Summary
Evidence Level
Moderate - Promising in vitro and animal studies with some clinical evidence
Mechanism
Well-Understood - Polysaccharides and cordycepin for energy and immune support
Safety
Excellent - No significant side effects reported in clinical studies
Dosage
Established - 1-3g/day effective dose range for energy support
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